Saturday, May 17, 2025


Climate change is melting ice roads — a lifeline for remote Indigenous communities

As the key winter connectors disappear, First Nations are looking for all-season solutions amid a push for mineral extraction on their lands
WE NEED AIRSHIPS FOR THE NORTH

Jessie Boulard / Grist

This story was supported by the Pulitzer Center. It was produced by Grist and co-published with IndigiNews.


It was the last night of February and a 4×4 truck vaulted down the 167-kilometre winter road to Cat Lake First Nation in northern “Ontario,” a road made entirely of ice and snow. Only the light of the stars and the red and white truck lights illuminated the dense, snow-dusted spruce trees on either side of the road. From the passenger seat, Rachel Wesley, a member of the Ojibway community and its economic development officer, told the driver to stop.

The truck halted on a snow bridge over a wide creek — one of five made of snow along this road. It was wide enough for only one truck to cross at a time; its snowy surface barely two feet above the creek. Wesley zipped up her thick jacket and jumped out into the frigid night air. She looked at the creek and pointed at its open, flowing water.

“That’s not normal,” she said, placing a cigarette between her lips.

Wesley, who wore glasses and a knit cap pulled over her shoulder-length hair, manages the crews that build the winter road — a vital supply route that the community of 650 people relies on to truck in lumber for housing, fuel, food, and bottled water. In the past, winters were so cold that she could walk on the ice that naturally formed over the creek. Now it no longer freezes, and neither do the human-made snow bridges.

“It’s directly caused by global warming,” she said, lighting the cigarette.

Jessie Boulard / Grist

More than 50 First Nations in Canada — with 56,000 people total — depend on approximately 6,000 kilometres of winter roads. There are no paved roads connecting these Indigenous communities to the nearest cities. Most of the year, small planes are their only lifeline. But in winter, the lakes, creeks, and marshes around them freeze, allowing workers to build a vast network of ice roads for truck drivers to haul in supplies at a lower cost than flying them in.

Despite their isolation, the ice roads are community spaces. They guide hockey and broomball teams from small reserves to big cities to compete in tournaments. They enable families to stock up on cheap groceries. They bring people to medical appointments in cities and facilitate hunting and fishing trips with relatives in neighboring communities.

But the climate crisis is making it harder to build and maintain the ice roads. Winter is arriving later, pushing back construction, and spring is appearing earlier, bringing even the most robust frozen highways to an abrupt end. Less snow is falling, making the bridges smaller and more vulnerable to collapse under heavy trucks. 

The rising temperatures give trucks only a few short weeks to bring in supplies — and often with half-loads due to thin lake ice and fragile snow bridges. Last year, chiefs in northern “Ontario” declared a state of emergency when the winter roads failed to freeze on time, and in March this year, rain shut down the ice roads to five communities.

First Nations urgently need permanent roads, but it’s unclear who will pay for them. Government of Canada officials say it’s not their responsibility, and with price tags running into the hundreds of millions of dollars for each community, First Nations typically don’t have the money to fund them. 

But there is a third, more complex option: Many communities that rely on disappearing ice roads sit atop lucrative minerals. And where mining is approved, road permits and government funding soon follow.

The Ring of Fire and development on Indigenous lands

For nearly two decades, companies and governments have eyed a circular mining area in northern “Ontario” as a promise of economic prosperity. Named after the Johnny Cash song, the Ring of Fire spans 5,000 kilometres and contains chromite, nickel, copper, platinum, gold, and zinc, all of which can be used to make EV batteries, cell phones, and military equipment. Scattered across the north are dozens of mines that extract gold, iron, and other minerals, but none compare to the scale of the Ring of Fire.

But resistance by First Nations and a lack of paved roads has stalled extraction. Mining the region could threaten the fight against climate change: “Ontario’s” northern peatlands, for instance, sequester an estimated 35 billion tons of carbon that could be released if the land is mined. The proposed Ring of Fire mining area alone holds about 1.6 billion tonnes of carbon. To put that in perspective, the Amazon rainforest sequesters about 112 billion tonnes of carbon

Ontario Premier Doug Ford has longed for years to develop the Ring of Fire, even promising to “hop on a bulldozer” himself. The province, which is responsible for natural resources and road permitting, has committed CAD$1 billion to build permanent roads to open up mining, asking the federal government to kick in another CAD$1 billion. Meanwhile, at least a dozen First Nations in “Ontario” are requesting government funding for all-season roads.

