Wednesday, March 26, 2025

 

How changing L.A.’s tree rules could cool more neighborhoods



A new USC Dornsife study finds that outdated guidelines are limiting tree growth — especially in lower-income neighborhoods — and offers a path forward.



University of Southern California






Expansive tree canopies are crucial for healthy ecosystems and livable cities. Yet, Los Angeles’ strict tree planting rules, originally meant to protect infrastructure and public safety, are now widening shade disparities, particularly in lower-income neighborhoods. A new study published in Landscape and Urban Planning, led by the Spatial Sciences Institute and Public Exchange, both based at the USC Dornsife College of Letters, Arts and Sciences, suggests that easing these decades-old restrictions could significantly grow the city’s urban tree canopy — without compromising safety.

This research builds on an earlier USC study comparing L.A.’s municipal codes, engineering standards and urban forestry guidelines to those of 25 other cities — 17 outside California and eight within the state. That study found L.A.’s tree placement rules are among the nation’s strictest, often limiting new planting. The team concluded that substantial changes could be made to existing tree-spacing guidelines without re-writing laws, but better coordination between city departments is essential.

“Fixing L.A.’s rules is a step toward addressing inequities and bringing the health and ecological benefits of green infrastructure to underserved communities,” said Laura Messier, PhD candidate in the population, health and place program at the Spatial Sciences Institute.

Testing looser tree spacing rules

To test how relaxing planting guidelines might increase tree coverage, Messier and her team compared two L.A. neighborhoods: Boyle Heights, a historically lower-income area east of downtown; and Studio City, a wealthier community in the San Fernando Valley. Both areas studied were similar in size, topography and parcel layout. But Studio City had about 3,020 trees per square mile, compared to 2,183 in Boyle Heights — a gap researchers linked to the neighborhood’s denser street grid, higher concentration of multi-family housing and smaller parcels, all of which limit where trees can be planted.

Using mapping software, the team identified obstacles like utility poles, gas lines and bus stops, then modeled potential new planting sites. They compared L.A.’s current planting restrictions with more flexible guidelines in other California cities — including San Francisco, Fremont, Oakland and Anaheim — and identified infrastructure changes that could further expand tree coverage.

The results were striking. Under L.A.’s current rules, Studio City could support up to 140 trees per square mile, while Boyle Heights maxed out at 121. But with looser guidelines, the gap nearly vanished — Studio City’s capacity rose to 158, while Boyle Heights jumped to 153, a 26% increase in the historically Latino neighborhood.

Still, Boyle Heights faces challenges beyond planting guidelines. Narrow sidewalks limit the ability to plant large shade trees. Even with the same number of trees, only 34.5% in Boyle Heights could be large-canopy species, compared to 61% in Studio City.

Small tweaks to tree spacing make big impact

Even modest policy changes could open up more space for tree planting in crowded areas.

The study found that easing restrictions near intersections could increase the number of trees in Boyle Heights by 7.6%, while relaxing rules around utility poles could add another 5.5%. Adjusting guidelines for gas lines (2.6%), streetlights (2.2%), driveways (1.4%) and other infrastructure could push the total canopy gain to 26%, helping expand shade in other dense, lower-income neighborhoods.

While planting trees at bus stops would add less than 1% to overall canopy coverage, it could make a big difference for transit riders exposed to extreme summer heat.

A major obstacle to planting more trees is L.A.’s 45-foot visibility rule at intersections, last updated in 1988. Studies show high-canopy trees don’t block drivers’ views, making this restriction ripe for revision.

Easier to change tree spacing rules than laws

Many of the restrictions are internal guidelines rather than laws, meaning changes could be implemented more easily. The city’s Urban Forestry Division would need to update its Tree Spacing Guidelines memo, but getting agreement from other departments — such as transportation and street lighting — could still be a challenge, Messier explained.

Ironically, the study found that half the street trees in Boyle Heights and nearly 40% in Studio City don’t comply with city guidelines. Yet, there’s little evidence that these violations create safety or liability issues.

Messier suggests that updating the guidelines is more practical than enforcing rules that are often ignored and seem to have little impact on safety.

While modernizing L.A.’s rules is an important step, closing the shade gap will require broader infrastructure changes. Messier and her team point to strategies like reducing street widths — known as “road diets” — to create more space for trees.

“To truly close the shade gap and ensure more equitable access to cooling and green spaces, the city must invest in infrastructure that makes room for more trees in underserved areas,” Messier said.

