Monday, February 05, 2024

 

Number of shark bites consistent with recent trends, with small spike in fatalities


Reports and Proceedings

FLORIDA MUSEUM OF NATURAL HISTORY

Infographic 

IMAGE: 

2023 SHARK BITE DATA.

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CREDIT: FLORIDA MUSEUM OF NATURAL HISTORY




There was an increase in the number of unprovoked shark attacks worldwide and an uptick in fatalities in 2023 compared to the previous year. The University of Florida’s International Shark Attack File (ISAF), a scientific database of global shark attacks, confirmed 69 unprovoked bites in 2023. Although this is higher than the most recent five-year average of 63 attacks, the data remain consistent with long-term trends.

Ten of the past year’s unprovoked attacks were fatal, up from five the year before, with a disproportionate number occurring in Australia. Although the country accounted for 22% of all attacks, it made up 40% of fatalities. There were also two confirmed deaths in the U.S., and one each in the Bahamas, Egypt, Mexico and New Caledonia. Other confirmed, non-fatal bites occurred in Costa Rica, Colombia, Brazil, New Zealand, Seychelles, Turks and Caicos, Ecuador (in The Galápagos Islands) and South Africa.

“This is within the range of the normal number of  bites, though the fatalities are a bit unnerving this year,” said Gavin Naylor, director of the Florida Museum of Natural History’s shark research program.

The United States had 36 unprovoked attacks, accounting for 52% of incidents worldwide. Of these, two — one in California and another in Hawaii — were fatal. As in previous years, Florida had more shark bites than any other state, with 16 attacks.

While ISAF documents and investigates all bites on humans by sharks, the annual report focuses primarily on unprovoked attacks. These are defined as any instance in which a shark is in its natural habitat and attacks without any human provocation, which includes intentionally approaching a shark or swimming in an area where bait is being used to lure fish. Unprovoked bites are the most useful for studying how sharks behave.

“We’re biologists, and we want to understand the natural behavior of the animals — not the unnatural behavior,” Naylor said.

ISAF’s records include an additional 22 attacks last year that were intentionally or unintentionally provoked. The most common victim activity at the time of provoked attacks was spearfishing.

Surfers and Australia get the brunt of fatal bites

Three fatalities in 2023 occurred at one remote surfing destination off the coast of Southern Australia. The Eyre Peninsula is known for its wild, untamed beaches and phenomenal surf breaks, and despite being challenging to access and navigate, it is an alluring spot for surfers.

The region is home to seal colonies and a high density of white sharks.

“If a white shark is going after a seal and the seal knows it, the white shark hasn’t got a chance,” Naylor said. “Seals are really agile, so the only ones that get caught are the ones that are goofing off and flopping around on the surface minding their own business. And that’s kind of what a surfer looks like.”

Surfers experienced 42% of bites worldwide, with swimmers and waders a close second at 39%.

Australia, in addition to its white shark populations on the coast, also has bull sharks in and around its estuarine rivers. A fatality from a bull shark attack occurred in early 2023 in a brackish river near the coast.

“Beach safety in Australia is second to none. They're fantastic,” said Joe Miguez, a doctoral student in the Florida Program for Shark Research. “However, if you go to remote regions where beach safety isn’t in place, there is a higher risk of a fatal shark attack. This is because when an attack happens and there is beach safety, you can get a tourniquet on sooner and save the person's life. So, the solution isn’t to not surf. It’s to surf in areas where there's a good beach safety program in place.”

Fatalities caused by white, bull and tiger sharks in 2023

The vast majority of unprovoked attacks are test bites, which occur when a shark misidentifies a human as their preferred prey. When this happens, the shark will typically swim away after a single bite. Some species like white sharks and tiger sharks, however, are large enough that even a single bite can be fatal.

Unusual incidents when a shark continues biting their victim, rather than swimming away, have been documented with tiger sharks, bull sharks and white sharks. This February marks the 50th anniversary of the book “Jaws,” and notably, the number of recorded white shark bites have increased precipitously over the last few decades. This pattern isn’t due to increased aggression from white sharks, but rather a combination of more of people being in the ocean each year and a stronger emphasis placed on reporting bites and fatalities.

Along the banks of the Red Sea in Egypt, an encounter with a tiger shark proved fatal.

“The bite in Egypt stood out because a video shows a tiger shark taking multiple passes at a human in the water. Even though predation events are exceedingly rare, it’s pretty clear that’s what it was,” Miguez said.

