Sunday, October 02, 2022

The mystery of Agatha Christie’s vanishing act – as solved by a TV sleuth

ByCraig Simpson
October 1, 2022 

The mystery over an event in the private life of Agatha Christie has remained as intriguing as one of her own whodunnits.

The crime author once disappeared for 11 days – an episode that made international headlines in 1926 and even saw speculation that she had been killed or had taken her own life.

Agatha Christie seen in 1946 with her husband, Max Mallowan, whom she married after her first marriage collapsed.

The incident has perplexed biographers ever since. However, television historian Lucy Worsley believes she has cracked the case, arguing that the disappearance – which Christie claimed not to remember – was the result of a rare psychological disorder caused by emotional trauma.

Worsley has said Christie entered a “fugue state”, in which sufferers lose all sense of self while experiencing amnesia and setting off on journeys to unexpected locations.

She researched the event for a biography and told BBC History magazine: “By 1926, Agatha was a successful novelist and under a lot of pressure to keep producing books. But her mother died that year and she went into what today would be described as a depression.

“She reported forgetfulness, tearfulness, insomnia, an inability to cope. Her mental state became so bad she considered suicide. She then entered, I believe, into a fugue state. This is a very rare condition, causing you to adopt another persona, so that you don’t have to think about the trauma you’ve been experiencing.”

Agatha Christie, centre, creator of the reliable Miss Marple (Geraldine McEwan) and Hercule Poirot (Kenneth Branagh), is inspiring a new wave of crime fiction.


In the same year as losing her mother, Christie, then 36, discovered her husband Archibald was having an affair. Worsley believes all this was sufficient to trigger a fugue state.

In December, Christie’s car was abandoned near Guildford, Surrey, and police began a search that involved up to 15,000 volunteers.

Rumours began to circulate that Christie had killed herself. Others speculated that the vanishing was a publicity stunt, a claim angrily denied by the author’s secretary.

Detectives consulted Christie’s own work in a bid to ascertain her motives, but the author eventually turned up in Harrogate, North Yorkshire, with no memory of what she did or who she was. The writer had booked into a hotel under the name Tressa Neele. Years later, Neele was revealed as the surname of her husband’s mistress.

The reference to her love rival led some to speculate that Christie had staged a stunt to spite her cheating husband or frame him.

Worsley disagrees. “That’s not framing your husband for murder, that is a really serious mental-health condition,” she said.

A few months after Christie’s ordeal, she filed for divorce. Two years later, she remarried and her ex-husband married Ms Neel
Zimbabwe Court Finds Author and Activist Tsitsi Dangarembga Guilty of Inciting Violence


ThisisAfrica
Tsitsi Dangarembga.

29 SEPTEMBER 2022
Deutsche Welle (Bonn)

The 2021 winner of the Peace Prize of the German Book Trade was among scores of people arrested during anti-government protests in 2020. Tsitsi Dangarembga has been given a suspended prison sentence.

Zimbabwean author and activist Tsitsi Dangarembgaon Thursday was found guilty on charges of inciting violence.

Her husband, Olaf Koschke, confirmed the ruling to the German press agency DPA.

The author was handed a six-month suspended prison sentence as well as a $120 (€123) fine.

The author, activist and playwright was among a number of people arrested in July 2020 for joining demonstrations against government corruption.

Why was Dangarembga convicted?

She was arrested and charged, alongside another friend and journalist Julie Barnes, with incitement of violence, breaching the peace and bigotry.

The two argued in court that they had been exercising their freedom of expression.

But the judge, Magistrate Barbara Mateko, said the pair were intent on provoking violence.

"Clearly they wanted to pass a message. It was not peaceful at all," Mateko said in her judgment. "They were expressing opinions, and it was meant to provoke."

The trial had dragged on for many months, with Dangarembga having already made dozens of court appearances.

Rights groups have said the charges are part of President Emmerson Mnangagwa's attempt to clamp down on opposition figures.

Dozens of opposition supporters, political activists, journalists, trade union members and church leaders have faced similar charges.

Dangarembga's artistic achievements

Dangarembga was the recipient of the 2021 Peace Prize of the German Book Trade.

She was the first Black woman to win, with the judges praising her as "not just one of her country's most important artists but also a widely audible voice of Africa in contemporary literature."

The author found her first success aged 25 with the novel "Nervous Conditions" in 1988. This was followed up by two other books in a trilogy, with the most recent one coming out in 2018.

ab,kmb/jcg (AP, dpa, EPD)
Nigeria: GMOs Flood Nigerian Markets, As Federal Govt Urged to Examine Biosafety Guidelines


Pixabay
(file photo).

29 SEPTEMBER 2022
Leadership (Abuja)

Over 30 different products mostly imported from USA, China, India and South Africa, labelled to be produced with genetically modified ingredients are in the Nigerian market, a research has showed, even as stakeholders have urged the government to re-examine the entire architecture of biosafety in this country, to protect Nigerians from consuming unwholesome foods.

Genetically Modified Organisms (GMOs) are products of genetic engineering which is also known as genetic modification (GM) or modern biotechnology. This technology allows scientists to create plants, animals and micro-organisms by manipulating genes in a way that is not possible via traditional or natural processes. A survey by Health of Mother Earth Foundation (HOMEF), carried out in nine major cities in Nigeria and at least 10 shops/supermarkets, revealed that over 30 products including vegetable oils, cereals, noodles, ice cream, salad creams and food spices, labelled to be produced with genetically modified ingredients are in the Nigerian market.



While these products may be cheap, stakeholders told me that crops are genetically modified to act as pesticides against target pests or to be resistant to herbicides, hence GMOs are accompanied by heavy doses of chemicals which are highly toxic and linked to serious health defects. Programmes manager, HOMEF, Joyce Brown said, genetic manipulation of crops poses grave concern for food systems, human and environmental health. For instance, glyphosate, a major component of roundup ready herbicide which accompany a majority of genetically modified products, has been said to be a possible-causing agent, Brown said.

She disclosed that several countries have taken a stand against genetically modified food products because they have found that these products do not give the benefits or show characteristics that they are acclaimed to possess. To regulate GMOs in Nigeria, the programmes manager said the federal government sets up a regulatory agency called the National Biosafety Management Agency; however, the agency has approved several genetically modified food products to be imported into the country.

