Sunday, July 26, 2026

SPACE/COSMOS

Venus: Dead? Far from it








ETH Zurich

Huge rift valleys on Venus 

image: 

There are huge rift valleys on Venus. They suggest that the planet is still geologically active.

view more 

Credit: (Image: NASA/JPL/USGS)





Venus is an inhospitable place, with temperatures soaring to several hundred degrees Celsius and no oceans like those on Earth. Planetary scientists long believed Venus was geologically dormant. However, recent research indicates that Venus remains geologically “alive” and even hosts active volcanoes. 

Rift valleys, which indicate tectonic activity, can be vast and resemble those on Earth, such as the African Rift Valley. On Venus, they can span up to 10,000 kilometres. 

The timing of these rifts’ formation is uncertain. Geoscientists believe they originated more than 100 million years ago and are therefore remnants of the past. 

Simulations indicate tectonic activity 

ETH researchers, led by Taras Gerya, Professor of Geodynamics at the Department of Earth and Planetary Sciences, have used a new computer model to demonstrate that some rift valleys may have formed relatively recently. The planetary scientists also addressed the long-standing question of whether Venus is geologically active. This study has been published in Nature Geoscience. Lead author Xi Yang conducted the research as part of his Master’s studies under Gerya’s supervision. 

Yang and his team used a new computer model to simulate high-resolution, 3D rifts for the first time. This allowed them to accurately replicate these rift structures in simulations and provide better explanations of their formation. Earlier models had relied on simplified material assumptions and been mostly two-dimensional. 

The models indicate that broad ridges, known as rift flanks, form along the edges of rift valleys when the rifts are geologically young and either still actively moving or have only recently stopped moving. The simulations also suggest that these rifts widen more rapidly than had been previously believed, at a rate of 3 to 10 centimetres per year. 

Yang and his colleagues also show that the rift flanks tend to flatten rapidly after movement ceases; the older the rift system, the less steep and narrow its flanks. Unlike Earth, where erosion gradually wears down features, Venus’s flanks subside due to crustal relaxation.  

Wide and high rift flanks are not only produced by the computer model but can also be seen in images of the Venusian surface from the Magellan probe during its 1990’s mission. 

Based on their simulations and observational data, the researchers conclude that Venus remains an active planet with a more dynamic interior than had been previously believed. “The results help us to better assess the tectonic activity on Venus,” says Gerya. 

Supporting future Venus missions 

The results of the ETH researchers’ model could help pinpoint active regions worthy of detailed investigation for these missions. Additionally, the study enhances our understanding of how rocky planets form. Importantly, the researchers aim to uncover clues that could improve the detection of rocky exoplanets. 

Growing interest in our neighbouring planet 

Interest in Venus is increasing as NASA and ESA prepare multiple missions to explore Earth’s neighbouring planet. 

ETH geophysics professors Paul Tackley and Taras Gerya, along with their collaborators, are participating in ESA’s EnVision mission. They are developing instruments for the Venus orbiter to analyse the planet’s surface. The mission, scheduled for launch in the early 2030s, will explore the planet more thoroughly, from its core to its upper atmosphere. 

Could alien signals be hiding on a different radio channel?




Royal Astronomical Society

ALMA's DV-59 antenna 

image: 

ALMA's DV-59 antenna in the foreground with multiple other antennas observing the sky in a night dominated by the Moon.

view more 

Credit: ALMA / Alex Pérez / CC BY 4.0





Astronomers searching for signs of extraterrestrial intelligence may have been missing alien signals in part of the radio spectrum that has not recently been explored.

Most radio SETI (Search for Extraterrestrial Intelligence) surveys have focused on frequencies between 1.42 and 1.66 GHz. This range is known as the 'water hole' because it lies between the natural radio frequencies emitted by hydrogen and hydroxyl, two molecules whose combination forms water.

Scientists have long thought that this relatively quiet part of the radio spectrum would be a logical place to communicate, as a technologically advanced civilisation might recognise the significance of hydrogen and hydroxyl and be likely to transmit and listen there.

But a new study suggests that higher radio frequencies could provide an important new avenue in the search for possible technological signals from other civilisations. The research is being presented this week at the Royal Astronomical Society's National Astronomy Meeting in Birmingham.

Using archived observations from the Atacama Large Millimeter/submillimeter Array (ALMA) in Chile, astronomer Louisa Mason, a PhD researcher at the University of Manchester, carried out the first-ever SETI survey using the telescope. Rather than making new observations, she analysed existing data originally collected for other astronomical purposes.

She looked for narrowband radio signals that might indicate the presence of technology rather than natural astrophysical processes.

"For decades, SETI searches have concentrated on a relatively small part of the radio spectrum. We wanted to ask what might happen if we looked somewhere very different," Mason said.

"The millimetre and submillimetre radio bands remain almost completely unexplored for SETI, so this is really about opening up a new area of parameter space to search."

Mason searched two small frequency windows in ALMA's Band 3 observations but found no candidate technosignatures (alien signals) above their thresholds.

Although the survey examined only four archived ALMA observations, Mason says the work demonstrates that high-frequency radio telescopes could play an important role in future SETI programmes.

The research also highlights an overlooked opportunity hidden within every radio observation: when astronomers point a telescope at a single target, they also capture many other stars within the telescope's field of view.

