Saturday, May 30, 2020

Global report: new clues about role of pangolins in Covid-19 as US severs ties with WHO

Experts condemn Trump’s actions; India records worst daily rise in infections; surges in Russia and Brazil; Australia tests sewage water

Chris Michael and Guardian staff Sat 30 May 2020
A researcher in Mexico works with reagent samples for taking Covid-19 tests. Photograph: Carlos Tischler/Rex/Shutterstock
Scientists claim to have found more clues about how the new coronavirus could have spread from bats through pangolins and into humans, as India reported its worst single-day rise in new cases, and the number of Covid-19 infections worldwide neared 6 million.

Writing in the journal Covid-19 Science Advances, researchers said an examination of the closest relative of the virus found that it was circulating in bats but lacked the protein needed to bind to human cells. They said this ability could have been acquired from a virus found in pangolins – a scaly mammal that is one of the most illegally trafficked animals in the world.

Dr Elena Giorgi, of Los Alamos national laboratory, one of the study’s lead authors, said people had already looked at the pangolin link but scientists were still divided about their role in the evolution of Sars-Cov-2, the virus that causes Covid-19.

“In our study, we demonstrated that indeed Sars-Cov-2 has a rich evolutionary history that included a reshuffling of genetic material between bat and pangolin coronavirus before it acquired its ability to jump to humans,” she said, adding that “close proximity of animals of different species in a wet market setting may increase the potential for cross-species spillover infections”.

The study still doesn’t confirm the pangolin as the animal that passed the virus to humans, but it adds weight to previous studies that have suggested it may have been involved.

However, Prof Edward Holmes, an evolutionary biologist at the University of Sydney, in Australia, said more work on the subject was needed. “There is a clear evolutionary gap between Sars-Cov-2 and its closest relatives found to date in bats and pangolins,” he said. “The only way this gap will be filled is through more wildlife sampling.”

The findings came as Donald Trump announced that the United States was severing its ties with the World Health Organization because it had “failed to reform”.

In a speech at the White House devoted mainly to attacking China for its alleged shortcomings in tackling the initial outbreak of coronavirus, Trump said: “We will be today terminating our relationship with the World Health Organization and redirecting those funds to other worldwide and deserving urgent global public health needs.”

The US is the biggest funder of the WHO, paying about $450m (£365m) in membership dues and voluntary contributions for specific programmes.

Trump’s declaration was condemned in the US and around the world, with Australian experts joining counterparts in the UK and elsewhere in voicing their support for the WHO. Prof Peter Doherty, a Nobel laureate and patron of the Doherty Institute, which is part of global efforts to find a Covid-19 vaccine, said the WHO had the “full support of the scientific community”.

Deaths in the US have climbed to more than 102,000, with 1,747,000 infections. It is by far the biggest total in the world. On Friday it emerged that one person who attended the controversial pool parties in the Ozarks last weekend had tested positive for the virus.

https://www.theguardian.com/world/2020/may/30/global-report-new-clues-about-how-coronavirus-formed-as-us-severs-ties-with-who

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