During the recent election, Ford vowed to “unlock” the Ring of Fire and has introduced legislation to fast-track development, actions that some First Nation leaders perceived as a threat. The Nishnawbe Aski Nation, or NAN for short, a regional Indigenous government representing 49 First Nations in northern “Ontario,” warned the province that it was overstepping its authority. 

“The unilateral will of the day’s government will not dictate the speed of development on our lands, and continuing to disregard our legal rights serves to reinforce the colonial and racist approach that we have always had to fight against,” said NAN Grand Chief Alvin Fiddler in a statement. First Nations in the Ring of Fire area are not necessarily antidevelopment, but Fiddler said they must be engaged as partners under regional treaties.

Responding to the premier’s promise to get on a bulldozer, Eabametoong First Nation Chief Solomon Atlookan said, “Nobody’s gonna come without our consent.”

Located in the Ring of Fire region, Eabametoong relies on a winter road for supplies, including lumber for housing. The seasonal window for their ice road has shrunk so much that the community struggles to bring in enough materials to address a severe housing crisis. According to Atlookan, some homes have as many as 14 people living under one roof. Eabametoong used to haul fuel over the winter road, but it is now flown in at a much higher cost.

Atlookan said that building a permanent road could threaten traditional ways of life by bringing in tourists, allowing settlers more access to lands to build cottages, and increasing competition over hunting and fishing. But climate change and rising costs are forcing him to seriously consider a paved road.

“We need to begin working on it now,” he said.

Atlookan is not against mining but knows there are trade-offs. His community’s traditional territories contain countless interwoven streams, lakes, and rivers, and mining upstream could contaminate nearby walleye spawning habitat.

“They don’t realize how interconnected those tributaries are, where the fish spawn,” he said. ”It’ll destroy that livelihood for our communities. So there’s a lot at stake here.”

The province is motivated to build all-season roads to allow a more sustainable flow of goods as climate change threatens the ice roads, according to a spokesperson for Greg Rickford, “Ontario’s” minister of Indigenous affairs and First Nations economic reconciliation. They’re committed to “meaningful partnerships” to advance economic opportunities in the region, the spokesperson added.

But that’s not how Atlookan views the situation. He described a conversation he had with Rickford, who offered to build him an all-season road. He said he asked Rickford if he wanted access to minerals, and the minister denied that the road would be for mining access. “I said, ‘Rickford, that is what this is all about.’”

While Eabametoong is located in the Ring of Fire region and shares a network of winter roads with a cluster of other communities, Cat Lake is in a different situation.

Cat Lake is 257 kilometres west of Eabametoong, as the crow flies. The reserve rests at the edge of a watershed where five major rivers flow in opposite directions, affording the community access to various rivers for travel, hunting, and living off the land. It is not located in the Ring of Fire region and has its own winter road that doesn’t connect to other communities.

Cat Lake is rushing to build an all-season road by 2030 at a cost of CAD$125 million, which the community cannot afford on its own. Cat Lake is considering two routes for an all-season road. One option involves construction over the current 167-kilometre winter road. The other option is to piggyback on an all-season road that would be built to a gold mine, if it is approved. The Springpole mine site is 40 kilometres from Cat Lake, giving the community the option to build a shorter all-season road.

Jessie Boulard / Grist

First Mining Gold wants to drain a lake and dig a 1.5-kilometre open-pit mine to reach the gold underneath. To access Springpole, the company needs to build an all-season road.

In past years, company vehicles reached the site by driving over a winter road that passed over a frozen lake. But several times those vehicles plunged through the thin ice due to warm weather, according to First Mining Gold’s 2023 ESG report. The company figured it was too risky to keep crossing the lake, so it asked the province for permits to build an overland winter road.

Ontario issued a permit for the company to build the winter road without Cat Lake’s consent, prompting the First Nation to request an injunction to stop construction. The community dropped its court case after reaching a settlement with the province last year. First Mining Gold did not reply when asked for comment.

In September 2020, as the company prepared to apply for permits, Wesley invited Elders to a meeting to ask two questions: Did they support Springpole, and did they want an all-season road?

“In order for us to get a road, we might have to let them open the mine,” Wesley explained.

The Elders said they don’t value gold but do value lake trout, and they believed the project would destroy fish habitat. Elders also said they wanted an all-season road that would allow young people to connect with the world while embracing their culture.

“We said ‘no’ to the mine, and we said ‘yes’ to the road,” she said.

