Thursday, April 17, 2025

 SPACE/COSMOS

  Bezos Versus Musk: Which Billionaire Will Trash Space the Most?


 April 15, 2025
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A Falcon 9 Starlink L-14 rocket successfully launches - NARA & DVIDS Public Domain Archive Public Domain Search

Photo credits: Public domain and Steve Jurvetson (CC BY-SA 2.0).

Amazon’s Project Kuiper is sending its first satellites into space. The company’s founder and executive chair, Jeff Bezos, seems keen to challenge all things Musk—including Elon’s SpaceX Starlink system.

The satellites in Amazon’s $10 billion-plus Kuiper Atlas project are being launched with the Lockheed Martin-designed Atlas V rocket, at Cape Canaveral’s Space Force Station.

OK, a few thoughts on the matter that corporate media probably won’t contemplate.

Astronomical Funding

Fifteen years ago, Barack Obama’s White House trumpeted an increase in NASA funding. Obama said it would “help improve the daily lives of people here on Earth” and help companies produce “new means of carrying people and materials out of our atmosphere”—first to an asteroid, later to Mars. I’m just a little unclear about how, overall, sending hundreds of billions of dollars into space has been improving my daily life so far. If you ask me, money for reliable bus service would help a lot more. Universal medical care. Free higher education.

The benefits to the planet’s most massive corporations are obvious. I hear Amazon’s lining up deals in Britain, Indonesia, Australia, and potentially Taiwan.

This lucrative new space race feeds off the human need for information, especially where internet access is sparse.

Profit Streams

Yes, Starlink connects people in far-flung places with internet services. And it calls these people markets. It’s not hard to imagine unbanked populations being converted into profit streams, once they’re online.

Moreover, when wealthy companies secure US government backing, they can become political instruments, manipulating the populations they claim to serve. Polish taxpayers have forked over an annual $50 million to provide Starlink’s services to Ukraine. But Poland’s foreign minister tweeted out concerns about the trustworthiness of US-based Starlink. Be quiet, small man, Musk snapped back. (Musk then bragged about having challenged Putin to one-on-one physical combat.)

People with unfathomable wealth take more billions in handouts from the US military in the name of national security. General Chance Saltzman, Chief of Space Operations for the US Space Force, recently named SpaceX as a recipient of nearly $6 billion more. Saltzman called the contract “a strategic necessity that delivers the critical space capabilities our warfighters depend on to fight and win.”

Got it. Warfighters gonna warfight. Blam! Zonk! Kapow! Splat!

Cosmic Sprawl

So here comes Jeff Bezos, a prominent player in Donald Trump’s troupe of lickspittles since January. With the Trump regime now describing Amazon Prime as a model for deportation, who knows? Maybe “alien enemies” (those people who have autism awareness tattoos or otherwise ruffle the regime’s feathers) could be shipped into orbit.

In any case, Amazon’s space project will pile 3,200+ satellites onto the tens of thousands that Elon’s launching into the low Earth orbit (within a 1,200-mile band around Earth). Space scientists have long pressed for reviews of the satellites’ impact on the delicate balance of elements and molecules in the air when these things ultimately burn up in our atmosphere.

And the Federal Communications Commission enables it all.

Welcome to outer space in the Anthropocene.

Lee Hall holds an LL.M. in environmental law with a focus on climate change, and has taught law as an adjunct at Rutgers–Newark and at Widener–Delaware Law. Lee is an author, public speaker, and creator of the Studio for the Art of Animal Liberation on Patreon

ELVIS has entered orbit: Pioneering imaging system to enhance space biology and life detection beyond earth



ISS National Lab-sponsored investigation to test a new holographic microscope will launch on NASA’s SpaceX CRS-32 mission




International Space Station U.S. National Laboratory

ELVIS launching to the International Space Station on next SpaceX mission for NASA 

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Portland State University's Extant Life Volumetric Imaging System (ELVIS) is shown during testing.

