Monday, September 08, 2025

 

Physicists devise an idea for lasers that shoot beams of neutrinos



Super-cooling radioactive atoms could produce a laser-like neutrino beam, offering a new way to study these ghostly particles — and possibly a new form of communication.




Massachusetts Institute of Technology





At any given moment, trillions of particles called neutrinos are streaming through our bodies and every material in our surroundings, without noticeable effect. Smaller than electrons and lighter than photons, these ghostly entities are the most abundant particles with mass in the universe. 

The exact mass of a neutrino is a big unknown. The particle is so small, and interacts so rarely with matter, that it is incredibly difficult to measure. Scientists attempt to do so by harnessing nuclear reactors and massive particle accelerators to generate unstable atoms, which then decay into various byproducts including neutrinos. In this way, physicists can manufacture beams of neutrinos that they can probe for properties including the particle’s mass. 

Now MIT physicists propose a much more compact and efficient way to generate neutrinos that could be realized in a tabletop experiment. 

In a paper appearing in Physical Review Letters, the physicists introduce the concept for a “neutrino laser” — a burst of neutrinos that could be produced by laser-cooling a gas of radioactive atoms down to temperatures colder than interstellar space. At such frigid temps, the team predicts the atoms should behave as one quantum entity, and radioactively decay in sync. 

The decay of radioactive atoms naturally releases neutrinos, and the physicists say that in a coherent, quantum state this decay should accelerate, along with the production of neutrinos. This quantum effect should produce an amplified beam of neutrinos, broadly similar to how photons are amplified to produce conventional laser light. 

“In our concept for a neutrino laser, the neutrinos would be emitted at a much faster rate than they normally would, sort of like a laser emits photons very fast,” says study co-author Ben Jones PhD ’15, an associate professor of physics at the University of Texas at Arlington.

As an example, the team calculated that such a neutrino laser could be realized by trapping 1 million atoms of rubidium-83. Normally, the radioactive atoms have a half-life of about 82 days, meaning that half the atoms decay, shedding an equivalent number of neutrinos, every 82 days. The physicists show that, by cooling rubidium-83 to a coherent, quantum state, the atoms should undergo radioactive decay in mere minutes. 

“This is a novel way to accelerate radioactive decay and the production of neutrinos, which to my knowledge, has never been done,” says co-author Joseph Formaggio, professor of physics at MIT.

The team hopes to build a small tabletop demonstration to test their idea. If it works, they envision a neutrino laser could be used as a new form of communication, by which the particles could be sent directly through the Earth to underground stations and habitats. The neutrino laser could also be an efficient source of radioisotopes, which, along with neutrinos, are byproducts of radioactive decay. Such radioisotopes could be used to enhance medical imaging and cancer diagnostics.

Coherent condensate

For every atom in the universe, there are about a billion neutrinos. A large fraction of these invisible particles may have formed in the first moments following the Big Bang, and they persist in what physicists call the “cosmic neutrino background.” Neutrinos are also produced whenever atomic nuclei fuse together or break apart, such as in the fusion reactions in the sun’s core, and in the normal decay of radioactive materials. 

Several years ago, Formaggio and Jones separately considered a novel possibility: What if a natural process of neutrino production could be enhanced through quantum coherence? Initial explorations revealed fundamental roadblocks in realizing this. Years later, while discussing the properties of ultracold tritium (an unstable isotope of hydrogen that undergoes radioactive decay) they asked: Could the production of neutrinos be enhanced if radioactive atoms such as tritium could be made so cold that they could be brought into a quantum state known as a Bose-Einstein condensate?

A Bose-Einstein condensate, or BEC, is a state of matter that forms when a gas of certain particles is cooled down to near absolute zero. At this point, the particles are brought down to their lowest energy level and stop moving as individuals. In this deep freeze, the particles can start to “feel” each others’ quantum effects, and can act as one coherent entity — a unique phase that can result in exotic physics.

BECs have been realized in a number of atomic species. (One of the first instances was with sodium atoms, by MIT’s Wolfgang Ketterle, who shared the 2001 Nobel Prize in Physics for the result.) However, no one has made a BEC from radioactive atoms. To do so would be exceptionally challenging, as most radioisotopes have short half-lives and would decay entirely before they could be sufficiently cooled to form a BEC. 

Nevertheless, Formaggio wondered, if radioactive atoms could be made into a BEC, would this enhance the production of neutrinos in some way? In trying to work out the quantum mechanical calculations, he found initially that no such effect was likely. 

“It turned out to be a red herring — we can’t accelerate the process of radioactive decay, and neutrino production, just by making a Bose-Einstein condensate,” Formaggio says. 