After the Elders’ meeting, Wesley began to look for ways to fund a permanent road without relying on mining. She said the federal government is hesitant to fund an all-season road to only one community, and the province won’t talk to Cat Lake about an all-season road. To unlock funding, she began pursuing economic partnerships like working with PRT Growing Services on forest regeneration and a local bioeconomy that would involve a tree-seedling nursery in the community. Cat Lake is also partnering with Natural Resources Institute Finland to do an assessment of their forests. 

“Relying on industry would mean that we would have to do mining with First Mining. And like I said, the community values land, air, and water. We don’t value gold,” she said.

‘Every year it’s been getting a little bit warmer’

The farther north you fly in “Ontario,” the fewer glimpses of infrastructure like power lines, cell towers, or paved roads. The winter landscape is composed of evergreen forests shot through with rivers and lakes, bright white from the snow resting on top. From a plane, the ice roads can be seen cutting through the trees and running over frozen lakes.

On a chilly, sunny afternoon on the Cat Lake winter road, Jonathan Williams drove a red truck with chains pulling heavy tires behind it. Known as “drags,” the tires smooth out the rough parts of the road. Warm weather makes the surface bumpy, requiring constant attention from workers like Williams, who has built winter roads for the last eight years.

“The year I started, it was minus 50 [degrees Celsius],” he said. “I was out fixing trucks on the road, and it was frickin’ crazy getting frostbite on your hands. After that, every year it’s been getting a little bit warmer, a little bit warmer.”

It costs about CAD$500,000 each year to build and maintain Cat Lake’s winter road. The warming climate is taking a toll on the machines used on the road, but the budget no longer covers the expense of a CAD$10,000 broken machine part.

Winter road construction, which splits the cost 50/50 between Indigenous Services Canada and the Ontario Ministry of Northern Development, typically starts in November or early December. That’s when crews drive heavy machines over the earth to press it down. When snow arrives, they use grooming machines to pack it.

Like many reserves, driving over Cat Lake’s winter road requires passing over a lake with no bridge. When winter arrives and lake ice begins to form, crews repeatedly flood the lake to make the ice sturdy enough for heavy trucks. When the ice is ready, workers celebrate by spinning their grooming machines in circles on the frozen surface, a ritual called their “happy dance.”

To build the required snow bridges, crews use grooming machines to jam huge piles of snow into creeks. They let the snow settle for about 36 hours and then flood it to form icy crossings. The flowing water underneath naturally forms the ice into a culvert shape. “That’s why you need such a massive pile of snow to push out there, because all the water will take it away if there’s not enough,” Williams said.

A century ago, before planes and trucks became ubiquitous, remote reserves used tractor trains to pull supplies in sleds over the frozen landscape.

“It’s a big bulldozer that pulls trailers behind them, sometimes 10 of them, and that’s where all the fuel came from, the groceries. Because they didn’t have big planes at the time,” explained Chief Atlookan of Eabametoong.

“Back in the day, you didn’t worry about ice conditions — the ice was 40 inches thick.”

The remoteness of reserves is a direct outcome of the country’s colonial history. In 1867, the British Parliament claimed “Canada” as a colony by passing the British North America Act, which later became its constitution. It granted the federal government exclusive authority over “Indians and lands reserved for Indians” and gave provinces authority over certain issues that affect First Nations, like mining.

Since European settlement, massive land grabs and the creation of reserves have left Indigenous peoples in “Canada” with only 0.2 percent of their original territories. Reserves were often deliberately sited in remote locations, away from critical waterways and productive farmland. There was never any intention of connecting reserves to cities; instead, they operated like jails, preventing people from moving off-reserve or seeking economic opportunities.

The federal government has a fiduciary responsibility to First Nations, as affirmed by the Supreme Court of Canada. Similar to the “U.S.” government’s relationship with tribes, this means the government has a legal duty to act in the best interest of Indigenous people.

“Since the [court’s] decision, they’ve been looking for ways to offload their fiduciary obligations,” said Russ Diabo, a First Nations policy analyst and member of the Mohawk Nation at Kahnawake.

Although the federal government is obligated to provide the necessities of life on the reserve, like housing and water systems, federal funding formulas are unregulated and up to the government’s discretion, explained Shiri Pasternak, professor at Toronto Metropolitan University. As a result, there are huge discrepancies between what is needed and what is approved. “The underfunding of reserves amounts to systematic impoverishment,” she said.