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Credit: Jay Nadeau





KENNEDY SPACE CENTER (FL), April 15, 2025 – Onboard the International Space Station (ISSInternational Space Station), the Extant Life Volumetric Imaging System, dubbed ELVIS, is not about resurrecting rock-n-roll legends but pioneering scientific discovery. Using innovative holographic technology to deliver detailed 3D views of cells and microbes, the system allows scientists to study the adaptability and resilience of life under extreme conditions. Knowledge gained could reveal how life might persist on distant moons and planets, significantly enhancing our search for life outside Earth.

Beyond the capabilities of traditional two-dimensional microscopes, ELVIS offers scientists a closer look at the intricate structure, volume, and environmental interactions of cellular organisms. This detailed view enables more accurate biological assessments that could shed light on the ability of life to thrive in the most extreme environments of space.

Portland State University (PSU), in collaboration with NASA’s Jet Propulsion Laboratory, is spearheading the ELVIS project, which is scheduled to launch on SpaceX’s 32nd Commercial Resupply Services (CRS) mission, contracted by NASA. The investigation, sponsored by the ISS National Laboratory®, combines expertise in biology, physics, and cutting-edge imaging technology, says Jay Nadeau, a physics professor at PSU and a principal investigator on the project.

“We are thrilled to leverage the ISS National Lab to prepare ELVIS for its future roles in space exploration missions,” says Nadeau. She added, “The successful operation of ELVIS in the demanding conditions of space not only paves the way for its use in off-Earth environments but also holds implications for enhancing biomedical and microbiological research on our planet.”

During its tenure in space, ELVIS will focus its analysis on two resilient types of Earth-based life forms: Euglena gracilis, a microalga lauded for its adaptability, and Colwellia psychrerythraea, a bacterium that thrives in frigid ocean waters. This study goes beyond merely observing organisms; it tests their observable and genetic adaptations to microgravity. The insights gained could illuminate how life might survive beneath the icy shells of distant moons like Europa and Enceladus.

Built to endure the rigors of space, ELVIS incorporates durable, low-maintenance components and features automation that minimizes astronaut involvement, ensuring experiments can run continuously without disruption. As ELVIS gears up for launch, the team looks forward to testing its full potential to explore the resilience and adaptability of life under extreme conditions, Nadeau noted.

SpaceX CRS-32 is scheduled to launch no earlier than April 21, 2025, at 4:15 a.m., from Launch Complex 39A at NASA’s Kennedy Space Center in Florida.

For additional information on ISS National Lab-sponsored investigations launching on NASA’s SpaceX CRS-32, visit our launch page. To learn more about the research and technology development sponsored by the ISS National Lab, including how to propose concepts for future space-based research, visit our website.

Download a high-resolution image for this release: Ph.D. Student Nikki Johnson and ELVIS

NSF-funded research heads to the international space station on NASA's SpaceX CRS-32 mission



ISS national lab-sponsored investigations aim to enhance drug manufacturing and develop new materials for aerospace, defense, energy, and robotics



International Space Station U.S. National Laboratory

NSF-funded research launching to the space station on next resupply mission 

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Left: A drop of protein solution less than two and a half centimeters in diameter formed in the RSD onboard the International Space Station. Right: An image showing a computed Newtonian flow diagram for the drop.

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Credit: J. Adam





KENNEDY SPACE CENTER (FL), April 16, 2025 – Three investigations funded by the U.S. National Science Foundation (NSF) and sponsored by the International Space Station (ISSInternational Space Station) National Laboratory are launching on SpaceX’s 32nd Commercial Resupply Services (CRS) mission, contracted by NASANational Aeronautics and Space Administration. These experiments leverage the microgravityThe condition of perceived weightlessness created when an object is in free fall, for example when an object is in orbital motion. Microgravity alters many observable phenomena within the physical and life sciences, allowing scientists to study things in ways not possible on Earth. The International Space Station provides access to a persistent microgravity environment. environment to advance fundamental science that could lead to improved pharmaceutical manufacturing, new materials with valuable industrial applications, and the next generation of soft active materials with lifelike properties.

These projects build on a strong, multi-year collaboration between the ISS National Lab and NSF, which allocates millions of dollars to space-based projects within the fields of tissue engineering and transport phenomena, including fluid dynamics. To date, more than 30 projects funded by NSF and sponsored by the ISS National Lab have launched to the orbiting laboratory, with nearly 70 additional projects preparing for flight. Below are details about the three NSF-funded investigations launching on NASA’s SpaceX CRS-32.