In sync with optics

Several years later, Jones revisited the idea, with an added ingredient: superradiance — a phenomenon of quantum optics that occurs when a collection of light-emitting atoms is stimulated to behave in sync. In this coherent phase, it’s predicted that the atoms should emit a burst of photons that is “superradiant,” or more radiant than when the atoms are normally out of sync. 

Jones proposed to Formaggio that perhaps a similar superradiant effect is possible in a radioactive Bose-Einstein condensate, which could then result in a similar burst of neutrinos. The physicists went to the drawing board to work out the equations of quantum mechanics governing how light-emitting atoms morph from a coherent starting state into a superradiant state. They used the same equations to work out what radioactive atoms in a coherent BEC state would do. 

“The outcome is: You get a lot more photons more quickly, and when you apply the same rules to something that gives you neutrinos, it will give you a whole bunch more neutrinos more quickly,” Formaggio explains. “That’s when the pieces clicked together, that superradiance in a radioactive condensate could enable this accelerated, laser-like neutrino emission.” 

To test their concept in theory, the team calculated how neutrinos would be produced from a cloud of 1 million super-cooled rubidium-83 atoms. They found that, in the coherent BEC state, the atoms radioactively decayed at an accelerating rate, releasing a laser-like beam of neutrinos within minutes. 

Now that the physicists have shown in theory that a neutrino laser is possible, they plan to test the idea with a small tabletop setup.

“It should be enough to take this radioactive material, vaporize it, trap it with lasers, cool it down, and then turn it into a Bose-Einstein condensate,” Jones says. “Then it should start doing this superradiance spontaneously.” 

The pair acknowledge that such an experiment will require a number of precautions and careful manipulation. 

“If it turns out that we can show it in the lab, then people can think about: Can we use this as a neutrino detector? Or a new form of communication?” Formaggio says. “That’s when the fun really starts.”

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Written by Jennifer Chu, MIT News

Paper: “Superradiant Neutrino Lasers from Radioactive Condensates”

https://journals.aps.org/prl/abstract/10.1103/l3c1-yg2l

 

UZH device searches for light dark matter




University of Zurich
superconducting nanowire single-photon detector (SNSPD) 

image: 

Using the improved superconducting nanowire single-photon detector (SNSPD), researchers are searching for very light dark matter. (Image: UZH)

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Credit: UZH





About 80 percent of the universe’s mass is thought to consist of dark matter. And yet, little is known about the composition and structure of the particles that make up dark matter, presenting physicists with some fundamental questions. To explore this elusive matter, researchers are attempting to capture photons, or light particles, which are produced when dark matter particles collide with the visible matter we are familiar with.

Most experiments to date have focused on dark matter particles with masses that more or less overlap with those of known elementary particles. If the particles are lighter than an electron, however, it is unlikely they would be detectable with the current standard, namely detectors based on liquid xenon. So far, no experiment has succeeded in directly detecting dark matter. Yet this in itself is an important finding, as it shows that dark matter particles do not exist within the mass range and interaction strength tested.

New device sensitive to lower-energy events

An international team led by Laura Baudis, Titus Neupert, Björn Penning and Andreas Schilling from UZH’s Department of Physics has now been able to probe the existence of dark matter particles across a wide mass range below one mega electron volt (MeV). Using an improved superconducting nanowire single-photon detector (SNSPD), the researchers reached a sensitivity threshold of about one-tenth the mass of an electron, above which dark matter particles are highly unlikely to exist. “This is the first time we’ve been able to search for dark matter particles in such a low mass range, made possible by a new detector technology,” says first author Laura Baudis.

In a 2022 proof of concept, the researchers had tested the first SNSPD device that’s highly sensitive to lower-energy photons. When a photon strikes the nanowire, it heats it up slightly and causes it to instantly lose its superconductivity. The wire briefly becomes a regular conductor, and the resulting increase in electrical resistance can be measured.

Detecting smallest dark matter particles

For their latest experiment, the UZH scientists optimized their SNSPD for dark matter detection. In particular, they equipped it with superconducting microwires instead of nanowires to maximize its cross section. They also gave it a thin, planar geometry that makes it highly sensitive to changes in direction. Scientists assume that the Earth passes through a “wind” of dark matter particles, and the particle’s direction therefore shifts over the course of the year depending on relative velocity. A device capable of picking up directional changes can help to filter out non-dark-matter events.

“Further technological improvements to the SNSPD could enable us to detect signals from dark matter particles with even smaller masses. We also want to deploy the system underground, where it will be better shielded from other sources of radiation,” Titus Neupert says. Below the mass range of electrons, current models to describe dark matter face considerable astrophysical and cosmological constraints.

