Wednesday, October 14, 2026

 

NASA awards Virginia Tech $5.8 million to advance aircraft design and certification



The project's goal is faster and more efficient aircraft design that incorporates certification requirements earlier, reducing costly redesigns later in development.



Virginia Tech





When designing new aircraft, aerospace engineers optimize for cost, fuel efficiency, and reduction in weight and noise. After a lengthy development process, the vehicle must then meet certifications and safety regulations. Miss the mark and you enter the dreaded redesign phase.

Virginia Tech researchers are developing design tools that could help new aviation technologies, such as electrified aircraft, reach commercial service faster. By building those certification and safety requirements into the design process from the start, engineers can reduce the time, cost, and risk of bringing new aviation technologies to market. 

To tackle this issue, NASA has awarded Virginia Tech and partners Auburn University and Tuskegee University $5.8 million as part of the agency’s University Leadership Initiative. The three-year project aims to integrate model-based systems engineering, multidisciplinary design optimization, and uncertainty quantification into a unified approach for next-generation aircraft design.

New technologies, new uncertainties

Electrified propulsion technologies, including hybrid-electric and distributed electric propulsion aircraft, have shown promise in reducing fuel use, emissions, noise, and operating costs. However, certifying these aircraft remains a significant hurdle.

“One of the greatest challenges is managing uncertainty early in the design process,” said Darshan Sarojini, assistant professor of aerospace engineering. “As development progresses, redesigning components becomes increasingly expensive and time consuming. This challenge is amplified for emerging technologies because there is limited historical data and regulations continue to evolve. Designers must evaluate hundreds of interconnected variables and understand how aerodynamics, structures, controls, operations, and certification requirements influence one another.”

The NASA project combines advanced computational design methods with experimental validation. Led by Sarojini, researchers will integrate model-based systems engineering and multidisciplinary design optimization approaches that traditionally operate in separate workflows.

This novel approach treats certification as a design driver from the earliest stages rather than a requirement checked after a design is largely complete.

The project brings together experts from across Virginia Tech:

A key advantage for the team is access to Virginia Tech’s Mid-Atlantic Aviation Partnership (MAAP), one of the nation’s FAA-designated drone test sites. MAAP, which is housed in the Institute for Critical Technology and Applied Science, provides a unique capability for safely conducting flight tests and collecting flight data. Its authorization and operational procedures for testing aircraft weighing more than 55 pounds allow researchers to evaluate designs under real-world conditions.

Working with Auburn University and Tuskegee University, MAAP will also support a verification and validation effort that compares simulation results with subscale flight-test data. This will help the team better understand how data collected from smaller test aircraft can inform the design of full-scale vehicles.

According to Sarojini, aircraft designers routinely make decisions in the face of incomplete information. Research conducted by NASA has shown that designs optimized without accounting for uncertainty can differ substantially from those developed using uncertainty-aware methods. 

“Virginia Tech will develop new approaches that enable uncertainty quantification and multidisciplinary optimization to be performed efficiently at scales relevant to industry,” said Sarojini. “The goal is to help engineers better understand risk and make more informed design decisions earlier in development.”


Preserving cross-gap differences improves GNSS noise analysis with missing values



Aerospace Information Research Institute, Chinese Academy of Sciences

Proportion of GNSS coordinate time series containing non-stationary noise in the East, North and Up components obtained at 60 global GNSS sites.

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Proportion of GNSS coordinate time series containing non-stationary noise in the East, North and Up components obtained at 60 global GNSS sites.

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Credit: Satellite Navigation





A new study presents two information-preserving maximum likelihood methods for analyzing Global Navigation Satellite System (GNSS) coordinate time series when colored noise is non-stationary and observations are missing. Standard first-order differencing can stabilize non-stationary noise, but it discards differenced observations involving missing epochs, losing valid information and biasing noise parameters and velocity uncertainty. The proposed methods retain cross-gap differences through either a linear transformation matrix or marginalization of missing values in the original series. Tests on simulated and real GNSS data show consistent, more accurate noise parameter and velocity uncertainty estimates, with computational efficiency depending on the percentage of missing values.

