Tuesday, January 16, 2024

A surgeon general report once cleared the air about smoking. Is it time for one on vaping?


MIKE STOBBE
 Mon, January 15, 2024 


Vaping Health Effects
 - A health warning is seen on the packaging of a disposable vaping pod device in Washington
on Monday, June 26, 2023. Sixty years ago, the U.S. surgeon general released a report that settled
a longstanding public debate about the dangers of cigarettes and led to huge changes in smoking
in America. Some public health experts say a similar report could help clear the air about vaping.
(AP Photo/Andrew Harnik, File)

NEW YORK (AP) — Sixty years ago, the U.S. surgeon general released a report that settled a longstanding public debate about the dangers of cigarettes and led to huge changes in smoking in America.

Today, some public health experts say a similar report could help clear the air about vaping.

Many U.S. adults believe nicotine vaping is as harmful as — or more dangerous than — cigarette smoking. That’s wrong. The U.S. Food and Drug Administration and most scientists agree that, based on available evidence, electronic cigarettes are far less dangerous than traditional cigarettes.

But that doesn’t mean e-cigarettes are harmless either. And public health experts disagree about exactly how harmful, or helpful, the devices are. Clarifying information is urgently needed, said Lawrence Gostin, a public health law expert at Georgetown University.

“There have been so many confusing messages about vaping,” Gostin said. “A surgeon general’s report could clear that all up.”

One major obstacle: E-cigarettes haven’t been around long enough for scientists to see if vapers develop problems like lung cancer and heart disease.

“There’s a remarkable lack of evidence,” said Dr. Kelly Henning, who leads the public health program at Bloomberg Philanthropies.

SMOKING AND VAPING

Cigarette smoking has long been described as the leading cause of preventable death in the United States. The Centers for Disease Control and Prevention puts the annual toll at 480,000 lives. That count should start to fall around 2030, according to a study published last year by the American Journal of Preventive Medicine, thanks in part to a decline in smoking rates that began in the 1960s.

Back then, ashtrays were everywhere and more than 42% of U.S. adults smoked.

On Jan. 11, 1964, U.S. Surgeon General Luther Terry released an authoritative report that said smoking causes illness and death — and the government should do something about it. The report is considered a watershed moment: In the decades that followed, warning labels were put on cigarette packs, cigarette commercials were banned, governments raised tobacco taxes and new restrictions were placed on where people could light up.

By 2022, the adult smoking rate was 11%.

Some experts believe e-cigarettes deserve some of the credit. The devices were billed as a way to help smokers quit, and the FDA has authorized a handful of e-cigarettes as less-harmful alternatives for adult smokers.

Vaping’s popularity exploded in the 2010s, among both adults but and teens. In 2014, e-cigarettes surpassed combustible cigarettes as the tobacco product that youth used the most. By 2019, 28% of high schoolers were vaping.

U.S. health officials sounded alarms, fearing that kids hooked on nicotine would rediscover cigarettes. That hasn’t happened. Last year, the high school smoking rate was less than 2% — far lower than the 35% rate seen about 25 years ago.

“That’s a great public health triumph. It’s an almost unbelievable one,” said Kenneth Warner, who studies tobacco-control policies at the University of Michigan.

“If it weren’t for e-cigarettes, I think we would be hearing the public health community shouting at the top of their lungs about the success of getting kids not to smoke,” he said.

VAPING’S BENEFITS AND HARMS

Cigarettes have been called the deadliest consumer product ever invented. Their smoke contains thousands of chemicals, at least 69 of which can cause cancer.

The vapor from e-cigarettes has been estimated to contain far fewer chemicals, and fewer carcinogens. Some toxic substances are present in both, but show up in much lower concentrations in e-cigarette vapor than in cigarette smoke.

Studies have shown that smokers who completely switch to vaping have better lung function and see other health improvements.

“I would much rather see someone vaping than smoking a Marlboro. There is no question in my mind that vaping is safer,” said Donald Shopland, who was a clerk for the committee that generated the 1964 report and is co-author of a forthcoming book on it.

But what about the dangers to people who have never smoked?

There have been 100 to 200 studies looking at vaping, and they are a mixed bag, said Dr. Neal Benowitz, of the University of California, San Francisco, a leading academic voice on nicotine and tobacco addiction. The studies used varying techniques, and many were limited in their ability to separate the effects of vaping from former cigarettes smoking, he said.