Literature
Laura Baudis et al. First Sub-MeV Dark Matter Search with the QROCODILE Experiment Using Superconducting Nanowire Single-Photon Detectors, Physical Review Letters, 20. August 2025. DOI: 10.1103/4hb6-f6jl

Contact
Prof. Titus Neupert
Department of Physics
University of Zurich
+41 44 635 4800
neupert@physik.uzh.ch

Prof. Laura Baudis
Department of Physics
University of Zurich
+41 44 635 5777
laura.baudis@physik.uzh.ch

 

The Healthy Trade Institute and the University of Tennessee partner to launch Nationwide Reptile, Amphibian (Herp) Adoption Program



A win-win for the pet trade and educating veterinary students




University of Tennessee Institute of Agriculture

Eragon the Bearded Dragon 

image: 

In a unique partnership with the UT College of Veterinary Medicine, the Healthy Trade Institute offers a safe new beginning for pet reptiles and amphibians in need and also provides invaluable hands-on training for future veterinarians. HTI accepts pet amphibians, ball pythons, and bearded dragons, like Eragon pictured above, into the program. Other snake species will be accepted later this fall. 

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Credit: Photo submitted by M. Gray, courtesy HTI.




The Healthy Trade Institute (HTI) announced the official launch of its nationwide Herp Adoption Program, a first-of-its-kind initiative that provides a health-verified, science-backed solution for surrendered reptiles and amphibians. Developed in a unique partnership with the University of Tennessee College of Veterinary Medicine, the program offers a safe new beginning for pet reptiles and amphibians in need and also provides invaluable hands-on training for future veterinarians.

The HTI Herp Adoption Program addresses a critical need in the pet trade for reputable and humane surrender options. Each animal entering the program receives a veterinary health assessment and is tested for common pathogens such as chytrid, ranavirus, adenovirus, and Cryptosporidium. This ensures that every animal rehomed through HTI is healthy, providing peace of mind to new owners and promoting a healthier pet trade.

“We are incredibly proud to partner with the University of Tennessee College of Veterinary Medicine to bring this much-needed program to life,” said Matt Gray, president of The Healthy Trade Institute. “This is a win-win for the pet trade. We are not only giving surrendered herps the care and attention they deserve, but we are also providing crucial training opportunities that will help shape the next generation of exotic pet veterinarians.”

"This program also protects wild amphibians and reptiles by reducing the likelihood that unwanted pets are released into the wild,” said Emi Knafo, a zoological medicine specialist at the veterinary college. “When owners have responsible alternatives, ecosystems stay healthier and responsible pet ownership is strengthened."

To sustain and expand this vital program, HTI is actively seeking donations from the public. Every contribution directly funds the veterinary care, pathogen testing, housing, and food for the surrendered animals, ensuring they receive the best possible care.

The program is currently accepting pet amphibians, bearded dragons and ball pythons. The HTI will expand to all snake species (excluding Burmese and reticulated pythons) in October 2025, with more reptile species added in 2026. The public is encouraged to stay tuned for future updates.

 

USF study: Reptile tongue movements could inspire biomedical and space tools


How the high-speed tongues of salamanders and chameleons could unlock engineering breakthroughs



University of South Florida

microscope.JPG 

image: 

University of South Florida scientist Yu Zeng examines a reptile under a miscroscope in USF's Deban Laboratory.

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Credit: USF





Key takeaways:

  • Salamanders and chameleons, despite evolving in different habitats, use the same “slingshot” tongue mechanism powered by ordinary tissues, tendons and bone.
  • This biological design could be scaled for human applications, from biomedical devices that clear blood clots to large-scale tools for disaster recovery or space exploration.
  • The findings underscore how nature’s solutions can guide technological innovation.

TAMPA, Fla. (Sept. 8, 2025) – The tongues of chameleons and salamanders might not seem like the inspiration for tomorrow’s engineering innovations, but inside the University of South Florida’s Deban Laboratory, biology and engineering are colliding to reveal how nature’s designs could help solve real-world challenges on Earth and beyond.

A new study from USF postdoctoral researcher Yu Zeng and integrative biology Professor Stephen Deban shows for the first time that salamanders and chameleons – though worlds apart in evolution – use the same biological mechanism to fire their tongues at extreme speeds. The discovery, published on the cover of the Sept. 8 edition of Current Biology, not only deepens understanding of animal movement but also opens the door to engineering applications inspired by nature.

Chameleons and salamanders thrive in very different habitats – with chameleons inhabiting warm, arboreal environments and salamanders favoring moist habitats such as rivers, ponds, leaf litter and caves.

“They have actually never met each other in the wild,” Zeng said.

And yet, the USF team found both groups developed a remarkably similar “ballistic” tongue-firing system.