This chronic underfunding means many First Nations experience crowded homes and broken-down water treatment plants. Although the federal government has committed to ensuring clean drinking water on reserves, more than 30 First Nations currently have long-term drinking water advisories. This includes Neskantaga in northern “Ontario,” which has been under a boil water advisory for three decades. Last year, in response to a lawsuit over “Canada’s” failure to provide clean drinking water to First Nations, the federal government argued it has no legal duty to ensure First Nations have clean water.

Despite the federal government’s history of abandoning its duties to First Nations, more communities are looking to Indigenous Services Canada, or ISC, for road funding. Of the 53 First Nations that depend on winter roads, 32 have asked ISC for funding to develop all-season roads.

Adapting to a warming climate

The sun’s pink light disappeared over the horizon and night fell over the frozen lake surrounding Wesley’s community. She sat in the driver’s seat of her 4×4 truck that was parked on the lake’s icy surface. She watched as workers, bundled up in coats, toques, and boots, drilled a hole in the ice and pumped murky lake water through a hose into a machine. The spout of the machine, pointed upward at a 40 degree angle, blasted a stream of snowflakes into the air. 

A couple of years ago, Wesley asked her band council for a snowmaker.

“They thought I was crazy,” she said. “The chief finally told me, ‘Go ahead and buy a snowmaker.’” 

Wesley has managed winter road construction for the past eight years. Her dad was the community’s economic development officer before her and was also responsible for the winter road. She grew up crawling around big machines; she would climb them and pretend the floor was lava. 

When she took over her father’s job, men cast doubt on her ability to oversee winter road construction.

“She’s a girl, we don’t have to listen to her,” Wesley said, describing how they perceived her. “My dad told me, ‘You’re the boss. Tell them what to do.’” She said she proved herself, and now the workers respect her. They don’t ask questions, they do what she says. 

The snowmaker is a short-term adaptation. Wesley said the community has asked the provincial and federal governments to support construction of its all-season road.

Jessie Boulard / Grist

In an interview in March, ISC minister Patty Hajdu recognized the disappearing ice roads as an emergency.

“‘Emergency’ doesn’t even feel strong enough [to describe the situation],” she said. “It’s so urgent that we do more together to figure out what this next stage of living with climate change looks like for, in particular, remote communities.”

But Hajdu stopped short of committing funding for specific all-season roads. Instead, she said the cost will likely be shared but that the federal government was committed to funding all-season roads. “In theory, yes, but it isn’t as simple as a yes or no — it is project by project,” she said. “I can’t speak about specific amounts. I can’t speak about specific routes.”

She said the situation is more complex than it seems, and the province has complete control over which routes are prioritized and built.

ISC provided about CAD$260,000 for Cat Lake’s feasibility study to confirm potential routes for an all-season road. Hajdu said this is “an important step to the finalization of any infrastructure funding.”

Hajdu vowed not to tie all-season road funding to the acceptance of mining projects. “We should not be increasing funding for First Nations in any realm as a condition of approval for anything. That is very coercive and it’s very colonial,” she said.

“I wouldn’t believe it, because they use money as a way to coerce decisions. They may not directly openly tie it,” said Diabo, the policy analyst. 

Last year, ISC allocated CAD$45 million for construction of a bridge and permanent road to Pikangikum First Nation, which has a winter road that crosses a lake. Although the government announcement did not mention mining, the road will also lead to a proposed lithium mine.

Each summer, more fires burn through northern forests, Diabo said.

“We’re in a time of emergency, and the issue of the disappearing winter roads is part of that.”

Under the dual pressures of climate emergencies and extractive industries, some communities will decide to go forward with mining to build all-season roads. “We’re seeing that already,” he added.

In October, Wesley visited the lake that First Mining wants to drain for its proposed Springpole project. The company’s open-pit mine is in the final stages of the permitting process, and the company expects to receive federal approval by the end of this year.

For Wesley, the area isn’t just beautiful, it’s a reminder of her connection as an Ojibway person to the water, trees, fish, and land. It’s a relationship she described by saying, “I belong to the land.”

“I was almost crying, because the land is forever going to be changed in that area,” she said. “We’re gonna have a hole in the ground that’s forever going to be there. I don’t know how not to be emotional about that. Those are my relatives.” 

Author

HILARY BEAUMONT

Hilary Beaumont‬‭ is an investigative journalist covering the climate crisis and‬ intersecting issues. Her work has appeared in The Guardian, Al‬ Jazeera, Rolling Stone, VICE News, The New Republic, and High Country News, among others.