Traditionally, researchers have estimated this 'stellar bycatch' using catalogues such as Gaia. Instead, Mason used the Besançon Galactic Model to estimate the full stellar population contained within each observation, including stars too distant, too faint or too difficult to identify reliably in existing catalogues.

Applying the technique to a previous SETI survey of 1,327 telescope pointings increased the estimated number of stars included in the search from around 288,000 identified using Gaia to more than 6.1 million using the galactic model.

Mason says this provides a much more realistic picture of how much of the galaxy has actually been surveyed for technosignatures. 

"One of the most exciting things about this work is realising that we've surveyed many more stars than initially thought," she said.

"Even a very small observation can contain a huge number and diversity of stars that we might never have intended to study. By combining high-frequency observations with galactic simulations, we can better understand exactly what we've searched and where we should look next."

Mason emphasises that the absence of any detected signal does not mean intelligent life does not exist, only that no candidate signal was found within the small frequency ranges examined in this study. Instead, she hopes the work will encourage future SETI surveys to search more widely across the radio spectrum and make better use of existing astronomical observations.

The work was done in collaboration with Professor Michael Garrett, Dr Andrew Siemion and Dr Kelvin Wandia.

ENDS


Images & captions

Image 1: ALMA's DV-59 antenna in the foreground with multiple other antennas observing the sky in a night dominated by the Moon.

https://drive.google.com/file/d/1qBkjttr8PMnIotJ3m1QM4znBIi7XcGnI/view?usp=drive_link 

Credit: ALMA / Alex Pérez / CC BY 4.0

 

Figure 1: Figure showing the frequency coverage and power of a signal that each facility could be sensitive to. This highlights the fact that no other instruments are conducting SETI at high frequencies, and ALMA has an exciting frequency coverage yet to be explored.

https://drive.google.com/file/d/1B3X3IycbX0bK6GRcQpfP7DPgWWyoUUCg/view?usp=drive_link  

Credit: Louisa Mason

 

Figure 2: Figure of stellar bycatch demonstrating the breadth of stellar objects that could be captured within a single pointing. This example is for a generic direction (l=0 deg, b = 30 deg) for a 5 arc second field of view.

https://drive.google.com/file/d/1FNo5Tupm-PUL_XqBl0PiTxybm235GMA4/view?usp=drive_link  

Credit: Louisa Mason

 

Figure 3: This figure shows the diversity in the stellar bycatch population considered through the use of galactic models (such as BGM). The red overlay is stars found through the Gaia catalogues, highlighting that galactic models simulate the full breadth of Main Sequence stars, as well as clearly distinguishing the white dwarf population.

https://drive.google.com/file/d/16zmO3fq2oeNwmDdz22RrjqUH1Ic-luOf/view?usp=drive_link 

Credit: Louisa Mason


Further information

Relevant papers

Louisa A Mason, Michael A Garrett, Andrew P V Siemion, Simulating the stellar bycatch: constraining the prevalence of extraterrestrial transmitters within radio SETI surveys, Monthly Notices of the Royal Astronomical Society, Volume 545, Issue 3, January 2026, staf2112, https://doi.org/10.1093/mnras/staf2112

Louisa A Mason, Michael A Garrett, Kelvin Wandia, Andrew P V Siemion, Conducting high-frequency radio SETI searches using ALMA, Monthly Notices of the Royal Astronomical Society, Volume 536, Issue 3, January 2025, Pages 2127–2134, https://doi.org/10.1093/mnras/stae2714

 

The poster 'Strategies Utilising High-Frequency Interferometric Data to Explore SETI Parameter Space' is part of the Statistical Challenges for Next-Generation Astronomical Surveys session at NAM2026 from 14:15-15:45 BST on Friday 24 July 2026 in room PW117. Find out more at: https://uobevents-national-astronomy-meeting-2026.eventsairsite.com/block-schedule.


Notes for editors

About the Royal Astronomical Society

The Royal Astronomical Society (RAS), founded in 1820, encourages and promotes the study of astronomy, solar-system science, geophysics and closely related branches of science.

The RAS organises scientific meetings, publishes international research journals, recognises outstanding achievements by the award of medals and prizes, maintains an extensive library, supports education through grants and outreach activities and represents UK astronomy nationally and internationally. Its more than 4,000 members (Fellows), a third based overseas, include scientific researchers in universities, observatories and laboratories as well as historians of astronomy and others.

The RAS accepts papers for its journals based on the principle of successful peer review, following which experts on the Editorial Boards accept the papers for publication. The Society issues press releases based on a similar principle, but the organisations and scientists concerned have overall responsibility for their content.

Keep up with the RAS on Instagram, Bluesky, LinkedIn, Facebook and YouTube.

Download the RAS Supermassive podcast

 

About the Science and Technology Facilities Council

The Science and Technology Facilities Council (STFC), part of UK Research and Innovation (UKRI), is the UK’s largest public funder of research into astronomy and astrophysics, particle and nuclear physics, and space science. We operate five national laboratories across the UK which, supported by a network of additional research facilities, increase our understanding of the world around us and develop innovative technologies in response to pressing scientific and societal issues. We also facilitate UK involvement in a number of international research activities including the ELT, CERN, the James Webb Space Telescope and the Square Kilometre Array Observatory.

linkedin.com/company/stfc 

ukri.org/councils/stfc

 

About The University of Birmingham

The University of Birmingham is ranked amongst the world's top 100 institutions. Its work brings people from across the world to Birmingham, including researchers, educators and more than 40,000 students from over 150 countries.