“If you look at the research, it’s all over the map,” Warner said.

Studies have detected bronchitis symptoms and aggravation of asthma in young people who vape. Research also indicates vaping also can affect the cells that line the blood vessels and heart, leading to looks for a link to heart disease. Perhaps the most cited concern is nicotine, the stimulant that makes cigarettes and vapes addictive.

Animal studies suggest nicotine exposure in adolescents can affect development of the area of the brain responsible for attention, learning and impulse control. Some research in people suggests a link between vaping and ADHD symptoms, depression and feelings of stress. But experts say that the research is very limited and more work needs to be done.

Meanwhile, there’s not even a clear scientific consensus that vaping is an effective way to quit smoking, with different studies coming up with different conclusions.

CLEARING THE AIR

Last month, the World Health Organization raised alarms about the rapidly growing global markets for electronic cigarettes, noting they come in thousands of flavors that attract young people.

In 2016, U.S. Surgeon General Dr. Vivek Murthy said efforts were needed to prevent and reduce e-cigarette use by children and young adults, saying nicotine in any form is unsafe for kids.

About four months before the report’s release, the FDA began taking steps to regulate e-cigarettes, believing they would benefit smokers.

The agency has authorized several e-cigarettes, but it has refused more than 1 million product marketing applications. Critics say the FDA has been unfair and inconsistent in regulation of products.

Meanwhile, the number of different e-cigarette devices sold in the U.S. has boomed, due largely to disposables imported from China that come in fruit and candy flavors. But vaping by youths has recently been falling: Last year, 10% of high school students surveyed said they had used e-cigarettes in the previous month, down from 14% the year before.

Why the decline? “It’s hard to say what’s working,” said Steven Kelder, a University of Texas researcher.

He mentioned a 2019 outbreak of hospitalizations and deaths among people who were vaping products with THC, the chemical that gives marijuana its high.

The illnesses were traced to a thickening agent used in black market vape cartridges, a substance not used in commercial nicotine e-cigarettes. But it may be a reason many Americans think of e-cigarettes as unsafe, Kelder said.

Sherri Mayfield, a 47-year-old postal worker, remembers the 2019 outbreak and reports of rapid illnesses and deaths in youths. Vaping “absolutely” needs to be studied more, Mayfield said last week while on a cigarette break in New York with some co-workers.

“Cigarettes aren't safe” but at least it can take them decades to destroy your health, she said.

The surgeon general's office said in a statement that the 1964 report “catalyzed a 60-year movement to address the harmful effects of smoking" and suggested similar action was needed to address youth vaping.

Murthy's website, however, currently lists neither vaping nor smoking as a priority issue.

___

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

Industries With the Most Greenhouse Gas Emissions – 2024 Study

Jaclyn DeJohn
Tue, January 16, 2024


While industries could drive the growth of local economies, high emissions can also have a negative impact on the environment of those markets and put the overall success of those communities at risk. Examining emissions levels may help communities understand the total impact and tradeoffs associated with local industries, as well as help inspire innovations to reduce emissions.

With these factors in mind, SmartAsset ranked 1,016 industries based on the estimated greenhouse gas emissions generated by individual supply chains, measured in equivalent kilograms of CO2 (CO2e) per dollar spent.

Key Findings

Solid waste landfills contribute more than 3x greenhouse gas emissions than the second-ranking industry. An estimated 10.99 kg of CO2 equivalent is emitted from the solid waste landfill industry. No other industry emits more than 3.8 kg of CO2 equivalent.

In manufacturing, cement and fertilizer are the biggest emitters of greenhouse gasses. Cement manufacturing is the second-biggest emitter of greenhouse gasses across all industries. Fertilizer production – particularly nitrogenous and phosphatic fertilizers, as well as the mixing of fertilizers – also tie for 14th place across all industries, generating about 2.03 kg of CO2e each.

Among recreational hobbies, these emit the most greenhouse gasses. Golf courses and country clubs, skiing facilities, marinas, bowling centers, and fitness and recreational sports centers emit about 0.31 kg CO2e. By comparison, hotels, casinos, museums, food service, amusement parks, sports teams and clubs emit just a fraction of that.