 

AI-enabled ECG algorithm performs well in the early detection of heart failure in Kenya




European Society of Cardiology





Belgrade, Serbia – 17 May 2025. An artificial intelligence-enabled electrocardiogram-based algorithm performed well in the early detection of heart failure among healthcare-seeking individuals in Kenya, according to late-breaking research presented today at Heart Failure 2025,1 a scientific congress of the European Society of Cardiology (ESC). 

Heart failure is highly prevalent in Sub-Saharan Africa, where patients are often younger and face worse outcomes than in high-income countries.2 Explaining the rationale for the current study, presenter Dr. Ambarish Pandey from the University of Texas Southwestern Medical Center, Dallas, Texas, USA, said: “Early detection of left ventricular systolic dysfunction (LVSD) represents an important strategy to identify patients who are likely to develop heart failure and yet there is little access to echocardiography, the gold standard method to diagnose LVSD, in resource-limited settings. We conducted a study in Kenya to determine whether LVSD could be assessed from an electrocardiogram (ECG) using validated artificial intelligence (AI)-based software3 as a potential scalable approach to screen large populations.” 

This prospective cross-sectional multicentre screening study included adult patients who attended eight healthcare facilities in Kenya. Cardiovascular risk factor burden was assessed with a classification of high cardiovascular risk based on prior cardiovascular disease (CVD) or Framingham Risk Score (FRS) >10%. All participants had a 12-lead ECG and the prevalence of LVSD (left ventricular ejection fraction <40%) was assessed by the AI-ECG algorithm (AiTiALVSD; Medical AI Co, Seoul, Republic of Korea). The AI-ECG algorithm predicted LVSD probability using a pre-established threshold of >0.097 to define high risk. A subset of participants had LVSD assessments by both the AI-ECG algorithm and echocardiography to evaluate the AI-ECG model’s performance. 

The evaluable study cohort included 5,992 participants who had a mean age of 55 years, two-thirds were female (66%) and 65% were classified as being at high cardiovascular risk. 

The prevalence of LVSD using the AI-ECG algorithm was 18.3%, with a higher prevalence among those with high Framingham risk score (FRS, 22.9%) or existing CVD (32.0%) than those with low FRS (9.9%). 

In 1,444 participants with paired assessments, echocardiography-confirmed LVSD was present in 14.1%. The AI-ECG algorithm demonstrated excellent performance metrics compared with echocardiography: sensitivity was 95.6%, specificity was 79.4% and the negative predictive value was 99.1%. “Our study shows the potential utility of AI-ECG algorithms as a relatively low cost and scalable tool for screening for heart disease including heart failure in at-risk populations in resource-limited societies,” added Dr. Bernard Samia, senior author and President of the Kenya Cardiac Society. 

Dr. Pandey concluded: “It was striking that the AI-ECG algorithm identified LVSD in almost 1 in 5 individuals, highlighting the large population at risk of heart failure. Given that the AI-ECG algorithm performed well against the gold standard method, we would now like to conduct larger screening studies across several countries in Africa. It will also be important to investigate whether identification of LVSD leads to greater use of evidence-based therapies.”  

ENDS  

 ESC Press Office 
Tel: +33 6 61 40 18 84   
Email: press@escardio.org 

Follow us on X @ESCardioNews  

Funding:  The study was funded by research grant support from Astra Zeneca and in-kind support from Tricog Health. 

Disclosures: Dr. Pandey reports research support from the National Institute on Minority Health and Disparities (R01MD017529), the National Institute of Heart, Lung, and Blood Institute (R21HL169708), American Heart Association, Ultromics, Anumana, SC Pharmaceuticals, SQ Innovation, Astra Zeneca and Roche Diagnostics. He serves as a consultant for and/or received honoraria outside of the present study as an advisor/consultant for Northwestern University, Tricog Health Inc, Lilly USA, Rivus, Cytokinetics, Roche Diagnostics, Sarfez Therapeutics, Edwards Lifesciences, Merck, Bayer, Anumana, Novo Nordisk, Alleviant, Pfizer, Abbott, iRhythm, Axon Therapies, Kilele Health, Acorai, Ultromics, Kardigan, Novartis, Idorsia Pharma, and Science37; and has also served as a consultant for Palomarin Inc. with stocks compensation. Dr. Samia has no disclosures to report. 

References and notes:   

1‘Implementing an AI-ECG based algorithm to screen for left ventricular dysfunction in Kenya: a prospective cohort study’ will be presented during Late-breaking science: diagnostic methods and assessment on 17 May from 13:45 to 14:45 CET in Room 1. 