Improving Medicine Manufacturing

An investigation by Rensselaer Polytechnic Institute (RPI), supported by Tec-Masters, builds on previous research to examine protein fluid flow and clumping—a problem that occurs during manufacturing of protein-based pharmaceuticals that affects the quality of the drug.

“Proteins are used to make various therapies and must be concentrated in medicines to avoid needing to administer large amounts of fluid,” says Amir Hirsa, professor of mechanical, aerospace, and nuclear engineering at RPI. “But above a certain concentration, the proteins tend to form aggregates or clump.”

On Earth, studying protein behavior is complicated by interactions between the solution and the container used to hold it. But on the ISS, researchers can use the Ring-Sheared Drop module to form liquid into a self-contained sphere held between two rings.

Hirsa and his team can use this device to study protein motion and create more accurate models of the factors that lead to clumping, especially during drug manufacturing and dispensation to patients. The team also can test computer models that predict the behavior of proteins of vastly different concentrations and types, such as hormones and antibodies. Findings from this research could help uncover ways to avoid or reverse protein clumping, which would have a significant impact on the pharmaceutical industry.

“Another very important aspect of this work is making this data, which is so difficult to get, available to other scientists through open data repositories,” says Joe Adam, a research scientist at RPI. “Other scientists may see something even more interesting than we do.”

Developing New Materials

An investigation from the University of Alabama at Birmingham, supported by Leidos, will examine the formation of ceramic composites, which have valuable applications in several industries, including aerospace, defense, and energy. The study focuses on polymer-derived titanium carbide and silicon carbide composites that have electrical conductivity, are stable at high temperature, can be made into almost any shape and size, and are lightweight yet strong.

“These materials can be used in different extreme conditions, such as high temperatures and highly acidic or oxidative environments, where other materials become unstable or cannot survive,” says Kathy Lu, a professor in the Department of Mechanical and Materials Engineering.

Studying these composites in microgravity could reveal unique behaviors that cannot be replicated on Earth. Findings from this research could inform new techniques for ground- and space-based manufacturing of materials with specific properties for applications such as heat exchangers, electric systems, energy storage, electrodes, and microsystems.

“Nobody has studied microgravity’s effects on these ceramics, and the results could be helpful for the broader family of ceramics and other possible additives, such as fibers and nanoscale materials,” Lu says.

Studying Active Matter

A research team at the University of California, Santa Barbara (UCSB) will leverage microgravity to study active matter—microscopic particles that use energy to produce motion—and its effects on the separation of non-mixable liquids. These liquids, such as oil and water, separate into concentrated droplets of one substance dispersed in the other, a phenomenon known as active liquid-liquid phase separation (LLPS). This investigation, supported by Redwire Space Technologies, seeks a better understanding of active LLPS, which plays a key role in physics, materials science, engineering, and biology.

“Active fluids are made of billions of small molecular motors that push and pull on each other and generate a turbulent flow, like a windy day stirs the water on a beach,” says UCSB professor Zvonimir Dogic. “A long-term goal is using active matter in microfluidic devices to stir and control the separation of two substances. We’re trying to create simplified systems that start to mimic biology.”

Active LLPS could be used to create materials with lifelike properties, such as the ability to move, change shape, and self-repair, that could be used to develop more lifelike robotics.

SpaceX CRS-32 is scheduled to launch no earlier than April 21, 2025, at 4:15 a.m., from Launch Complex 39A at NASA’s Kennedy Space Center in Florida. For additional information on ISS National Lab-sponsored investigations launching on NASA’s SpaceX CRS-32, visit our launch page. To learn more about the research and technology development sponsored by the ISS National Lab, including how to propose concepts for future space-based R&D, visit our website.

