Monday, October 13, 2025

Life after near death: Research reveals how to improve support for near-death experiencers



University of Virginia Health System





Near-death experiences can have lasting, life-changing effects, and new University of Virginia School of Medicine research sheds light on the types of counseling and support that can best help people cope.

The research, from UVA’s Division of Perceptual Studies, is believed to be the first to explore the most common and effective ways to assist people grappling with potentially profound changes to their world view. For most, near-death experiences, or NDEs, have a positive effect; the brush with death can give experiencers renewed purpose in life, a desire to serve others and an appreciation for being part of a greater whole. But even then some people may struggle to make sense of the experience, especially if their NDE conflicts with their religious or existential beliefs, personal values or scientific views. Additionally, individuals who have had an NDE may struggle with incorporating changes in priorities, relationships and values into their lives.

In dealing with the aftermath of a near-death experience, people can benefit from the right type of support, says researcher Marieta Pehlivanova, PhD, of UVA Health’s Department of Psychiatry and Neurobehavioral Sciences.

“We know a lot about these experiences from decades of research, including their typical manifestations, incidence, medical circumstances, their impact on individuals and even the physiological conditions of patients who have them,” she said. “However, the research on how to support these patients and their specific needs is still limited. We hope to begin addressing this gap and to inspire other researchers, especially clinicians, to devote time and care in pursuing these questions.”

Effects of Near-Death Experiences

Pehlivanova and her colleagues looked at the types of professional help, therapy and other forms of support sought by 167 people after their near-death experiences and the factors that predict who will need support after the experience. The researchers also asked the experiencers how helpful they found the different forms of support.

More than half of the experiencers – 64% – had reached out for help, and 78% of those found the support helpful. The greater the intensity of the NDE, the more likely the experiencers were to seek help, the researchers found. People with a history of psychological difficulties were also significantly more likely to seek support.

One key to successful support was acceptance and validation. Many people hesitate to seek help for fear they will be labeled “crazy,” the researchers note. Strikingly, people who received a positive or accepting first reaction when they disclosed their experiences were much more likely to describe the overall support they received as beneficial. 

People were also likely to describe the support as helpful if they were older, if they described their childhoods as happy – hinting at greater resilience – and if they received support from groups or online sources that are “friendly” to and knowledgeable about the phenomenon of near-death experiences, the researchers report in a new scientific paper outlining their findings.

Further, people who described their mental health as good were less likely to report seeking support after  their NDE and more likely to report that support was helpful, if they sought it. This may because they have greater mental-health resiliency allowing them to process the NDE without the need for external support, or their current mental health may have been the result or receiving validating support, the researchers say.

Notably, support received from mental-health professionals was associated with lower perceived helpfulness. This may reflect a need for more counselors, therapists and health professional specifically trained in helping people cope with near-death experiences, the researchers conclude.

“We are hoping that this work brings light to the support needs of individuals who have had a near-death experience and are trying to make sense of it and its impact,” Pehlivanova said. “In a new era of holistic patient care and extensive research on these experiences, including in medical journals, it is important to highlight the need for education of healthcare providers to address the gap of care for these patients.”

About the Findings

Pehlivanova and her colleagues have published their findings in the scientific journal Psychology of Consciousness: Theory, Research and Practice. The article is open access, meaning it is free to read. The research team consisted of Pehlivanova, Katherine C. McNally, Sabina Funk and Bruce Greyson.

To keep up with the latest medical research news from UVA, subscribe to the Making of Medicine blog.

About the Division of Perceptual Studies

Established in 1967 under the leadership of Dr. Ian Stevenson, DOPS stands as the most productive university-based research group in the world dedicated to exploring phenomena that challenge conventional scientific paradigms concerning human consciousness. At the core of DOPS’s research mission lies the commitment to rigorous evaluation of empirical evidence surrounding exceptional human experiences and capacities, including utilization of a state-of-the-art neuroimaging lab. DOPS extends its focus beyond fundamental empirical research and explores the profound implications of such research for scientific theory and society at large. By actively sharing insights and findings, DOPS strives to contribute meaningfully to the understanding of consciousness, bridging the gap between scientific inquiry and public awareness.   

For more information, visit the division's site

 

Exploring the therapeutic potential of hypothermia



Triggering a reversible, hibernation-like hypothermic state—without external cooling—in male mice after brain injury protects neural health and promotes motor recovery



Society for Neuroscience





Hypothermia can preserve neuron health following brain injury, but complications from external cooling make it less promising therapeutically. Recent evidence suggests that activating a specific neuron population triggers a reversible, hibernation-like hypothermic state without external cooling, but does this form of hypothermia still preserve neuron health? In a new JNeurosci paper, researchers led by Takeshi Sakurai at the University of Tsukuba explored this question using male mice. 

The researchers found that triggering this specific hypothermic state in mice improved motor performance following brain injury. Imaging methods showed that neurons also had improved survival in the injured brain area accompanied by less signs of neuroinflammation. The researchers further identified cellular features consistent with the idea that this form of hypothermia may preserve neural health. 

