Sunday, February 05, 2023

 

Hitler became German chancellor 90 years ago. The world is still recovering.

The events of January 30, 1933, instilled a still-persistent yearning for xenophobic totalitarian rule.

The Garrison Church in Potsdam, Germany, is notorious in modern German history as the place where Reich President Paul von Hindenburg, a former general resplendent in full uniform, medals and spiked helmet, symbolically handed over power to the new Chancellor, Adolf Hitler, on March 21, 1933. Photo courtesy of Creative Commons

(RNS) — Nine decades ago today (Jan. 30), Adolf Hitler legally became chancellor of Germany. It’s often forgotten he gained that position without a successful insurrection, a violent coup d’état — or a rigged national election. 

But, in fact, in Germany’s legislative election in November 1932, Hitler’s National Socialist German Workers Party — the Nazis — gained only 33.7% of the vote. Even after Hitler became chancellor, in March 1933, his party was still a minority, garnering only 43.9% of the vote. 

The election set the stage for a catastrophic world war with tens of millions of deaths, including the mass murders of the Holocaust that nearly destroyed the global Jewish community. It poisoned many political systems with a bitter brew of hate and bigotry and instilled a long-lasting yearning among countless people for anti-democratic totalitarian rule.

In the Germany of 1933, the politically weak Weimar Republic was besieged by well-organized Communists and Nazis, hyperinflation and a lack of broad public support. Teetering on the verge of collapse, the fledgling republic could not withstand a Hitler incensed by his low vote total. He made certain the 1933 election would be Germany’s last until his suicide in late April 1945 and the crushing military defeat of Nazi Germany in World War II.



In appointing Hitler chancellor, the ailing German president, Paul von Hindenburg, falsely believed that he and leaders of the aristocratic conservative political and business establishment — Germany’s ruling class — could control and “civilize” the fanatical Nazis.

After all, they told themselves, Hitler had been a lowly army corporal, not even an officer, in World War I. Before that he’d been an unsuccessful artist, a raucous “nobody.” Perhaps the only thing the German establishment liked about Hitler was his public expression of virulent antisemitism.     

But, of course, they utterly failed to rein in Hitler.

Their mistake in judgment was the more puzzling, and horrific, because the Nazi leader had clearly proclaimed his goal of ruling Germany as the “führer” — the ultimate dictator. Under his personal leadership, the Nazi Party would come to control all aspects of German life: Politics, culture, communication, industry, education, labor, family life, medicine, sports, science, economics and, of course, literature and religion.

A Nazi book burning in Berlin's Opera Plaza on May 11, 1933. Photo by Georg Pahl/German Federal Archive/Creative Commons

A Nazi book burning in Berlin’s Opera Plaza in May 1933. Photo by Georg Pahl/German Federal Archive/Creative Commons

On May 10, 1933, more than 40,000 people gathered in Berlin to witness the burning of 25,000 books, including works by Ernest Hemingway, Helen Keller, Sigmund Freud, Albert Einstein, Thomas Mann, Jack London and Theodore Dreiser. The book-burning area, Berlin’s Opera Plaza, is now a historical landmark that includes the 1820 prescient prediction by the German Jewish poet Heinrich Heine: “Where they burn books, they will also ultimately burn people.”

It was Hitler’s policy to subordinate both Protestantism (Germany’s largest religious community) and the Roman Catholic Church to the political power of his party. But there was much more on the Nazi agenda — there usually is in a dictatorship.

The Nazis organized the nationalistic “Deutsche Christen” (German Christian) church, so antisemitic that it renounced the Hebrew Bible (what Christians call the Old Testament) as well as the New Testament Letters of Paul because of their Jewish authorship.

The Nazi leadership and its sycophantic clergy supporters reshaped Christianity into an Aryan religion cut off from its deep theological and historical Jewish taproots.

In her excellent book, “The Aryan Jesus: Christian Theologians and the Bible in Nazi Germany,” Susannah Heschel of Dartmouth College documents how Ludwig Müller became the Reichsbischof (Reich Bishop) of the Nazi Church. During the Third Reich, many despicable theologians, consumed with traditional Christian antisemitism, transformed Jesus, the Jew of Nazareth, into an antisemitic Aryan warrior.