Download a high-resolution image for this release: SpaceX CRS-32 NSF Science



Curiosity rover finds large carbon deposits on Mars



UCalgary scientist Ben Tutolo lead author in groundbreaking study published in the journal, Science



University of Calgary

UCalgary scientist Ben Tutolo 

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Ben Tutolo, associate professor in the Department of Earth, Energy and Environment in the Faculty of Science at the University of Calgary, is the lead researcher on a paper about Mars. Tutolo is a participating scientist on the NASA Mars Science Laboratory Curiosity Rover team.

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Credit: University of Calgary 2025 Riley Brandt/University of Calgary




Research from NASA’s Curiosity rover has found evidence of a carbon cycle on ancient Mars, bringing scientists closer to an answer on whether the Red Planet was ever capable of supporting life.
Lead author Dr. Ben Tutolo, PhD, an associate professor with the Department of Earth, Energy and Environment in the Faculty of Science at the University of Calgary, is a participating scientist on the NASA Mars Science Laboratory Curiosity Rover team.
The team is working to understand climate transitions and habitability on ancient Mars as Curiosity explores Gale Crater.
The paper, published this week in the journal Science, reveals that data from three of Curiosity’s drill sites had siderite, an iron carbonate material, within sulfate-rich layers of Mount Sharp in Gale Crater.
“The discovery of large carbon deposits in Gale Crater represents both a surprising and important breakthrough in our understanding of the geologic and atmospheric evolution of Mars," says Tutolo.
Reaching the strata, he says, was a long-term goal of the Mars Science Laboratory mission.
“The abundance of highly soluble salts in these rocks and similar deposits mapped over much of Mars has been used as evidence of the ‘great drying” of Mars during its dramatic shift from a warm and wet early Mars to its current, cold and dry state,” says Tutolo.
Sedimentary carbonate has long been predicted to have formed under the CO2-rich ancient Martian atmosphere, but Tutolo says identifications had previously been sparse.
NASA’s Curiosity rover landed on Mars on Aug. 5, 2012, and has travelled more than 34 kilometres on the Martian surface.
The discovery of carbonate suggests that the atmosphere contained enough carbon dioxide to support liquid water existing on the planet’s surface. As the atmosphere thinned, the carbon dioxide transformed into rock form.
NASA says future missions and analysis of other sulfate-rich areas on Mars could confirm the findings and help to better understand the planet’s early history and how it transformed as its atmosphere was lost.
Tutolo says scientists are ultimately trying to determine whether Mars was ever capable of supporting life – and the latest paper brings them closer to an answer.
“It tells us that the planet was habitable and that the models for habitability are correct,” he says.
“The broader implications are the planet was habitable up until this time, but then, as the CO2 that had been warming the planet started to precipitate as siderite, it likely impacted Mars’ ability to stay warm.
“The question looking forward is how much of this CO2 from the atmosphere was actually sequestered? Was that potentially a reason we began to lose habitability?”
The latest research, he says, fits with his ongoing work on Earth – trying to turn anthropogenic CO2 into carbonates as a climate change solution.
“Learning about the mechanisms of making these minerals on Mars helps us to better understand how we can do it here,” he says. “Studying the collapse of Mars’ warm and wet early days also tells us that habitability is a very fragile thing.”
Tutolo says it’s clear that small changes in atmospheric CO2 can lead to huge changes in the ability of the planet to harbour life.
“The most remarkable thing about Earth is that it’s habitable and it has been for at least four billion years,” he adds. “Something happened to Mars that didn’t happen to Earth.”

 

Curious isolation: New butterfly species discovered



Pensoft Publishers
Satyrium curiosolus 

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Satyrium curiosolus

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Credit: MacDonald et al.





In the heart of Canada’s Rocky Mountains, an unassuming yet remarkable butterfly has been quietly flying under our scientific radar for years. With a wingspan of an inch to an inch and a half, and wings that are brown on top and greyish brown with black spots below, this population was long thought to belong to the Half-moon Hairstreak (Satyrium semiluna). However, the isolated hairstreak butterflies of Blakiston Fan in Waterton Lakes National Park, Alberta, have now been recognized as a distinct species: Satyrium curiosolus, or the Curiously Isolated Hairstreak.

A recent study by an international collaborative team, published in ZooKeys, uncovered the unique evolutionary history of this population. The results were striking: Satyrium curiosolus has been completely isolated from its closest relatives for quite a while—possibly up to 40,000 years— becoming more and more genetically and ecologically unique along the way.