While this work is preclinical, the authors suggest that it unveils a potential way to work around complications from external cooling when using hypothermia as a treatment for traumatic brain injury. Speaking on future experimental plans, says Sakurai, “Optimizing the timing and duration of this treatment after injury, testing across additional injury models, and evaluating safety and efficacy in larger animals will be important next steps.”

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Please contact media@sfn.org for full-text PDF. 

About JNeurosci 

JNeurosci was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship. 

About The Society for Neuroscience 

The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 35,000 members in more than 95 countries. 

Music for the brain: Study tests the effect of slow-tempo relaxing music to address delirium in critically ill older adults 


Findings support longer-duration or targeted approaches



Regenstrief Institute





A multi-center randomized controlled trial with critically ill adults aged 50 years and older admitted to intensive care units (ICUs) found that twice-daily slow-tempo music (60 to 80 beats per minute) did not shorten the duration of delirium or coma, or reduce delirium severity, pain or anxiety compared with a silence-track control.

While the trial did not mitigate delirium, it showed a trend to fewer days with delirium/coma among patients who received at least seven doses of slow-tempo music. There was also a trend toward fewer days of delirium/coma among patients who had received benzodiazepines, a type of sedative that increases the risk of delirium. These results suggest the need for further study of music as an adjunctive therapy in critically ill older adults.

Delirium is a state of confusion and has serious short and long-term health consequences including an increased risk of post-ICU dementia. About 75 percent of older adults develop delirium in the ICU.

The Decreasing Delirium through Music in Critically Ill Older Adults (DDM) Trial was conducted at Indiana University School of Medicine-affiliated hospitals (Indiana University Health and Sidney and Lois Eskenazi Hospital, Indianapolis) and Mayo Clinic, Rochester, Minnesota. The team included researchers from IU School of Medicine, Mayo Clinic, Regenstrief Institute, Anglia Ruskin University and Area 10 Labs.

The two-arm trial featured concealed outcome assessments and compared a carefully curated selection of slow-tempo music vs. silence-track control. Listening sessions in both arms were delivered twice daily for up to seven days via computer tablets and over-the-ear active noise-cancelling headphones. The DDM Trial demonstrated the feasibility of centralized, app-based, music playlist delivery and in the busy ICU environment.

The study, “Slow-Tempo Music and Delirium/Coma-Free Days Among Older Adults Undergoing Mechanical Ventilation: A Randomized Controlled Trial,” is published in the Journal of the American Medical Association’s JAMA Internal Medicine.

“Despite the intuitive appeal of calming music in the ICU, our rigorously conducted multi-center trial shows prescribed slow-tempo playlists did not reduce delirium, pain or anxiety, nor change length of ventilation or stay,” said Babar Khan, M.D., M.S., co-lead author. “These data refine practice and suggest future studies focus on personalized, therapist-guided approaches and targeted populations.”

Linda L. Chlan, PhD, R.N., Mayo Clinic and co-lead investigator, added, “We conceptualized music as a meaningful, complex stimulus to activate the brain among ICU patients. It is possible that a prescribed selection of music was not meaningful to patients which highlights the importance of music preferences in designing future clinical trials.”

“In DDM, we were able to demonstrate it’s feasible to deliver and track music ‘dose’ reliably in critically ill patients using an app,” said Sikandar Khan, D.O., M.S., co-lead author, “Our post hoc analyses, while exploratory, show a trend towards greater coma-free days in patients who were in the ICU long enough to receive seven days of intervention, and those patients who had received benzodiazepines. This raises new questions about the interaction between sedation and the effect of slow-tempo music.”

The study also:

  • Refines practice: Findings counter the assumption that early, slow-tempo playlists via headphones will improve delirium/coma-free days in the ICU.
  • Advances evidence: Adds rigorous, multi-center randomized trial data with concealed outcomes assessment to a field where many pharmacologic delirium trials have also been negative.
  • Guides future research: The findings suggest that future studies should evaluate longer duration, targeted subgroups (e.g., specific sedation profiles), or post-ICU timing of music intervention. Non-significant trends in those receiving at least seven sessions and in benzodiazepine-exposed patients suggest potential subpopulations for study.
  • Demonstrates feasibility and fidelity: This is the first trial to use the Soundese iPad app to deliver/track music “dose,” establishing a scalable model for intervention fidelity in ICU behavioral trials.
  • Confirms safety and implementation: There were no serious adverse events; adherence and timing windows were reliable, informing practical deployment parameters even if efficacy was not shown.