They also created a Nazi form of Christianity that was the archenemy of Jews and Judaism. Infused with such religious hatred, it was only a short step for millions of Germans to agree with Hitler’s policy of killing every Jew under his control.

There are numerous photos of Christian clergy wearing ecclesiastical robes in public that feature the abhorrent Nazi swastika symbol as they proudly offer the stiff-armed Nazi salute.

FILE - A busload of arrested Jewish men are questioned by government officials before being taken away in Berlin on April 11, 1933, shortly after Adolf Hitler's takeover of power in Germany. The notion of being Jewish is complicated and includes a combination of religion, race, nationality, ethnicity, culture and history, says Greg Schneider, executive vice president the Conference on Jewish Material Claims Against Germany, also referred to as the Claims Conference. (AP Photo/File)

FILE – A busload of arrested Jewish men are questioned by government officials before being taken away in Berlin on April 11, 1933, shortly after Adolf Hitler’s takeover of power in Germany. (AP Photo/File)

Heschel notes that in 1939, the Nazi regime established the Institute for the Study and Eradication of Jewish Influence on German Church Life. She focuses especially on the Institute’s academic director, the antisemitic theologian Walter Grundmann, who was responsible for developing the Nazi version of Christianity.

Some Christian leaders, led by the philosopher Karl Barth, founded the anti-Nazi Confessing Church. Their efforts, historians agree, were mostly tepid and ineffective. Confessing Church leaders focused too heavily on protecting Jewish converts to Christianity and not upon the desperate genocidal removal of Germany’s Jews.  



After World War II was underway, the young Lutheran pastor and scholar Dietrich Bonhoeffer abandoned the Confessing Church to join the anti-Nazi underground resistance movement. He was captured, imprisoned for two years and hanged in April 1945, a month before the end of the war. Bonhoeffer has become a Christian martyr because of his courageous anti-Nazi actions.

Even though Germany’s sharp descent into Nazi darkness began 90 years ago, the lights of freedom of conscience, political democracy and religious liberty still remain dim in many parts of the world. That is the still-urgent warning and the tragic legacy of January 30, 1933.

(Rabbi A. James Rudin is the American Jewish Committee’s senior interreligious adviser and the author of The People in the Room: Rabbis, Nuns, Pastors, Popes and Presidents,” and was recently knighted by Pope Francis for his ecumenical outreach to Catholics. He can be reached at jamesrudin.com. The views expressed in this commentary do not necessarily reflect those of Religion News Service.) 



After 30 years, Buddhist-inspired message of ‘Groundhog Day’ still holds spiritual power

Part Hollywood love story and part secular spiritual parable, the 1993 film shows life can be better if we pay attention.

Actor Bill Murray, with the groundhog Punxsutawney Phil, plays a cynical weatherman in the 1993 film “Groundhog Day.” Photo courtesy of Columbia Pictures

WOODSTOCK, Ill. (RNS) — Woodstock Willie, perhaps the second most famous groundhog in the country, saw his shadow Thursday (Feb. 2), predicting another six weeks of winter.

The early morning prediction, viewed by a crowd who braved below-freezing temperatures, was part of a five-day celebration of the release of “Groundhog Day,” a now classic film starring Bill Murray released in 1993 and filmed in this small town about an hour northwest of Chicago.


Despite almost no mention of God or religion, the filmmakers made one of the more spiritual films of the era. 

“You can argue about whether it is a Buddhist, Christian or Jewish movie — but it is deeply religious,” said author and Boston University religion professor Stephen Prothero, who has shown the film in his classes.

“Groundhog Day” tells the story of Phil Connors, a self-centered TV weatherman sent to Punxsutawney, Pennsylvania, to cover the annual Groundhog Day festival at Gobbler’s Knob, where it’s been celebrated since 1887. (The movie’s creators chose to film it in Woodstock because the city’s historic square and downtown shops meant most of the film could be shot nearby.)



Stephen Prothero. Photo by Meera Subramanian

Stephen Prothero. Photo by Meera Subramanian

A blizzard blocks the departure of Connors and his colleagues, forcing them to stay overnight. But when he awakes a second morning to the same song on the radio —  Sonny and Cher’s 1965 hit “I Got You Babe” — Connors discovers he’s stuck reliving the same day, over and over again.