"As at 2020 when we counted, there were over 20 approvals. We have written to the agency to see the report of the risk assessment conducted on these products before it was approved for importation and we found out that for some products, the assessment was on environmental implication like how crops interact with other crops, but there was no research done in terms of how GMOs affect human health in the long run. Nigerians are being ambushed into using genetically modified products," Brown revealed.

The other issue is that of labelling, environmental justice and food sovereignty activist, Nnimmo Bassey tells me, adding that, "Though the agency said the GM products are labelled, to enable Nigerians decide whether they want to consume them or not, it is not possible for labelling to work in Nigeria, because of the way we sell and consume food. We have foods being sold in basin and baskets in the common market where majority of Nigerians buy their products. How can Nigeria detect beans that was preserved with GMOs? As a country, we need to take a stand against these products."
GLOBALIZED OUTSOURCING
Kenya to list skilled refugees for online work
POST FORDIST PROLETARIAT

SATURDAY OCTOBER 01 2022

Students at a school in Dadaab Refugees Complex in northeastern Kenya.

By MARY WAMBUI

Kenya plans to start a programme to list skilled refugees in a digital database to enable them get work from international organisations interested in outsourcing services.

The Ajira Digital Programme will be implemented by the Kenya Private Sector Alliance (KEPSA) and funded by the MasterCard Foundation, both of which say they will help push for adoption of refugees into legal work by also providing constant training opportunities.

Read: CLEMENTS: Kenya’s generosity towards refugees is impressive

Also read: How refugees bring along their music and culture, creating a melting pot

KEPSA, with the Amahoro Coalition, a platform of private organisations in the region, will target refugees in Kakuma and Dadaab, Kenya’s refugee centres that host more than 400,000 people.

Nairobi is taking advantage of the programme to entice refugees to leave the camps once they get legal work.

Kenya has traditionally allowed refugees to stay out of camps if they prove they can afford basic needs on their own.

But the refugee camps have had security issues in the past with Nairobi promising to close the two camps down on several occasions, citing terror threats.

Read: Kenya plans to close world's biggest refugee camp Dadaab: document

Also read: Kenya revises refugee camp closure to June 2022

Last year, however, Kenya’s Interior Ministry agreed to stagger the closure of the camps based on voluntary departure as well as gradual programmes to enable refugees live normally in the country or find work abroad.

Officials did not indicate how many refugees will initially benefit from the Ajira programme, but they said that many refugees in camps may face challenges due to lack of adequate skills, limited movement, limited access to formal education, and lack of a form of identity.

“We have a lot of talent waiting to be tapped among the refugee population in Kenya,” said Dr Ehud Gachugu, Project Director- Ajira Digital Program and Youth Employment at KEPSA.

Read: Kenya targets easier integration of refugees

“We have seen many examples of bright but marginalised young people delivering quality work to global clients through online platforms. Our aim is, therefore, to help grow and harness this talent to also deliver work for our local businesses, thus creating even more opportunities for refugees to add value not only in their local communities but also nationally.”

Ajira Digital Programme initially only served Kenyans with beneficiaries now at 1.9 million people since 2020 when it was launched for Kenyans.

A study dubbed ‘Private Sector Digital Outsourcing Practices in Kenya’ further indicates that 59 percent of the private sector in Kenya are currently outsourcing digital services with another 75 percent intending to outsource in the future.

Read: Education still elusive goal for refugees even with Uganda’s open door policy

Another study by the Amahoro Coalition and the International Trade Center (ITC) on “Kenya’s Private Sector Digital Outsourcing Landscape and Its Potential to Support Refugee Economic Inclusion” indicates that a lack of awareness of the skills and potential available among the refugee community is the greatest barrier to companies working with refugees. This is despite companies that had previously worked with refugee freelancers expressing satisfaction with their ability to deliver quality, timely and cost-effective work.

Kenya’s two refugee camps are located in Turkana and Garissa counties, some of the driest areas in Kenya. They host refugees from Somalia, Ethiopia, South Sudan, DR Congo and Burundi.
Protesters rally across Iran in third week of unrest over Amini's death

October 2, 2022

Iranian protesters march down a street on October 1, 2022 in Tehran, Iran. Protests over the death of 22-year-old Iranian Mahsa Amini have continued to intensify despite crackdowns by the authorities, The 22-year-old Iranian fell into a coma and died after being arrested in Tehran by the morality police, for allegedly violating the countries hijab rules.
[Getty Images]

Protesters rallied across Iran and strikes were reported throughout the country's Kurdish region on Saturday as demonstrations ignited by the death of a woman in police custody entered their third week.

The protests, sparked by the death of Mahsa Amini, a 22-year-old from Iranian Kurdistan, have spiralled into the biggest show of opposition to Iran's clerical authorities since 2019, with dozens killed in unrest across the country.

People also demonstrated in London, Rome, Madrid and other Western cities in solidarity with Iranian protesters, holding pictures of Amini, who died three days after being arrested by the Islamic Republic's morality police for "unsuitable attire".

In Iran, social media posts showed rallies in large cities including Tehran, Isfahan, Rasht and Shiraz.

In Tehran's traditional business district of Bazaar, anti-government protesters chanted "We will be killed one by one if we don't unite", while elsewhere they blocked a main road with a fence torn from the central reservation, videos shared by the widely followed Tavsir1500 Twitter account showed.

READ: Iran security forces were ordered to 'mercilessly' crack down on protests, leaked documents show

Students also demonstrated at numerous universities. At Tehran University, dozens were detained, Tavsir1500 said. The semi-official Fars news agency said some protesters were arrested in a square near the university.

A video posted on social media appeared to show protesters giving flowers to members of the riot police in Tehran, a recreation of Iranians winning over the military to their side in the 1979 Islamic revolution.

Reuters could not verify the social media reports.

The protests began at Amini's funeral on Sept. 17 and spread to Iran's 31 provinces, with all layers of society, including ethnic and religious minorities, taking part and many demanding Supreme Leader Ayatollah Ali Khamenei's downfall.
Hundreds injured

Amnesty International has said a government crackdown on demonstrations has so far led to the death of at least 52 people, with hundreds injured. Rights groups say dozens of activists, students and artists have been detained.

In London, about 2,500 people, many of them Iranians, staged a noisy protest in Trafalgar Square. In Paris, a crowd of several dozen people held Iranian flags and pictures of victims who have died in the protests. In Madrid, an Iranian woman cut her hair during a protest attended by dozens of people, echoing demonstrations in Iran where women have also been waving and burning their veils during demonstrations.