The cattle and beef industry contributes some of the highest emissions rates
. Beef cattle ranching and farming, cattle feedlots, and dual-purpose cattle ranching and farming each contribute an equivalent of 3.23 kg of CO2, tying for the third-most prominent industry for greenhouse gas emissions. Other prominent emitters in farming include dry peas and beans, wheat, corn, rice, oilseed and grain – each of which contributes an estimated 2.87 kg of CO2e.

Artists have particularly low emissions impacts. Independent artists, writers and performers collectively only emit the equivalent of 0.013 kg of CO2e. Music publishers, sound recording studios, record production and distribution, and other sound recording industries similarly come in at only about 0.026 kg each. Many insurance-related industries, including claims adjusting and agencies and brokerages, also emit particularly low levels of emissions (0.034 kg).

Bottled water manufacturing generates more greenhouse gasses than tobacco manufacturing. The bottled water supply chain is estimated to be responsible for about 0.322 kg of carbon dioxide equivalent, while tobacco manufacturing contributes 0.073 kg.

Financial advice and management has very low associated emissions. Financial advisors, which fall under the investment advice industry, contribute 0.062 kg of CO2e, ranking near the bottom of the list. Other aspects of financial management including portfolio management, trust, fiduciary and custody activities, and securities brokerages have similarly low emissions.

Data and Methodology

This study ranked 1,016 commodities as defined by the 2017 North American Industry Classification System (NAICS) according to the most recent data on the respective supply chain's greenhouse gas emissions without margins, as expressed in kilograms of carbon dioxide equivalent (CO2e) per 2021 USD. Emissions data is from 2019. Data comes from the United States Environmental Protection Agency.

Questions about our study? Contact us at press@smartasset.com

Photo credit: ©iStock.com/Sergey Bukharev
First Quantum Is Halting Its Dividend and Selling Mines Amid Panama Woes

Jacob Lorinc
Tue, January 16, 202


(Bloomberg) -- First Quantum Minerals Ltd. will cut spending, pause its dividend and put smaller mines up for sale in a sweeping effort to free up cash after it was ordered to shutter its $10 billion copper operation in Panama.

The Canadian miner said Monday that it’s considering a range of capital-market options to maintain its financial position and is working with banks to “address and extend” its bank loan facilities. It’s also considering selling stakes in larger mining assets after receiving expressions of interest from potential investors.

Shares of First Quantum fell 2.2% to C$13.11 at 9:32 a.m. in Toronto.

First Quantum is reeling from the fallout of Panama President Laurentino Cortizo’s abrupt orders to shutter its biggest asset late last year, following a ruling from the Supreme Court that invalidated the mine’s operating contract. The closing of Cobre Panama, which accounted for 78% of First Quantum’s operating profit in the first nine months of 2023, has wiped out more than half of the miner’s market value and cast the company’s finances into uncertainty as billions of dollars of its debt mature in the coming years.

First Quantum plans to cut capital spending by $400 million this year — to a range of $1.2 billion to $1.4 billion — in part from slowed spending on Cobre Panama, as well as moves to combat cost growth at its Zambian mines.

Without Cobre Panama operating, the company also said it expects copper output to fall by nearly half from last year. The company produced 708,000 metric tons of copper in 2023 and expects to produce 370,000 tons to 420,000 tons in 2024.

The strategy released on Monday “doesn’t have all the answers yet — and that could be modestly disappointing to the market — but we continue to believe that First Quantum will manage through this difficult situation,” Bank of Montreal analyst Jackie Przybylowski said in a Tuesday note to investors.

First Quantum had previously announced plans to pause mining operations at its Australian nickel mine. Bloomberg also reported last week that the company has started a process to sell a copper mine in Spain.

The crisis has drawn attention from rival Barrick Gold Corp., which Bloomberg reported earlier this month has approached some of First Quantum’s top shareholders to gauge support for a potential takeover.

Read More: Barrick Said to Gauge First Quantum Holders on Possible Bid

In Monday’s statement, First Quantum said it has held discussions this month with Panama’s ministry of commerce and industries related to the mine’s current status of suspension, which it described as “preservation and safe management.” The costs to maintain the site are estimated at $15 million to $20 million per month, the company said. It is due to present an initial plan to the government on Jan. 16.