High-precision Global Navigation Satellite System (GNSS) coordinate time series underpin studies of plate motion, earthquakes, terrestrial water storage, sea level change, and landslides. Their noise is often temporally correlated colored noise, and power-law (PL) noise with spectral index alpha ≤ -1 is non-stationary, making covariance matrices non-Toeplitz. First-order differencing can transform such noise into stationary processes, but missing values cause extra loss: one missing epoch removes two adjacent first differences. This loss can bias noise model parameters and velocity uncertainty, especially when non-stationary noise and many gaps coexist. Given these challenges, in-depth research is needed on information-preserving noise analysis for GNSS coordinate time series with missing values in the first-differenced domain.

Researchers from the China University of Mining and Technology, the State Key Laboratory of Spatial Datum, the Jiangxi University of Science and Technology, and the University of Beira Interior published (DOI: 10.1186/s43020-026-00220-0) their study in Satellite Navigation on 05 October 2026. The work develops two modified first-differenced maximum likelihood estimation (MLE) algorithms for GNSS coordinate time series with missing values. One uses a linear transformation matrix; the other uses a marginal likelihood function. Both aim to preserve valid differenced information that standard first-differenced MLE discards.

The first algorithm constructs free differenced observations from consecutive available epochs, even across missing segments, using a linear transformation matrix. The second treats missing original observations as latent variables and integrates them out through a marginal likelihood, while preserving the Toeplitz structure of the complete first-differenced covariance matrix. The authors evaluated the methods using 10,800 simulated GNSS coordinate time series covering stationary, weakly non-stationary, and strongly non-stationary power-law noise. Missing values percentages ranged from 0% to 50% in the main comparative experiments and were extended to 65% for the computational efficiency analysis. The evaluation also included 180 real GNSS coordinate time series from 60 global GNSS sites. The two modified algorithms produced highly consistent estimates, with Pearson correlation coefficients of 0.9999 for key noise parameters and velocity uncertainty and near-zero mean differences. Their main difference was speed. The marginal likelihood algorithm was generally faster when missing values were below about 60%, whereas the linear transformation algorithm became more efficient at higher missing percentages. In real data, 12% of series favored the linear transformation approach, close to the share with more than 60% missing values. Both modified algorithms outperformed normal MLE and standard first-differenced MLE under non-stationary noise and high missingness.

The authors said the key advance is not filling gaps but keeping valid differences that span them. They said that instead of treating every difference near a missing epoch as unusable, their methods preserve the information already present in available observations. They explained that the two algorithms are statistically equivalent in parameter estimates but differ in speed: the marginal likelihood approach is often faster with low-to-moderate missing data, while the linear transformation approach gains an edge when gaps are extensive. They added that this makes the framework practical for large global GNSS archives.

More reliable GNSS velocity uncertainty can improve interpretations of plate motion, earthquake deformation, sea level change, water storage, and landslide monitoring. The framework also offers a complementary first-differenced extension to existing fast Toeplitz-based MLE tools, rather than replacing them. Likelihood values from the proposed algorithms can support model selection criteria such as the Akaike information criterion (AIC) or Bayesian information criterion (BIC). The authors caution that applying the methods to other geophysical time series may require adapting the functional model, sampling interval, and covariance construction, especially for irregular sampling, non-Gaussian errors, or noise processes different from white noise plus power-law (WN+PL).

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References

DOI

10.1186/s43020-026-00220-0

Original Source URL

https://doi.org/10.1186/s43020-026-00220-0

Funding information

This work is supported by the National Natural Science Foundation of China (42364002); Outstanding Youth Fund of Jiangxi Natural Science Foundation (20252BAC220015); the Graduate Innovation Program of China University of Mining and Technology (2026WLKXJ086); the Postgraduate Research & Practice Innovation Program of Jiangsu Province (26CXJH4871).