Iran's currency neared historic lows reached in June as desperate Iranians bought dollars to protect their savings, amid little hope Tehran's nuclear deal with world powers would be revived and concerns over the economic consequences of the unrest.

The rial fell to 331,200 per U.S. dollar, compared with 321,200 on Friday, according to the foreign exchange site Bonbast.com. The currency had plummeted to an all-time low of 332,000 per dollar on June 12.

Iranian authorities say many members of the security forces have been killed, accusing the United States of exploiting the unrest to try to destabilise Iran.

The Revolutionary Guards said four members of its forces and the volunteer Basij militia were killed on Friday in attacks in Zahedan, capital of the southeastern Sistan-Baluchistan province.
Zahedan Shootout

State television had said on Friday that 19 people, including members of the security forces, had been killed in Zahedan after unidentified individuals opened fire on a police station, prompting security forces to return fire.

Authorities blamed a separatist group from the Baluchi minority for starting the shootout in Zahedan. State media said two prominent militants linked to that group had been killed.

IRNA posted a video showing destroyed cars, an overturned and burning trailer or bus and fires in burnt-out buildings and shops, describing it as footage of "what the terrorists did to people's shops last night in Zahedan".

Reuters could not verify the footage.

Protests have been particularly intense in Iran's Kurdistan region, where authorities have previously put down unrest by the Kurdish minority numbering up to 10 million.

READ: Iran threatens celebrities supporting Mahsa Amini protests

Shops and businesses were on strike in 20 northwestern cities and towns in protest against attacks on Iraq-based armed Kurdish opposition parties by Iran's Revolutionary Guards, the Kurdish rights group Hengaw reported.

Fearing an ethnic uprising, and in a show of power, Iran launched rocket and drone attacks on targets in Iraq's Kurdish region this week after accusing Iranian Kurdish dissidents of being involved in the unrest.

Iran's Tasnim news agency reported new attacks by the Revolutionary Guards on Iraqi Kurdistan on Saturday.

A senior member of Komala, an exiled Iranian Kurdish opposition party, told Reuters that two party offices in Halgurd mountain in Iraq's Erbil were struck in Iranian shelling.

A Kurdish security official said Iranian artillery also shelled Choman district in Erbil.

The Iranian woman whose death led to mass protests was shy and avoided politics.

Protesters rally across Iran in third week of unrest over Amini's death


Protest over the death of Mahsa Amini, in Tehran

Sat, October 1, 2022 

DUBAI (Reuters) -Protesters rallied across Iran and strikes were reported throughout the country's Kurdish region on Saturday as demonstrations ignited by the death of a woman in police custody entered their third week.

The protests, sparked by the death of Mahsa Amini, a 22-year-old from Iranian Kurdistan, have spiralled into the biggest show of opposition to Iran's clerical authorities since 2019, with dozens killed in unrest across the country.

People also demonstrated in London, Rome, Madrid and other Western cities in solidarity with Iranian protesters, holding pictures of Amini, who died three days after being arrested by the Islamic Republic's morality police for "unsuitable attire".

In Iran, social media posts showed rallies in large cities including Tehran, Isfahan, Rasht and Shiraz.

In Tehran's traditional business district of Bazaar, anti-government protesters chanted "We will be killed one by one if we don't unite", while elsewhere they blocked a main road with a fence torn from the central reservation, videos shared by the widely followed Tavsir1500 Twitter account showed.

Students also demonstrated at numerous universities. At Tehran University, dozens were detained, Tavsir1500 said. The semi-official Fars news agency said some protesters were arrested in a square near the university.

A video posted on social media appeared to show protesters giving flowers to members of the riot police in Tehran, a recreation of Iranians winning over the military to their side in the 1979 Islamic revolution.

Reuters could not verify the social media reports.

The protests began at Amini's funeral on Sept. 17 and spread to Iran's 31 provinces, with all layers of society, including ethnic and religious minorities, taking part and many demanding Supreme Leader Ayatollah Ali Khamenei's downfall.

HUNDREDS INJURED

Amnesty International has said a government crackdown on demonstrations has so far led to the death of at least 52 people, with hundreds injured. Rights groups say dozens of activists, students and artists have been detained.

In London, about 2,500 people, many of them Iranians, staged a noisy protest in Trafalgar Square. In Paris, a crowd of several dozen people held Iranian flags and pictures of victims who have died in the protests. In Madrid, an Iranian woman cut her hair during a protest attended by dozens of people, echoing demonstrations in Iran where women have also been waving and burning their veils during demonstrations.

Iran's currency neared historic lows reached in June as desperate Iranians bought dollars to protect their savings, amid little hope Tehran's nuclear deal with world powers would be revived and concerns over the economic consequences of the unrest.

The rial fell to 331,200 per U.S. dollar, compared with 321,200 on Friday, according to the foreign exchange site Bonbast.com. The currency had plummeted to an all-time low of 332,000 per dollar on June 12.

Iranian authorities say many members of the security forces have been killed, accusing the United States of exploiting the unrest to try to destabilise Iran.

The Revolutionary Guards said four members of its forces and the volunteer Basij militia were killed on Friday in attacks in Zahedan, capital of the southeastern Sistan-Baluchistan province.

ZAHEDAN SHOOTOUT


State television had said on Friday that 19 people, including members of the security forces, had been killed in Zahedan after unidentified individuals opened fire on a police station, prompting security forces to return fire.

Authorities blamed a separatist group from the Baluchi minority for starting the shootout in Zahedan. State media said two prominent militants linked to that group had been killed.

IRNA posted a video showing destroyed cars, an overturned and burning trailer or bus and fires in burnt-out buildings and shops, describing it as footage of "what the terrorists did to people's shops last night in Zahedan".

Reuters could not verify the footage.

Protests have been particularly intense in Iran's Kurdistan region, where authorities have previously put down unrest by the Kurdish minority numbering up to 10 million.

Shops and businesses were on strike in 20 northwestern cities and towns in protest against attacks on Iraq-based armed Kurdish opposition parties by Iran's Revolutionary Guards, the Kurdish rights group Hengaw reported.

Fearing an ethnic uprising, and in a show of power, Iran launched rocket and drone attacks on targets in Iraq's Kurdish region this week after accusing Iranian Kurdish dissidents of being involved in the unrest.