First Quantum has said it is still “committed” to Panama despite the setbacks, and has embarked on a campaign to advertise the mine’s benefits ahead of a key presidential election in May that could determine the project’s fate.

Cobre Panama is one of the world’s newest and largest copper operations, and generated about 1.5% of the world’s supply of the metal before it halted operations last year because of protests that blocked access to key supplies.

©2024 Bloomberg L.P.

First Quantum Halts Australian Nickel Mine on Weak Metal Price


Jacob Lorinc
Mon, January 15, 2024 


(Bloomberg) -- First Quantum Minerals Ltd. said it will halt mining at its nickel and cobalt operation in Australia and cut a third of the workforce in response to weaker metal prices and higher costs.

The Canadian mining company said the suspension at the Ravensthorpe Nickel Operation, located in Western Australia, reflects a three-year plan to stop mining activity at the site and produce nickel concentrate from existing stockpiles.

“The decision results from the significant downturn in the nickel price experienced during 2023, combined with currently higher operating costs in Western Australia, and a requirement to improve the financial viability of RNO at current nickel prices,” the company’s Australian unit said in a statement on Monday.

The new operating model would allow the plant to continue producing and exporting nickel from stockpiles, while the company would be able to resume mining activities when prices improved, it said.

Nickel dropped 45% last year, weighed down by a flood of cheap supply from Indonesia, where new techniques to produce battery-grade material are threatening to disrupt the industry. The plunge across battery metals has forced mining companies to stall projects, abandon deals and scramble for cash.

First Quantum is also facing pressure to cut costs following orders from Panama’s government to permanently shutter its flagship copper mine, Cobre Panama, which generated 78% of the company’s operating profit in the first nine months of last year. The company initiated a process to sell a copper mine in Spain in December after Panama’s sudden directives left the company facing financial uncertainty.

The suspension of mining will reduce the facility’s direct workforce by approximately 30%, with contractors to be redeployed by their employers, the company said.

 Bloomberg Businessweek
JP Morgan to pay $18 million fine over whistleblower protection violations -SEC

Reuters
Tue, January 16, 2024 


WASHINGTON (Reuters) -A JP Morgan Chase & Co unit will pay a $18 million civil penalty to settle charges it violated whistleblower protection rules, the U.S. Securities and Exchange Commission said on Tuesday.

J.P. Morgan Securities LLC impeded "hundreds of advisory clients and brokerage customers from reporting potential securities law violations" to financial regulators, the SEC said in a statement, adding that the company also agreed to cease the alleged violations.

From March 2020 through July 2023, the firm asked retail clients to sign confidential agreements if they were issued a credit or settlement from JPM of more than $1,000, the SEC said. The agreements required the clients to keep the underlying facts of the regulators said.

Representatives for JPM did not respond immediately to request for comment.

(Reporting by Susan Heavey and Chris Prentice; Editing by Doina Chiacu, Alexandra Hudson)
JPMorgan Hires for Private-Asset Push Targeting Canada’s Rich

Christine Dobby
Tue, January 16, 2024 


(Bloomberg) -- JPMorgan Chase & Co. is building up its Canadian asset management team, with new hires planned for Toronto and Montreal, as it looks to tap into growing demand from the wealthy for private investments.

The bank is working on creating new alternative-investment products to offer to major wealth management firms in the country in the first half of this year. High-net worth individuals are the bank’s ultimate target, Travis Hughes, who heads JPMorgan Asset Management in Canada, said in an interview.

The bank’s Canadian asset management division is relatively small — it has about C$36 billion ($26.8 billion) under management and primarily serves institutional investors. But Hughes, who has been in the role for two years, said he’s trying to fill a need.

“If you look not only in the US but in Europe, Asia, Latin America, Australia, there has been a concentrated push to bring these private alternatives to individual investors,” he said.

Private assets represent about 1% to 2% of Canadian retail investors’ portfolios, Hughes estimated, while that same figure is at least 6% or 7% in the US. “We’re hoping to be in the early days of the growth of the asset class in Canada.”

JPMorgan hired Jay Rana, a former senior vice-president at Pacific Investment Management Co., to help run its Canadian adviser business and Hughes said other new additions will follow this year, mainly in the country’s two largest cities.