The science behind the discovery

“Our whole-genome sequencing of S. curiosolus revealed strikingly low genetic diversity and exceptionally high levels of historical inbreeding compared to the geographically nearest S. semiluna populations in British Columbia and Montana, more than 400 km distant,” says co-first author Zac MacDonald, a La Kretz postdoctoral researcher at University of California Los Angeles Institute of the Environment and Sustainability. Despite its small population size, genetic data suggest that S. curiosolus has likely maintained itself as a stable, independent lineage for tens of thousands of years. “Like the Channel Island Fox, S. curiosolus may have purged some of its harmful recessive genetic variation through a long, gradual history of inbreeding, allowing it to persist as a small and completely isolated population today,” MacDonald adds.

Satyrium curiosolus is found in a distinct habitat unlike any other population of S. semiluna that we know of. While its relatives thrive in sagebrush steppe, S. curiosolus occupies a single alluvial fan that is more accurately described as prairie-grassland, where it associates with different plants and ant species. Satyrium curiosolus relies exclusively on silvery lupine (Lupinus argenteus) for larval development, a plant not known to be used by S. semiluna populations in British Columbia.

“Furthermore, we recently discovered that S. curiosolus larvae have mutualistic relationships with a particular species of ant (Lasius ponderosae), which has not been observed in other S. semiluna populations,” says James Glasier of the Wilder Institute/Calgary Zoo, who was also part of the study. Satyrium curiosolus caterpillars provide the Lasius ants with a sugary excretion called honeydew to eat, while in return the ants protect the caterpillar from parasites and predators. Caterpillars also retreat into ant galleries when disturbed, or when it gets too hot out, and adult females have been observed laying eggs right near the entrances to Lasius colonies under Silvery Lupines.

Why it matters

The recognition of S. curiosolus as a species has important implications, highlighting its unique evolutionary trajectory and emphasizing an urgent need for tailored conservation strategies.

Satyrium curiosolus faces a somewhat unique challenge: its long-term isolation has resulted in very low genetic diversity, which means that the species has a reduced potential to adapt to changing climatic conditions. While conservationists often consider genetic rescue—introducing individuals from related populations to boost genetic diversity—as a solution to low genetic diversity, the distinctiveness of S. curiosolus raises concerns about potential outbreeding depression when mixed with S. semiluna. It is likely that the two species are not even reproductively compatible, meaning S. curiosolus may be on its own. Conservation efforts must now consider new solutions, such as establishing additional S. curiosolus populations, to help this butterfly persist as climate change threatens ecological change at Blakiston Fan.

A case study in genomics and conservation

“The discovery of S. curiosolus is a powerful demonstration of how genomics is revolutionizing taxonomy and conservation,” remarked co-first author Julian Dupuis, an Assistant Professor in the Department of Entomology at University of Kentucky. “While traditional taxonomic methods often rely on morphology alone, our study underscores the importance of integrating genomic and ecological data to uncover hidden diversity. With the rise of genomic tools, previously unrecognized species like S. curiosolus are being discovered, highlighting the need for conservation strategies that account for cryptic biodiversity.” Dupuis adds.

Collaboration in conservation

“Our studies on S. curiosolus and S. semiluna highlight the importance of collaboration between academic scientists, nonprofit organizations, and conservation managers. All of this work was made possible through partnerships between academic researchers, Parks Canada, and the Wilder Institute/Calgary Zoo. By combining expertise in genomics, field ecology, and conservation management, we were able to produce findings that not only reshape our understanding of biodiversity but also provide actionable insights for species protection. Moving forward, these interdisciplinary collaborations will be critical for tackling complex conservation challenges and ensuring the long-term survival of species like S. curiosolus,” added MacDonald.

The future of Satyrium curiosolus

Recognizing S. curiosolus as a distinct species is just the beginning, the researchers say. Future research should explore its evolution and interactions with other species like host plants and ants. Additionally, long-term monitoring by Parks Canada and the Wilder Institute/Calgary Zoo will be essential to assess how this species copes with climate change and what conservation actions are appropriate. "This is a wonderful example of how such monitoring can connect diverse approaches and impactful answers to a simple question like ‘that’s odd - why is it there?’”, says anchor author Felix Sperling, a professor at the University of Alberta and curator of the U of A’s Strickland Museum of Entomology.