About Satellite Navigation

Satellite Navigation (ISSN: 2662-1363; ISSN: 2662-9291) Satellite Navigation is the official journal of the Aerospace Information Research Institute. The journal aims to report innovative ideas, new results, and progress in the theories, techniques, and applications of satellite navigation. The journal welcomes original articles, reviews and commentaries.


 

Frequent and unintentional daytime napping linked to higher dementia risk in older adults



Study of nearly 1,000 older Americans finds napping habits, not just nighttime sleep, may signal or contribute to dementia risk




Johns Hopkins Bloomberg School of Public Health






Daytime napping is common among older adults. New research from the Johns Hopkins Bloomberg School of Public Health suggests that how often, how intentionally, and how long older people nap may be linked to their risk of developing dementia.

The study, published online October 5 in The Journal of Gerontology: Medical Sciences, followed 995 U.S. Medicare beneficiaries age 65 and older who were free of dementia at the start of the study in 2013 and tracked them for up to 10 years using data from the National Health and Aging Trends Study, a nationally representative survey of older adults.

The researchers found that participants who napped frequently—defined as most days or every day—had a 48% higher risk of developing dementia compared to those who rarely or never napped, even after accounting for demographic factors, health conditions, and nighttime sleep characteristics such as sleep duration, daytime sleepiness, and a measure of obstructive sleep apnea risk. 

Unintentional napping—defined as falling asleep without meaning to rather than planning a nap—was associated with a 39% higher risk of dementia. Napping for 30 minutes or less was also linked to a 40% higher risk, an association that held up after accounting for a range of potential confounders, while the association for naps longer than 30 minutes weakened once nighttime sleep factors were considered.

“More frequent napping could be a marker of changes in the brain, rather than a cause of brain changes that lead to dementia,” says Adam Spira, PhD, MA, senior author of the paper and professor in the Bloomberg School’s Department of Mental Health.

The researchers point to the likely two-way relationship between napping and dementia. Napping is a potential risk factor for dementia at the same time that degenerating brain regions that help to regulate wakefulness—which can occur early during dementia—may also lead to more frequent napping.

To help address this possibility, the team excluded dementia cases diagnosed within the first five years of follow-up and found that the associations for frequent and unintentional napping remained similar, lending support to the idea that napping patterns may meaningfully precede a dementia diagnosis rather than simply reflect it.

“Monitoring napping behaviors could serve as an early and accessible marker to help identify older adults at higher risk for dementia and guide targeted interventions for dementia prevention,” says Kening Jiang, PhD, a postdoctoral fellow in the Bloomberg School’s Department of Mental Health and first author of the paper. 

Past research investigating the relationship between napping and cognitive decline has yielded mixed results, with some studies linking longer or more frequent naps to greater dementia risk and others finding no association or even potential benefits from short naps. The researchers note that differences in study design—including whether napping was self-reported or measured with wearable devices—and cultural attitudes toward napping across regions may help explain these inconsistent findings.

The researchers caution that the findings are observational and cannot establish that napping causes dementia. The study relied on self-reported napping habits, which can be subject to recall bias, and dementia status was determined using a validated algorithmic classification rather than clinical diagnosis. 

The researchers say that longer-term studies that combine detailed, objective measures of both daytime napping and nighttime sleep are needed to clarify how napping patterns relate to dementia risk and to determine whether changing napping habits could help delay or prevent dementia onset.

“Napping Characteristics and Incident Dementia: Results From the National Health and Aging Trends Study” was written by Kening Jiang, Alden L. Gross, Catriona Tingsea Wu, Junxin Li, Halima Amjad, Emerson M. Wickwire, Jennifer S. Albrecht, Atul Malhotra, Chien-Yu (Irene) Tseng, Marc Kaizi-Lutu, Chunyu Liu, Christopher N. Kaufmann, and Adam P. Spira.

The study was supported in part by the National Institute on Aging (R01AG079391, K02AG095384, P30AG028740, U01AG032947, K23AG064036, 5T32AG027668-19).

