Thursday, March 26, 2026

BIDEN REFORM

Fewer seniors with heart disease report skipping meds after Medicare reforms



Survey shows less cost-related medication rationing after Inflation Reduction Act took effect in 2024




American College of Cardiology




Medicare beneficiaries with heart disease or major cardiovascular risk factors reported less cost-related medication non-adherence—skipping or reducing doses, delaying prescription fills or foregoing medications due to cost—after new provisions went into effect limiting out-of-pocket drug costs for Medicare beneficiaries, according to a study being presented at the American College of Cardiology’s Annual Scientific Session (ACC.26) and simultaneously published in JACC, the flagship journal of the ACC.

The study focuses on impacts from two provisions of the 2022 Inflation Reduction Act (IRA) that took effect January 1, 2024. Researchers compared survey data from 2024 against prior years to analyze trends in self-reported medication non-adherence among older adults with heart disease or major cardiovascular risk factors.

“In the low-income group, we saw a pretty big benefit—it really helped people afford their medications,” said Lucas Marinacci, MD, a physician at Beth Israel Deaconess Medical Center, a faculty member at the Richard A. & Susan F. Smith Center for Outcomes Research in Boston, and the study’s lead author. “Our findings suggest that the 2024 IRA provisions supported better medication adherence, and better adherence may translate into better health.”

Heart disease is the leading cause of death worldwide. Newer drug classes like GLP-1 receptor agonists, SGLT2 inhibitors and novel anticoagulants have grown in prominence alongside conventional cholesterol and blood pressure-lowering medications for reducing the risk of serious cardiac events among people with conditions like atrial fibrillation, heart failure or a history of heart attack or stroke. However, the combination of these medications can be expensive, and prior studies have shown that patients sometimes do not take medications as prescribed if they feel they cannot afford them.  

The policy changes that went into effect January 1, 2024, included two provisions intended to make prescription drugs more affordable for Medicare beneficiaries. One provision expanded eligibility for “extra help” subsidies, which reduce drug co-payments for individuals with incomes up to 135% of the federal poverty level to include those with incomes up to 150% of the federal poverty level. A separate provision eliminated the 5% coinsurance requirement for catastrophic coverage, essentially capping the amount a person will spend on out-of-pocket drug costs.

Researchers used data from the National Health Interview Survey, a nationally representative survey of U.S. adults, to analyze trends in medication non-adherence among respondents reporting a history of coronary heart disease, angina (chest pain or tightness), heart attack, stroke, transient ischemic attack, high blood pressure, high cholesterol, diabetes or obesity. Survey questions asked participants whether they had skipped, reduced, delayed or foregone doses of their prescribed medications due to cost (cost-related medication non-adherence) and whether they worried about or were unable to pay their medical bills (health care-related financial strain). To analyze changes related to the new Medicare provisions, researchers compared survey responses from 2024 with responses from 2021-2023.

In one analysis, researchers compared responses from 4,710 Medicare beneficiaries aged 65 years and older with incomes below 135% of the federal poverty level (who were eligible for “extra help” subsidies before 2024) and 923 beneficiaries with incomes between 135% and 150% of the federal poverty level (who were newly eligible for the full subsidies starting in 2024). The results showed a significant 5.5 percentage point decrease in reported cost-related medication non-adherence among beneficiaries who were newly eligible for the subsidies.

In another analysis, researchers compared responses from 25,522 Medicare beneficiaries aged 65 years or older with a control group of 5,332 privately insured respondents aged 60-64 years. They found that cost-related medication non-adherence dropped by 2.1 percentage points among Medicate beneficiaries compared with the control group. This trend held true even after adjusting for income, race and ethnicity, employment status and educational attainment. There was no change in health care-related financial strain.

A third analysis examined responses from Medicare beneficiaries with incomes above 150% of the federal policy level and those with incomes below 135% of the federal poverty level. That analysis did not show a significant difference in medication non-adherence between these groups.