The Red Sea has a deep narrow trench in its center and extensive coral reefs. Its deep walls allow fish most often found in deep waters to come unusually close to shore.

“You see pelagic fishes like oceanic white tip sharks only 700 feet off the beach, when usually you have to go 20 miles out to find that species,” Naylor said. “These pelagic animals are used to living in a food desert, so when they come across anything they’ll give it a try. The Red Sea’s geomorphology brings very large, pelagic predatory fishes into juxtaposition with tourists that are diving and enjoying their holiday.”

Shark bites correlated with temperature and population density

Despite the increase, the number of bites and fatalities that occurred in 2023 are within the average for the last decade. Each year, there are consistently fewer than 100 unprovoked bites, making it more likely for someone to win the lottery than to be attacked by a shark.

When there are more attacks, it often means that more people are spending time in the water — not that sharks have become more dangerous. Miguez described it as a numbers game. Increased human activity in sharks’ natural habitats naturally leads to an increase in the number of animal encounters.

Something as simple as a holiday weekend falling on particularly hot days can contribute to a spike in attacks.

Water quality around New York has increased over the last two decades, and experts attribute the greater number of marine mammals — such as whales and dolphins — observed off the coast to bigger fish populations. More fish often means more sharks as well.

This contributed to several bites over a few weeks over the summer, including the first known shark attack in New York City in more than half a century.

“It causes a lot of fear, but the reality is you’re putting a lot of people in the water on a hot day with bait fish in the water,” Naylor said.

Most shark bites typically occur during the Northern and Southern hemispheres’ summers, both because that is when many species are more active and because that is when more people spend time in the water.

While the odds of being bitten by a shark are incredibly low, ISAF provides recommendations for further precautions people can take. These include staying close to shore, not swimming at dawn or dusk, and avoiding excessive splashing.

For more resources, including the full 2023 report, you can visit the International Shark Attack File’s website.




 




 

How food availability could catalyze cultural transmission in wild orangutans


Social learning is affected by ecology, study finds


Peer-Reviewed Publication

MAX-PLANCK-GESELLSCHAFT

Sumatran orangutan 

IMAGE: 

A UNFLANGED MIGRANT SUMATRAN ORANGUTAN MALE MOVING BETWEEN TREES.

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CREDIT: SAFRIADI / SUAQ PROJECT




The proverb “necessity is the mother of invention” has been used to describe the source from which our cultural evolution springs. After all, need in times of scarcity has forced humans to continually invent new technologies that have driven the remarkable cumulative culture of our species. But an invention only becomes cultural if it is learned and spread by many individuals. In other words, the invention must be socially transmitted. But what are the forces that drive social transmission? A long-term study covering 18 years of data on wild orangutans suggests that the answer can be found in an animal’s environment and the respective resource availability. A team of two Max Planck Institutes and the University of Leipzig looked at how male orangutans learn from others, finding that individuals who grew up in habitats with plentiful food had a higher propensity to attend to social information. This finding demonstrates how an animal’s ecology can impact their opportunities to socially learn, and thus the likelihood that a new behavior can become an innovation with cultural properties.

“We’ve shown that animal’s ecological environment and respective resource availability has knock-on effects on an individual’s social learning opportunities, but also on their propensity for social learning over evolutionary time,” says first author Julia Mörchen.

The team from the Max Planck institutes of Evolutionary Anthropology (MPI-EVA) and Animal Behavior (MPI-AB) and the University of Leipzig (UL) studied adult male orangutans from wild populations in Borneo and Sumatra. “Because of their unique life history, adult males offer unique insight into orangutan social learning,” says Mörchen, a doctoral student at the University of Leipzig.

Once males reach independence, they leave the natal habitats in which they were raised and spend the rest of their lives as nomads roaming the rainforest. “This means that males are like perpetual tourists, so they have to constantly learn crucial behaviors, like what food is safe to eat, from experienced locals,” says Mörchen. To learn the necessary new skills, migrant males watch resident orangutans in a behavior known as “peering”.

The researchers studied orangutans in Borneo and Sumatra, collecting data on instances when migrant males were peering at locals. In both populations, they found that males spent more time close to others, and peered more at them, when food was more plentiful in the environment. The authors say that this provides evidence that an animal’s environment can modulate social learning. “When times are good, orangutans spend more time in close contact, and so there are more opportunities for social learning,” says Mörchen.