No matter what he does, Connors wakes up every morning to the same song, in the same room at a Woodstock bed-and-breakfast. Not even death gives him release.

It turns out that immortality and reincarnation, at least for Connors, is not such a good thing. 

When Americans think of reincarnation, they think it means an opportunity for a new life. But the Buddhist idea of reincarnation is actually a curse, said Prothero, because it often means reliving the same life over and over.

Brook Ziporyn, a professor of Chinese religion, philosophy and comparative thought at the University of Chicago, said Connors appears to be stuck in what Buddhists call “samsara” — a cycle of death and rebirth that’s marked by suffering. The fact that Connors is stuck in a place he despises reinforces that idea.

Brook Ziporyn. Photo by Howard Wallach

Brook Ziporyn. Photo by Howard Wallach

“It has to be in a place that he hates,” said Ziporyn, who has taught about the Buddhist themes in “Groundhog Day” and other films, including “What About Bob?”, which also starred Bill Murray. During the movie, Connors discovers his eternal life is without consequences. At first, he uses that as a license to do whatever he wants by indulging in all seven deadly sins. He robs an armored car, steals the groundhog, seduces women in town by lying to them and gorges himself at the local diner, for starters.

All of that proves meaningless.

He finally has a moment of clarity when he is rejected by his colleague Rita, played in the film by Andie MacDowell. Despite his best efforts, and repeated failure, he can’t win her heart because she sees through him.

“I could never love someone like you. You only love yourself,” she tells him.

“That’s not true,” Connors replies. “I don’t even like myself.”

Connors begins to change at that moment, not because God or a spiritual figure tells him to, but because in the end, being a jerk makes him unhappy. He devotes his time to improving himself — learning to play the piano, for example — and to doing good deeds. He eventually practices most of the so-called seven heavenly virtues — things like patience, diligence, kindness and humility.

By giving up his own ambitions, he eventually wins Rita’s heart.

“It is not that he has a revelation of God’s law,” said Ziporyn. “He just realizes that the only thing he can do that makes himself meaningful is to start engaging others.”

Bhante Amitha with a groundhog. Courtesy photo

Bhante Amitha with a groundhog mascot in Woodstock, Illinois. Courtesy photo

Bhante Amitha, the deputy abbot of the Blue Lotus Temple, a Buddhist center located about a block from where “Groundhog Day” was filmed, said he’d only seen the trailer for the movie, so he could not comment on the specific religious themes in it.

A Theravada monk originally from Sri Lanka, Bhante Amitha said meditation and good works can help people find relief from the stresses and worries of life. About 60 people, most of whom were brought up in Christian or Jewish traditions, take part in the regular Saturday meditation classes at the temple, according to the abbot.

He said that striving and attachment and anger can be like poisons — and that relief can be found in meditation and good deeds. Those deeds and compassion can help people escape the cycle of samsara.

“Our main goal is to practice meditation and generosity and having a virtuous life,” he said.

Tessa Fisher, the office manager for the temple and an adherent, said she’d seen “Groundhog Day” a few times but had never really thought about the parallels between Buddhist teaching and the film. But she said people who come to the temple, housed in what was built as a Congregationalist church, are often struggling.

“They are on a spiritual journey,” she said. “They are seeking something. And by practicing or reading they have this kind of awakening in themselves. They realize they need to give love and kindness to themselves so that they can do good to others.”

Dhamma hall in the Blue Lotus Temple in Woodstock, Ill. Courtesy photo

Dhamma hall in the Blue Lotus Temple in Woodstock, Illinois. Courtesy photo

In that way, she said, they are like the main character of “Groundhog Day.”

“They take that step and say I want to break out of my struggles.”

Part of the genius of “Groundhog Day” is that it is open to interpretation. The film’s screenwriter, Danny Rubin, has said he’s heard from preachers and rabbis and Buddhist practitioners and grief counselors, all of whom say the movie reflects their teaching.

The first draft of the screenplay for the movie, published in Rubin’s 2012 book “How to Write Groundhog Day,” included scenes with a Catholic priest and a street preacher.