Based on the results, researchers estimated that around 70,000 low-income seniors did not skip or delay medication doses in 2024 who otherwise would have done so in the absence of the policy changes that went into effect that year. This provides early evidence that the Medicare reforms had a meaningful benefit in terms of reducing medication non-adherence, which they said is likely to translate into better health outcomes for some patients. Researchers said that making similar changes to reduce out-of-pocket drug costs for people with other types of health insurance, such as Medicaid or private insurance, could also have similar effects.

However, researchers said that patients are only likely to change their behavior in response to policy changes if they are aware of what those changes mean for them. Since many seniors struggle to understand their health coverage—for example, some Medicare beneficiaries may be unaware that their total out-of-pocket costs are now capped under the IRA—Marinacci said that clinicians need to play an active role in helping patients understand that their medications may be more affordable than they think.

“Cardiology providers should continue asking Medicare patients about cost barriers and connecting them to financial counselors who can help them understand their drug coverage and take advantage of these reforms,” Marinacci said. “If clinicians aren’t aware of this and don’t tell their patients, oftentimes people may forego medications that they could otherwise afford if they were aware of the policy.”

Since the study is based on survey data, researchers said that it may be affected by inconsistencies in how respondents self-reported their health conditions or medication adherence behavior. In addition, the study did not assess health outcomes, and Marinacci said that future studies could examine whether the observed trends in medication adherence translate into improved health outcomes.

He said that other data sources such as pharmacy claims could be used to evaluate the potential impacts of the change in catastrophic coverage on medication adherence. In addition, in light of subsequent changes in policy related to prescription drug costs that have occurred since 2024, he said it would be useful to assess the impacts of those changes and the ways insurers respond to them.

The study was funded by the National Institutes of Health.

This study was simultaneously published online in JACC at the time of presentation.

Marinacci will present the study, “The Inflation Reduction Act and Medication Adherence Among Adults with Cardiovascular Conditions: A Quasi-Experimental Policy Analysis,” on Monday, March 30, at 9:30 a.m. / 14:30 UTC at the Engage Stage for the Young Investigators Award Competition.

ACC.26 will take place March 28-30, 2026, in New Orleans, bringing together cardiologists and cardiovascular specialists from around the world to share the newest discoveries in treatment and prevention. Follow @ACCinTouch@ACCMediaCenter and #ACC26 for the latest news from the meeting.

The American College of Cardiology (ACC) is the global leader in transforming cardiovascular care and improving heart health for all. As the preeminent source of professional medical education for the entire cardiovascular care team since 1949, ACC credentials cardiovascular professionals in over 140 countries who meet stringent qualifications and leads in the formation of health policy, standards and guidelines. Through its world-renowned family of JACC Journals, NCDR registries, ACC Accreditation Services, global network of Member Sections, CardioSmart.org patient resources and more, the College is committed to ensuring a world where science, knowledge and innovation optimize patient care and outcomes. Learn more at ACC.org.

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New journal Health Engineering launches to bridge engineering innovation and the future of human health



Tsinghua University Press introduces open-access platform advancing interdisciplinary solutions for disease prevention and health maintenance




Tsinghua University Press

New journal Health Engineering launches to bridge engineering innovation and the future of human health 

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Tsinghua University Press has launched Health Engineering, a new international open-access journal designed to unite engineering, biotechnology, and medical science in addressing some of the most pressing global health challenges. The journal aims to accelerate research that applies engineering principles to improve health outcomes, enable earlier disease intervention, and support the transition from treatment-focused medicine toward proactive health management.

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Credit: Health Engineering, Tsinghua University Press





Tsinghua University Press has launched Health Engineering, a new international open-access journal designed to unite engineering, biotechnology, and medical science in addressing some of the most pressing global health challenges. The journal aims to accelerate research that applies engineering principles to improve health outcomes, enable earlier disease intervention, and support the transition from treatment-focused medicine toward proactive health management.

