Influenza is one of the most ancient and intriguing diseases that has been accompanying our civilization for millennia. While mankind has successfully defeated many dangerous influenza infections in the last couple of centuries, influenza control remains a serious problem for public health. A number of influenza vaccines and antiviral compounds have been licensed in recent times. However, the influenza virus is still ahead of us, as it continues to persistently infect humans to this day. Influenza: A Century of Research shows how influenza virology has developed historically and the tremendous knowledge that has been uncovered in the study of influenza. In this monograph, the authors present a historical perspective on influenza, chronologically, with an emphasis on its virology. Chapters cover information about the isolation of the first influenza viruses, substrates, and models for studying influenza, structure, and life cycle of the influenza virus, mechanisms of attenuation and virulence. Chapters progress into the multidisciplinary aspects of influenza research such as influenza virus ecology and the evolutionary origin of epidemic and pandemic influenza viruses. A significant part of the book also covers the description of the prevention and treatment of influenza and reasons that have contributed to insufficient control for influenza. The questions of how the COVID-19 pandemic affects the circulation of seasonal respiratory viruses, and if we can eliminate this virus are also addressed.
The eBook covers a variety of influenza viruses and models for studying influenza, from the classic to the exotic, the tragic life of “the father of the Russian anti-flu bomb”, the development of the first live cold-adapted influenza vaccine, and much more. After analyzing advances in the field of influenza, the authors raise the question: Will we ever be able to defeat human influenza?
Influenza is one of the most mysterious and ancient diseases that have been accompanying our civilization for centuries. Humankind has successfully defeated many dangerous infections that caused harm to human health and safety. However, influenza control remains a serious problem for public health. A number of influenza vaccines and antiviral compounds have been licensed. However, the influenza virus is still ahead of us. This eBook aims to show how influenza virology has developed historically and the tremendous success that has been achieved in the study of influenza.
In this eBook, the authors have tried to illuminate knowledge on influenza from a historical perspective, chronologically, with an emphasis on the virological part of the studies. The eBook describes a history of isolation of the first influenza viruses, substrates, and models for studying influenza, structure, and life cycle of the influenza virus. Mechanisms involved in the attenuation and virulence of the influenza virus are also discussed. Influenza virus ecology and evolution, the origin of epidemic and pandemic influenza viruses is discussed as well. A significant part of the eBook is occupied by a description of the prevention and treatment of influenza and reasons that contributed to insufficient control for influenza. The question of how the COVID-19 pandemic affects on circulation of seasonal respiratory viruses was also aroused.
The intended audience for this eBook includes students of biological and medical colleges, Ph.D. students, post-docs, a wide range of virologists who are specialized in the field of influenza, and everyone interested in this infection.
Influenza: A Century of Research is an informative source of information for a broad range of readers, academic or otherwise, who are interested in knowing more about the disease.
About the authors
The eBook is written by two Russian virologists who work for the Institute of Experimental Medicine (IEM), St Petersburg, Russia.
Irina Kiseleva, Ph.D., D.Sc., a Professor in Virology, Head of the Laboratory of General Virology at the IEM. The areas of her specialized expertise are influenza prophylaxis by chemotherapeutic drugs and vaccine therapy, development of egg-derived and tissue culture-derived live attenuated influenza vaccines. Since 2013 she is also a full professor of Virology at St Petersburg University (St Petersburg, Russia). Irina Kiseleva is a prolific author, having published over 300 publications including 50 patents of the Russian Federation.
Natalie Larionova, Doctor of Biology, Leading Research Associate of the Laboratory of General Virology at the IEM, has extensive research experience in the evolution of influenza viruses, preventing flu using drug therapy, and live attenuated influenza vaccines. Together with her colleague, Prof. Irina Kiseleva, she developed the first Russian live attenuated vaccine against pandemic influenza virus A/California/7/2009 (H1N1)pdm09. She has published over 200 articles and 30 patents.
Keywords:
Vaccine Side Effects, antivirals vs antibiotics,genetics in influenza Virus, Viral infection, Thermal Stability of influenza Virus, Flu shots and symptoms, Influenza vaccine, History of influenza
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