“Forswear your ways, your greed, your selfishness,” the street preacher says in that first draft. “Realize your true destiny, for only then you will live in the world.”

Those scenes were removed as Rubin and director Harold Ramis revised the screenplay. In his book, Rubin included a series of lessons he learned from the process of writing and rewriting the movie.

Danny Rubin. Courtesy photo

Danny Rubin. Courtesy photo

Those lessons included the importance of perspective: In the movie, Connors experiences both the worst day of his life and the best day. Things change for him, Rubin wrote, as he changes the way he looks at things. Rubin wrote that he also learned the importance of paying attention — that Connors learns to see the people he encounters every day and to hear their stories, rather than just focusing on himself.

Rubin also learned that even a single day in a small town can be filled with possibilities.

“Every day held an infinite number of stories,” he wrote.

Ramis, who died in 2014, said in a short documentary about the making of “Groundhog Day” that the film reflected his philosophy of life.

What Danny and I both wanted to say with the movie is, you can live better,” he said. “You can have a better life. People can change. And when you do change you get those rewards you think you want from life.”

Author and Hamilton College religion professor Brent Rodriguez-Plate, who has often taught “Groundhog Day” in classes about religion and film, said removing explicitly religious elements from the script helps give the film its power.

People are free to interpret the film however they want, he said.

“The fun thing about it is that it is so completely secular,” said Rodriguez-Plate. “It’s the Hollywood myth that trumps all the other religious myths — annoying man finally gets his stuff together and figures out how to be worthy of the beautiful woman. That’s why we keep coming back to it.”  

Groundhog Day: Fred is dead in Quebec, Willie and Sam at odds over spring's arrival


Thu, February 2, 2023

The death of a prognosticating rodent in Quebec cast a shadow over Groundhog Day festivities on Thursday, while the notable furry forecasters who made their predictions were split over spring’s arrival.

Fred la Marmotte is dead, organizers in Val D’Espoir, Que., told the crowd that had gathered in anticipation of the rodent's annual prediction.

The announcement came after most of the event, including a dance break with a large Fred mascot, had taken place without indication of the animal's death.


"In life, the only thing that is certain is that nothing is certain,” Roberto Blondin, an organizer, eventually told the crowd.

Blondin explained that Fred did not have vital signs when efforts were made to wake the animal from a winter slumber. He said the nine-year-old groundhog likely passed away in the late fall or early December.


In Fred's place, organizers pulled a stuffed toy groundhog from Fred's miniature wooded cabin, handed it to a young boy and then lifted the child in the air. The boy later convened with other kids on a stage before calling for six more weeks of winter.

According to folklore, if a groundhog sees its shadow on Groundhog Day, winter will drag on. However, if it doesn't spot its shadow, spring-like weather will soon arrive.

Among the famous Canadian groundhogs who made it to sunrise, predictions were divided.

Ontario's Wiarton Willie called for an early spring while Shubenacadie Sam, Nova Scotia's most famous groundhog, apparently saw her shadow Thursday morning as she emerged from a snow-covered enclosure at a wildlife park north of Halifax.

The turn of events in Quebec recalls Groundhog Days gone by.

On Groundhog Day 1999, children burst into tears when Wiarton Willie's handlers announced the groundhog had died two days before. In his place, a white groundhog they claimed to be Willie was brought out in a tiny pine coffin, holding a carrot.

The scene made international headlines but the mayor of the Town of South Bruce Peninsula had to later admit the stuffed groundhog in the casket was not, in fact, Willie, but a stand-in.

On Groundhog Day 2021, there was more Willie controversy.

The groundhog was nowhere to be seen for the virtual festivities on the decisive morning – the town released a video that showed the mayor tossing a fur hat and making the annual prediction. There was no in-person event due to the pandemic.

It took nine months before the town acknowledged the white-furred albino rodent had died.

Willie's handlers in South Bruce Peninsula brought in an understudy last year, but that animal was the usual brown colour — a break from a decades-old tradition.

This year's replacement — another white groundhog — was recruited last summer from Cleveland, Ohio, said town spokesperson Danielle Edwards.