As populations age and chronic diseases continue to rise worldwide, researchers are increasingly turning to engineering-based approaches to redesign how health is monitored, maintained, and restored. Advances in artificial intelligence, biomaterials, synthetic biology, and precision medicine are reshaping biomedical research, creating a need for a dedicated platform that connects technological innovation with biological and clinical discovery. Health Engineering was established to serve this emerging interdisciplinary frontier.

Health engineering represents a shift in how we approach medicine and human well-being,” said Professor Xin-Hui Xing, Co-Editor-in-Chief of Health Engineering at the Tsinghua Shenzhen International Graduate School. “Instead of reacting to disease after it develops, engineering enables us to design systems and technologies that maintain health and prevent illness. The journal provides a platform where engineering and life sciences converge to generate practical solutions for global healthcare challenges.”

Co-Editor-in-Chief Professor Peter E. Lobiea molecular medicine researcher at Tsinghua Shenzhen International Graduate School and Fellow of the Royal Society of New Zealand, noted that rapid technological convergence is transforming biomedical discovery. “Breakthroughs in genetics, biotechnology, and artificial intelligence now allow unprecedented insight into disease mechanisms and therapeutic development. Health Engineering brings these advances together, helping translate interdisciplinary discoveries into real-world health applications.”

A platform for interdisciplinary health innovation

Health Engineering publishes peer-reviewed research spanning both fundamental and applied studies across engineering-driven health sciences. The journal welcomes contributions from engineers, chemists, physicists, biologists, biomedical scientists, and clinicians working across areas including biomaterials and regenerative medicine, biosensors and bioimaging, drug and gene delivery, synthetic biotechnology, precision medicine and nutrition, diagnostic technologies, therapeutic devices, vaccine engineering, and AI-enabled health technologies.

Article types include Original Research Articles, Reviews, Short Communications, Technical Reports, Correspondence, invited Perspectives, and Editorials, supporting rapid exchange of ideas across disciplines traditionally separated by academic boundaries.

Engineering health as an emerging scientific paradigm

The launch of Health Engineering reflects growing recognition that engineering frameworks can provide systematic solutions to complex health challenges. Modern advances in genetic, chemical, cellular, and computational technologies are enabling integrated approaches that emphasize prevention, precision intervention, and long-term health maintenance. By promoting collaboration across disciplines, the journal aims to advance a new research paradigm focused not only on treating disease but also on engineering human health itself.

Open access and global visibility

Published by Tsinghua University Press, Health Engineering operates as a fully open-access journal under a Creative Commons Attribution license, ensuring immediate global accessibility of all published research. The journal is initially published quarterly and is designed to facilitate rapid dissemination of interdisciplinary discoveries to researchers and healthcare innovators worldwide.

International editorial leadership

The journal is led by Editors-in-Chief Xin-Hui Xing and Peter E. Lobie and supported by an international editorial board comprising leading researchers from institutions including Harvard Medical School, Seoul National University, the University of Tokyo, Washington University in St. Louis, the Chinese University of Hong Kong, the University of Birmingham, and other globally recognized centers of research excellence.

About Health Engineering

Health Engineering is a multidisciplinary open-access journal published by Tsinghua University Press. The journal focuses on engineering-driven science and technology addressing health promotion, disease prevention, diagnostics, therapeutics, and health maintenance through interdisciplinary innovation at the interface of engineering and biomedical sciences.

OH&S

Medical societies call for ‘ALARA+’ safety standard to reduce radiation and injury risks in fluoroscopy labs



Teams delivering minimally invasive care face radiation exposure and orthopedic injuries that could be reduced through new policies and modern technology.



Society for Cardiovascular Angiography and Interventions





WASHINGTON—Nine leading medical societies are calling for updated safety standards in fluoroscopy laboratories, often called “cath labs,” where clinicians performing minimally invasive procedures face radiation exposure and orthopedic injuries from heavy protective equipment. A report published simultaneously today in JSCAIHeart RhythmJVIR, and JVS–Vascular Insights details the health, financial, and workforce impacts of fluoroscopy-guided settings and proposes an enhanced safety framework: ALARA+, or “As Low and As Light as Reasonably Achievable.”