Canadian financial players are also angling to sell clients on private credit, private equity, real estate and other alternatives to stocks and bonds. Bank of Nova Scotia, for example, said in October it was partnering with Sun Life Financial Inc.’s asset management business to offer private alternatives. Last year, Royal Bank of Canada’s wealth division absorbed a number of employees from Onex Corp. and agreed to carry the latter’s private funds.

Hughes observed that there’s growing competition in Canada from global asset managers. Morgan Stanley expanded its wealth management business in the country in 2020, while Blackstone Inc. increased its presence by establishing a real estate office in Toronto and hiring Janice Lin to run it in 2022.

Private assets can be challenging to sell to individual investors, with less liquidity, opaque fee structures and infrequent valuations compared with public securities.

JPMorgan’s Canadian offerings will be similar to what it offers clients in the US, which includes private equity, real estate and infrastructure investments, with features such as lockup provisions and minimum investments tailored to retail investors, Hughes said.

Most Read from Bloomberg Businessweek
Boeing’s board faces scrutiny yet again: ‘It’s a bad board, and it has been a bad board for a long time’


Lila MacLellan
Tue, January 16, 2024 

Christopher Pike—Bloomberg/Getty Images


Good morning,

Business pundits are watching closely to see whether CEO Dave Calhoun can lead Boeing through the aftermath of its latest crisis or if he’ll be replaced. But Boeing’s board also deserves scrutiny, according to Nell Minow, vice chair of ValueEdge Advisors and a noted authority on corporate governance.

In 2021, Boeing’s board famously paid a hefty $246 million fine to settle a shareholder lawsuit that accused it of failing in its fiduciary duty to monitor safety, and initially lying about its response to the first of two fatal 737 Max 8 crashes. Now, as investigations continue into why a fuselage panel recently blew off a 737 Max 9 mid-flight, Minow asserts that the board is a “serial offender” that “doesn’t learn from past mistakes.”

“It’s a bad board, and it has been a bad board for a long time,” she tells Fortune.

Part of the problem is that the board hasn’t felt enough pressure to change, Minow explains. Boeing, as half of a duopoly, has only one major competitor, Airbus. It also holds government and commercial airline contracts that guarantee it business. Given the company’s market dominance, the board has allowed Boeing to put financial—not aviation—engineering first. “The inevitable results were what we saw,” says Minow, who owns Boeing shares.

Others may criticize the company for not sufficiently overhauling its board and leadership immediately after the Max 8 fatalities. Four years ago, Calhoun’s predecessor, Dennis Muilenburg, was fired, accused of leading a culture that put production deadlines and profits ahead of safety. But Calhoun, a veteran GE executive, had been the board's lead director overseeing Muilenburg’s term and close ally to the prior chief executive who led the firm into the rushed development of the 737 Max 8.

Meanwhile, Boeing’s current chair Larry Kellner has been a director since 2011 and previously led its audit committee.

“But will this fix what needs fixing?” Jon Ostrower, editor-in-chief of The Air Current and former Wall Street Journal aerospace reporter, asked in 2019 in response to the leadership revamp. Both Calhoun and Kellner had “consistently blessed [Boeing’s] long-term strategy,” he wrote.

He wasn’t the only one with misgivings. In 2020, proxy advisor Glass Lewis urged investors to vote against Kellner at the company’s shareholder meeting, citing his role as audit committee chair during the 737 Max 8 crashes. Vanguard, Boeing’s top shareholder, voted against Kellner that year, referencing "control failures" by the audit committee. The following year, Glass Lewis advised against reelecting Kellner a second time.

A handful of other board directors were also singled out by advisors, and consumer advocate Ralph Nader, whose grandniece died in the second Boeing 737 Max 8 crash, called for the whole board to resign.

But during board shakeups, companies are expected to hang on to key people for the sake of continuity as they introduce new talent with fresh perspectives. After reviewing recent board changes at Boeing, Jo-Ellen Pozner, associate professor of management at Santa Clara University’s Leavey School of Business, says she applauds the company for adding aviation and risk experts while replacing directors with financial, government, and trade expertise. “If I were putting together a board for Boeing, this is what I would choose,” she says of the current group. (More than half of the 13 current board members have joined since 2019.)

Still, Pozner cautions that organizational culture is sticky. It takes time for transformational changes to trickle down from the board into a company’s operations, and the newest directors on Boeing’s board are likely only hitting their stride about now. What happens over the next few weeks will reveal whether the board is indeed prepared for adversity and attuned to the right issues.