England’s first civic university, the University of Birmingham, is proud to be rooted in one of the most dynamic and diverse cities in the country. A member of the Russell Group and a founding member of the Universitas 21 global network of research universities, the University of Birmingham has been changing the way the world works for more than a century.

The University of Birmingham is committed to achieving operational net zero carbon. It is seeking to change society and the environment positively, and use its research and education to make a major global contribution to the UN Sustainable Development Goals. Find out more about our approach to sustainability.


Analysis of defense technology for large-sized near-Earth asteroids




Beijing Institute of Technology Press Co., Ltd
Virtual potential threat asteroid database. (A) Virtual asteroid orbit that will impact Earth 1 year later. 

image: 

Virtual potential threat asteroid database. (A) Virtual asteroid orbit that will impact Earth 1 year later.

view more 

Credit: Space: Science & Technology






Near‑Earth asteroid impacts pose a major threat that could lead to the destruction of human civilization, having already caused catastrophic environmental changes and mass extinctions multiple times in history. In recent years, asteroids with diameters ranging from tens to hundreds of meters have frequently made close flybys of Earth, and a large number of large‑sized asteroids remain undiscovered, with warning times often only a few days to weeks. For large‑sized asteroids exceeding 100 meters in diameter, or even kilometer‑scale ones, traditional kinetic impact or long‑term force deflection methods offer limited energy and cannot achieve effective deflection within short timeframes. Using the enormous energy generated by nuclear detonation to directly destroy or rapidly deflect the asteroid's orbit is the most effective, and in extreme cases the only feasible, approach for dealing with large asteroids or those with short warning times. However, existing research on detonation defense has mostly focused on the direct rendezvous impact mode, in which the impact and detonation positions cannot be autonomously selected and energy coupling is relatively weak. Moreover, there is a lack of systematic analysis of the capability coverage and overall effectiveness of different defense modes, severely constraining the optimization of engineering designs.

In a recent study published in Space: Science & Technology, the team led by Researcher Wang Xiaowei from the China Academy of Launch Vehicle Technology proposed a novel approach to detonation defense technology for large‑sized near‑Earth asteroids. Building on the energy advantages of nuclear detonation, the study proposed two defense modes: a direct rendezvous impact detonation mode and a novel flyby pre‑excavation detonation mode. By establishing a virtual threat asteroid database and using the finite element method‑smoothed particle hydrodynamics adaptive method to simulate damage effects under various yields and burial depths, the study systematically analyzed the influence of key factors, including launch vehicle characteristic energy (C3), impact velocity, and velocity increment provided by the space transfer platform, on defense coverage and deflection effectiveness. The results demonstrate that the flyby pre-excavation detonation mode, due to its ability to autonomously select the cratering location and achieve deep detonation, offers stronger energy coupling. It can directly destroy hundred-meter-scale asteroids and achieve velocity increments of tens of centimeters per second or more for kilometer‑scale asteroids, several times higher than those of the direct rendezvous mode, while also entailing lower technical difficulty, making it the preferred option when warning time permits. When the velocity increment reaches 1 m/s, the deflection target can be achieved in only 60 days. This study provides an important theoretical foundation for mission planning and engineering design of defense against large-sized or short-warning-time near-Earth asteroids, and holds profound strategic significance for enhancing humanity's capability to respond to asteroid impact threats.

 

The study focuses on the severity of impact threats posed by large-sized near-Earth asteroids and the necessity of detonation defense technology, and proposes two detonation defense modes. Asteroids with diameters exceeding 100 meters can trigger large‑scale, intercontinental, or even global catastrophes, yet a large number of such asteroids remain undiscovered, with warning times often being extremely short (for example, 2024 MK had only 13 days). Nuclear detonation, due to its enormous energy, is the most effective means of dealing with large asteroids with short warning times. On this basis, the study proposes two defense modes: Mode 1 is the direct rendezvous impact detonation mode, in which a defender directly impacts the asteroid's surface at high speed to form a shallow crater, after which a nuclear device detonates within that shallow crater. Mode 2 is a novel flyby pre-excavation detonation mode, in which a space transfer platform first releases a conventional penetration device to pre-excavate a deep crater on the asteroid, and then guides a nuclear device into the deep crater for detonation. The core difference between the two modes is that Mode 1 has a simple system and can be launched immediately, but the impact location is random, energy coupling is weak, and requirements for the nuclear device's impact resistance and detonation timing are extremely stringent. Mode 2 has a more complex system and requires a longer warning time, but it can autonomously select the cratering location, achieve deep nuclear detonation, and provides strong energy coupling. To comprehensively evaluate defense capability, the study established a virtual threat asteroid database (as shown in Fig. 1), taking relative velocity (10 km/s) and angular ranges α (0°-360°) and β (40°-90°) as variables, and generated virtual asteroid orbit libraries for 1‑year and 20‑year warning times through backward integration of orbital dynamics, providing a baseline for subsequent effectiveness analysis.