 

Study finds no difference between phenobarbital and benzodiazepine for treating alcohol withdrawal syndrome



Results suggest not only therapeutic equivalence, but safety as well




Boston University School of Medicine




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(Boston)—Alcohol withdrawal is a very common and dangerous medical emergency. Although benzodiazepines remain the standard treatment for this condition, the use of the barbiturate phenobarbital has increased by more than 200% in the last decade with limited evidence to suggest that this practice is safe and effective.


In the first large-scale study to compare phenobarbital to diazepam—a long-acting benzodiazepine -– researchers found no differences in outcomes between phenobarbital and diazepam, potentially suggesting similar effectiveness. 


“Past studies have compared phenobarbital to a short-acting benzodiazepine called lorazepam and concluded that phenobarbital was better. Our study shows that when you compare phenobarbital to a similarly long-acting drug, they are actually almost equal in how well they work. This is important because hospitals are rapidly adopting phenobarbital for the treatment of alcohol withdrawal,” explains corresponding author Nicholas Bosch MD, MSc, assistant professor of medicine at Boston University Chobanian & Avedisian School of Medicine. 

 

The researchers analyzed the health records of 24,643 adult patients across 754 hospitals in the U.S. focusing on two groups of patients who were hospitalized for alcohol withdrawal. On their first day of admission, the first group of patients was given phenobarbital while the second group of patients was given diazepam. Because this was a look-back study of real-world data rather than a clinical trial, researchers used advanced computer programs to balance out differences between the two groups (such as age, other illnesses and overall health) to make the groups as identical as possible. They then compared how long both groups stayed in the hospital and whether they ended up needing a breathing machine, among other outcomes.


In addition to finding similar effectiveness between phenobarbital and long-acting benzodiazepines, the researchers found that patients who received phenobarbital were less likely to leave the hospital early against medical advice compared to those who got diazepam. “These findings may suggest differences in patient experiences between the medications, a finding that will require more research to confirm,” added Bosch, a pulmonologist at Boston Medical Center.


According to the researchers, this study is reassuring because it shows that hospitals have two highly safe and effective treatment options available. “For doctors and healthcare systems, these results might mean they do not need to rush to completely replace diazepam protocols with phenobarbital, as both drugs appear to offer nearly similar benefits and risks. It also shows doctors and healthcare systems that have already adopted phenobarbital now have better evidence that this practice is safe and effective.”

 

These findings appear online in JAMA Internal Medicine.

This study was funded by The Boston University Chobanian & Avedisian School of Medicine Department of Medicine Career Investment Award.

Note to editors:
Dr. Bosch is a panelist on the forthcoming Society of Critical Care Medicine Alcohol Withdrawal Syndrome Guidelines.

 

 

 

 

 

Treating life-threatening blood clots in minutes with swirling sound waves



The NIH is funding a U-M-led team developing a device that breaks up pulmonary embolisms with 'vortex ultrasound'




University of Michigan

 





Photo series of unblocking a mock blood vessel

 

What's the study: For a faster, safer way to treat pulmonary embolism—potentially deadly blood clots stuck in the lungs—engineers and vascular surgeons are joining forces to develop a minimally invasive "vortex ultrasound" device. 

 

The tiny ultrasound source will be mounted on the end of a catheter, to be delivered to the clot through blood vessels. Once there, it will send out twisting sound waves to break up the clot without damaging the blood vessel walls. The team believes that the swirling waves break up the clot's internal structure more quickly by creating bubbles within it.

 

Why it matters: Pulmonary embolism is the third most common cardiovascular killer in the United States after heart attack and stroke. When large blood clots break loose from the legs and travel to the lungs, they block oxygen exchange and put sudden, deadly strain on the heart. 

 

Current emergency options present tough trade-offs: clot-busting drugs can take up to 24 hours to work, fail about a third of the time and carry a serious risk of internal bleeding, while mechanically removing the clot with a catheter device risks tearing fragile blood vessel walls. The most severe clots must be removed through open-chest surgery. 