“For now, the Curiously Isolated Hairstreak reminds us that even the smallest and most overlooked species can hold extraordinary scientific and conservation significance,” the researchers say in conclusion.

 

Research article:

MacDonald ZG, Dupuis JR, Glasier JRN, Sissons R, Moehrenschlager A, Shaffer HB, Sperling FAH (2025) Genomic and ecological divergence support recognition of a new species of endangered Satyrium butterfly (Lepidoptera, Lycaenidae). ZooKeys 1234: 291-307. https://doi.org/10.3897/zookeys.1234.143893



Satyrium curiosolus.

Satyrium curiosolus.





S. curiosolus larvae being attended to by Lasius ponderosae ants.

Credit

MacDonald et al.

 

Personality test for bees



Researchers from the Cluster of Excellence "Collective Behaviour" at the University of Konstanz have discovered that honey bees from the same colony have different preferences in terms of defensive behaviour




University of Konstanz




Honey bee colonies are well organized. Some collect nectar, others water, a few fan the hive with air to cool it down – and some defend the colony by stinging enemies. But when exactly does this happen? And do some individuals have a greater propensity to attack than others? A research team from the University of Konstanz is investigating these questions in more detail. In a recent study the researchers have now discovered that there are bees that attack, while other conspecifics always stay calm. They also show how social factors regulate this decision and that the personality of the individual bees is more important for the group dynamics than assumed.

For her research, doctoral student Kavitha Kannan at the University of Konstanz, led by neurobiologist Morgane Nouvian, specifically captured guard bees at the university's own beehives. The idea was to have a homogeneous group with assumed identical stinging behaviour. "Basically, you can expect that, simply by the distribution of tasks, a collector will have a different stinging behaviour than a guard. As we wanted to exclude as many influencing factors as possible, this selection was the first logical step. We were then able to gradually test other influencing factors", explains Kannan.

One bee sounds the alarm, but not everyone follows
The researchers knew from previous studies that the animals are influenced by pheromones. If a bee decides to sting, an alarm pheromone is released that encourages other bees to do the same. With each additional sting, the concentration of this pheromone increases, which in turn provides information on how many bees are already involved in the attack. Studies have shown that after a certain concentration has been reached, the stinging behaviour starts to decrease. Especially in view of the fact that bees usually lose their stinger after using it and consequently die, this is a sensible method to prevent mass mortality as a result of an attack. According to studies, the likelihood that a bee will respond to a given concentration of alarm pheromone also depends on the size of the group.

What had been unknown so far is how the bees decide which of them will ultimately sting. The results of the current study by Nouvian suggest that the personality of each bee plays a major role in this context. "We simulated several situations in our tests in order to gradually explore various influencing factors", explains Nouvian. To provoke the bees to sting, the team used dummies in which the bees' stings did not stick. This way the animals could be repeatedly exposed to such situations in order to verify its respective reaction and rule out random behaviour.

Blend in or stand out
"In one group, for example, we tested whether stinging behaviour was affected by the presence of a conspecific, and in another group we tested the effect of the alarm pheromone", Nouvian says. "Ultimately, it turned out that although these factors had an influence, they did not impact the predictability of individual stinging behaviour", she adds. The respective personality therefor prevailed over conformism. This was also confirmed in a final experiment where the researchers determined that bees did not change their stinging behaviour as a function of group composition. Thus, even honeybees, which are renowned for their highly social lifestyle and for putting the needs of the colony before their own, retain some individuality.