2Siddikatou D, Linwa EMM, Ndobo V, et al. Heart failure outcomes in Sub-Saharan Africa: a scoping review of recent studies conducted after the 2022 AHA/ACC/HFSA guideline release. BMC Cardiovasc Disord. 2025;25:302. 

3Kwon JM, Kim KH, Jeon KH, et al. Development and validation of deep-learning algorithm for electrocardiography-based heart failure identification. Korean Circ J. 2019;49:629–639. 

 

About the European Society of Cardiology 

The ESC brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people to live longer, healthier lives. 

 

About Heart Failure 2025  
Heart Failure is the annual congress of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).  #HeartFailure2025 

  

About the Heart Failure Association 

The Heart Failure Association (HFA) is a branch of the European Society of Cardiology (ESC). Its aim is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research. 

   

Information for journalists about registration for Heart Failure 2025 

Heart Failure 2025 takes place from 17 to 20 May at the Sava Centar, Belgrade, Serbia and online. Explore the scientific programme 

  • Credentials: A valid press card or appropriate letter of assignment with proof of three recent published articles. Read the ESC media and embargo policy

  • The ESC Press Office will verify the documents and confirm by email that your press accreditation is valid. 

  • The ESC Press Office decision is final regarding all press registration requests. 

SPAGYRIC HERBALISM

No cardiac safety concerns reported with a pharmaceutically manufactured cannabidiol formulation



European Society of Cardiology






Belgrade, Serbia – 17 May 2025. A pharmaceutically produced cannabidiol formulation had a good overall safety profile, including cardiac safety, according to research presented today at Heart Failure 2025,1 a scientific congress of the European Society of Cardiology (ESC). 

Currently, there are limited treatment options for inflammatory conditions of the heart, such as myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the membrane surrounding the heart). Cannabidiol – which lacks the psychotropic effects of cannabis – has been shown to inhibit activation of the inflammasome pathway,2 an intracellular process known to be involved in the development and progression of myocarditis, pericarditis and heart failure. 

Explaining the rationale for the current trial, Co-Principal Investigator, Dr. Leslie Cooper from the Mayo Clinic, Jacksonville, Florida, USA, said: “We knew that patients with cardiovascular disease (CVD) or CVD risk factors who were hospitalised for COVID-19 infection may be at high risk of cardiac inflammation. We conducted a placebo-controlled trial of an oral pharmaceutically manufactured (GMP) cannabidiol formulation to assess its efficacy and safety. The pandemic ended before we had recruited sufficient participants to analyse whether GMP-cannabidiol had a positive effect on the primary efficacy endpoint but we thought that the lack of safety signals was important data to share.” 

This prospective trial included adult patients with a prior history of CVD and/or at least one major risk factor for CVD who had been hospitalised for non-critical COVID-19 infection. Participants were randomised to either GMP-cannabidiol titrated up to 7.5 mg/kg twice daily (or maximum tolerated dose) or placebo. The primary safety endpoint was the number of serious adverse events (SAEs) and adverse events (AEs) during the 60 days following randomisation. 

The trial was terminated early due to a lack of eligible patients with COVID-19 to support full recruitment. The recruited safety population included 89 patients (mean age of 61 years; 43% female): 45 patients received GMP-cannabidiol and 44 received placebo. 

Overall safety was similar between the groups. The frequency of investigator-assessed treatment-related AEs was 24.4% with GMP-cannabidiol and 22.7% with placebo. The frequency of SAEs was 11.1% with GMP-cannabidiol and 9.1% with placebo. There were 0 deaths in the GMP-cannabidiol group and 2 deaths in the placebo group, both due to respiratory failure. 

There were no significant differences between groups in the most common AEs of gastrointestinal disorders (GMP-cannabidiol: 22.2%; placebo: 20.5%); nervous system disorders (GMP-cannabidiol: 17.8%, placebo: 18.2%); and respiratory, thoracic and mediastinal disorders (GMP-cannabidiol: 11.1%, placebo: 9.1%). 

Of note, the cardiovascular safety profile of GMP-cannabidiol appeared similar to that of placebo. Cardiac disorders were reported in 4 patients (9%) in both the GMP-cannabidiol group and the placebo group. One patient (2%) in the GMP-cannabidiol group developed mild QTc prolongation detected by electrocardiogram (ECG). However, overall, changes in ECG measurements were minimal, with similar mean QTc values from baseline to day 28 in the GMP-cannabidiol group (425 msec and 418 msec, respectively) and in the placebo group (418 msec and 419 msec, respectively). 