 

External ultrasound approaches may sound safer for blood vessel walls than catheter removal or surgery, but they often fail to accurately target the clot and hardly work in the lung because its internal structures interfere with ultrasound waves. However, by changing the kind of ultrasound used and administering it inside the blood vessel, the team believes they can achieve fast treatment while reducing the risk of internal bleeding. Preliminary tests suggest that their twisted ultrasound waves could break up clots in as little as 30 minutes.

 

How much and for how long: A $3.74 million grant from the National Institutes of Health will fund the five-year project.

 

The current project builds on early proof-of-concept testing in which the research team demonstrated that vortex ultrasound could restore blood flow through a three-inch-long blood clot in just eight minutes, using blood from cows. Over the next five years, the team will refine the catheter design, optimize the shape and frequency of the ultrasound waves, and evaluate short- and long-term safety in pigs to prepare the technology for human clinical use.

 

Who's involved: Principal investigator Chengzhi Shi is an associate professor of mechanical engineering whose research focuses on physical acoustics, metamaterials and ultrasound technologies for medical treatments.

 

"With this approach, we hope to treat clots in the lungs more quickly and safely while potentially providing an alternative to open-chest surgery for severe pulmonary embolism," Shi said.

 

Key collaborators on the grant include Daniel Myers, the Conrad and Caroline Jobst Research Professor of Vascular Surgery, and Andrea Obi, the Wakefield Family Research Professor, both from the U-M Medical School; Zhen Xu, the Li Ka Shing Endowed Professor of Biomedical Engineering at U-M; and Xiaoning Jiang, professor of mechanical and aerospace engineering at North Carolina State University.

 

Long-term viral hepatitis control and changing patterns of liver cancer mortality in Japan




Hiroshima University
Long-term trends in cancer-specific mortality in Japan between 1958 and 2022, by sex

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Long-term trends in cancer-specific mortality in Japan between 1958 and 2022, by sex. Mortality rates for major cancers among males and females, including liver (blue, including both viral- and non-viral-related liver cancer), stomach (orange), pancreatic (grey), lung (yellow), colon (black), breast (light blue), and uterine cancers (green). Liver cancer mortality increased until the early 2000s and subsequently declined, contrasting with continuing increases in mortality from several other major cancers. (Junko Tanaka, et al. The Lancet Regional Health - Western Pacific. August 17, 2026) 

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Credit: Junko Tanaka, et al. The Lancet Regional Health - Western Pacific. August 17, 2026






Over decades of sustained, integrated national viral hepatitis control, Japan has seen substantial reductions in HBV- and HCV-related disease burden and hepatocellular carcinoma mortality.

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major causes of liver cirrhosis and hepatocellular carcinoma (HCC). Due to the public health burden of viral hepatitis, Japan enacted systematic, nationwide countermeasures, starting with improvements in blood safety and reductions in healthcare-associated transmission (from the 1970s onward); prevention of mother-to-child transmission (from 1986 onwards); and institutionalization of hepatitis control through legal and financial frameworks and expanded access to antiviral treatment (from the 2000s onwards).

A review paper by a research team at Hiroshima University investigated how coordinated policy frameworks and robust epidemiological infrastructure have been associated with reductions in viral hepatitis–related HCC in Japan, and what gaps remain toward achieving hepatitis elimination. In doing so, they highlight transferable lessons for countries seeking to eliminate viral hepatitis.

The review was published in the journal The Lancet Regional Health - Western Pacific on August 17, 2026.

“This study examines how the epidemiology of viral hepatitis and liver cancer in Japan has changed over nearly five decades of national hepatitis control measures, and what challenges remain as the country approaches the WHO 2030 hepatitis elimination targets,” says Tomoyuki Akita, lecturer at Hiroshima University’s Graduate School of Biomedical and Health Sciences. “Understanding the long-term population impact of [Japan’s viral hepatitis control] measures is important not only for evaluating Japan’s progress toward hepatitis elimination, but also for identifying the next priorities for liver cancer prevention.”