The study also conducted quantitative analyses of the key influencing factors for both modes. For Mode 1, a two-pulse optimal transfer orbit model was established to analyze the effects of launch vehicle characteristic energy (C3) and maximum impact velocity on deflection time. As shown in Fig. 2, when C3 is 30 km²/s² and the maximum impact velocity is 10 km/s, only 30% of asteroids can achieve a deflection time exceeding 50 days. When the velocity is increased to 20 km/s, all asteroids have deflection times exceeding 30 days, with approximately 16% exceeding 150 days. Further increasing the velocity to 30 km/s yields only marginal gains, indicating that 20 km/s represents a more favorable design point for Mode 1, though this velocity poses significant challenges for the design of nuclear devices resistant to high-speed impact. For Mode 2, a three-pulse transfer orbit model was established to analyze the influence of the velocity increment provided by the space transfer platform on asteroid defense coverage. Fig. 3 shows that the velocity increment requirements for all virtual asteroids are below 10 km/s, with about 45% requiring less than 6 km/s. Therefore, space transfer platforms using chemical propulsion (specific impulse 300-460 seconds) or electric propulsion (specific impulse 4,000-10,000 seconds) can achieve coverage for most threat sources. In addition, the finite element method-smoothed particle hydrodynamics method was used to simulate damage effects under various explosive yields and burial depths. Fig. 4 illustrates the damage morphology of a kilometer-scale asteroid under a 3-megaton TNT equivalent detonation at a burial depth of 5 meters, showing that craters on the order of hundreds of meters can be formed and significant velocity increments can be generated.

Finally, the study compared the defense effectiveness of the two modes against large-sized asteroids and provided recommended solutions. For hundred-meter-scale asteroids, both modes can directly destroy them. For kilometer-scale asteroids, Mode 1, under a 3‑megaton TNT equivalent detonation at a shallow crater depth of 5 meters, produces a velocity increment of 8 to 9.2 cm/s. In contrast, Mode 2, with a deep crater detonation at 20 meters, achieves a velocity increment exceeding 30 cm/s, representing an order of magnitude improvement in effectiveness. Based on the virtual database, the study further analyzed the minimum warning time required for successful deflection under different velocity increments (as shown in Figs. 5 to 8). When the velocity increment is 0.5 cm/s, a minimum of 4.45 years is required; at 3 cm/s, 560 days are needed; at 18 cm/s, 139 days suffice; and at 1 m/s, only 60 days are required. This indicates that Mode 2, due to its ability to generate higher velocity increments, can substantially shorten the required warning time. In a comprehensive comparison, Mode 1 is suitable for emergency defense under extremely short warning times, though it entails high technical difficulty. Mode 2, when warning time permits, offers lower technical complexity and more reliable defense effectiveness, and can therefore serve as the preferred solution for large-sized near-Earth asteroid defense. This study provides a systematic theoretical foundation and data support for the engineering design and mission planning of future asteroid defense missions in China.


Distribution of minimum number of days prior to impact when the speed increment is 3 cm/s. 

Distribution of minimum number of days prior to impact when the speed increment is 3 cm/s.

Distribution of minimum number of days prior to impact when the speed increment is 1 m/s. 

Distribution of minimum number of days prior to impact when the speed increment is 1 m/s.

Credit

Space: Science & Technology



Why Europa’s hidden ocean may be more difficult to reach than scientists thought



A Rutgers scientist says shallow water on Jupiter’s icy moon may not offer a direct window into its deep subsurface




Rutgers University

Europa 

image: 

Europa, one of Jupiter’s icy moons, has drawn scientific interest because its frozen surface may hide a global ocean with conditions that could support life. 

view more 

Credit: NASA/JPL-Caltech/SETI Institute




Europa, one of Jupiter’s icy moons, long has fascinated scientists because of what may lie beneath its frozen shell: a global ocean of liquid water.

That hidden ocean has made Europa one of the most compelling places in the solar system to study the conditions that might support life. But new research led by Rutgers scientist Lujendra Ojha suggests one of the most promising shortcuts to Europa’s ocean may be far more complicated than previously thought.

In a study published in Nature Astronomy, Ojha and colleagues used computer simulations to test whether liquid water from Europa’s deep ocean could rise through cracks in the ice and collect in shallow reservoirs closer to the surface. Such reservoirs, if they exist, could be easier for future missions to detect or sample than the ocean buried far below.

“The mystery we wanted to solve was whether this journey is actually possible,” said Ojha, an associate professor in the Department of Earth and Planetary Sciences at the Rutgers School of Arts and Sciences. “Can liquid water rise from Europa’s deep ocean toward the surface without freezing along the way?”

Their conclusion: The route from deep ocean to shallow ice is probably much more difficult than scientists have assumed.

“There’s an icy shell, there’s water underneath, and there’s all this speculation about how that water can come from deep underground and make its way all the way up without freezing en route,” Ojha said. “That’s really what we think we disproved.”

The finding has important implications for future exploration of Europa. If shallow pockets of liquid water are found beneath the moon’s surface, they may not necessarily contain water from Europa’s deep ocean. Instead, they may have formed locally, from ice that melted within the shell itself.