Boeing didn’t immediately respond to Fortune’s request for comment.

Lila MacLellan
lila.maclellan@fortune.com
@lilamaclellan

This story was originally featured on Fortune.com
GREENWASHING

US energy tax credit trading grows to as much as $9 billion, study finds

Isla Binnie
Tue, January 16, 2024

FILE PHOTO: U.S. President Joe Biden visits the Flatirons Campus Laboratories and Offices of the National Renewable Energy Laboratory (NREL), in Arvada

By Isla Binnie

NEW YORK (Reuters) - Developers of renewable energy projects selling unused U.S. tax credits to other companies now account for a market worth between $7 billion and $9 billion, buoyed by legislation in 2022 that made these trades possible, a new study shows.

President Joe Biden's climate law aimed to stoke trillions of dollars of investment to wean the economy off planet-warming fossil fuels, partly through tax breaks for builders of projects like wind farms and solar plants.

The government made some of these new credits tradable, in the hope of bringing fresh money to projects which have long relied on a group of banks that are big and expert enough to invest directly and take the associated tax breaks.

In the first six months since tax authorities set guidance for the trades in June of last year, deals were struck to transfer credits worth between $7 billion and $9 billion, online platform Crux calculated.

That represents more than one third of the roughly $20 billion traditionally raised each year through tax equity for such projects in the United States. In total, $64 billion was invested nationally in clean energy and transportation in the three months to September, the Rhodium Group think tank says.

Crux, which lets sellers post details of their projects and buyers browse and make bids, surveyed developers selling the credits, corporate buyers and intermediaries like banks and brokers in late 2023, and received 150 responses.

They counted deals worth $3.5 billion, and separately parsed other accessible information to reach the $7-9 billion estimate for the 2023 tax year.

"This market has scaled faster than anyone anticipated," said Crux CEO and co-founder Alfred Johnson, a former Treasury Department staffer.

Buyers paid an average 92-94 cents on the dollar for credits. Crux and other companies like it say they charge fees ranging from less than 1% to 3% of the value of the credits, which can only be sold once.

"We saw behavior like a bidding war on the platform." Johnson said. "In 2024 we expect many more net new buyers."

(Reporting by Isla Binnie; Editing by Andrea Ricci)

 

Novel railway point switching technology, inspired by aircraft control systems


Peer-Reviewed Publication

UNIVERSITY OF BIRMINGHAM





Researchers from the University of Birmingham, U.K., are working on Repoint, a new cutting-edge railway switch (points) technology to improve upon the traditional design, which has been in use for over 200 years. 

While conventional railway switches guide trains from one track to another by sliding a pair of tapering rails horizontally, the new design, which is called Repoint, uses a lift and move mechanism, which includes a passive lock for when the points are in place.  This is combined with a stub-switch type layout, which offers advantages in many situations. Importantly, the switch is ‘fault-tolerant’, continuing to work even when two of the three actuators, which control the movement of the points, have failed.

Research published today by the team (now at University of Birmingham, Leeds, Loughborough, and Network Rail) describes the team’s development of a digital twin (dynamic simulation model) which has been used to show that the design meets and exceeds requirements for speed and performance.

The research investigated the performance of the switch using a novel method for simulating track system behaviour, which combines rail bending with physics-based models of actuators and control systems. The simulation scenarios included one of power failure to four of the six motors that drive the actuators, and showed that a single actuator is capable lifting and moving the points to the desired position. 

Repoint was developed by Professor Roger Dixon, who led a team at Loughborough University until 2018, and is now Professor of Control Systems Engineering at the Birmingham Centre for Railway Research and Education (BRCCE). 

The journey to a new railway switch started when Roger, then Head of Loughborough’s Control Systems Research Group, responded to a joint call from the Engineering and Physics Research Council (EPSRC) and the UK Rail Safety and Standards Board (RSSB) to look at ways of improving capacity on existing lines.  It was clear that one significant limiting factor to growing capacity was the railway track switch, and so a project to re-imagine the switch was proposed and subsequently funded (having ranked 1st in the peer review for the call).

Professor Dixon commented: “Although switches account for less than 5% of railway track miles, they contribute to 18% of delay minutes, and 17.5% of delay costs in the UK.” 