The researchers collected peer-reviewed research articles related to HCC, liver cancer, viral hepatitis, liver cirrhosis, and Japan, published between January 1970 and January 2026, through online searches of the PubMed database. They also manually searched government reports for additional sources, included data from their Epidemiological Research Group on Viral Hepatitis and its Long-term Course (VH-Epi), and incorporated data from national vital statistics and multiple large-scale statistics and surveillance databases.

Decades of hepatitis control have brought Japan closer to elimination ...

The prevalence of HBV and HCV has fallen drastically across Japan. In first-time blood donors—generally considered a healthy population—Hepatitis B surface antigen (HBsAg, a positive marker of HBV infection) fell from 0.63% in 1995–2000 to 0.13% in 2017–2021; in the same period, HCV antibody (anti-HCV, a positive marker of HCV infection) fell from 0.49% to 0.16% over the same periods. Among residents aged ≥40 years at health checkups, HBsAg fell from 1.16% in 2002 to 0.55% in 2021, while anti-HCV fell from 1.16% to 0.21% in the same period. The incidence of newly acquired HBV and HCV infections in blood donors representing historically low levels in Japan, at 2.38 per 100,000 person-years for HBV and 0.4 per 100,000 person-years for HCV.

“One particularly striking finding is that among pregnant women born in or after 2000, HBsAg-positive individuals have become extremely rare, illustrating the intergenerational impact of Japan’s HBV mother-to-child transmission prevention program since 1986,” says Akita.

Viral hepatitis remains an important concern among several high-risk populations in Japan, including persons who inject drugs (PWID), men who have sex with men (MSM), migrants from regions where HBV is endemic, and incarcerated populations. Addressing viral hepatitis among these populations remains an important challenge as Japan moves toward elimination.

... while reshaping the landscape of liver cancer

At the same time, the decline in viral hepatitis-related HCC has reshaped the relative distribution of liver cancer causes in Japan. The proportion of HCC deaths attributed to non-viral causes increased from 6.8% in 1992 to 56.0% in 2019. This shift largely reflects the substantial decline in viral hepatitis-related HCC, rather than a comparable increase in the absolute burden of non-viral HCC. “In other words,” Akita says, “more than half of hepatocellular carcinoma deaths in Japan are now attributable to non-viral causes—a dramatic reversal from the era when viral hepatitis dominated the country’s liver cancer burden.”

Non-viral causes include alcohol-related liver disease and metabolic dysfunction-associated steatotic liver disease (MASLD). As Japan approaches viral hepatitis elimination, maintaining the achievements of hepatitis control remains essential, while liver cancer prevention will also need to address these emerging non-viral causes. “Japan’s long-term, integrated hepatitis control strategy has substantially reduced HBV and HCV infections and related liver cancer deaths, bringing the country closer to hepatitis elimination,” Akita says. “The next step is to achieve and sustain viral hepatitis elimination while adapting liver cancer prevention to Japan’s changing disease landscape.”

The study was co-authored by Junko Tanaka, Ko Ko, Aya Sugiyama, Chanroth Chhoung, Akemi Kurisu and Tomoyuki Akita at Hiroshima University; Masahiro Satake at the Japanese Red Cross; and Tatsuya Kanto and Takaji Wakita at the Japan Institute for Health Security. Junko Tanaka and Tomoyuki Akita are corresponding authors.

This work was supported by the Ministry of Health, Labour and Welfare (MHLW) Policy Research for Hepatitis Measures Program (JPMH 22HC1001, JPMH 25HC1001).

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About Hiroshima University 
Since its foundation in 1949, Hiroshima University has striven to become one of the most prominent and comprehensive universities in Japan for the promotion and development of scholarship and education. Consisting of 12 schools for undergraduate level and 5 graduate schools, ranging from natural sciences to humanities and social sciences, the university has grown into one of the most distinguished comprehensive research universities in Japan. English website: https://www.hiroshima-u.ac.jp/en