The report addresses the dual occupational hazards linked to fluoroscopic procedures—radiation exposure and orthopedic strain from traditional protective equipment—and aims to ensure that safety is built into the environment, equipment, and standard of care.

“How we think about radiation safety has been historically guided by the ALARA principle, or ‘as low as reasonably achievable.’ But that approach has proven to be not safe enough for healthcare staff working in fluoroscopic labs,” said Robert F. Riley, MD, MS, FSCAI, chair of the 2025 Summit on Radiation and Orthopedic Risks in Fluoroscopic Labs. “Traditional ALARA principles focused on incomplete methods of minimizing radiation exposure. Additionally, they did not fully account for the orthopedic strain caused by wearing heavy lead protective equipment during long procedures. The new framework, ALARA+, calls for responsible protection strategies that are ‘as low and as light as reasonably achievable’ for the entire team.”

“ALARA+: Summit on Radiation and Orthopedic Risks in Fluoroscopic Laboratories” is endorsed by the Society for Cardiovascular Angiography and Interventions (SCAI), American College of Cardiology (ACC), Alliance for Cardiovascular Professionals (ACVP), American Society of Echocardiography (ASE), Heart Rhythm Society (HRS), Society of Interventional Radiology (SIR), Society of NeuroInterventional Surgery (SNIS), Society of Vascular and Interventional Neurology (SVIN), and the Society for Vascular Surgery (SVS).

Fluoroscopy is widely used to perform minimally invasive procedures that treat conditions such as heart attack, stroke, and vascular disease. Using real-time X-ray imaging, clinicians guide catheters and other devices through blood vessels to diagnose and treat disease without open surgery. While these procedures improve patient outcomes and shorten recovery times, they carry long-term occupational risks for the teams performing them, as they receive thousands of low but repeated radiation doses over the course of their career. To reduce exposure, clinicians often wear heavy lead or lead-equivalent protective garments that can weigh 15 to 20 pounds. However, the strain of wearing them during long procedures contributes to chronic neck, back, and joint injuries.

“These occupational harms affect every member of the procedural team and the healthcare system as a whole, carrying major financial and human costs,” said Summit Co-Chair Arnold H. Seto, MD, MPA, FSCAI. “Across fluoroscopy laboratories, clinicians and staff face both cumulative radiation exposure and the physical burden of heavy protective equipment. Over time, that means years of strain from protective gear and nonergonomic lab setups. The consequences are real. People develop chronic pain, require surgery, and some are left with severe spinal conditions that limit or even end their procedural careers. Maintaining a skilled workforce in these labs, which is already in limited supply, is essential to ensuring patients have access to these lifesaving procedures. As demand for minimally invasive procedures continues to grow, protecting and retaining experienced teams will be critical to preserving and expanding access to care.”

A 2023 Occupational Health Hazards Survey from SCAI found that roughly two-thirds of interventional cardiologists report musculoskeletal pain related to working in the catheterization laboratory or wearing radiation protection equipment. These risks affect the entire procedural team, including physicians, nurses, technologists, and imaging specialists. Trainees may accumulate higher exposure near the radiation source while developing procedural skills. Concerns about radiation exposure during pregnancy and the physical burden of protective lead are often cited as discouraging many women from entering or remaining in fluoroscopy-based specialties.

To address these risks, the multi-society summit report calls for several actions to improve safety in fluoroscopy laboratories, including:

  • Accelerating the adoption of modern radiation protection technologies, such as suspended, freestanding, or table-mounted shielding systems that reduce exposure without requiring clinicians to wear heavy protective garments
  • Expanding real-time radiation monitoring to enable clinicians to receive immediate feedback and reduce exposure during procedures.
  • Strengthening education and training in radiation safety and exposure reduction for physicians, trainees, nurses, and technologists.
  • Continuing technological innovation to protect all catheterization lab clinicians.
  • Supporting regulatory and accreditation standards that promote safer fluoroscopy laboratory environments.