Authors and affiliations, as listed in the publication
Babar A. Khan, MD, MS;*1,2,3 Sikandar H. Khan, DO, MS;*1,2,3 Anthony J. Perkins, MS;4 Annie Heiderscheit, PhD;5 Frederick W. Unverzagt, MD;6 Sophia Wang, MD;6 J. Hunter Downs III, PhD;7.8 Sujuan Gao, PhD;4 Linda L. Chlan, PhD, RN, ATSF, FAAN7, 9
*Co-First Author

1Indiana University School of Medicine, Indianapolis, IN

2Indiana University Center for Aging Research, Indianapolis, IN

3Regenstrief Institute, Inc., Indianapolis, IN

4Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN 

5Anglia Ruskin University, Cambridge, UK

6Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana

7Mayo Clinic, Rochester, MN

8Area10 Labs, LLC, Rochester, MN

9Mayo Clinic College of Medicine and Science, Rochester, MN

Funding/Support: Source of Funding
The study was supported by a grant from the National Institutes of Health’s National Institute on Aging (NIA R01AG067631), awarded to Dr. Babar Khan and Dr. Linda Chlan.

 

New lab-grown human embryo model produces blood cells



University of Cambridge
The self-organising embryo-like structures at day 14 of development 

image: 

The team observed the emergence of the three-dimensional embryo-like structures under a microscope in the lab. These started producing blood (seen here in red) after around two weeks of development - mimicking the development process in human embryos.

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Credit: Jitesh Neupane, University of Cambridge




University of Cambridge scientists have used human stem cells to create three-dimensional embryo-like structures that replicate certain aspects of very early human development - including the production of blood stem cells.

Human blood stem cells, also known as hematopoietic stem cells, are immature cells that can develop into any type of blood cell, including red blood cells that carry oxygen and various types of white blood cells crucial to the immune system.

The embryo-like structures, which the scientists have named ‘hematoids’, are self-organising and start producing blood after around two weeks of development in the lab - mimicking the development process in human embryos.

The structures differ from real human embryos in many ways, and cannot develop into them because they lack several embryonic tissues, as well as the supporting yolk sac and placenta needed for further development.

Hematoids hold exciting potential for a better understanding of blood formation during early human development, simulating blood disorders like leukaemia, and for producing long-lasting blood stem cells for transplants.

The human stem cells used to derive hematoids can be created from any cell in the body. This means the approach also holds great potential for personalised medicine in the future, by allowing the production of blood that is fully compatible with a patient’s own body.

Although other methods exist for generating human blood stem cells in the laboratory, these require a cocktail of extra proteins to support the stem cells’ growth and development. The new method mimics the natural developmental process, based on a self-organising human embryo-like model, where the cells’ intrinsic support environment drives the formation of blood cells and beating heart cells within the same system.

The findings are published today in the journal Cell Reports.

Dr Jitesh Neupane, a researcher at the University of Cambridge’s Gurdon Institute and first author of the study, said: “It was an exciting moment when the blood red colour appeared in the dish – it was visible even to the naked eye.”

He added: “Our new model mimics human foetal blood development in the lab. This sheds light on how blood cells naturally form during human embryogenesis, offering potential medical advances to screen drugs, study early blood and immune development, and model blood disorders like leukaemia.”

Professor Azim Surani at the University of Cambridge’s Gurdon Institute, senior author of the paper, said: “This model offers a powerful new way to study blood development in the early human embryo. Although it is still in the early stages, the ability to produce human blood cells in the lab marks a significant step towards future regenerative therapies - which use a patient’s own cells to repair and regenerate damaged tissues.”

Dr Geraldine Jowett at the University of Cambridge’s Gurdon Institute, a co-first author of the study, said: “Hematoids capture the second wave of blood development that can give rise to specialised immune cells or adaptive lymphoid cells, like T cells opening up exciting avenues for their use in modelling healthy and cancerous blood development.”

Self-organising structures

The new human embryo-like model simulates the cell changes that occur during the very early stages of human development, when our organs and blood system first begin to form.

The team observed the emergence of the three-dimensional hematoids under a microscope in the lab. By the second day, these had self-organised into three germ layers - called the ectoderm, mesoderm, and endoderm - the foundations of the human body plan that are crucial for shaping every organ and tissue, including blood.

By day eight, beating heart cells had formed. These cells eventually give rise to the heart in a developing human embryo.

By day thirteen, the team saw red patches of blood appearing in the hematoids. They also developed a method which demonstrated that blood stem cells in hematoids can differentiate into various blood cell types, including specialised immune cells, such as T-cells.

Shining a light on early human development

Stem cell-derived embryo models are crucial for advancing our knowledge of early human development.

The blood cells in hematoids develop to a stage that roughly corresponds to week four to five of human embryonic development. This very early stage of life cannot be directly observed in a real human embryo because it has implanted in the mother’s womb by this time.

There are clear regulations governing stem cell-based models of human embryos, and all research modelling human embryo development must be approved by ethics committees before proceeding. This study received the necessary approvals, and the resulting paper has been peer reviewed.

The scientists have patented this work through Cambridge Enterprise, the innovation arm of the University of Cambridge, which helps researchers translate their work into a globally leading economic and social impact.

  

The team observed the emergence of the three-dimensional hematoids under a microscope in the lab. After just a few days these had self-organised into three germ layers - called the ectoderm, mesoderm, and endoderm - the foundations of the human body plan that are crucial for shaping every organ and tissue, including blood.

Credit

Jitesh Neupane, University of Cambridge