That distinction matters. Scientists are interested in Europa because liquid water, chemistry and energy are all essential ingredients in the search for habitable environments beyond Earth. A shallow reservoir would be easier to reach than the deep ocean. But if that reservoir isn’t connected to the ocean, it may not reveal what is happening in Europa’s most intriguing environment.

The work arrives as two major spacecraft missions are on their way to the Jupiter system. NASA’s Europa Clipper mission launched in October 2024 and is scheduled to arrive at Jupiter in April 2030, where it will orbit the planet and make 49 close flybys of Europa. The European Space Agency’s Jupiter Icy Moons Explorer mission, known as JUICE, launched in April 2023 and is scheduled to arrive at Jupiter in July 2031.

Together, the missions are expected to give scientists a far more detailed view of Europa’s ice shell, surface composition and possible subsurface water. Europa Clipper’s radar instrument may help scientists determine whether shallow reservoirs exist and how they are structured.

Beneath Europa’s extremely cold surface, a global ocean may remain liquid because Jupiter’s powerful gravity continually squeezes and stretches the moon, generating internal heat that is trapped by the overlying ice shell. 

The study focuses on dikes, narrow cracks or fractures that could, in theory, allow water from the ocean to rise upward through the ice. The idea is somewhat similar to the way molten rock can move through cracks on Earth before feeding volcanic activity. On icy worlds, the process is known as cryovolcanism, or volcanism involving ice and water rather than molten rock.

Ojha said that comparison is useful only up to a point.

“Ice and liquid water are fundamentally different than lava and the volcanoes that we see here on Earth,” he said. “I think there’s some fundamental physics that’s missing here, and so I wanted to explore that.”

One missing piece, Ojha said, is turbulence. Earlier models often treated water rising through Europa’s ice as if it moved in a relatively orderly way. But the Rutgers-led simulations suggest the water would likely move fast and turbulently through the fractures, mixing against the cold walls of the crack and losing heat quickly into the surrounding ice.

“This water that’s going to come up, it’s going to be turbulent,” Ojha said. “It’s going to be left and right, it’s going to be up and down, it’s going to have a swirling motion. And when that happens, that liquid water is going to cool very, very fast as it approaches the surface.”

As the water cools, it can become supercooled, meaning it remains liquid even after dropping below its normal freezing temperature. Under those conditions, tiny ice crystals called frazil ice can form, build up and clog the pathway.

The simulations show that narrow cracks could freeze shut within hours. Wider cracks could carry more water under idealized conditions, but turbulence makes those scenarios far less favorable. The researchers found that to deliver enough water to form some of Europa’s surface features, the fractures would need to be unrealistically long or occur in large numbers.

The result is a picture of Europa in which shallow water, if present, may have a different origin than many scientists have hoped. Rather than rising directly from the ocean, the water may be produced by localized heating and melting inside the ice shell.

“Our work suggests that Europa’s ice shell may be a stronger barrier between the ocean and the surface than previously assumed,” Ojha said. “This helps future missions interpret what they find and better understand where to look for signs of habitability.”

Explore more of the ways Rutgers research is shaping the future.

 

Scientists solve mystery behind contradictory behaviours of new weight-loss drugs





University of Cambridge





Cambridge scientists have solved the mystery of why both stimulating and blocking a particular ‘switch’ in the brain can help people lose weight – findings which could help boost the effectiveness of obesity drugs.

Published today in Nature Metabolism, the study in mice shows that the answer lies in where the switch is located: stimulating the switch in the brainstem suppresses appetite, while the same effect can be achieved by blocking the switch in the hypothalamus.

More than a billion people worldwide are living with obesity, which increases the risk of diseases such as 2 diabetes, cardiovascular disease and cancer. Weight loss can help mitigate these complications, but losing weight through diet and exercise alone can prove challenging.

In the past few years, a new generation of weight loss drugs has emerged that target particular receptors in the brain, reducing appetite and leading to weight loss, as well as helping control blood sugar levels. Several of these, such as Wegovy and Ozempic, work by stimulating a protein ‘switch’ known as the glucagon-like peptide 1 receptor (GLP-1R).

Other weight loss drugs act on both this receptor and a second one, the glucose-dependent insulinotropic polypeptide receptor (GIPR). However, some of these drugs, such as Mounjaro and Zepbound, stimulate GIPR, while others, such as MariTide, block it. Why these opposite actions have the same result has puzzled scientists.

Now, researchers at the Institute of Metabolic Science, University of Cambridge, have used mice to solve the puzzle, showing that the two different types of GIPR drugs act on distinct regions of the brain – but also that they can boost weight loss when combined with certain GLP-1-based weight-loss drugs.

The team used genetically engineered mice and selectively removed GIPR from different parts of the brain to see which regions were responsible for the effects of the obesity drugs. One group of mice lacked GIPR in the brainstem – the area at the base of the brain, just above the spinal cord, involved in appetite and nausea. A second group lacked GIPR in the hypothalamus, a major centre controlling hunger and body weight. The third, control group were normal, unmodified mice.

The researchers then treated these mice with various combinations of a GIPR agonist (which activates the receptor), a GIPR antagonist (which blocks the receptor) and a GLP-1 drug, and measured food intake, body weight, fat mass, glucose control and brain activity.