Iran’s Tasnim news agency reported new attacks by the Revolutionary Guards on Iraqi Kurdistan on Saturday.

A senior member of Komala, an exiled Iranian Kurdish opposition party, told Reuters that two party offices in Halgurd mountain in Iraq's Erbil were struck in Iranian shelling.

A Kurdish security official said Iranian artillery also shelled Choman district in Erbil.

(Additional reporting by Ali Sultan in Sulaimaniya; Christian Hartmann and Anthony Panone in Paris and Yann Tessier in London, Marco Trujillo and Elena Rodriguez in Madrid; Writing by Tom Perry; Editing by Nick Macfie and David Holmes)


GUNRUNNERS
Germany approves new arms exports to Saudi Arabia despite ban since 2018

September 30, 2022 

An image of Saudi Arabia's Prince Ben Salman depicting him with bloody hands full of US Dollar notes buying arms and missiles from Donald Trump and Theresa May which are used against Yemeni people on October 29, 2019 in Belfast, United Kingdom. [Kaveh Kazemi/Getty Images]

September 30, 2022 

Germany's coalition government has approved new arms export deals to Saudi Arabia, despite the ban imposed as a result of its involvement in the war in Yemen.

According to DW News, Germany's Economy Minister and Vice Chancellor, Robert Habeck, confirmed in a letter to the German federal parliament that several deals on arms exports had been approved by Chancellor Olaf Scholz before his trip to Saudi Arabia.

The export licences are part of a joint programme with Italy, Spain and Britain, according to the letter.

Riyadh will be able to purchase equipment and ammunition for Eurofighter and Tornado jets worth €36 million ($35.2 million), reported Der Spiegel.

READ: Saudi women take up shooting after change in gun ownership laws

The European cooperation project will also supply spare parts for the Airbus A330 MRTT worth €2.8 million ($2.73 million).

The decision to approve new arms exports comes after Saudi Arabia criticised Germany's arms embargo, earlier this year, describing the act as a "very wrong signal."

The Saudi Foreign Minister, Faisal Bin Farhan, told DPA that the kingdom was "in need of weapons to defend itself against Houthi attacks from neighbouring Yemen."

"We do not need weapons to be aggressive but, rather, to be able to protect our country and people," he said, adding that the kingdom had been cooperating with Germany on armament "for a long time".

In November 2018, the former German Chancellor, Angela Merkel, had halted arms exports to Saudi Arabia. The incumbent government, led by Olaf Scholz, the Social Democratic Party, the Green Party and the Free Democratic Party, recently said they would continue the embargo.

The German government had previously allowed some exceptions for joint NATO projects, under which it had issued export licences to Saudi Arabia.

READ: US State Department approves billions of dollars' worth of arms sales to Saudi Arabia, UAE


NAVIGATING THE HIGHS AND LOWS OF PSYCHEDELIC THERAPIES

Regulators face new challenges over whether — and how — to allow people to receive mind-altering drugs to treat mental health conditions.



By Helen Collis
POLITICO
SEPTEMBER 28, 2022 

LONDON — David was paralyzed by fear. The only thing stopping him from falling was his rigid fingers gripping to the rock face. The worst part was knowing he had to hold on for another five hours.

That was how long he knew it would take before his LSD trip would wear off and he could finally abandon the pretense of clinging on to some sense of his perceived self through what felt like an unbearable feat of endurance.

David, who asked that his true identity be concealed to allow him to speak freely, is not alone in having sought out illegal psychedelics to self-medicate a mental health condition. He’s also not alone in having had a bad trip.

His experience, and others like it, serve as cautionary tales, as drug companies develop psychedelics like magic mushrooms and acid to help people with some of the hardest-to-treat mental illnesses.

With clinical research into psychedelics in its early stages, and a rapidly growing and unregulated industry of therapeutic psychedelic retreats, there’s much researchers still have to learn about how to prevent harm from potentially paralyzing experiences like David’s.

“There’s way too much hype, way too much enthusiasm [for psychedelic therapies],” said George Goldsmith, executive chair and co-founder at COMPASS Pathways, which is developing a psilocybin therapy, derived from mushrooms, for mental health disorders. “It doesn’t help anyone.”

Still, Goldsmith believes psychedelics have the potential to help people with mental health disorders who have not responded to other treatments.

“What we’re really focused on is: what does preparation [for a trip] look like? And how do we know to the highest level of certainty that someone is really ready?” said Goldsmith.

Ultimately, with the right counseling and support before and after the trip, his company wants to prevent a bad trip from ever happening with its psilocybin treatment.

Wrong time, wrong place

Researchers are working to fine-tune a suite of before- and after-care for those participating in clinical trials of psilocybin | Cole Burston/AFP via Getty Images

David’s experience with LSD took place about a decade ago when he was in his 20s, after a long period of social anxiety and depression that started in his teens and, despite trying antidepressants, persisted through university. He was looking for a magic bullet — and psychiatry had failed to deliver.

Fascinated by stories of psychedelics from South America, he finally plucked up the courage to try LSD with his friends.

“It was a really bad idea,” he said. “I had an absolutely horrible time, a really brutal time. And so much so that I thought afterward I had broken my brain.”

In the weeks and months that followed, he started having flashbacks and panic attacks “out of nowhere.”

Researchers at Kings College London (KCL) are working to fine-tune a suite of before- and after-care for those participating in clinical trials of psilocybin, to reduce the risk of harm. Some of these steps have been borne out of participant demand.

Psychiatrist James Rucker, of KCL, worked on a safety study — of psilocybin in healthy volunteers — for Compass in 2018.

The researchers did some preparatory work with the participants beforehand, and offered some support after their trip, “but it wasn’t enough for some people,” said Rucker. Some participants needed more support in the weeks after their treatment, even though they did not have a mental health diagnosis.

So Rucker set up monthly “integration” sessions, open not only to trial participants but also members of the public who are curious about psychedelics or who wanted to share their own experiences.

“We wanted a forum for people to be able to get advice and to talk about their experiences in a safe and confidential way,” said Rucker. This allowed people to speak openly about an activity that was otherwise shrouded in stigma, he said.

Every month, new and old faces join the sessions, opening up on the often life-altering experiences they have had — and have struggled to comprehend. People listen and then offer their thoughts.