The team engaged with operators, maintainers and designers to understand the limits and issues with existing switch technology.

One of the most significant findings was the ‘single point of failure’ that is embedded in the traditional switches and their detection systems, so the new switch incorporates fault-tolerant design.

Inspired by aircraft control systems, the team designed a switch that remains operational even when two (out of three) components fail.

Professor Dixon said: “While railway networks continue to carry more passengers and freight, building new track is always difficult and expensive, and increasing the reliability and exploiting the capacity of existing routes is generally the preferred option.”

Repoint actuation is at Technology Readiness Level (TRL) 4-5.  It has been successfully tested at a test track, which demonstrated its compatibility and functionality with conventional switch rail arrangements.  The researchers are now seeking partners and funding to design and fully test the full repoint system including the actuators, p-way and interfaces to signaling.

 

UK

Landmark national study supports use of whole genome sequencing in standard cancer care


In the largest study of its kind, scientists today report how combining health data with whole genome sequence (WGS) data in patients with cancer can help doctors provide more tailored care for their patients

Peer-Reviewed Publication

QUEEN MARY UNIVERSITY OF LONDON



  • Study shows that combining whole genome sequence and clinical data together at scale supports the delivery of precision cancer care, where cancer diagnosis and treatment is tailored to the individual patient
  • Results support increased use of genomic testing in cancer care via the NHS Genomic Medicine Service
  • The research shows the value of data from the ground-breaking 100,000 Genomes Project to improve understanding of cancer and help researchers to develop new treatments.

In the largest study of its kind, scientists today report how combining health data with whole genome sequence (WGS) data in patients with cancer can help doctors provide more tailored care for their patients.

The research, published today in Nature Medicine, shows that linking WGS data to real-world clinical data can identify changes in cancer DNA that may be relevant for an individual patient’s care, for example by helping identify what treatment might work best for them based on their cancer.

The study, led by Genomics England, NHS England, Queen Mary University of London, Guy's and St Thomas' NHS Foundation Trust and the University of Westminster, analysed data covering over 30 types of solid tumours collected from more than 13,000 participants with cancer in the 100,000 Genomes Project. By looking at the genomic data alongside routine clinical data collected from participants over a 5-year period, such as hospital visits and the type of treatment they received, scientists were able to find specific genetic changes in the cancer associated with better or worse survival rates and improved patient outcomes.

The study showed that WGS could provide a more comprehensive view of a tumour's genetic landscape by detecting various genetic changes using a single test. This research uncovered significant findings across different cancer types, such as:

  • Over 90% of brain tumours and over 50% of colon and lung cancers showed genetic changes that could affect how patients are treated, guiding decisions about surgery or specific treatments they might need.
  • In more than 10% of sarcomas, larger DNA changes, known as structural variants, were identified that can impact clinical care and treatment.
  • In over 10% of ovarian cancers, the study pinpointed inherited risks offering crucial insights for clinical care.

The analysis also revealed patterns across several cancers and uncovered different types of genetic changes that might explain response to treatment or predict possible patient outcomes. Together, the findings show the value of combining genomic and clinical data at scale to help healthcare professionals make the best treatment decisions with their patients.

WGS allows us to read someone’s entire genome – the 3.2 billion letters that make up our DNA – with just one single test. For patients with cancer, this technique can be used to compare DNA from their tumour to the DNA in their healthy tissues.

The 100,000 Genomes Project laid the foundations for the NHS to become the first national health system to offer WGS as part of routine care via the NHS Genomic Medicine ServiceThis study shows the value of investment in national infrastructure to generate clinical and genomic data at scale on patients and participants who consent to research in an NHS setting - allowing researchers to uncover insights to drive improved diagnosis, care and treatment for patients with cancer.

Dr Nirupa Murugaesu, Principal Clinician - Cancer Genomics and Clinical Studies at Genomics England, Oncology Consultant and Cancer Genomics Lead at Guy's and St Thomas' NHS Foundation Trust said: "This study is an important milestone in genomic medicine. We are starting to realise the promise of precision oncology that was envisioned ten years ago when the 100,000 Genomes Project was launched.