Summarising the findings, Dr. Cooper said: “GMP-cannabidiol was well tolerated overall and most importantly, the rate of cardiac side effects was low and similar compared with placebo. These safety data are encouraging as two larger trials assessing efficacy and safety are underway with GMP-cannabidiol. The phase II ARCHER trial3 in patients with acute myocarditis is expected to report later in 2025, while results from the phase III MAVERIC trial4 in patients with recurrent pericarditis are expected in 2026.” 

ENDS  

ESC Press Office 
Tel: +33 6 61 40 18 84   
Email: press@escardio.org 

Follow us on X @ESCardioNews  

Funding: The trial was funded by Cardiol Therapeutics Inc. 

Disclosures: Dr. Cooper serves as a consultant to Cardiol Therapeutics Inc. 

References and notes: 

1‘Cardiac safety of pharmaceutically manufactured cannabidiol in patients at increased cardiovascular risk’ will be presented during ePosters in myocardial disease (1) on 17 May at 10:46 CET on ePosters screen 13 in the Research Gateway. 

2Martinez Naya N, Kelly J, Corna G, et al. Molecular and cellular mechanisms of action of cannabidiol. Molecules. 2023;28:5980. 

3McNamara D, Cooper LT, Arbel A, et al. Impact of cannabidiol on myocardial recovery in patients with acute myocarditis: Rationale & design of the ARCHER trial. ESC Heart Fail. 2024;11:3416–3424. NCT05180240

4NCT06708299

 

About the European Society of Cardiology 

The ESC brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people to live longer, healthier lives. 

 

About Heart Failure 2025  
Heart Failure is the annual congress of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).  #HeartFailure2025 

  

About the Heart Failure Association 

The Heart Failure Association (HFA) is a branch of the European Society of Cardiology (ESC). Its aim is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research. 

   

Information for journalists about registration for Heart Failure 2025 

Heart Failure 2025 takes place from 17 to 20 May at the Sava Centar, Belgrade, Serbia and online. Explore the scientific programme 

  • Credentials: A valid press card or appropriate letter of assignment with proof of three recent published articles. Read the ESC media and embargo policy

  • The ESC Press Office will verify the documents and confirm by email that your press accreditation is valid. 

  • The ESC Press Office decision is final regarding all press registration requests. 

 

Climate-smart ocean solutions require distinguishing marine spatial planning and marine conservation planning



Faculty of Sciences of the University of Lisbon




Peer-Reviewed Publication

Faculty of Sciences of the University of Lisbon

Sea turtle swims in a coral reef in Hawaii 

image: 

A sea turtle swims in a coral reef in Hawaii. Ocean acidification, found to be on the brink of crossing a boundary into higher-risk territory, can affect coral skeleton formation.

view more 

Credit: Toby Matthews via Ocean Image Bank





In a paper published this week in npj Ocean Sustainability (Nature group), researchers propose pathways to optimise synergies between marine spatial planning (MSP) and marine protected area (MPA) planning under a rapidly changing climate. The team highlights that both concepts serve different goals and result in different outcomes. This recognition is stressed as a prerequisite to dispel confusion and provide a clear pathway to climate-smart sustainable solutions.

Led by Dr. Catarina Frazão Santos, an invited assistant professor at the Faculty of Sciences of the University of Lisbon, affiliated member of the Marine and Environmental Sciences Centre at the University of Lisbon and honorary research associate at the University of Oxford, the team includes scientists and practitioners from Portugal (University of Lisbon and University of the Azores), United States (Sound Seas), Italy (National Research Council), Canada (Fisheries and Oceans Canada), and the United Kingdom (University of Oxford).

MSP and MPA planning are two area-based management processes used worldwide to support sustainable ocean use and conservation. While they share a variety of similarities, they target different goals and objectives, and use different methodologies, tools, and practitioner skillsets. Still, the concepts of MSP and MPA planning are often used interchangeably in multiple contexts, leading to confusion, conflict, and missed opportunities to support sustainable ocean solutions. 

“Marine spatial planning and marine protected area planning are not the same. But both play a key role in addressing the current climate-biodiversity crisis. We must move from conflation to leveraging synergies to support a sustainable ocean effectively.” Catarina Frazão Santos, Invited Assistant Professor at the University of Lisbon (CIÊNCIAS and MARE), and Honorary Research Associate at the University of Oxford.