For many, it’s the support they need to move on

Letting go

David was one of the participants of Rucker’s integration sessions who had not taken part in a study. He participated virtually in a session in 2020 and found it to be a breakthrough.

“What would have happened if you’d let go of the cliff?” he recalled another participant asking him.

This is how psychedelics differ from other psychotherapies, he concluded. They’re not supposed to suppress your emotions and numb the pain; you’re meant to let go and explore them.

Scientists have learned that during psychedelic trips, the brain becomes more neuroplastic, opening up neurological pathways that have been dormant, or suppressed, for years. This flexibility can endure for weeks — even months. It allows people to see things differently, and often in a more positive light.

But even as they develop these chemicals for treatment-resistant depression and other mental health disorders, researchers admit frankly that they are not a miracle cure.

Still, in COMPASS’s Phase 2b clinical trial testing psilocybin therapy on people with depression for whom no other treatments had worked, the company found that 24 percent of participants responded well. That’s a significant outcome in a particularly hard-to-treat illness.

It’s that type of result that has ignited an explosion of interest in these chemicals from a much wider audience.

Each reported study has lifted an ingrained taboo slightly more, inspiring people who are simply curious or who are desperate to find a healing therapy to give them a try. Psychedelics are becoming so mainstream that author Michael Pollan, best known as a food writer, has presented a Netflix series that delves into LSD, psilocybin, MDMA and mescaline.
Wild West
No one should be prevented from choosing to expand their consciousness, but the world of retreats can become “the Wild West” | Brent Lewin/Getty Images

That surge in demand has been met with a range of offerings, despite the limitations of the early data.

Psychedelic retreats have sprung up in Portugal, Spain and the Netherlands, countries where the rules on their use are lax.

Portugal decriminalized possession of all drugs in 2001, allowing individuals to consume and possess small quantities of psilocybin mushrooms. The Netherlands allows personal consumption of psilocybin truffles that have a similar effect to the mushrooms, which remain banned. And in Spain, possession, production and distribution of psilocybin is illegal, but its consumption in private places is decriminalized.

People are also traveling to Jamaica, where psilocybin is legal, as well as seeking ritualistic experiences with indigenous tribes in South America.

To Goldsmith, at COMPASS, no one should be prevented from choosing to expand their consciousness, but he cautioned that the world of retreats is like “the Wild West.”

Some retreats are set up with ethically sound intentions and run by trained therapists — including those with advanced research experience and academic qualifications. But others are run by profit-hungry opportunists with little training to help people navigate through challenging experiences. They promise to transform lives, misappropriating early clinical trial data from companies as evidence that psychedelics work.

While COMPASS’s Phase 2b data is compelling, it also showed that “well over 50 percent didn’t respond,” Goldsmith said. “I don’t quite hear those numbers when I look at retreats.”

According to Rucker, at KCL, the retreats industry needs checks and balances. And currently, there are none.

“I’ve had some reports of people over the years who’ve had terrible times at retreat centers but also reports of people who’ve had wonderful times,” he said. The main concern is the promises made: “There’s a fine line here between what is personal development and what is treatment.”

Share the love

Others, like Myles Katz co-founder of the Synthesis Institute, a Dutch center offering psilocybin therapy with truffles, argue that retreats are vital to expanding access to people who need it.

“The only place psychedelic medical treatment is currently available is in clinical trials, which are incredibly rare and notoriously difficult to get into,” said Katz. Retreats are a more accessible option, he said, “for people wanting to have a legal, professionally facilitated, psychedelic experience.”

Synthesis “thoroughly” screens applicants prior to accepting them, he said. Many retreats in Europe are attempting to align their screening protocols with the medical research that is available on psychedelics, Katz added. This in itself is an evolving process given the limited research available.

With so much variation across the sector, a lack of transparency over the benefits and the risks of the experience, and little data, if any, on the rates of traumatic trips and how they are managed, some people would like to see retreats formally regulated.

One idea being floated is for retreats to vet people who are most vulnerable, and to exclude those with a history of treatment-resistant mental health disorders — those who may be most vulnerable to bad experiences without the right support, but also most likely to seek to cure their illness through psychedelics.

Kirk Rutter was one of the few who got accepted onto a psilocybin study in the U.K. after being diagnosed with treatment-resistant depression. Before his mental health deteriorated, he had tried ayahuasca, a South American plant-based psychedelic, at an underground retreat in England. He didn’t enjoy the experience but nonetheless has no regrets.

“I didn’t feel as safe,” he said. “I didn’t know the people who were going to be looking after me. We were basically out in the middle of nowhere.” Compared with his psilocybin trip, “it was a much darker experience,” he said.

Given the opportunity of taking a psychedelic again, he would opt hands-down for the controlled clinical approach, “for the feeling of safety.” That’s because he knows exactly what would happen, what dose he would receive, who would be with him, and where he would be. He underwent extensive medical vetting and questionnaires before and after the trip and had doctors and psychotherapists on hand throughout the experience. “I got a lot of reassurances,” he said.

For Rutter, the treatment also worked. Seven years after the trial he remains free of depression. He’s even become a poster child for COMPASS’s research — albeit reluctantly.

Imperial College, which led the trial, asked him to talk to the press about his experience. His immediate reaction was: No! “Talk about depression? And psychedelics? They’re both really taboo, really uncomfortable subjects,” he said.

But then he realized, if he couldn’t share his experiences, then society would never get over this stigma and others wouldn’t have the opportunity to benefit like he did. So he relented.

Training society

As the anticipated arrival of the first medical psychedelics nears, no one yet knows what impact this will have on the retreats industry | Fabrice Coffrini/AFP via Getty Images

On top of the calls to regulate retreats, some are also concerned about the need to prepare health systems and society for the anticipated arrival of the first psychedelics in Western medicine.

Medicines regulators in the U.S., the European Union and the U.K. are working with companies to ensure that the development of these therapies fits within the parameters of tried and tested measures demonstrating that the benefits outweigh the risks. The U.S. said this summer that it anticipated the first psychedelic medicine to be approved within two years.

One major hurdle however is the critical suite of before- and after-care to minimize potential harm from traumatic trips. The COMPASS trial showed that 3.8 percent of participants had suicidal behaviors in the aftermath of the study — a behavior the company noted could be more likely among people with treatment-resistant depression.