“They evolved the same architecture in their bodies to fire their tongues at high speed,” Zeng explained. “What’s surprising is that they achieve this using the same ordinary tissues, tendons and bone that other vertebrates have.”

Deban, who has studied animal movements for more than three decades, said Zeng brought a new lens to the research. A specialist in insect flight, Zeng expanded the scope of the lab’s work by connecting biomechanics with engineering possibilities.

Video analysis collected over more than a decade in Deban’s lab shows that both salamanders and chameleons can project their tongues at speeds of up to 16 feet per second. The study is the first to place these species side by side and reveal a unifying mechanical model.

The mechanism works much like a slingshot, and that’s what excites Zeng and Deban about its potential beyond the animal world.

“This mechanism can be scaled up or down, using soft or flexible materials,” Zeng said. “We’re already talking with engineers about possible biomedical applications, like devices that could clear blood clots. On a larger scale, it could inspire tools to retrieve objects in hard-to-reach places like a collapsed building or even grabbing debris in outer space.”

The researchers plan to expand their studies to examine how animal tongues retract with such speed and precision. Their work reflects the growing scientific movement of “bioinspiration,” in which researchers develop new technologies by adapting solutions already perfected in nature.

“It is gratifying to have a unifying story about these amazing tongues, as well as potential engineering applications after so many years of focusing on the biology of these animals,” Deban said. “Nature has already solved these problems, now we’re learning how to adapt those solutions for us.”

###

University of South Florida scientist Yu Zeng displays a chameleon in USF's Deban Laboratory.

A reptile's high-speed tongue in action catching an insect in the University of South Florida's Deban Laboratory.

Video.1_all-ballistics-sal.mp4 [VIDEO] | 

Video.3_all-protrusive.mp4 [VIDEO] |

SPAGYRIC HERBALISM

High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis





Compuscript Ltd





https://doi.org/10.1016/j.apsb.2025.06.004

This new article publication from Acta Pharmaceutica Sinica B, discusses an efficient strategy for discovering anti-Notum compounds from herbal medicines.

Notum, a negative feedback regulator of the Wnt signaling, has emerged as a promising target for treating glucocorticoid-induced osteoporosis (GIOP). This study showcases an efficient strategy for discovering the anti-Notum constituents from herbal medicines (HMs) as novel anti-GIOP agents. Firstly, a rapid-responding near-infrared fluorogenic substrate for Notum was rationally engineered for high-throughput identifying the anti-Notum HMs. The results showed that Bu-Gu-Zhi (BGZ), a known anti-osteoporosis herb, potently inhibited Notum in a competitive-inhibition manner. To uncover the key anti-Notum constituents in BGZ, an efficient strategy was adapted via integrating biochemical, phytochemical, computational, and pharmacological assays. Among all identified BGZ constituents, three furanocoumarins were validated as strong Notum inhibitors, while 5-methoxypsoralen (5-MP) showed the most potent anti-Notum activity and favorable safety profiles. Mechanistically, 5-MP acted as a competitive inhibitor of Notum via creating strong hydrophobic interactions with Trp128 and Phe268 in the catalytic cavity of Notum. Cellular assays showed that 5-MP remarkably promoted osteoblast differentiation and activated Wnt signaling in dexamethasone (DXMS)-challenged MC3T3-E1 osteoblasts. In dexamethasone-induced osteoporotic mice, 5-MP strongly elevated bone mineral density (BMD) and improved cancellous and cortical bone thickness. Collectively, this study constructs a high-efficient platform for discovering key anti-Notum constituents from HMs, while 5-MP emerges as a promising anti-GIOP agent.

 

Keywords: Notum, NIR fluorogenic substrate, High-throughput screening, Glucocorticoid-induced osteoporosis (GIOP), A high-efficient platform, 5-Methoxypsoralen, Wnt signaling, Osteoblast differentiation

 

Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383525004010-ga1_lrg.jpg   

A high-efficient platform for discovering key anti-Notum constituents from HMs was constructed, while 5-MP was identified as a potent Notum inhibitor capable to activate the Wnt/β-catenin signaling pathway, showing good safety profiles and impressive anti-GIOP effects.

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 24.3

Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy) 

JIF without self-citation: 13.8

ISSN 2211-3835

 # # # # #

Yuqing Song, Feng Zhang, Jia Guo, Yufan Fan, Hairong Zeng, Mengru Sun, Jun Qian, Shenglan Qi, Zihan Chen, Xudong Jin, Yunqing Song, Tian Tian, Zhi Qian, Yao Sun, Zhenhao Tian, Baoqing Yu, Guangbo Ge, High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis, Acta Pharmaceutica Sinica B, Volume 15, Issue 8, 2025, Pages 4174-4192, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2025.06.004