 

 

Study identifies Shisa7 gene as key driver in heroin addiction



Findings published in Biological Psychiatry provide valuable insights for the development of new treatments based on identifying novel biological targets



Elsevier

Shisa7 expression in the orbitofrontal cortex was identified by machine learning as the gene signature reliably predictive of heroin use in human heroin users as compared to controls 

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Overexpression of Shisa7 in the orbitofrontal cortex in drug-free rats induced comparable up and down changes in gene expression as that induced by the self-administration of heroin. The concordant overlapping transcriptional changes strongly related to neurodegenerative processes.

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Credit: Biological Psychiatry/Ellis et al.




Philadelphia, March 26, 2025  Opioid use disorder is associated with more than 350,000 deaths annually worldwide. Guided by the need for an increased understanding of critical neurobiological features of addiction, researchers have now found a unique molecular signature and genes in the orbitofrontal cortex associated with heroin-seeking behavior. A preclinical rodent model implicated a gene called Shisa7 as the key predictor. A new study in Biological Psychiatry, published by Elsevier, provides valuable insights into the neurobiological mechanisms underlying heroin addiction and may have implications for the development of innovative strategies to combat the ongoing opioid epidemic.

Lead investigator Yasmin L. Hurd, PhD, Departments of Neuroscience and Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, and Addiction Institute of Mount Sinai, New York, says, "My research team and I are driven to expand the neurobiological insights underlying addiction. By examining molecular signatures in the brains of human opioid users, we hope to gain insights into the neuropathology of opioid use disorder beyond acute reward mechanisms and to identify new pathways for treatments relevant to core phenotypes that perpetuate substance use.”

In this study, the research team applied machine learning to distinguish the molecular signature in the orbitofrontal cortex, a brain region critical for aspects of impulse control, drug-seeking behavior, and cognitive functions related to substance use disorders.

The investigators found that the machine learning algorithm was not only effective in identifying which signatures distinguished the brain of a human heroin user, but it also identified the gene most predictive of that molecular signature called Shisa7 that had not been explored previously in the field. Further investigation revealed that modulating this gene's expression in the orbitofrontal cortex influences heroin-seeking behavior and cognitive flexibility.

Dr. Hurd adds, "We also observed that when we overexpressed Shisa7 in drug-naïve animals, it completely mimicked the transcriptome signature observed with repeated heroin use. Interestingly, the Shisa7 signature related to neurodegenerative disease and neuroimmune processes. Moreover, we determined that the proteins that bind to Shisa7 were linked to both GABA (the primary inhibitory neurotransmitter in the central nervous system of mammals) and glutamate (the primary excitatory neurotransmitter in the central nervous system) receptor signaling, which are also highly related to neurodegenerative disease pathways."

Lead author of the study Randall Ellis, PhD, Department of Neuroscience and Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, and Addiction Institute of Mount Sinai, New York, notes, "The use of our advanced machine learning approach led us down a very exciting path of discovery, which highlights the potential of AI in understanding complex biological systems. Applying machine learning in this way is exceptionally useful to better understand high-dimensional datasets, such as the thousands of genes captured by RNA sequencing, to uncover novel patterns in gene expression that can effectively predict disease states. This strategy in leveraging data from human opioid users is particularly important as we seek innovative strategies to combat the ongoing opioid epidemic. Moreover, our findings highlight the potential long-term risks of opioid use for future neurodegenerative disease."

John Krystal, MD, Editor of Biological Psychiatry, says, “This study highlights the complex biology of opioid use disorder. Careful studies of postmortem brain tissue, employing AI-guided analyses, are critical for identifying the molecular building blocks of addiction. It is interesting that a target identified in this process, Shisa7, also alters learning and promotes opioid self-administration when levels are increased in animals.”

Dr. Hurd concludes, "These translational findings highlight the importance of studying the human brain, which can help uncover novel biological systems underlying the disorder that could ultimately open up new treatment avenues."

 

 

New study shines a light on the mechanics of bioluminescence in the rare fish Vinciguerria mabahiss



Natural History Museum of Los Angeles County
A 6.2 mm total length Vinciguerria mabahiss from the northern Red Sea 

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A 6.2 mm total length Vinciguerria mabahiss from the northern Red Sea

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Credit: Dr. Todd Clardy




Los Angeles (February –, 2025)—Evolving roughly 27 different times in the long history of fish, bioluminescence—the biological production of light—is one of the flashier survival tools used for luring prey, communication, and recognizing potential mates among various species. In a new study published in Ichthyological Research, an international team of researchers studied the organs that produce light in Vinciguerria mabahiss, a rare species of fish from the Red Sea. This paper marks the first-ever close examination of these organs, providing key information on their structure and how V. mabahiss uses bioluminescence to make its way through the water—and laying the foundational groundwork for future scientists studying fish bioluminescence. 

