Wednesday, December 24, 2025

 

Exposure to multiple fine particulate matter components and incident depression in the US Medicare population



JAMA Network Open





About The Study: 

In this cohort study of the U.S. Medicare population, specific fine particulate matter (PM2.5) components (sulfate, elemental carbon, and soil dust) were associated with increased depression risk in older adults, particularly those with preexisting comorbidities. These findings underscore the importance of targeted regulation of harmful PM2.5 components to protect vulnerable populations.



Corresponding Author: To contact the corresponding author, Yang Liu, PhD, email yang.liu@emory.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.51042)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

Risk of burdensome health care spending over time in the US



JAMA Internal Medicine


About The Study:

 This cohort study found that the U.S. health care system imposes cost burdens on a larger share of the population than suggested by cross-sectional analyses, and most individuals in the U.S. will experience such burdens during their lifetimes. Policies that reduce out-of-pocket costs might improve the well-being of individuals in the U.S. 



Corresponding Author: To contact the corresponding author, Adam Gaffney, MD, MPH, email agaffney@challiance.org.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamainternmed.2025.6948)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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GLP-1s are changing the foods Americans buy


Cornell University






ITHACA, N.Y. – When Americans begin taking appetite-suppressing drugs like Ozempic and Wegovy, the changes extend well beyond the bathroom scale. According to new Cornell University research, the medications are associated with meaningful reductions in how much households spend on food, both at the grocery store and at restaurants.

The study, published in the Journal of Marketing Research, links survey data on GLP-1 receptor agonist use – a class of drugs originally developed for diabetes and now widely prescribed for weight loss – with detailed transaction records from tens of thousands of U.S. households. The result is one of the most comprehensive looks yet at how GLP-1 adoption is associated with changes in everyday food purchasing in the real world.

The headline finding is striking: Within six months of starting a GLP-1 medication, households reduce grocery spending by an average of 5.3%. Among higher-income households, the drop is even steeper, at more than 8%. Spending at fast-food restaurants, coffee shops and other limited-service eateries falls by about 8%.

Among households who continue using the medication, lower food spending persists at least a year, though the magnitude of the reduction becomes smaller over time, says Sylvia Hristakeva, assistant professor of marketing. 

“The data show clear changes in food spending following adoption,” Hristakeva said. “After discontinuation, the effects become smaller and harder to distinguish from pre-adoption spending patterns.”

Unlike previous studies that relied on self-reported eating habits, the new analysis draws on purchase data collected by Numerator, a market research firm that tracks grocery and restaurant transactions for a nationally representative panel of about 150,000 households. The researchers matched those records with repeated surveys asking whether household members were taking GLP-1 drugs, when they started and why.

 

That combination allowed the team to compare adopters with similar households that did not use the drugs, isolating changes that occurred after medication began. The reductions were not evenly distributed across the grocery store.

Ultra-processed, calorie-dense foods – the kinds most closely associated with cravings – saw the sharpest declines. Spending on savory snacks dropped by about 10%, with similarly large decreases in sweets, baked goods and cookies. Even staples like bread, meat and eggs declined.

Only a handful of categories showed increases. Yogurt rose the most, followed by fresh fruit, nutrition bars and meat snacks.

“The main pattern is a reduction in overall food purchases. Only a small number of categories show increases, and those increases are modest relative to the overall decline,” Hristakeva said. 

The effects extended beyond the supermarket. Spending at limited-service restaurants such as fast-food chains and coffee shops fell sharply as well. For food manufacturers, restaurants and retailers, widespread GLP-1 adoption could mean long-term shifts in demand, particularly for snack foods and fast food. Package sizes, product formulations and marketing strategies may need to change.

For policymakers and public-health experts, the results add context to ongoing debates about the role of medical treatments in shaping dietary behavior – and whether biologically driven appetite changes succeed where taxes and labels have struggled.

 

For additional information, see this Cornell Chronicle story.

Cornell University has dedicated television and audio studios available for media interviews.

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Study quantifies ‘hot drought’ impact: 2025 Los Angeles wildfire risk amplified by up to 210%





Institute of Atmospheric Physics, Chinese Academy of Sciences

2025 LA wildfires 

image: 

How can science improve wildfire diagnosis, early warning, and climate adaptation? This special collection in Advances in Atmospheric Sciences seeks answers on the path to greater resilience.

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Credit: Advances in Atmospheric Sciences




As the one-year anniversary of the devastating early January 2025 wildfires in Los Angeles approaches, a pressing question remains: what made these fires, among the most destructive in the region's history, so extreme? New research now provides a quantifiable answer, pinpointing the critical role of combined high temperatures and drought conditions.

Global climate change is intensifying extreme weather events like heatwaves and droughts, which in turn are altering the frequency, intensity, and spatial patterns of wildfires worldwide. In early January 2025, catastrophic wildfires erupted in the Los Angeles region, causing severe societal and environmental impacts. The mechanisms behind their unprecedented ferocity, particularly the contribution of meteorological conditions, have been unclear.

To address this, an international team of scientists from the Institute of Atmospheric Physics at the Chinese Academy of Sciences, Nanjing University of Information Science and Technology, and the University of Wisconsin-Madison investigated the fires’ characteristics. They used a Copula-based Bayesian probability framework to quantify how "hot drought" conditions influenced the likelihood of such an event.

Their study, published in Advances in Atmospheric Sciences, reveals that the 2025 Los Angeles wildfires represent a roughly once-in-67-year event for the region's typical rainy season. The fires were primarily driven by compound hot and dry conditions. The analysis shows that the extreme drought during the fire period increased the probability of wildfires with similar intensity and burned area by 54% and 75%, respectively. When compounded by high temperatures, these probabilities were dramatically amplified further—by 149% for intensity and 210% for burned area.

Beyond hot drought, other factors converged to fuel the disaster. Above-average precipitation in the late winters of 2023 and 2024 promoted abundant vegetation growth. This was followed by an extended period of hot, dry conditions that desiccated this vegetation, creating ample fuel. Additionally, strong, dry Santa Ana winds played a significant role in fire spread. Compared to weak wind conditions, strong winds increased the probability of such severe fires under hot-drought scenarios by 119% for intensity and 387% for burned area.

"Our findings indicate a sharply increasing risk of large, intense wildfires under hot drought conditions, even outside the traditional fire season," said lead author Dr. Feng Ma. "This highlights an urgent need for enhanced attention and adaptive response strategies for year-round wildfire risk in a changing climate."

The research underscores how climate change and variability is creating novel and dangerous fire weather scenarios, extending risk into seasons historically considered less vulnerable.

The research team includes: Feng Ma from Nanjing University of Information Science and Technology; Xing Yuan from the Institute of Atmospheric Physics, Chinese Academy of Sciences; and Jason A. Otkin from the University of Wisconsin-Madison.

The study is part of an ongoing special collection on the 2025 LA wildfires organized by Advances in Atmospheric Sciences .  The collection is dedicated to advancing the science of wildfire diagnosis, early warning, and climate services, and is actively inviting further submissions.