 

 

 

 

Key facts:

 

  • Original publication: Kannan K., Galizia C. G., Nouvian M. (2025) Consistency and individuality of honeybee stinging behaviour across time and social contexts. Royal Society Open Science 12:241295. DOI: 10.1098/rsos.241295
  • Dr. Morgane Nouvian is a neurobiologist at the University of Konstanz and a member of the Cluster of Excellence "Collective Behaviour". Her research focuses on the defensive behaviour of social bees.
  • Kavitha Kannan is a doctoral researcher at the University of Konstanz. In her thesis, she is researching the stinging behaviour of honeybees.
  • The Cluster of Excellence "Collective Behaviour" at the University of Konstanz is a global hotspot for the study of collective behaviour across a wide range of species and across scales of organization.

 

Note to editors:
Photos are available here:

  1. https://www.uni-konstanz.de/fileadmin/pi/fileserver/2025_extra/bienen_im_persoenlichkeitstest_1.jpg
    Caption: Kavitha Kannan catches honey bees for her research at the university's own beehives.
    Copyright: University of Konstanz
     
  2. https://www.uni-konstanz.de/fileadmin/pi/fileserver/2025_extra/bienen_im_persoenlichkeitstest_2.jpg
    Caption: During a short stay in the experimental container, the bees are exposed to various situations and observed.
    Copyright: University of Konstanz
     
  3. https://www.uni-konstanz.de/fileadmin/pi/fileserver/2025_extra/bienen_im_persoenlichkeitstest_3.jpg
    Caption: Kavitha Kannan (right) and Morgan Nouvian (left) while working with the bees.
    Copyright: University of Konstanz

 

 

Real-world study finds hydroxyurea effective long-term in children living with sickle cell disease



Children taking hydroxyurea visited emergency department less, had fewer hospital days



American Society of Hematology





(WASHINGTON, April 17, 2024) — Hydroxyurea remains effective long-term in reducing emergency department visits and hospital days for children living with sickle cell disease (SCD), according to new research published in Blood Advances.  

“This is one of the first large, real-world, long-term studies to assess the efficacy of hydroxyurea outside of a controlled setting,” said study author Paul George, MD, a pediatric hematology/oncology fellow and PhD candidate at Emory University School of Medicine and Aflac Cancer and Blood Disorders Center at Children’s Healthcare of Atlanta. “Our results reinforce that hydroxyurea, the most efficacious medicine available for SCD, continues to have really important benefits over time for pediatric patients.” 

SCD is the most common inherited red blood cell disorder in the United States, affecting an estimated 100,000 people. According to the Centers for Disease Control and Prevention, SCD affects one out of every 365 Black or African American births and one out of every 16,300 Hispanic American births. The disorder is characterized by abnormally shaped blood cells that can become lodged in the veins, blocking blood flow and leading to organ damage, infection, and episodes of severe pain.  

Hydroxyurea, an oral, once-daily, and typically life-long medication, reduces the frequency and severity of SCD pain crises, in addition to decreasing the need for blood transfusions, improving anemia, and reducing the risk of acute chest syndrome, when abnormally shaped blood cells block vessels in the lungs. Currently, the National Heart, Lung, and Blood Institute recommends that hydroxyurea be offered as a therapy to every patient with the more severe variant of SCD, HbSS/HbSβ0 starting between nine to twelve months of age. 

“Hydroxyurea has been a mainstay in SCD treatment for a long time, but was initially used as a chemotherapy, so there have always been some lingering fears about its safety and efficacy, especially for children,” said study author Wilbur Lam, MD, PhD, a professor of pediatrics and biomedical engineering at Emory University and at the Georgia Institute of Technology and a pediatric hematologist at Children’s Healthcare of Atlanta. “This study can provide some reassurance to patients and their families that this therapy, one of the most accessible for SCD, continues to be a safe option with a true benefit outside of a controlled setting.”  

The study’s total cohort was made up of 2,147 children under the age of 18. All participants had the  HbSS/HbSβ0 variant of SCD, had more than three clinical encounters between 2010 and 2021 at Children’s Hospital of Atlanta, and had not received a bone marrow transplant, gene therapy, chronic transfusion therapy, or treatment with disease-modifying medications outside of hydroxyurea. Of the 2,147 participants, 1,240 (58%) had used hydroxyurea; of those, the average time on hydroxyurea was 5.1 years, with 304 children aged eight or older on continuous hydroxyurea therapy.  