As the world moves to incorporate climate change considerations into planning, it is fundamental to dispel confusion and provide a clear pathway for practitioners to adopt ‘climate-smart’ approaches in MSP and MPA planning practices. Clearly recognising MSP and MPA planning as serving different goals and resulting in different outcomes is a prerequisite to moving from conflation towards leveraging synergies between them.

“We need a clearer, consistent approach to defining concepts in maritime spatial planning and marine protected areas, escaping the current trend of excessive wording/rewording that risks creating unnecessary confusion and hampering effective implementation”. Helena Calado, Associate Professor at the University of the Azores.

To this purpose, the authors highlight and discuss five key aspects that set MSP and MPA planning apart: (i) the use of zonation, (ii) scale (temporal and spatial), (iii) stakeholder involvement, (iv) ability to take a systems view, and (v) integration of climate change considerations. The authors further identify seven key pathways to leverage synergies on how climate-smart MSP can support MPA planning: (i) supporting MPA site identification, (ii) setting the stage for dynamic MPA’s, (iii) informing MPA redesign and adaptation, (iv) promoting ecosystem recovery and restoration, (v) examining trade-offs between use and conservation, (vi) strategically allocating ocean uses, and (vii) anticipating and adapting to potential futures.

While recognizing differences, planners and managers should note that MSP and MPA planning are not interchangeable (nor competing) approaches. MSP is not intended to substitute MPA planning or promote economic growth at the expense of biodiversity, ecosystem health, and collective human well-being. The processes are mutually synergistic and should work in parallel and be further integrated to support ocean sustainability under dramatic and rapid change.

Forest and coastal line in Indonesia.

Credit

Erik Lukas via Ocean Image Bank

Sea turtle over a coral reef, Fiji.

Credit

Tom Vierus via Ocean Image Bank

 

Dual associations with two fungi improve tree fitness



Agroecology and plant-microbiome interactions



University of Zurich

Clitocybe 

image: 

Clitocybe are fungi that form a mycorrhiza: a symbiosis with a tree in which the fungal filaments are in contact with the fine root system of the plant.

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Credit: Christian Körner, University of Basel





When trees and soil fungi form close associations with each other, both partners benefit. Many tree species have further enhanced this cooperation by forming a concurrent symbiosis with two different groups of mycorrhizal fungi. Those trees cope better with water and nutrient scarcity, which is an important trait for forestry in the face of climate warming.

Despite having enormous root systems, trees often are unable to take up enough water and nutrients from soil to grow in a healthy manner. That’s why most terrestrial plants have formed symbiotic associations with fungi over the course of evolution. These mycorrhizal fungi, which either wrap themselves around roots or penetrate the cells of root systems, receive part of the sugar produced by plant photosynthesis from trees as a source of energy. In exchange, trees receive nutrients like phosphate and nitrate as well as water from the fungi in an unromantic marriage of convenience of sorts.

Dual symbioses expand habitat

Using more than 400 different tree species spread around the world as a basis, researchers at the University of Zurich (UZH) and Agroscope have shown that many of them have further improved this cooperation system. Although most tree species form an association only with a single type of mycorrhizal fungi, “some woody plants form an alliance with two fungus types simultaneously,” says Ido Rog from the Department of Plant and Microbial Biology at UZH.

The researchers now show that “bigamy” of this kind improves tree fitness, making trees less sensitive to drought and rendering them better able to cope with nutrient scarcity. “They thus are able to colonize a much larger territory than tree species that form a symbiosis with only one fungus type can,” lead author Rog says. The broader geographical range and the expanded environmental niche space occupied by those trees are independent of their phylogenetic architecture and evolutionary history.

More resistant to heat and drought

The concurrent associations with two different mycorrhizal fungi enlarge the diversity of trees’ nutrient supply because their roots cover a more extensive soil profile and are capable of coping with a more diverse range of soil properties. “Our findings indicate that polygamy with two fungus varieties served as a strategy enabling trees to adapt to rougher environmental conditions and to thus colonize nutrient-poorer niches and endure harsher climates,” UZH professor Marcel van der Heijden says. So, the distribution of trees with dual symbioses is much more pronounced in dryer areas, for example, than in rainier habitats.

“In forestry, this knowledge could be helpful in the future for selecting tree species specialized in dual fungal associations because they are likely to be better at coping with ongoing global warming and could be used to colonize dry climate zones,” van der Heijden explains.


The milk-caps (Lactarius) also form a mycorrhiza, a symbiotic relationship with deciduous or coniferous trees.

Credit

Ido Rog, University of Zurich