The finding deepened when the team compared migrant males from Sumatra and Borneo to see how rates of peering differed. Sumatran orangutans live in habitats with high food supply while Bornean populations live with low and fluctuating food availability. Unsurprisingly, males from Sumatran populations spent more time peering than did males from Borneo. But the finding persisted, even after the effects of food availability was taken into account.

“It’s not just that Sumatran males had more food around and so they spent more time peering,” says Mörchen. “We found that Sumatran males had an overall higher propensity for peering than their Bornean counterparts.” The authors say that the study cannot disentangle the mechanisms driving the difference in the propensities to attend to social information. “It could be the result of developmental effects, of Bornean and Sumatran orangutans growing up under different ecological conditions,” says Mörchen. “Or, it could be the result of genetic differences between the species that have split approximately 674 thousand years ago, or a combination of both.”

Senior author Caroline Schuppli, from MPI-AB, explains: “Our study provides a glimpse into how ecology may affect cultural transmission. We show that availability of food modulates social learning opportunities and thus how likely new behaviors are to become cultural.”

Senior author Anja Widdig, from MPI-EVA and UL adds: “Discovering such effects of prevailing food availability on social tolerance and peering in the least sociable great ape species that is most distantly related to humans points toward a deep evolutionary origin of ecological effects on social learning propensities in the hominid lineage and their potential presence in other lineages.”

 

Smells like evolution: Fruit flies reveal surprises in chemical sensing


Peer-Reviewed Publication

QUEEN MARY UNIVERSITY OF LONDON

Fig. 1 

IMAGE: 

CHEMOSENSORY TISSUE TRANSCRIPTOME EVOLUTION

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CREDIT: GWÉNAËLLE BONTONOU ET. AL./NATURE COMMUNICATIONS




A new study in Nature Communications unveils the hidden world of sensory evolution in fruit flies. By delving into the genes and cells behind their delicate noses and tongues, researchers have discovered surprising secrets about how these tiny insects adapt their senses to different environments. 

"Imagine a world where a ripe peach tastes and smells like tangy vinegar to one fly, but like a burst of summer to another," explains principal author of the study Dr Roman Arguello, a Lecturer in Genetics, Genomics and Fundamental Cell Biology at Queen Mary University of London. "Our study shows that this is not just possible, but it's actually quite common." 

The research team analysed the gene expression patterns in five key scent-detecting tissues across six different Drosophila species. This comprehensive approach allowed them to delve deeper than ever before into the molecular underpinnings of smell. 

One surprising discovery was the prevalence of "stabilising selection," a force that keeps most genes expressed at the same levels across generations. However, within this sea of stability, the researchers found thousands of genes that had undergone significant changes in expression, shaping the unique olfactory landscapes of different fly species. 

"It's like finding hidden islands of diversity within a vast ocean of uniformity," says Dr Arguello. "These changes in gene expression tell us about the evolution of new smells, new sensitivities, and even new ways of using scent to navigate the world." 

The study also reveals intriguing differences between the sexes. In fruit flies, as in many other animals, males and females often experience the world through different olfactory lenses. The researchers identified a surprising excess of male-biased gene expression in the front legs of D. melanogaster, suggesting that these limbs play a crucial role in male-specific scent detection. 

"These findings open up exciting new avenues for understanding how sex differences evolve and how they impact animal behavior," says Dr Arguello. 

The study's implications extend beyond the fascinating world of flies. It provides valuable insights into the general principles of how sensory systems evolve, offering clues to understanding how other animals, including humans, perceive their chemical environments. 

 

Study finds LA County pilot program to aid gravely disabled residents could improve housing, hospitalization rates


UCLA evaluation found 81% of homeless residents were no longer unsheltered by end of first year

Peer-Reviewed Publication

UNIVERSITY OF CALIFORNIA - LOS ANGELES HEALTH SCIENCES





A UCLA Health-led evaluation of Los Angeles County’s pilot program aimed at bolstering aid to gravely disabled homeless residents found the initiative could offer a promising framework to improve housing and health outcomes for this vulnerable population while also relieving overburdened psychiatric hospitals. 

Led by the county and including a partnership of more than 40 different organizations and agencies, the outpatient conservatorship pilot program sought to offer wraparound housing, health care and social services to 43 homeless residents who had severe illnesses such as schizophrenia, delusional disorders, substance use disorders and other medical illnesses. Many of the residents had been homeless for more than five years.  