“There are a lot of different ways that fish go about producing and using light,” says lead author Dr. Todd Clardy, Collections Manager of Ichthyology at the Natural History Museum of Los Angeles County.  “One of the things that we wanted to do was find out how this species of fish was using the light it produced. And part of that was by examining the structure of the photophore and not just how they looked at the cellular level, but we examined the size and the distribution of them across the body of the fish to try to assess what this fish was doing with these cool photophore organs, and it turns out they're using it as counter illumination.” 

While most of us might think of bioluminescence as an attractor—picture anglerfish luring prey with light in the depths—Clardy and his teammates found that V. mabahiss used its light to hide. Counter illumination is a kind of camouflage where an animal produces lights to make itself harder to be seen by predators. 

“We live in basically a two-dimensional world”, says Clardy. “I never think to look for a cheeseburger up above me. But fish are always looking up for a shadow passing over them because it’s either going to be food or a predator.” Counter illumination breaks up that shadow to mimic the light of the surface. “The fish is camouflaged, almost invisible.” 

Clardy and his team found that V. mabahiss have between 140 and 144 photophores of varying sizes throughout their bodies, all pointed downwards. Each photophore produces a blue light, breaking up the silhouette of the fish and camouflaging them from any predator looking up. They looked at five juvenile V. mabahiss specimens to better understand how the fish used its light. 

While the photophores varied in size, the researchers found that they all shared the same structure. The light is produced through a well-understood bacterial reaction, and the sophisticated composition of the photophores directs that bioluminescence into useful camouflage. “They have this thick pigment layer to block the light from entering the fish, reflective cells that amplify the light, and a lens that lets the light pass through,” says Clardy. 

A small fish only known to the Red Sea, V. mabahiss lives deep underwater and is seldom encountered by people, so much so that it has no common name. The findings from this study will provide bedrock information for future researchers to study bioluminescence in fish. “Its rarity means that V. mabahiss may be difficult to collect for most researchers,” says Clardy “We hope to provide information that other scientists can use for the broader study of bioluminescence.” 

A screenshot of photophores being measured on a juvenile Vinciguerria mabahiss


A two-dimensional slice of a photophore from a 6.2 mm total length V. mabahiss. The thick tissues in the back ensure that the light shines downward and not through the body of the fish


Dr. Clardy collecting a zooplankton sample from coastal waters of the Arabian Gulf

Credit

Dr. Todd Clardy

 

Research: Young adults in pain start using cannabis earlier and are more likely to mix it with alcohol


Two journal articles authored by Binghamton psychology researchers explore the link between pain and substance use among emerging adults


Binghamton University

Cannabis sativa 

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New research from Binghamton University, State University of New York provides a starting point for pain as a predictor of cannabis initiation.

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Credit: "Cannabis sativa" by M. Martin Vicente is licensed under CC BY 2.0.




BINGHAMTON, N.Y. -- Contrary to popular belief, young adults can experience significant acute and even chronic pain — which can motivate them to use cannabis.

A pair of recent articles by researchers in Binghamton University’s Psychology Department shed light on this dynamic. “Pain Predicts Cannabis Initiation Among Emerging Adults: Results from the Population Assessment of Tobacco and Health (PATH) Study” was recently published in Behavioral Medicine, while “Pain Predicts Past-Month Co-Use of Alcohol and Cannabis Among Emerging Adults” appeared in the journal Alcohol.

The research for both articles derives from lead author Callon Williams’ doctoral dissertation; additional authors include Professor Nadine R. Mastroleo, Distinguished Professor Mark F. Lenzenweger and Williams’ advisor, Assistant Professor Emily L. Zale.

“Emerging adults are thought of as a healthy, pain-free population, and there’s a lot of normative substance use that occurs. And yet, pain is still predictive of cannabis initiation among this group,” said Williams ’17, MS ’21, PhD ’24, who currently has a postdoctoral fellowship at Toronto General Hospital.

The research focuses on emerging adults, the period between ages 18 and 25, using data from PATH, an epidemiological survey that provides nationally representative data concerning substance use and health-related behaviors among youth and adults. The study includes 45,971 adults and youth in the United States, a sizeable research sample, from 2013 to 2019.