That Willie was brought out on stage in a Plexiglas box on Thursday and South Bruce Peninsula Mayor Garry Michi put an ear to the box and declared the rodent had heralded spring's arrival. Local legend has it the mayor is the only person who can speak "Groundhogese".

Just after 8 a.m. local time in Shubenacadie, N.S., the door to Sam's pint-sized barn was opened, and she slowly backed out into the cold, and then scurried over the snow towards a fence.

The annual tradition at the Shubenacadie Wildlife Park, broadcast live on Facebook, has been closed to visitors for the past two years because of COVID-19 gathering restrictions – and the in-person festivities were cancelled in 2020 because of a storm.

But a small crowd, including a group of children, braved the -20 C weather Thursday.

As expected, Sam was the first groundhog in North America to make a prediction — thanks to the Atlantic time zone.

Meanwhile, in the United States, Punxsutawney Phil agreed with Sam, predicting six more weeks of winter. Phil's prediction came during a week when ice, sleet and snow has lingered across much of the southern U.S.

Folklorists say the Groundhog Day ritual may have something to do with Feb. 2 landing midway between winter solstice and spring equinox, but no one knows for sure. In medieval Europe, farmers believed that if hedgehogs emerged from their burrows to catch insects, that was a sure sign of an early spring.

However, when Europeans settled in eastern North America, the groundhog was substituted for the hedgehog.

In a playful, peer-reviewed study published by the American Meteorological Society, researchers at Lakehead University in Thunder Bay, Ont., concluded that groundhogs are "beyond a shadow of a doubt" no better at predicting spring's arrival than flipping a coin.

- with files from Sidhartha Banerjee in Montreal and Michael MacDonald in Halifax.

This report by The Canadian Press was first published Feb. 2, 2023.

Jordan Omstead, The Canadian Press

Pope, Anglican, Presbyterian leaders denounce anti-gay laws

 
Justin Welby
British Anglican bishop and 105th Archbishop of Canterbury (born 1956)

The Moderator of the General Assembly of the Church of Scotland Iain Greenshields meets the journalists during an airborne press conference aboard the airplane directed to Rome, at the end of Pope Francis pastoral visit to Congo and South Sudan, Sunday, Feb. 5, 2023. (Tiziana Fabi/Pool Photo Via AP)


NICOLE WINFIELD
Sun, February 5, 2023 at 10:02 AM MST·3 min read

ABOARD THE PAPAL PLANE (AP) — Pope Francis, the head of the Anglican Communion and top Presbyterian minister together denounced the criminalization of homosexuality on Sunday and said gay people should be welcomed by their churches.

The three Christian leaders spoke out on LGBTQ rights during an unprecedented joint airborne news conference returning home from South Sudan, where they took part in a three-day ecumenical pilgrimage to try to nudge the young country’s peace process forward.

They were asked about Francis’ recent comments to The Associated Press, in which he declared that laws that criminalize gay people were “unjust” and that “being homosexual is not a crime.”

South Sudan is one of 67 countries that criminalizes homosexuality, 11 of them with the death penalty. LGBTQ advocates say even where such laws are not applied, they contribute to a climate of harassment, discrimination and violence.

Francis referred his Jan. 24 comments to the AP and repeated that such laws are “unjust.” He also repeated previous comments that parents should never throw their gay children out of the house.

“To condemn someone like this is a sin,” he said. “Criminalizing people with homosexual tendencies is an injustice.”

“People with homosexual tendencies are children of God. God Loves them. God accompanies them,” he added.

The Archbishop of Canterbury, Justin Welby, recalled that LGBTQ rights were very much on the current agenda of the Church of England, and said he would quote the pope’s own words when the issue is discussed at the church’s upcoming General Synod.

“I wish I had spoken as eloquently and clearly as the pope. I entirely agree with every word he said,” Welby said.

Recently, the Church of England decided to allow blessings for same-sex civil marriages but said same-sex couples could not marry in its churches. The Vatican forbids both gay marriage and blessings for same-sex unions.

Welby told reporters that the issue of criminalization had been taken up at two previous Lambeth Conferences of the broader Anglican Communion, which includes churches in Africa and the Middle East where such anti-gay laws are most common and often enjoy support by conservative bishops.