Beginning in 2020, county officials prioritized offering voluntary services to these residents before referring any of them to an involuntary conservatorship, known as a Lanterman-Petris-Short Act conservatorship. For those referred to a conservatorship, the pilot program allowed the county’s Homeless Outreach & Mobile Engagement team, known as HOME, to continue providing services to the resident in the least restrictive setting deemed appropriate, including street-based services in some cases, as the residents awaited their court proceedings.  

At the end of the pilot program’s first year, 81% of the 43 homeless residents were no longer unsheltered, according to the study. While the study did not include a matched cohort as a control group, the housing placement rates in the pilot program were significantly higher than those observed by the county in recent studies. In the year before the pilot program began, about 20% of all people served by Los Angeles County’s homeless outreach had obtained housing placement within 12 months.  

About 65% of the residents were placed under a conservatorship with most requiring treatment at a psychiatric hospital. More than half of these residents were able to leave these locked settings and transfer to licensed residential facilities earlier than would have been possible prior to the pilot program, according to study lead author and UCLA Health psychiatry professor Dr. Elizabeth Bromley

“This pilot really shows that if you have a well-staffed, very assertive, expert team that is practicing with high intensity, they’re able to both identify people who can benefit from conservatorship and they’re able to build enough care continuity into the process to minimize the amount of coercion,” said Bromley, who also serves as director of the UCLA-Los Angeles Department of Mental Health Public Mental Health Partnership.  

The evaluation found a large number of the homeless residents were placed in acute psychiatric hospitals given the severity of mental illnesses, Bromley said. But the pilot program’s results showed there are opportunities to minimize the time individuals spent in locked settings. For residents under a conservatorship under the pilot program, the average number of inpatient days was 97. This is at least two months less time compared to residents placed under involuntary psychiatric holds in Los Angeles County in recent years, according to the study. 

The pilot program began prior to the enactment of California laws this year that reform involuntary conservatorship rules. One bill that took effect this year, Senate Bill 43, expanded the definition of a “gravely disabled” person to include those whose substance use prevents them from providing their own personal safety and medical care. The law allows the courts to place these individuals under an involuntary conservatorship. 

Bromley said that it is the responsibility of state and local agencies to understand how to minimize coercion involved in processes that take away personal autonomy. 

"Coercion is something we have to minimize in any situation that we can because it depletes trust in our systems, it makes people flee from services that might be helpful to them,” Bromley said. “It needs to be very carefully and ethically balanced in terms of patient preferences and needs.”  

The evaluation was published in the journal Psychiatric Services.  

Article: Addressing Mental Health Disability in Unsheltered Homelessness: Outpatient Conservatorship in Los Angeles, Published Jan. 25, 2024, Bromley et al., Psychiatric Services, 2024, ISSN 1075-2730, https://doi.org/10.1176/appi.ps.20230235 

A UCLA Health-led evaluation of Los Angeles County’s pilot program aimed at bolstering aid to gravely disabled homeless residents found the initiative could offer a promising framework to improve housing and health outcomes for this vulnerable population while also relieving overburdened psychiatric hospitals. 

Led by the county and including a partnership of more than 40 different organizations and agencies, the outpatient conservatorship pilot program sought to offer wraparound housing, health care and social services to 43 homeless residents who had severe illnesses such as schizophrenia, delusional disorders, substance use disorders and other medical illnesses. Many of the residents had been homeless for more than five years.  

Beginning in 2020, county officials prioritized offering voluntary services to these residents before referring any of them to an involuntary conservatorship, known as a Lanterman-Petris-Short Act conservatorship. For those referred to a conservatorship, the pilot program allowed the county’s Homeless Outreach & Mobile Engagement team, known as HOME, to continue providing services to the resident in the least restrictive setting deemed appropriate, including street-based services in some cases, as the residents awaited their court proceedings.  

At the end of the pilot program’s first year, 81% of the 43 homeless residents were no longer unsheltered, according to the study. While the study did not include a matched cohort as a control group, the housing placement rates in the pilot program were significantly higher than those observed by the county in recent studies. In the year before the pilot program began, about 20% of all people served by Los Angeles County’s homeless outreach had obtained housing placement within 12 months.  