“We are showing how cancer genomics can be incorporated into mainstream cancer care across a national health system and the benefits that can bring patients. By collecting long-term clinical data alongside genomic data, the study has created a first-of-its-kind resource for clinicians to better predict outcomes and tailor treatments, which will allow them to inform, prepare, and manage the expectations of patients more effectively.”

Professor Sir Mark Caulfield, VP Health at Queen Mary University of London, said: “This study shows how we can transform cancer care from a ‘one size fits all’ approach into precision healthcare and defines specific genomic signatures that predict treatment response and outcomes, which may usher in expanded use of whole genomes for cancer care.”

Dr Alona Sosinsky, Scientific Director for Cancer at Genomics England, said: “The 100,000 Genomes Project paved the way for delivering whole genome sequencing in cancer. This technology opens tremendous opportunities for precision oncology. Together with centrally collected clinical data our genomic cohort provides a rich dataset for basic and translational research. In this study, we demonstrate how Genomics England’s unique national genomic research dataset can provide vital information to inform genomic testing in healthcare.”  

Helen White, Participant Panel Vice Chair for Cancer at Genomics England said: “This study has opened doors to better ways of diagnosing and treating cancer, but was only made possible by all those who, despite the challenges of a cancer diagnosis, gave their consent for their or their loved one’s genomic and health data to be used in the 100,000 Genomes Project. Their invaluable contribution has made these advances possible, bringing hope to people affected by cancer of living well for longer.”

Professor Dame Sue Hill, Chief Scientific Officer for NHS England and Senior Responsible Officer for Genomics, said: “With this new study, data from the 100,000 Genomes Project continues to build the evidence for the use of genomic testing to deliver precise molecular diagnoses to inform personalised treatments and interventions for patients.

“The insights gained in this study, in which genomic patterns or profiles have been mapped out in thousands of patients with different types of cancer, support and inform the NHS Genomic Medicine Service in providing a comprehensive genomic testing service for patients with cancer and signals a promising future for healthcare as we continue to hone and enhance the NHS use of genomics and tailor interventions for improved outcomes.”

Andrew Stephenson, Health Minister, said: “This ground-breaking research demonstrates the power of genomics and is already helping to transform care, allowing patients to receive more tailored treatment and driving improved diagnosis.

“But we won’t stop there. We want to harness this innovation to improve care for patients and affirm our position as a life sciences superpower – leading to quicker and more targeted interventions.”

 

A methodology for regulating fuel stratification and improving fuel economy of GCI mode via double main-injection strategy


Peer-Reviewed Publication

HIGHER EDUCATION PRESS

Schematic of experimental setup 

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 SCHEMATIC OF EXPERIMENTAL SETUP

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CREDIT: HIGHER EDUCATION PRESS




Exploring advanced combustion mode with high efficiency and low emissions has been the dream of successive generations of researchers. Conventional diesel engines have high compression ratios thus with thermal efficiencies of 35%–45%, but the diffusion combustion

characteristics of diesel make NOx and soot emissions high. Gasoline compression ignition (GCI) is an advanced combustion mode in the field of internal combustion engines, which combines the advantages of the high efficiency of diesel engines and the low emissions of gasoline engines.  Although the GCI mode can achieve a high efficiency while maintaining low NOx and soot emissions, the GCI combustion still faces problems such as high maximum pressure rise rate (MPRR) and combustion deterioration at high loads.

 

A research group of Yong QIAN from Shanghai Jiao Tong University proposes a new methodology to improve the problems of high MPRR and combustion deterioration of the GCI mode at high loads. The new methodology called double main-injection (DMI) strategy was that two direct injectors were used for the simultaneously main-injection. By comparing DMI strategy with the single main-injection (SMI) strategy and conventional diesel combustion at high loads, they found that ① the simultaneous main-injection of the two direct injectors can achieve a rapid fuel supply and control of fuel stratification in the DMI mode, ② exhaust gas recirculation has a significant effect on the combustion and emissions of the DMI mode, ③ the DMI strategy achieves a highly efficient and stable combustion of the GCI mode, ④ the DMI strategy can alleviate the requirement of the GCI

mode on injection pressure and improve the problems of high MPRR and combustion deterioration.

 

The proposed new methodology-DMI strategy can improve the fuel economy and reduce MPRR at high loads, and it is of great significance to GCI mode. These findings were published in Frontiers in Energy on Jan. 10, 2023.

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