The broader Lambeth Conference has come out twice opposing criminalization, “But it has not really changed many people’s minds,” Welby said.

The Rt. Rev. Iain Greenshields, the Presbyterian moderator of the Church of Scotland who also participated in the pilgrimage and news conference, offered an observation.

“There is nowhere in my reading of the four Gospels where I see Jesus turning anyone away,” he said. “There is nowhere in the four Gospels where I see anything other than Jesus expressing love to whomever he meets.

“And as Christians, that is the only expression that we can possibly give to any human being, in any circumstance.”

The Church of Scotland allows same-sex marriages. Catholic teaching holds that gay people must be treated with dignity and respect, but that homosexual acts are “intrinsically disordered.”

___

Associated Press religion coverage receives support through the AP’s collaboration with The Conversation US, with funding from Lilly Endowment Inc. The AP is solely responsible for this content.

The Catholic Church’s upcoming discussion of homosexuality

The relaxation of doctrine for pastoral purposes is itself a Christian doctrine. Is Pope Francis headed that way?

Pope Francis speaks during an interview with The Associated Press at the Vatican, Tuesday, Jan. 24, 2023. Francis acknowledged that Catholic bishops in some parts of the world support laws that criminalize homosexuality or discriminate against the LGBTQ community, and he himself referred to homosexuality in terms of

(RNS) — Pope Francis stirred the pot last week by calling for an end to criminal penalties for homosexuality. “Being gay is not a crime, it’s a human condition,” he told the AP in a wide-ranging interview in Spanish.

Harking back to his famous “Who am I to judge?” remark, Francis imagined an exchange with an objector:

We are all children of God and God loves us as we are and with the strength that each one of us fights for our dignity. Being homosexual is not a crime. It is not a crime.

Yes, but it’s a sin.

Well, first let’s distinguish sin from crime. But the lack of charity with the neighbor is also a sin, and how are you doing?

In other words, who are you to judge?

It’s possible Francis was sending a message to the bishops of Africa, where he is visiting this week and where 35 of the 54 countries have anti-gay criminal laws. Bishops who support such laws, he said in the interview, “have to have a process of conversion” and should apply “tenderness, please, as God has for each one of us.”

As has almost always been the case, Francis gave no indication that he intends to change church doctrine in order to advance his inclusive vision of the church. The sole exception has been his allowing (on a case-by-case basis) people who are divorced and remarried to have access to the Eucharist. The question is whether a similar opening might be made for those in same-sex unions.



According to the Catholic Catechism, while homosexual persons “must be accepted with respect, compassion, and sensitivity,” they are “called to chastity” — i.e. no licit sex for them. As for same-sex unions, the church will not bless them because, the Vatican declared two years ago, God “does not and cannot bless sin.”

Those teachings are likely to be up for discussion in the church-wide Synod on Synodality that will bring bishops to Rome for October sessions this year and next. Per the pope’s instructions, the preparations for it have entailed extensive consultations with ordinary Catholics.

Last September, the United States Conference of Catholic Bishops issued a report on the consultations that highlighted criticism of the church for not doing a better job of including those suffering from “the wound of marginalization.”

Among these are members of the LGBTQ+ community, persons who have been divorced or those who have remarried without a declaration of nullity, as well as individuals who have civilly married but who never married in the Church. Concerns about how to respond to the needs of these diverse groups surfaced in every synthesis.

In October, the Vatican issued a synthesis of reports from around the world that noted, “Issues such as the Church’s teaching on abortion, contraception, ordination of women, married clergy, celibacy, divorce and Holy Communion, homosexuality, LGBTQIA+ were raised up across the Dioceses both rural and urban.”

Last week, San Diego Bishop Robert McElroy, whom the pope made a cardinal last year, wrote an article in the Jesuit magazine “America” that openly questioned the exclusion of sexually active people who are not in what the church considers a legitimate marriage.



Calling such exclusion “pre-eminently a pastoral question, not a doctrinal one,” McElroy took direct aim at the church’s refusal to concede to gay people a right to same-sex sexual expression.