About 65% of the residents were placed under a conservatorship with most requiring treatment at a psychiatric hospital. More than half of these residents were able to leave these locked settings and transfer to licensed residential facilities earlier than would have been possible prior to the pilot program, according to study lead author and UCLA Health psychiatry professor Dr. Elizabeth Bromley

“This pilot really shows that if you have a well-staffed, very assertive, expert team that is practicing with high intensity, they’re able to both identify people who can benefit from conservatorship and they’re able to build enough care continuity into the process to minimize the amount of coercion,” said Bromley, who also serves as director of the UCLA-Los Angeles Department of Mental Health Public Mental Health Partnership.  

The evaluation found a large number of the homeless residents were placed in acute psychiatric hospitals given the severity of mental illnesses, Bromley said. But the pilot program’s results showed there are opportunities to minimize the time individuals spent in locked settings. For residents under a conservatorship under the pilot program, the average number of inpatient days was 97. This is at least two months less time compared to residents placed under involuntary psychiatric holds in Los Angeles County in recent years, according to the study. 

The pilot program began prior to the enactment of California laws this year that reform involuntary conservatorship rules. One bill that took effect this year, Senate Bill 43, expanded the definition of a “gravely disabled” person to include those whose substance use prevents them from providing their own personal safety and medical care. The law allows the courts to place these individuals under an involuntary conservatorship. 

Bromley said that it is the responsibility of state and local agencies to understand how to minimize coercion involved in processes that take away personal autonomy. 

"Coercion is something we have to minimize in any situation that we can because it depletes trust in our systems, it makes people flee from services that might be helpful to them,” Bromley said. “It needs to be very carefully and ethically balanced in terms of patient preferences and needs.”  

The evaluation was published in the journal Psychiatric Services.  

Article: Addressing Mental Health Disability in Unsheltered Homelessness: Outpatient Conservatorship in Los Angeles, Published Jan. 25, 2024, Bromley et al., Psychiatric Services, 2024, ISSN 1075-2730, https://doi.org/10.1176/appi.ps.20230235 

 

Immune response, not acute viral infections, responsible for neurological damage, McMaster researchers discover


Peer-Reviewed Publication

MCMASTER UNIVERSITY





For years, there has been a long-held belief that acute viral infections like Zika or COVID-19 are directly responsible for neurological damage, but researchers from McMaster University have now discovered that it’s the immune system’s response that is behind it.

The research, published on Feb. 5, 2024 in Nature Communications, was led by Elizabeth Balint, a PhD student at McMaster, and Ali Ashkar, a professor with the Department of Medicine and the Canada Research Chair in Natural Immunity and NK Cell Function.

“We were interested in trying to understand why so many viral infections are associated with neurological diseases,” says Balint. “Our evidence suggests that it's not the virus itself that causes the damage, but a unique population of T cells, which are part of the immune system, that are actually responsible for the damage."

To come to this conclusion, the McMaster team focused on Zika virus. During laboratory testing, researchers, as expected, found T cells that were specific for Zika and designed to eliminate infected cells. They found something else, too.

“What was interesting in our study is that although we did find some T cells specific for Zika, we identified cells that weren’t functioning like a normal T cell and were killing lots of cells that weren’t infected with Zika."

These cells are called NKG2D+CD8+ T cells and researchers say their aggressive response is responsible for neurological damage suffered from infections beyond just Zika, like COVID-19 and even septic shock.

The aggressive response is the result of the body producing large amounts of inflammatory proteins called cytokines, which in moderation help to coordinate the body’s response in battling an infection or injury by telling immune cells where to go and what to do when they arrive.

"If our body’s immune cells overreact and over produce inflammatory cytokines, this condition will lead to non-specific activation of our immune cells which in turn leads to collateral damage. This can have severe consequences if it happens in the brain,” Ashkar says.

The discovery offers researchers and scientists a new target for treatments of neurological diseases sparked by acute viral infections. In fact, Balint has already found a treatment that holds promise.

“Elizabeth has experimented with an antibody that can completely block and treat devastating neurotoxicity in the animal model, which is already in clinical trials  for different uses in humans," says Ashkar.

Balint hopes to continue her work towards finding a treatment that would be effective in humans.

"There are a few different other viruses we’re interested in studying, which will aid us in creating the best treatment options," Balint says.

Funding for this study was provided by the Canadian Institutes of Health Research. Balint is also a recipient of a Canada Graduate Scholarship Doctoral Award.

 

World’s largest childhood trauma study uncovers brain rewiring


Peer-Reviewed Publication

UNIVERSITY OF ESSEX





The world’s largest brain study of childhood trauma has revealed how it affects development and rewires vital pathways.  
 