The researchers found that, generally, children using hydroxyurea visited the emergency department less (0.36 fewer visits per patient-year) and spent fewer days in the hospital (0.84 fewer days per patient-year) across prolonged use when compared to children not on hydroxyurea. These results remained consistent even when the researchers accounted for disease severity and adherence by including only patients who began hydroxyurea at age one – before severe symptoms typically emerge – and limiting the sample to patients with laboratory markers that indicated consistent medication intake. 

“Overall, hydroxyurea remained effective over time in these children,” said Dr. George. “However, one important takeaway from this study is that improvements in hemoglobin concentration – or reductions in anemia – were seen only in patients whose data indicated they were regularly taking the medication.”  Dr. George added that these results reflect real-world use and point to a continued need for providers to emphasize to patients the importance of taking hydroxyurea every day. 

The researchers cautioned that the study does have some data limitations due to its real-world nature, including the reliance on laboratory markers to determine hydroxyurea adherence and lack of data on intermittent transfusions and acute events causing ongoing anemia, such as pain crises. They hope to make up for these gaps in data in future studies and incorporate patient-reported outcomes to better gauge how hydroxyurea impacts children outside of the hospital setting. 

### 

Blood Advances (bloodadvances.org) is an online, open-access journal publishing more peer-reviewed hematology research than any other academic journal worldwide. Blood Advances is part of the Blood journals portfolio (bloodjournals.org) from the American Society of Hematology (ASH) (hematology.org). 
 
Claire Whetzel, 202-629-5085 
cwhetzel@hematology.org 

 

 

Securing our food future with controlled environment agriculture




TUMCREATE Limited





Singapore –

• Controlled environment agriculture (CEA), including vertical farming, offers substantial gains in productivity while reducing environmental impact.

• CEA systems can complement traditional agriculture by providing local, year-round food production that is independent of climate, region, or weather.

• Policy support, technological innovation, and public engagement are crucial to unlock the full potential of CEA.

 

Climate change and a decline in available arable land are reducing crop yields which can significantly impact food security. Sustainable solutions to feed the increasingly growing population are urgent.

 

A research team as part of the Proteins4Singapore (P4SG) project, co-led by TUMCREATE in Singapore and the Technical University of Munich (TUM), proposes that future controlled environment agriculture - CEA systems can boost productivity for several food sources. In CEA, all growth conditions are carefully controlled to optimise growth and yield. Controllable parameters impacting these growth conditions span temperature, humidity, light, carbon dioxide concentration, and nutrients. All the outputs can be finely tuned, largely minimising environmental impact.

 

CEA enables a consistent year-round production of safe food and can complement traditional farming, according to Dr Vanesa Calvo-Baltanás, research fellow at TUMCREATE and the lead researcher of this finding. The team investigated the yield potential of six food groups cultivated under CEA conditions, including crops, algae, mushrooms, insects, fish and cultivated meat.

 

“Controlled environment agriculture systems can be set up anywhere in the world and remain unaffected by climate, weather, and location. Additionally, they can reduce water use by over 90%, which greatly benefits water-scarce regions. This can greatly enhance food security for drought-prone areas,” says Dr Vanesa Calvo-Baltanás, who works with Prof Senthold Asseng, Professor of Digital Agriculture at TUM and a co-Lead-Investigator of the P4SG project.

 

Despite the current high energy requirements combined with high electricity prices, as nations work towards climate resilience and food security goals, CEA could play a key role in supporting initiatives like Singapore’s ‘30 by 30’ food security strategy and the European Union’s ‘Farm to Fork’ policy by reducing the environmental and climate impact of primary production. The ‘30 by 30’ agenda aims to locally produce 30% of the city-nation’s nutritional needs by 2030.

 

“Controlled environment agriculture can revolutionise food production. However, to fully unlock its full potential, technological advancements to reduce energy requirements, policy incentives, and public engagement are needed. Our study provides a framework to help policymakers, industry leaders, and researchers to make informed decisions for developing sustainable food production systems,” says Dr Calvo-Baltanás.

 

The research is carried out by TUMCREATE, and supported by the National Research Foundation Singapore under its Campus for Research Excellence And Technological Enterprise (CREATE) programme.