“The regulatory authorities … were set up to regulate drugs,” said Rucker at KCL. “They were not set up to regulate psychotherapy, and they are not interested in regulating psychotherapy … Our point is that you can’t give the drug without the psychotherapy.”

Companies are in talks with regulators over the possibility of licensing a package that defines that the drug must come with preparation, dosing, day support and integration, “because otherwise, the therapeutic effect you’re looking for is in jeopardy,” said Rucker.

Adding to the complexity, “that package of care, if licensed, would require optimization over time,” said Liam Modlin, psychology and psychotherapy lead in psychedelics, also at KCL. “That’s an ongoing, long-term process.”

Health systems also need to prepare for such a step change in psychiatric treatment. “Psychiatrists and psychotherapists are going to be administering psychedelics if they are licensed,” Modlin said, adding they would need governance bodies to provide professional, standardized training and oversight.

Some people are working with patient groups to try to raise awareness and cut through the stigma of these therapies, ingrained by decades of illegality.

Chris Jenkins, at consultancy OEV, is working with police and firefighters who have among the highest rates of post-traumatic stress disorder in any profession, at around 20 percent. He’s hoping to break down the multiple stigmas that might prevent them from seeking treatment with psychedelics: from speaking about mental health, perceptions of masculinity and weakness, and taking psychedelics.

“We’re working to try and engage with the police and say, ‘Look, this is something that can really benefit you,’” said Jenkins. But overcoming these multiple stigmas requires work and preparation now, he said.
Fork in the road    
Psilocybe mushrooms at the Numinus Bioscience lab in Nanaimo, British Columbia, Canada | James MacDonald/Bloomberg via Getty Images

As the anticipated arrival of the first medical psychedelics nears, no one yet knows what impact this will have on the retreats industry.

The pharmaceutical sector is highly regulated and will provide treatment for a narrow cohort of people with mental health disorders; retreats are an unregulated sector providing broader access but at greater risk and cost.

“I would hope that this is one of those situations where there’s coexistence,” said Goldsmith, at COMPASS, as opposed to fueling conflict between the two.

For Tadeusz Hawrot, founder and policy lead at the Psychedelic Access and Research European Alliance (PAREA), it could be an opportunity for the two industries to work together.

He sees a day when doctors could triage patient care based on the severity of mental health concerns. The most serious, treatment-resistant cases could be referred for clinical therapy with psychedelics, in a controlled setting, with standardized before- and after-care, and doctors and psychotherapists on hand. People with less severe mental health worries could be referred to a retreat and might prefer to seek help outside of the medical model.

This would require retreats to be regulated, he said, underscoring the importance of accurate data collection and transparency. “Perhaps there could be a network of licensed retreats,” he said, providing real-world evidence to add to the body of knowledge on these therapies.

For people who, like David, have experimented independently with psychedelics, this approach would provide more of a safety net in case of a bad trip.

As it happened, it would be a decade after his LSD experience before David would experiment again, in a second attempt to self-medicate for his mental health conditions. This time it was with psilocybin and just one close friend. It was a much better experience, but there’s still more work to be done to let go, he said.

With the support of the integration sessions and armed with a new understanding of psychedelics’ effect on the mind, he’s confident they can now help him, not least in opening his eyes to how he needs to change his life.

It’s a process that for the Davids of the future may come with less trial and error: a licensed, safe treatment and more professional and peer support.



SEE



China Is Unnerved by Increasing Attacks on Chinese in Pakistan

Police are investigating the targeted killing of a Chinese Pakistani dentist who was shot dead in Pakistan’s largest commercial hub, Karachi, on September 28.

A lone shooter pretending to be a dental patient opened fire on Chinese Pakistani dual nationals, killing one and injuring two other people at a clinic in the southern port city of Karachi. The suspect escaped from the scene. Those killed and injured were identified as Ronald Chow, Richard Hu, 74, and his wife Margaret, 72.

Police say the victims were a soft target and have lived in Pakistan for many years. Detectives are investigating whether the injured and killed hold Chinese nationality or not, as China doesn’t allow dual citizenship.

A new Sindhi ethno-nationalist militant group, the Sindhudesh People’s Army, from Pakistan’s southern Sindh province, said they were behind the attack in a statement claiming responsibility. Not much is known about the group.

However, Karachi-based journalist and researcher Zia Ur Rehman believes it could be a new breakaway group with links to separatist ethno-nationalists who have been behind such attacks on Chinese nationals in Karachi, Sindh province’s capital, in the past.

Ethnic Baloch separatists and Sindh separatists alike have recently launched a series of targeted attacks on Chinese citizens in Karachi and restive southwestern Balochistan province. Separatist nationalists say China is involved in large-scale resource extraction and exploitation in Sindh and Balochistan.

In its statement, the largely unknown Sindhudesh People’s Army also expressed similar reservations.

“We warn China to stop its exploitative projects on our homeland and leave immediately,” the militant group said in a statement released to the media.

Interior Minister Rana Sana Ullah Khan condemned the Wednesday shooting. “Such incidents aren’t tolerable,” he wrote on Twitter. “The security of Chinese nationals should be ensured in every way.”

Sporadic Attacks on Chinese Nationals Creating Distrust and Fear

Despite strict security measures by the Pakistani authorities to guard Chinese citizens working on the China-Pakistan Economic Corridor (CPEC), an estimated $62 billion bundle of infrastructure projects launched in 2015, militant groups have continued to spread chaos and panic among Chinese nationals and authorities, mainly by pursuing soft targets.

“Karachi is one of the largest trading hubs of Pakistan in terms of trade, investment, and economic activities. It also has its geostrategic importance. This is why the Chinese are an easy target in this crowded city,” said Rehman.

“Apart from the Karachi Consulate attack in November 2018 and the April suicide bombing on Confucius Institute [workers], in the past, there had been low-scale targeted attacks on Chinese nationals, too. Militants with such low-scale attacks have been receiving widespread media attention globally,” he added.

Rehman also believes this rise in such soft targets indicates this is a new strategy militants have recently adopted. He says militants chose soft targets like ordinary Chinese citizens because targeting high-profile figures isn’t easy after the city’s security improved. Yet such attacks still create media hype.

Recently Pakistani law enforcement agencies have largely been successful in averting high-profile attacks on the Chinese. Still, small-scale sporadic but soft targets have been a cause of tension and distrust for the Chinese.