The distinction between orientation and activity cannot be the principal focus for such a pastoral embrace because it inevitably suggests dividing the L.G.B.T. community into those who refrain from sexual activity and those who do not. Rather, the dignity of every person as a child of God struggling in this world, and the loving outreach of God, must be the heart, soul, face and substance of the church’s stance and pastoral action.

“We must,” wrote McElroy, “examine the contradictions in a church of inclusion and shared belonging that have been identified by the voices of the people of God in our nation and discern in synodality a pathway for moving beyond them.”

It’s important to recognize that the relaxation of doctrine for pastoral purposes is itself a Christian doctrine — known in Eastern Orthodoxy as the principle of oikonomia. Based on the idea that in a fallen world there are circumstances that require doctrinal relaxation, the principle is employed within Orthodoxy, for example, to permit divorced people to be married in church a second and even a third time.

Under Francis, the synodal path appears to be leading in that direction. Whether it gets there is another question.




Kisspeptin hormone injection could treat low sex drive in women and men


Peer-Reviewed Publication

IMPERIAL COLLEGE LONDON

The hormone kisspeptin could be used to treat women and men distressed by their low sexual desire, according to two new studies.

The studies, both published in JAMA Network Open, found that giving kisspeptin can boost sexual responses in women and men who have hypoactive sexual desire disorder (HSDD) – a condition characterised by low sexual desire that is distressing to the individual. HSDD affects up 10 percent of women and 8 percent of men worldwide and can have devastating psychological and social impacts.

The studies were led by clinicians and scientists at Imperial College London and Imperial College Healthcare NHS Trust. They were funded by the National Institute for Health and Care Research (NIHR) Imperial Biomedical Research Centre (NIHR-Imperial BRC) and the Medical Research Council, part of UK Research and Innovation.

Kisspeptin is a naturally-occurring hormone that stimulates the release of other reproductive hormones inside the body. The team have previously shown in men with intact sexual desire that kisspeptin can enhance responses to sexual stimuli, and boost attraction brain pathways, independent of other reproductive hormones like testosterone. Now, they investigated the effects in women and men with low sexual desire for the first time.

These two clinical trials involved 32 pre-menopausal women and 32 men with HSDD. In both studies, patients underwent scanning of the brain using MRI, as well as blood and behavioural tests. Kisspeptin administration improved sexual brain processing in both women and men, resulting in positive effects on sexual behaviour compared to placebo. These are the first clinical studies to explore the ability of kisspeptin to boost sexual pathways in women and men distressed by their low sexual desire.

The researchers believe that the results lay the foundations for kisspeptin-based treatments for women and men with HSDD.

Dr Alexander Comninos, from the Department of Metabolism, Digestion and Reproduction at Imperial College London, Consultant Endocrinologist at Imperial College Healthcare NHS Trust and co-senior author of the study, said:

“Low sexual desire can be distressing and so result in HSDD. This can have a major detrimental impact on relationships, mental health, and fertility. Even though it is relatively common, treatment options in women are limited, carry significant side-effects and in some cases can be harmful to even try. And unfortunately, these treatments have limited effectiveness. In men there are currently no licensed treatments and none on the horizon. Therefore, there is a real unmet need to find new, safer and more effective therapies for this distressing condition for both women and men seeking treatment. 

“Our two studies provide proof-of-concept for the development of kisspeptin treatments, as we provide the first evidence that kisspeptin is a potentially safe and effective therapy for both women and men with distressing low sexual desire. Additionally in men, we demonstrate that kisspeptin can have positive effects not only in the brain but also in the penis by increasing rigidity. Furthermore, kisspeptin was well-tolerated by both women and men with no side-effects reported, which is crucial from a drug development point of view. We now plan to take things forward to hopefully realise the potential of kisspeptin therapeutics in psychosexual disorders - sexual problems which are psychological in origin, such as unexplained low libido.”

Professor Waljit Dhillo, an NIHR Senior Investigator, also from the Department of Metabolism, Digestion and Reproduction at Imperial College London, Consultant Endocrinologist at Imperial College Healthcare NHS Trust and co-senior author of the study, added:

“Our studies build on our previous work to assess the effectiveness of kisspeptin and its boosting effects in terms of arousal and attraction. It is highly encouraging to see the same boosting effect in both women and men, although the precise brain pathways were slightly different as might be expected. 