By comparing the responses of normal mice with mice lacking GIPR in different brain areas, they showed that GIPR agonists act on the brainstem to suppress appetite and reduce weight.

They then showed that GIPR antagonists help weight loss by acting on this receptor, but in the hypothalamus, where they release a ‘brake’ that otherwise limits the brainstem’s ability to respond to signals telling us we are full. Blocking GIPR also appeared to boost the effect of emerging new drugs targeting the amylin receptor, suggesting that GIPR antagonists could potentially be used to strengthen several types of anti-obesity medicines.

The findings explain why drugs such as MariTide, currently in phase 3 clinical trials, which combines GIPR antagonism with GLP-1 receptor agonism, are effective, and suggests how to design even better combination therapies.

Dr Jo Lewis, the study’s first author from the Institute of Metabolic Science at the University of Cambridge, said: “Understanding which brain circuits respond to these medications – and how they do so – could help us design better drugs that produce more weight loss with fewer side effects, and which might work in combination with other obesity medicines to even greater effect.

“Our work also strengthens the idea that the brain is central to obesity treatment. Obesity drugs are not acting simply on the gut or pancreas. Instead, they have important effects on specific, identifiable brain circuits that regulate appetite and food intake.”

The research was funded by the Medical Research Council and Wellcome.

Reference

Lewis, JE, et al. Distinct brain regions mediate regulation of food intake in response to GIPR agonism and antagonism. Nature Metabolism; 24 July 2026; DOI: 10.1038/s42255-026-01575-z

 

New drug could contribute to stopping measles outbreaks






Georgia State University

Richard Plemper 

image: 

Richard Plemper, a Regents’ Professor and director of the Center for Translational Antiviral Research (CTAR) at Georgia State University

view more 

Credit: Georgia State University





ATLANTA — A new oral antiviral drug candidate administered either before or after direct contact or airborne exposure to canine distemper virus, which causes measles-like disease in ferrets, blocks transmission of the virus and reduces clinical symptoms, according to a study published in the journal Nature Microbiology1 by researchers in the Center for Translational Antiviral Research (CTAR) at Georgia State University.

The study explored whether prophylactic (shortly before or after exposure) administration of the recently developed clinical candidate GHP-88310 (described in Science Advances2), a broad-spectrum inhibitor of the viral polymerase, prevents virus transmission through close contact or through the air. The results demonstrate that GHP-88310 efficiently blocks both forms of viral spread. In addition, the study showed that treatment of infected animals shortened the time period in which infected animals could transmit the virus.

“Silencing measles outbreaks quickly is essential to reestablish control over the virus,” said senior author Richard Plemper, a Regents’ Professor and director of the CTAR. “This study follows our recent development of the drug candidate GHP-88310. It demonstrates that the drug is suitable to augment traditional ring vaccination against measles.”

Since 2025, measles has reemerged in the United States with thousands of cases across multiple states, hundreds of hospitalizations and three confirmed deaths. Large outbreaks in Canada and Mexico with multiple deaths have challenged the measles elimination status of North America.

“We were very excited to see that GHP-88310 given by mouth completely prevented airborne transmission in our ferret model of measles,” said first author Carolin Lieber, a senior postdoctoral fellow in the Plemper lab. “This finding is unprecedented for a viral polymerase inhibitor and demonstrates the extraordinary antiviral potency of this drug.”

To explore relevant conditions of viral transmission, the researchers developed a system that allowed them to pair infected and uninfected animals in direct physical contact or shared airspace, each under controlled environmental parameters.

“We designed the study to recapitulate viral spread between people with direct contact, for instance in a household, and between more distant social contacts, for example in classrooms or other indoor settings that bring people into proximity without direct interaction,” said Plemper. “In addition to this prophylactic benefit, GHP-88310 used therapeutically shortened the duration of disease in our model. If equally applicable to human hosts, it may shorten the severe social and economic burden of prolonged quarantine of patients and further aid outbreak management.”

The investigators are now readying GHP-88310 for formal clinical testing.

Additional authors of the study include Josef Wolf, Claire Ruckel and Lauren Harrison of the Center for Translational Antiviral Research in the Institute for Biomedical Sciences at Georgia State.

The study was funded by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH).

To read the studies, visit

1 DOI 10.1038/s41564-026-02419-y. Once published online, it will be available at URL: https://www.nature.com/articles/s41564-026-02419-y

2 DOI: 10.1126/sciadv.aef1594. URL: https://www.science.org/doi/10.1126/sciadv.aef1594?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

 

 

A study in non-human primates revealed a species-specific function of MANF, a non-canonical neurotrophic factor




Higher Education Press
Image: 

image: 

Species-specific mechanism of MANF in the brain. In monkeys, MANF knockdown triggers a reduction in downstream LIF expression, subsequently decreasing the STAT3 signaling pathway and leading to selective astrocyte apoptosis. This mechanism is absent in mice. Notably, supplementation with exogenous LIF protein effectively rescues astrocytes from MANF-deficiency-induced death, establishing the MANF-LIF-STAT3 axis as a survival regulator for primate astrocytes.

view more 

Credit: HIGHER EDUCATION PRESS

 




Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a non-canonical neurotrophic factor broadly expressed throughout the brain. Previous work has shown that MANF modulates neuronal functions in various disease contexts; however, its cell-type-specific roles within the brain remain incompletely understood. Notably, clinical data link MANF deficiency to microcephaly in humans, yet traditional rodent models fail to replicate this pathology.