“Pakistan had done a very good job protecting Chinese nationals from the late 2000s until relatively recently. A series of special measures that had been put in place back then, and reinforced when CPEC was launched, meant that for a long time Chinese officials and Chinese workers on economic projects had been kept largely safe,” Andrew Small, an expert on China and a transatlantic fellow with the German Marshall Fund Asia program, told The Diplomat.

But recently, that security seems to have become less effective. “China had already grown concerned about the near misses at the consulate in Karachi and the attack in Quetta. Still, the Dasu attack last July in which 9 Chinese were killed really crossed a threshold – a major loss of life on a protected project – and the Confucius Institute attack reinforced that, even if it was different groups involved in the different cases,” Small said.

“The concern on China’s part is that the protection measures no longer seem to be working as well, they don’t entirely understand why, and they have been asking questions about, for instance, having more of their own security personnel in the country.”

Earlier this month, reports in the Pakistani press indicated that Chinese economic engagement with Pakistan has decreased, and the work on CPEC dramatically slowed down, particularly during former Prime Minister Imran Khan. A Western diplomat said the Chinese ambassador to Pakistan remained out of the country for around five months between February and early July, possibly due to mistrust and political reasons.

In addition, recently, China has been eager to bring its own private security companies to guard its nationals working on CPEC-led projects in Pakistan.

Adnan Aamir, an independent analyst and researcher from Balochistan covering the Belt and Road in Pakistan, agrees that such small-scale infrequent attacks have created distrust between China and Pakistan.

“Especially after the Confucius Institute attack in April this year, Chinese came up with a proposal to bring its security to guard Chinese citizens. Pakistan politely turned that proposal down,” Aamir said. “Still, the issue remains unsettled.”

Aamir also told The Diplomat that the Chinese have recently made their investment conditional in Pakistan: “Some sources have informed me all new Chinese investment remained defined by Pakistan agreeing to Chinese proposal of allowing Chinese security firms here or not.”

China’s Talks With Ethnic Baloch Nationalists

In another sign of mistrust between the two nations, China has recently attempted to talk directly with ethnic Baloch parliamentarians to address their concerns, bypassing Pakistani authorities.

In August, the Chinese envoy to Pakistan, Nong Rong, held a series of one-to-one meetings in Islamabad with politicians from Balochistan to discuss Baloch nationalists’ grievances with China. Nong also arranged a joint dinner for several politicians from Balochistan that same month.

“What I observed from my conversation with Mr. Nong, I felt Beijing has realized the scale and sensitivity of the conflict in Balochistan,” said a Baloch politician who met the Chinese ambassador in August in Islamabad upon his invitation.

“The ambassador has a feeling that Pakistan alone cannot resolve the Balochistan conflict. That is why [China] is interested in direct talks with stakeholders from Balochistan for stability so that the CPEC goes on without any opposition from Baloch nationalists,” said the Baloch politician.

Chinese working on CPEC projects in the port city of Gwadar in Balochistan province also raised donations for the flood victims of Balochistan as a sign of sympathy and generosity.

On September 30, the Chinese ambassador announced more scholarships for the students of Balochistan while meeting a politician from the province.

Balochistan, where CPEC’s gateway Gwadar port is located, has been gripped by violence and lawlessness since early 2000. However, Baloch ethno-nationalist militants have recently stepped up their presence by launching suicide bombings and lethal ambushes on Pakistani law enforcement agencies and Chinese installations inside and outside the Balochistan region. Mounting insecurity and sporadic attacks by Baloch insurgents have created deep worries for Beijing.

“All of this has created some tension. The most recent attack appears to be on another soft target, of the kind that is somewhat familiar to the Chinese in Karachi but will still add to the sense of threat. In the past, China has threatened to pull personnel from projects, and there are indications that in Gwadar, for instance, there has been a paring back of Chinese presence as a result of the worsening threats,” said Small.

In 2018 Financial Times reported that Beijing was attempting to hold talks secretly with Baloch separatists living in exile in the West to end the two-decades-old insurgency in Balochistan. Radio Free Europe/Radio Liberty confirmed Financial Times’s report but said that China hadn’t achieved any real gains from the outreach.

But Baloch rights activists claim Beijing has taken a less gentle approach.

Abdullah Abbas, information secretary of the independent Human Rights Council of Balochistan, said that following an attack on the Chinese consulate in Karachi by Baloch separatist insurgents in 2018, the United Arab Emirates deported Rashid Hussain, a Baloch activist, to Pakistan after holding him incommunicado for seven months. Abbas believes it was due to Chinese pressure. In February this year, Abdullah said another cousin of Hussain was arrested by Emirati intelligence and forcefully deported to Pakistan under the same circumstances.

“We have substantial evidence Beijing continuously pushes the Gulf states, including the United Arab Emirates, to hand over to Pakistan Baloch activists it considers are opposing Chinese investment,” Abbas said.

EAST AFRICA
Erratic weather, global crises push cost of food to record high levels

SATURDAY OCTOBER 01 2022


Workers offload relief food for distribution in Kenya. 

By JOINT REPORT
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Governments in East and Horn of Africa have rolled out food aid programmes to communities hit hard by inconsistent weather patterns and global crises that have pushed food costs beyond the reach of many.

This week, Kenya launched a relief food programme for communities trapped in a cycle of four failed agriculture seasons, and Uganda had already been distributing relief food to people in Karamoja regions.

UN Office for the Co-ordination of Humanitarian Affairs (Ocha)is predicting the likelihood of a fifth failed crop season. Uganda, which has generally enjoyed above average food production from its arable fertile soils, having two harvest seasons annually, is now increasingly facing food challenges due to less erratic and less predictable rains and unprecedented prolonged dry spells.

According to the Uganda National Meteorological Authority (UNMA), some rainy months now have only 18 wet days compared with 20 previously which impacts on food yields.

According to meteorological information, 40 per cent of all rainfall received in Uganda is influenced by natural features such as wetlands and forests, which have been encroached on and destroyed by developers for housing or peasants for farming and others decimated for firewood and charcoal.

Hilary Onek, the Minister for Relief, Disaster Preparedness and Refugees, says the Ugandan government has been forced to provide food to areas that have “had pockets of hunger,” costing upwards of Ush19 billion ($4.9 million) in the past three months alone.

Related

East Africa in distress as cost of living soars


According to the Meteorological department, the country steadily been receiving less rainfall over the past 16 years. However, there are those that argue that the food shortages being currently experienced in the region is also effects of bad national policies, rather than the weather.