“Collectively, the results suggest that kisspeptin may offer a safe and much-needed treatment for HSDD that affects millions of people around the world and we look forward to taking this forward in future larger studies and in other patient groups.”

The study in women involved a randomised, double-blind, two-way crossover, placebo-controlled trial at Invicro and Hammersmith Hospital (part of Imperial College Healthcare NHS Trust), between October 2020 and April 2021. Data analysis was carried out by Imperial College London researchers.

32 pre-menopausal heterosexual women with HSDD (aged 19-48 years) completed two study visits, one for administration of kisspeptin and another visit for placebo. Participants completed psychometric questionnaires before and towards the end of kisspeptin or placebo administration to assess their mood and behaviour. During kisspeptin or placebo administration, participants underwent functional MRI while watching erotic videos and viewing male faces to see how brain activity was affected. Non-erotic exercise videos were used as a control.

The team found that kisspeptin improved sexual and attraction brain activity in key brain areas in women. They also found that women who were more distressed by their sexual function showed greater kisspeptin-enhanced brain activity in the hippocampus (a key structure implicated in female sexual desire). Furthermore, the more kisspeptin activated the posterior cingulate cortex - a key behavioural brain area - in response to attractive male faces, the less sexual aversion was reported by participants. Crucially, the psychometric analyses revealed that the women reported feeling ‘more sexy’ during kisspeptin, compared to placebo.

In the second study, which was also a randomised, double-blind, two-way crossover trial, 32 heterosexual men with HSDD (aged 21-52 years) underwent a similar study with the addition of the measurement of penile rigidity, between January and September 2021.

The study demonstrated that kisspeptin significantly boosted brain activity in key structures of the sexual brain network while also increasing penile rigidity by up to 56 per cent compared to placebo, while viewing an erotic video. Similarly to the study in women, kisspeptin also had greater effects in key brain regions in men more distressed with their low sexual desire. Furthermore, psychometric analyses revealed that kisspeptin improved ‘happiness about sex’ reported by the men.

Dr Comninos and Professor Dhillo now plan to take this forward with larger scale studies, studies in different populations and collaborations to develop kisspeptin as a realistic treatment for both women and men with distressing psychosexual disorders.

ENDS

Kisspeptin to Women with HSDD paper: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797718

Kisspeptin to Men with HSDD paper: https://imperialcollegelondon.app.box.com/s/91u2erklf0m6nqkrnah3xm03r5ftoisi/file/1126695946014

*Peter* (age 44)

*Name changed*

“I got involved in the trial because I had previous problems with my sexual appetite and performance.

“The issue had always been detrimental to sustaining relationships. I would often make excuses as to why my sexual appetite was low. For example, I would blame stress at work or tiredness as a reason instead of being honest. I had tried other performance supporting medication like Viagra. However, this proved ineffective as the issue was simply one of low desire. It was highly embarrassing and not something I felt able to talk to my previous partners about. I feared they would confuse it with lack of attraction to them.

“I was keen to learn whether there was a solution to my problem and learn more about my condition. 

“I received the kisspeptin infusion in June 2021 and I noticed a difference in terms of my sexual desire. The week I had the kisspeptin infusion we conceived our son, who was born in March 2022. I had the best possible outcome as a result of the trial. 

“I also learnt a lot more about myself and my condition. I am really pleased to have contributed to this trial, which has been life-changing for me. I’m glad that others in a similar position could benefit from the treatment.”

*Eve* (43)

*Name changed*

“I took part in the trial as I was experiencing low sexual libido. Initially, I put it down to having small children and being exhausted as a result. However, this continued and started to impact my wellbeing. I wanted to see whether there was another reason for why I was feeling this way. 

“I had two study visits in 2020 where I received the placebo and the kisspeptin infusions without knowing which one I was getting at the time. I did notice a bit of a difference once I received the kisspeptin infusion and it was fascinating to be part of the process.

“I am glad that I took part in the study as many women wouldn’t like to admit they are experiencing this and may not seek help. I’m glad to know that kisspeptin could be a treatment option for other women.”