 

To address this discrepancy, researchers investigated the role of MANF in the brain by comparing mice and monkeys. Using CRISPR/Cas9 gene editing, they knocked down MANF both in vivo and in primary cell cultures. By integrating molecular biology, transcriptome sequencing, and functional rescue experiments, the team discovered that MANF is essential for astrocyte survival specifically in monkeys.

 

Key findings from the study include:

 

  1. Primate-specific mechanism governing astrocyte survival. Acute MANF reduction produces distinct cellular consequences: while MANF depletion does not affect neuron or astrocyte survival in mice, it leads to astrocyte loss in monkeys. This finding aligns with previous observations that MANF knockout mice exhibit no overt neurological defects, whereas humans carrying MANF deletions show severe neurodevelopmental abnormalities and microcephaly. Together, these data uncover a previously unappreciated, primate-specific role of MANF in regulating astrocyte survival.

 

  1. The MANF-LIF-STAT3 Axis. The study identified the LIF-STAT3 pathway as a downstream effector of MANF in regulating monkey astrocyte survival, providing a mechanistic explanation for MANF’s primate-specific role in astrocyte maintenance. Furthermore, enhancing the LIF-STAT3 pathway mitigated the apoptotic signaling induced by MANF depletion, highlighting LIF as a promising therapeutic target for neurodevelopmental disorders in MANF-deficient individuals.

 

Collectively, this study underscores the significance of utilizing non-human primate models to investigate MANF neurobiology and to evaluate therapeutic strategies targeting MANF-related pathways. The work entitled “MANF is essential for astrocyte survival in the monkey brain” was published on Protein & Cell.

 

Scientists reveal major blind spot over gardens and air pollution



Review finds lack of evidence showing whether planting around our homes reduces the pollution we breathe





University of East London





A new review led by the University of East London (UEL) has uncovered a major blind spot in air pollution research. Despite domestic gardens covering vast areas of Britain's towns and cities, researchers found no direct  evidence showing whether they reduce pollution levels or improve the air people breathe at home. There is a huge gap about the role of domestic gardens on air quality.

Published in Nature-Based Solutions, the research examined more than 34,000 studies. Just 43 met the criteria for investigating gardens and air pollution, and none directly measured whether domestic gardens reduced pollutant concentrations or improved household air quality.

The finding is significant given the scale of domestic green space. In the UK alone, an estimated 25.8 million gardens cover around 959,800 hectares, while domestic gardens account for approximately 41 per cent of London's total area.

Evidence from larger green spaces may not apply to gardens

The review found strong evidence from wider green infrastructure research that trees, hedges, shrubs, green walls and other vegetation can capture particulate matter on their surfaces and absorb gaseous pollutants.

However, the authors warn that these findings cannot simply be applied to domestic gardens, where buildings, fences, sheds, parked cars and mixed planting create very different patterns of airflow and pollutant movement.

Dense vegetation, for example, may trap pollution on leaf surfaces but can also reduce ventilation, potentially allowing polluted air to build up. Hedges may shield parts of a garden from traffic emissions, but their effectiveness depends on factors including their height, density, distance from roads, surrounding buildings and weather conditions.

Lead author Dr Karina Corada-Pérez, Research Fellow in Air Quality and Green Infrastructure at UEL’s Sustainability Research Institute, said:

"Most of us think of gardens as healthy green spaces, and they absolutely provide many important benefits. But when it comes to air quality, we simply don't yet know enough.

"Plants can capture pollutants, but a garden is much more than a collection of individual plants. Its layout, boundaries, proximity to roads and buildings, and the way air moves through the space may all influence whether vegetation helps reduce pollution or allows it to accumulate.

"Because millions of people spend time in their gardens, grow food in them and open their homes onto them, we urgently need research in real domestic gardens. Only then can we give homeowners, planners and policymakers reliable advice about which planting choices are most likely to support cleaner air."

Questions for people growing food near busy roads

The review also raises important questions for people growing fruit, vegetables and herbs close to busy roads or industrial areas.

Previous studies have found elevated concentrations of metals, including lead, in some edible plants grown near major traffic routes. Leafy herbs such as parsley and mint tended to accumulate more than root vegetables or legumes, while some crops grown within ten metres of busy roads exceeded European threshold values.

The researchers stress that this is not a reason to stop growing food at home. Instead, they say more research is needed to understand how garden location, barriers, vegetation and planting arrangements influence the transfer of airborne pollutants into soils and crops, particularly in heavily polluted neighbourhoods.

Cleaner air may involve trade-offs

The study also found that choosing the "right" plants is unlikely to be straightforward.

Rough, hairy or waxy leaves can be effective at trapping pollution particles, while conifers may capture more fine particles because of their dense evergreen foliage.

However, some species also release naturally occurring compounds that may contribute to secondary air pollution under certain conditions, while others produce highly allergenic pollen.

Even routine gardening practices, including mowing, pruning and using petrol-powered equipment, may influence air quality through emissions or the release of plant-derived compounds, although these effects remain poorly understood in domestic gardens.