During that period, cannabis was legalized for medicinal or recreational use in an additional 15 and nine states, respectively. Because of this, the definition of cannabis use expanded over subsequent waves of the survey, to include smoking, vaping and using hash oils, although edibles weren’t included.

Coping strategies

It’s a common misconception that pain — acute or chronic — is limited to older adults. Instead, rates of some pain conditions pain in younger population mirror those in older populations around the world.

“We know that the prevalence of certain chronic pain conditions reaches its peak and then remains stable past emerging adulthood,” Zale explained. “They don’t necessarily get the same attention because the expectation is they’re young and healthy, but we are able to consistently replicate rates of both acute and chronic pain in our emerging adult samples that we would expect based on world-wide data.”

The survey relies on the 10-point pain rating scale common in doctors’ offices. The research in both articles focuses on moderate to severe pain, with a score of 4 or greater.

What Williams found is that individuals with moderate to severe pain were more likely to start using cannabis over a four-year period, and to take it up earlier during that period, than those with low or no pain at baseline. They were also 1.4 times more likely to use both alcohol and cannabis together, a riskier behavior associated with heavier use of both substances and more consequences, such as impaired driving, risky sexual behavior or impaired mental health.

While the published studies don’t determine whether cannabis use, alone or with alcohol, persists or worsens over time, other research indicates that this is likely the case, Zale said.

Clinicians and other practitioners who work in substance use intervention among emerging adults may consider assessing patients’ pain levels to ascertain whether they are using cannabis and/or alcohol as a coping strategy, Williams noted.

“When we do substance use work with emerging adults, we need to know how much pain is a factor in their decisions,” she said. “This research provides a starting point for pain as a predictor of initiation.”

 

Pleasing 'angry citizen' with citizen budgets and referendums works




Radboud University Nijmegen

 




‘Angry’ citizens often experience a lack of trust in politics and democracy. Governments are doing everything they can to involve this group in democracy again with referendums and participatory budgets. Research by Rosa Kindt shows that this is having an effect: these meetings provide satisfaction and a feeling of being heard, especially among right-wing populist citizens. Kindt’s PhD defence will take place on 1 April at Radboud University.

In the public debate, there is often talk of angry, populist citizens who feel that they are not being listened to, as political scientist Rosa Kindt points out: ‘We often hear about groups that want to take power back from the elite, for the people. But of course these are rather empty concepts. What kind of power do they want, and for which people? After all, a left-wing populist citizen may have a very different idea of which ‘people’ are not being heard than a right-wing populist citizen.

Kindt's research shows that right-wing populists in any case make a strict distinction between ‘ethnic Dutch’ and everyone else, while on the left side of the spectrum there is hardly any distinction between who does and does not belong to ‘the people’. ‘These are quite radical differences. I was curious to see if this has consequences for how these groups think about democratic innovations. Because if you have a very narrow definition of the people, how do you feel about a meeting where people also have a role that doesn’t meet that definition?’

Legitimacy

More and more local governments are experimenting with these kinds of innovations, such as participatory budgets in which citizens can decide how (part of) the municipal budget is spent, or referendums. The goal of these initiatives is to increase trust in democracy by putting citizens at the centre of the decision-making process. But is that really how (populist) citizens experience it?

The surprising answer (also for Kindt): yes. ‘Citizens were not only happy to participate in these meetings, but almost all of them indicated that they appreciated the outcome and saw it as a good reflection of what is going on in society. For her research, Kindt spoke with participants in participatory budgets in Duiven, Maastricht and Amsterdam. She conducted interviews and distributed questionnaires to a wide range of citizens, both populist and non-populist, left-wing and right-wing.

Being heard

The right-wing populist group, which had indicated beforehand that it was concerned that many non-ethnic Dutch people might attend the meeting, resulting in a non-representative representation, also appeared to have a positive experience. Kindt: ‘They greatly appreciate the opportunity to share their opinions with other citizens, where there is room for every story. The fact that they are being listened to leads to a positive outcome, especially for this group.‘ According to Kindt, this is an important starting point for future citizens’ initiatives: it suggests that the mistrust of democracy is mainly rooted in the feeling of not being heard.

Although many people are increasingly fearful of populist sentiments, Kindt warns that it is important not to tar all populists with the same brush. The survey shows that many populist citizens want democracy to better represent the people, with the people being understood to be a very broad group. These populist citizens can therefore give democracy a boost by ensuring that citizens play a greater role in the public debate. Local politics has a big task ahead of it: ‘If you really want to do something with those angry citizens, you have to keep involving them in citizens’ initiatives. They too will then feel more connected to our democracy.'