"ALARA+ represents a shift from accepting risk to expecting better," said SCAI President  Srihari S. Naidu, MD, MSCAI. "Fluoroscopy-guided procedures save lives every day by allowing minimally invasive treatment for heart disease, vascular disease, and stroke. The clinicians and teams delivering that care deserve laboratories that protect them just as thoughtfully as we protect our patients. "This multi-society call to action is about modernizing safety expectations, not creating new obligations. We are calling for the acceleration of practical changes in technology, policy, and laboratory design so radiation exposure is minimized, and the physical toll of protective equipment is no longer treated as inevitable." 

 

An international team led by the Universitat Politècnica de València has developed one of the most detailed brain atlases in the world




HoliAtlas will be especially useful for the study and early diagnosis of neurological and neurodegenerative diseases such as Alzheimer's or Parkinson's




Universitat Politècnica de València

HoliAtlas Project Brain Images 

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HoliAtlas Project Brain Images

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Credit: Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València





An international team led by the ITACA Institute at the Universitat Politècnica de València (UPV) has developed one of the most comprehensive and detailed structural atlases of the human brain to date. Known as HoliAtlas, it will be particularly useful for the study and early diagnosis of neurological and neurodegenerative diseases, such as Alzheimer's or Parkinson's.

The new map is based on ultra-high-resolution multimodal magnetic resonance imaging (MRI) and far exceeds the level of detail found in existing MRI-based atlases.

The study, published in the journal Scientific Reports (Nature), was led by Professor José V. Manjón, coordinator of the MIALAB group at ITACA-UPV, in collaboration with international institutions such as the CNRS and the University of Bordeaux, as well as Spanish and European centres.

More personalised diagnoses and treatments

"HoliAtlas provides a complete, multi-level representation of the brain, from global structures down to very specific substructures, in a holistic manner. Its resolution and multimodal integration facilitate the identification of deep structures

and enable the development of more accurate automatic segmentation methods, improved morphological analysis, and the detection of very subtle anatomical changes.

"For this reason, this atlas could be of great help in studying conditions such as Alzheimer's and/or Parkinson's and facilitating a more accurate diagnosis. Having increasingly precise brain atlases is key to understanding the architecture of the human brain, integrating data from different studies and moving towards more personalised diagnoses and treatments," explains José Vicente Manjón, head of the MIA-LAB group at ITACA-UPV.

A leap in resolution and anatomical detail

Brain atlases function as reference maps, essential for precisely locating anatomical structures and comparing data across studies or populations. Furthermore, they are key tools in both neuroscientific research and clinical applications, such as surgical planning or the analysis of neurological diseases.

"Until now, most MRI-based atlases had a resolution of approximately 1 mm³. The new atlas developed achieves a resolution of 0.125 mm³, allowing much smaller and more complex brain structures to be observed," notes Sergio Morell, a researcher with the MIA-LAB group at ITACA and co-author of the study.

Based on data from 75 healthy brains

To construct this atlas, the researchers used brain images from 75 healthy volunteers from the prestigious Human Connectome Project, one of the largest international repositories of neuroimaging data. Using this data, they applied advanced processing and normalisation techniques to generate an average brain model.

"At its most detailed level, the atlas includes up to 350 anatomical regions obtained by integrating seven different segmentation protocols, combining neuroanatomical analysis tools, artificial intelligence algorithms, and manual corrections by experts," concludes Sergio Morell.

Reference

José V. Manjón, Sergio Morell-Ortega, Marina Ruiz-Perez, Boris Mansencal, Edern Le Bot, Marien Gadea, Enrique Lanuza, Gwenaelle Catheline, Thomas Tourdias, Vincent Planche, Remi Giraud, Denis Rivière, Jean-Francois Mangin, Nicole Labra-Avila, Roberto Vivo-Hernando, Gregorio Rubio, Fernando Aparici-Robles, Maria de la Iglesia-Vaya & Pierrick Coupé. Ultra-high resolution multimodal MRI densely labelled holistic structural brain atlas. Scientific Reports. NATURE. DOI: https://www.nature.com/articles/s41598-026-40186-2