Turning an everyday green space into a research priority

The authors say future research should focus on how pollution moves through small residential spaces, how plant type, density and placement affect exposure, and how air-quality benefits interact with biodiversity, cooling, flood management, food production and wellbeing.

Rather than recommending particular plants or garden designs, the paper argues that future guidance should be based on evidence gathered in real homes and neighbourhoods, rather than assumptions drawn from parks, street canyons and other larger green spaces.

Dr Corada-Pérez added:

"Domestic gardens already support biodiversity, help cool our cities, reduce flood risk, provide space for growing food and improve our wellbeing. Understanding how air quality fits alongside those benefits could help us make better use of one of the most widespread - but least studied - forms of green infrastructure in our cities."

By filling this knowledge gap, the researchers believe domestic gardens could become a more meaningful part of future clean-air, climate resilience and public health strategies, while giving residents practical, evidence-based advice about how their own gardens can contribute to healthier urban environments.

Impact of domestic gardens on local air quality - How much do we know? Nature-Based Solutions, Karina Corada-Pérez, Caroline Nash, Stuart Connop, Laura Wendling, University of East London, and Kumar Prashant, University of Surrey.

 

Scientists pinpoint where cells first begin copying DNA




Medical Research Council (MRC) Laboratory of Medical Sciences






Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy of its genome. The findings, published in Nature Communications, reveal where DNA first starts to "unzip" inside living cells and identify a molecular gate that helps prepare DNA for copying.

Every time a cell divides, it must faithfully copy its entire genetic instruction manual. Errors during this process can damage the genome, making DNA replication one of the most carefully controlled activities in biology.

Before DNA can be copied, cells must activate specialised molecular machines called helicases, which separate the two strands of the DNA double helix. A key part of this machinery is a protein complex of six subunits called MCM2-7, which forms a dimer of two rings around DNA at specific starting points called replication origins. When activated, these two rings split and form the core machinery of the two emerging replication forks – the structures where DNA copying takes place.

Despite decades of research, scientists have struggled to observe exactly how this process begins inside living cells. Important questions remained unanswered, including where DNA first opens, how one strand exits the helicase ring, and how the molecular changes needed to start replication are coordinated.

Now, research led by Dr Christopher Weekes, working with senior authors Professor Christian Speck at the MRC Laboratory of Medical Sciences and Imperial College London and Dr Maximilian Reuter at the Institute of Molecular Biology in Mainz, Germany, have captured key steps in this transition in detail.

 “DNA replication is fundamental to every cell division, yet we still did not fully understand how it begins inside living cells. We wanted to find out where the DNA first opens and how the helicase, the molecular machine zipper that separates the two DNA strands, is reorganised into its active form. By identifying these first steps, we can now explain more clearly how cells start copying their DNA in the right place and at the right time.” Dr Maximilan Reuter, Team Leader, IMB Mainz

 

Capturing where DNA first opens

Before DNA can be copied, helicases must first separate the two strands of the DNA double helix. Scientists often compare this process to unzipping a zip before reading or copying the information inside.

Using a combination of synthetic biology, genome-wide DNA mapping and protein analysis, the team was able to track this process inside living yeast cells. They found that DNA begins opening at a highly specific location close near the interface where the two MCM2-7 rings meet.

The study also showed that this first opening event occurs in the same small region of DNA that is used earlier to recruit the proteins responsible for starting replication, suggesting that multiple stages of DNA copying are coordinated within a compact area of the genome.

Revealing DNA’s molecular exit gate

The researchers also identified a specialised “gate” within the helicase complex used during the earliest stages of DNA replication. They found evidence that this opening acts as a molecular doorway through which one strand of DNA exits as the replication machinery becomes active.

When the team attached a molecular string to neighbouring subunits of each helicase,replication forks, as the strings would lead to entanglement of the dual replication forks.

This revealed that the gate plays a critical role during activation of the replication machinery helping cells transition from preparing for DNA replication to actively copying the genome.

Building a complete picture of replication initiation

As well as identifying where DNA first opens, the study linked several previously separate steps into a single framework. The researchers showed how DNA opening, helicase separation, strand release and the arrival and departure of replication proteins are coordinated as replication begins.

They also captured previously unseen intermediate states of the replication machinery, helping to explain how cells transform inactive protein complexes into fully operational DNA-copying machines.

Why does this matter?

This research is a fundamental advance in our understanding of how cells preserve and pass on genetic information. Accurate DNA replication is essential for genome stability, and mistakes during the process can leave DNA damaged or incompletely copied.

While the work does not have an immediate clinical application, many of the proteins involved are conserved from yeast to humans, meaning the principles uncovered in this study could help researchers better understand replication and genome maintenance across a wide range of organisms.

The study also highlights the value of investigating molecular processes inside living cells, revealing not just what biological machines look like, but how and where they operate across the genome.

Starting DNA replication is not simply a matter of switching on a molecular motor. Two helicase rings must separate, open the DNA, release temporary assembly factors and move past one another in precisely the correct order. By mapping where DNA first opens in living cells and identifying the gate through which one strand exits, we can now explain this fundamental transition with much greater precision.” Professor Christian Speck, Head of the DNA Replication Group, LMS

This study was funded by the Biotechnology and Biological Sciences Research Council, Cancer Research UK and Deutsche Forschungsgemeinschaft.