In Kenya, President William Ruto flagged off relief food to drought-stricken counties on Tuesday, but admitted it was only a short-term measure.

The programme is targeting 3.5 million people. Kenya’s Meteorological Department has declared severest drought in 23 out of the 47 counties.

And Ocha’s National Drought Early Warning data for September 2022, says 10 counties are under an alarming drought phase with at least 4.35 million people in danger.

The Horn of Africa, including parts of Kenya, is facing the worst drought with at least 20 million people in immediate need of food. This includes Somalia, Ethiopia, Sudan, Uganda and South Sudan, and Djibouti and Eritrea

Kipkorir Arap Menjo, the director of the Farmers Association, a lobby for local food producers, said Kenya’s maize growing regions are expecting a harvest early October. But even in countries touted as having almost sufficient food supplies, like Tanzania, prices are soaring and limiting access for many.

As countries struggle to get cheaper grain from traditional sources like Russia and Ukraine, world prices and growing world demand is making the situation harder in the region.

According to the Bank of Tanzania, the price of maize alone has more than doubled over the past year, hitting Tsh87,383 ($37.66) per 100-kilogramme sack in July compared with Tsh43,371 ($18.69) in the same month last year. Other key basic foods like rice and beans have also registered sharp price increases.

In its latest monthly review report for August 2022, the BoT says wholesale food prices had increased "mainly due to low harvests associated with delayed short rains and a high demand for food from neighbouring countries."

Reporting by Gilbert Mwijuke, Luke Anami, Apolinari Tairo and Bob KarashaniADVERTISEMENT

ALS Drug Wins FDA Approval Despite Questionable Data

HEALTH
The Associated Press Oct 1, 2022

 
The drug Relyvrio. (Amylyx Pharmaceuticals via AP)


WASHINGTON—A much-debated drug for Lou Gehrig’s disease won U.S. approval Thursday, a long-sought victory for patients that is likely to renew questions about the scientific rigor behind government reviews of experimental medicines.

The Food and Drug Administration approved the drug from Amylyx Pharmaceuticals based on results from one small, mid-stage study in which patients with the debilitating disease appeared to progress more slowly and survive several months longer. Typically, the FDA requires two large studies or one study with “very persuasive” survival results for approval.

“This approval provides another important treatment option for ALS, a life-threatening disease that currently has no cure,” FDA’s neurology drug director Dr. Billy Dunn said in a statement.

The drug, Relyvrio, is the third U.S.-approved medicine for amyotrophic lateral sclerosis, or ALS, which destroys nerve cells needed for basic functions like walking, talking, and swallowing. About 20,000 people in the United States are living with the disease.

The FDA’s review has become a flashpoint in broader debates about the regulatory agency, including how flexible it should be when reviewing drugs for deadly diseases and how much weight it should give to appeals from patients and other outside voices.

“I think it demonstrates the FDA’s ability to be facile and I think it demonstrates a lot of tenacity on the part of ALS patients and advocates,” said Dr. Catherine Lomen-Hoerth, an ALS specialist at the University of California San Francisco. “The company really tried to do everything possible to get this potentially promising drug out to patients.”

Amylyx’s drug is the latest in a string of neurological drugs that have won FDA approval despite questionable effectiveness data. The agency is still facing two government probes into its approval of the Alzheimer’s drug Aduhelm last year, which has not yet been shown to slow the disease.

In an online memo summarizing its decision, the FDA said “regulatory flexibility” was appropriate for approving Relyvrio, “given the serious and life-threatening nature of ALS and the substantial unmet need.”

The latest approval followed a remarkably turbulent path, including two negative reviews by the FDA’s internal scientists, who called the company’s results “borderline” and “not persuasive.” A panel of outside advisers backed that negative opinion in March, narrowly voting against the drug.

But the FDA has faced intense pressure from ALS patients, advocates and members of Congress. In recent weeks the agency received more than 1,300 written comments from the ALS community supporting the treatment.

That outpouring helped sway the same expert panel when FDA reconvened them earlier this month to revisit Amylyx’s drug. The second time around, they backed the drug, 7–2. The vote was not binding, but it seemed to open the door for FDA approval.

Several panelists said they were also reassured by an extraordinary exchange at the meeting in which FDA’s Dr. Dunn requested—and Amylyx affirmed—that the company would voluntarily pull its drug from the market if a large, ongoing study doesn’t confirm its benefit.

That 600-patient study is expected to report results in 2024.

But experts have pointed to the many potential problems with such an informal commitment. The FDA and the company could disagree on whether the final data supports the drug; or a company that acquires the drug in the future may not feel bound by Amylyx’s pledge.

The powder-based drug is a combination of two older ingredients: a prescription medication for liver disorders and a dietary supplement associated with traditional Chinese medicine. Cambridge, Massachusetts-based Amylyx has patented the combination and says the chemicals work together to shield cells from premature death.

Some ALS patients already take both drugs separately, sometimes paying $5,000 a month for the prescription component, according to physicians. FDA approval is expected to compel insurers to cover Amylyx’s medication.

Amylyx did not immediately disclose the price Thursday but said it planned to announce the information on a call with investors Friday morning. In Canada, where the drug received approval in June, the company has proposed a price equating to $165,000.

One outside group that analyzes the cost effectiveness of new treatments pegged the drug’s value at between between $9,100 and $30,700 per year. The Institute for Clinical and Economic Review also noted that many patients are expected to take Amylyx’s drug in combination with an older therapy, which costs over $170,000 per year.

Sunny Brous was diagnosed with ALS in 2015 and hopes to add Relyvrio to the two older FDA-approved medications she already takes for the disease.

“I’ve made it this far without this drug and I’m hoping having it now will extend my life further,” said Brous, who is 35 and lives near Fort Worth, Texas.

Amylyx’s data came from a 6-month study in 137 patients that showed some benefit in slowing the disease, based on functionality questionnaires completed by patients. Patients who continued taking Relyvrio after the study concluded appeared to survive longer than patients who originally received a placebo, the FDA noted.

“The ALS community has proven that our advocacy can impact decisions that are being made about our health,” said Larry Falivena, an ALS Association board member who was diagnosed with the disease in 2017, in an emailed statement. The group invested $2.2 million in Amylyx’s early research and stands to recoup $3.3 million from drug sales.

By Matthew Perrone