The University of Essex study – led by the Department of Psychology’s Dr Megan Klabunde – uncovered a disruption in neural networks involved in self-focus and problem-solving. 
 
This means under-18s who experienced abuse will likely struggle with emotions, empathy and understanding their bodies.  

 
Difficulties in school caused by memory, hard mental tasks and decision making may also emerge. 

 
Dr Klabunde’s cutting-edge research used AI to re-examine hundreds of brain scans and identify patterns. 

 
It is hoped the research will help hone new treatments for children who have endured mistreatment. 

 
This could mean therapists focus on techniques that rewire these centres and rebuild their sense of self. 

 
Dr Klabunde said: “Currently, science-based treatments for childhood trauma primarily focus on addressing the fearful thoughts and avoidance of trauma triggers.  

 
“This is a very important part of trauma treatment. However, our study has revealed that we are only treating one part of the problem.  

 
“Even when a child who has experienced trauma is not thinking about their traumatic experiences, their brains are struggling to process their sensations within their bodies.  

 
“This influences how one thinks and feels about one’s ‘internal world’ and this also influences one’s ability to empathise and form relationships.”  

 
Dr Klabunde reviewed 14 studies involving more than 580 children for the research published in Biological Psychiatry Cognitive Neuroscience and Neuroimaging.

 
The paper re-examined functional magnetic resonance imaging (fMRI) scans.  

 
This procedure highlights blood flow in different centres, showing neurological activity. 

 
The study discovered a marked difference in traumatised children’s default mode (DMN) and central executive networks (CEN) – two large scale brain systems.  

 
The DMN and the posterior insula are involved in how people sense their body, the sense of self and their internal reflections. 
 

New studies are finding the DMN plays an important role in most mental health problems - and may be influenced by experiencing childhood trauma.  

 
The CEN is also more active than in healthy children, which means that children with trauma histories tend to ruminate and relive terrible experiences when triggered.  

 
Dr Klabunde hopes this study will be a springboard to find out more about how trauma affects developing minds. 

 
She said: “Our brain findings indicate that childhood trauma treatments appear to be missing an important piece of the puzzle.  

 
“In addition to preventing avoidance of scary situations and addressing one’s thoughts, trauma therapies in children should also address how trauma’s impacts on one’s body, sense of self, emotional/empathetic processing, and relationships.  

 
“This is important to do so since untreated symptoms will likely contribute to other health and mental health problems throughout the lifespan.” 

 
Dr Klabunde worked with Dr Anna Hughes, also from the Department of Psychology, and Masters student Rebecca Ireton on the study. 

 

 

Bullied teens’ brains show chemical change associated with psychosis


Peer-Reviewed Publication

UNIVERSITY OF TOKYO

The association of bullying victimization, impaired brain development and psychotic experiences 

IMAGE: 

THE STUDY ELUCIDATES HOW BULLYING VICTIMIZATION IMPAIRS BRAIN METABOLISM THAT COULD BE LINKED TO SUSCEPTIBILITY FOR PSYCHOTIC EXPERIENCES.

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CREDIT: NAOHIRO OKADA, INTERNATIONAL RESEARCH CENTER FOR NEUROINTELLIGENCE (WPI-IRCN)




Researchers have found that adolescents being bullied by their peers are at greater risk of the early stages of psychotic episodes and in turn experience lower levels of a key neurotransmitter in a part of the brain involved in regulating emotions. The finding suggests that this neurotransmitter — a chemical messenger that transmits nerve impulses for communication by a nerve cell — may be a potential target for pharmaceutical interventions aimed at reducing the risk of psychotic disorders.

Psychosis is a mental state characterized by loss of contact with reality, incoherent speech and behavior, and typically hallucinations and delusions seen in psychiatric disorders such as schizophrenia.

Recent studies investigating links between neurological and psychiatric features of certain disorders have found that individuals who experience their first episode of psychosis or have schizophrenia that remains treatable, have lower-than-normal levels of glutamate, a neurotransmitter in the brain’s anterior cingulate cortex (ACC) region. The ACC is known to play a crucial role in regulating emotions, decision-making and cognitive control, while glutamate is the most abundant neurotransmitter in the brain and is involved in a wide range of functions, including learning, memory and mood regulation.

Alterations in glutamate levels have been implicated in various psychiatric disorders, including schizophrenia, depression and anxiety, and so measuring ACC glutamate levels can provide valuable insights into the mechanisms of the nervous system underlying these disorders and their treatment.

However, until now, changes in glutamate levels in the ACC in those individuals at high risk of psychosis, and the relationship between this and the effects of bullying in adolescents has remained unclear.

And so researchers at the University of Tokyo used magnetic resonance spectroscopy, or MRS, a type of radiological imaging applied to depict brain structure and function, to measure glutamate levels in the ACC region of Japanese adolescents. They then measured the glutamate levels at a later point, allowing them to assess changes over time, and compare these changes to experiences with bullying or lack thereof, as well as with any intention on the part of those experiencing bullying to seek help.

Bullying victimization was tracked via questionnaires completed by the adolescents. The researchers then used formalized psychiatric measurement to assess experiences of bullying victimization based on those questionnaires, such as tallying the frequency and assessing the nature of events involving physical or verbal aggression, and also capturing their impact on overall mental health.

They found that bullying was associated with higher levels of subclinical psychotic experiences in early adolescence — those symptoms come close to psychosis but do not meet the full criteria for a clinical diagnosis of a psychotic disorder, such as schizophrenia. These symptoms or experiences can include hallucinations, paranoia or radical alterations in thinking or behavior and can have a significant impact on well-being and functioning, even in the absence of a psychotic disorder diagnosis.

“Studying these subclinical psychotic experiences is important for us to understand the early stages of psychotic disorders and for identifying individuals who may be at increased risk for developing a clinical psychotic illness later on,” said Naohiro Okada, lead author of the study and project associate professor at the University of Tokyo’s International Research Center for Neurointelligence (a research center under Japan’s World Premier International Research Center Initiative program).

Crucially, the researchers found that higher levels of these subclinical psychotic experiences were associated with lower levels of anterior cingulate glutamate in early adolescence.

“First and foremost, anti-bullying programs in schools that focus on promoting positive social interactions and reducing aggressive behaviors are essential for their own sake and to reduce the risk of psychosis and its subclinical precursors,” said Okada. “These programs can help create a safe and supportive environment for all students, reducing the likelihood of bullying and its negative consequences.”

Another potential intervention is to provide support and resources for adolescents who have experienced bullying victimization. This might include counseling services, peer support groups and other mental health resources that can help adolescents cope with the negative effects of bullying and develop resilience.

While Okada’s group has identified a potential target of pharmacological interventions, he added that nonpharmacological interventions such as cognitive behavioral therapy or mindfulness-based interventions may also serve to target this neurotransmitter imbalance.

###

Funding:

This work is a part of the Tokyo TEEN Cohort Study and was supported by MEXT/JSPS KAKENHI, JST Moonshot R&D, AMED and NIH. This work was also partially supported by WPI-IRCN, UTIAS, and Open Access funding provided by The University of Tokyo.

 

Related links:

International Research Center for Neurointelligence: https://ircn.jp/en/

 

About the World Premier International Research Center Initiative (WPI)

The WPI program was launched in 2007 by Japan's Ministry of Education, Culture, Sports, Science and Technology (MEXT) to foster globally visible research centers boasting the highest standards and outstanding research environments. Operating at institutions throughout Japan, the 18 centers that have been adopted are given a high degree of autonomy, allowing them to engage in innovative modes of management and research. The program is administered by the Japan Society for the Promotion of Science (JSPS).

See the latest research news from the centers at the WPI News Portal: https://www.eurekalert.org/newsportal/WPI

Main WPI program site: https://www.jsps.go.jp/english/e-toplevel

 

About the International Research Center for Neurointelligence (IRCN), The University of Tokyo

The IRCN was established at the University of Tokyo in 2017, as a research center under the WPI program to tackle the ultimate question, “How does human intelligence arise?” The IRCN aims to (1) elucidate fundamental principles of neural circuit maturation, (2) understand the emergence of psychiatric disorders underlying impaired human intelligence, and (3) drive the development of next-generation artificial intelligence based on these principles and function of multimodal neuronal connections in the brain.

Find out more at: https://ircn.jp/en/

 

About the University of Tokyo

The University of Tokyo is Japan's leading university and one of the world's top research universities. The vast research output of some 6,000 researchers is published in the world's top journals across the arts and sciences. Our vibrant student body of around 15,000 undergraduate and 15,000 graduate students includes over 4,000 international students. Find out more at https://www.u-tokyo.ac.jp/en/ or follow us on X (formerly Twitter) at @UTokyo_News_en