Friday, June 26, 2020

Both the famous Hope diamond and British Crown Jewel diamonds, may be "super-deep"

GOLDSCHMIDT CONFERENCE
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IMAGE: AN ANALYSIS OF THE FIRST LARGE DIAMONDS CONFIRMED TO COME FROM DEEP UNDER THE EARTH'S SURFACE SUPPORTS INITIAL PREDICTIONS SHOWING THAT THE SMITHSONIAN'S FAMOUS HOPE DIAMOND MAY BE "SUPER... view more 
CREDIT: PHOTO COURTESY OF THE SMITHSONIAN INSTITUTION
An analysis of the first large diamonds confirmed to come from deep under the Earth's surface supports initial predictions showing that the Smithsonian's famous Hope diamond may be "super deep", originating from more than three times deeper in the Earth than most diamonds. It also suggests, in a new finding, that the "Crown Jewels" Cullinan diamond may also be a super-deep diamond.
Presenting the work at the Goldschmidt geochemistry conference, Dr Evan Smith of the Gemological Institute of America (GIA) confirmed: "We examined the first large gem diamonds confirmed to originate from Earth's lower mantle, which is several times deeper than most other diamonds. The results support earlier predictions based on smaller gems, suggesting that diamonds with properties similar to those studied, including both the Cullinan and Hope diamonds, are super-deep diamonds".
Diamonds are formed under high pressure in the Earth's mantle, the middle layer between the surface crust and the central core. While the majority of diamonds form in the base of the continental tectonic plates, at depths of 150-200 km, some rare diamonds form deeper in the mantle. These "super-deep" diamonds originate beneath the rigid and stable continental plates, down where the mantle is slowly moving, or convecting. The Hope diamond is classified as a type IIb diamond, which contains the element boron, which can cause a blue tinge. Until now there has been uncertainty over whether "type IIb" diamonds formed in a shallow or deep environment. In particular, the uncertainty revolves around the origin of large type IIb diamonds, larger than 3 carats (about the size of a pea). It is only within the past couple of years that scientist have begun to understand where in the Earth these dazzling blue crystals form.
Now researchers Drs Evan Smith and Wuyi Wang, working at the GIA laboratory in New York, have detected the remains of the mineral bridgmanite in a large type IIb diamond. Smith said:
"Finding these remnants of the elusive mineral bridgmanite is significant. It's very common in the deep Earth, at the extreme pressure conditions of the lower mantle, below a depth of 660 km, even deeper than most super deep diamonds. Bridgmanite doesn't exist in the upper mantle, or at the surface. What we actually see in the diamonds when they reach surface is not bridgmanite, but the minerals left when it breaks down as the pressure decreases. Finding these minerals trapped in a diamond means that the diamond itself must have crystallized at a depth where bridgmanite exists, very deep within the Earth".
Smith examined a large, 20 carat type IIb blue diamond from a mine in South Africa. By aiming a laser at the tiny inclusions trapped inside this diamond they found that the way the light scattered (using a Raman spectrometer) was characteristic of bridgmanite breakdown products.
He said "We also examined a large 124 carat diamond from the Letseng mine in Lesotho. This diamond, which is around the size of a walnut, is very pure, containing no nitrogen in its crystal structure, and is known as a "CLIPPIR" diamond. This is from the same class of diamond as the famous Cullinan Diamond, which is now the centrepiece of the British Crown Jewels. This large diamond showed the same characteristic bridgmanite breakdown products, meaning that it too had been formed as a super-deep diamond. What is special about this one is that it is the first CLIPPIR diamond for which we can firmly assign a lower mantle origin, that is, below 660 km. Previously, we had known that CLIPPIR diamonds are super-deep and speculated that their depth of origin might span 360 to 750 km depth, but we hadn't actually seen any that were definitely from the deeper end of this window. This gives us a better idea of exactly where CLIPPIR diamonds, such as the Crown Jewel diamonds, come from. What we have learned here is that there is some overlap in the birthplace for CLIPPIR diamonds, such as the Cullinan, and type IIb diamonds, such as the Hope. This is the first time this has been found".
Boron-rich type IIb diamonds, such as the Hope diamond, are rare; less than 1 in a thousand diamonds being classified as type IIb.
"Discovering the deep mantle origin means that the material in these diamonds undergoes a remarkable journey. We believe that the boron, which give the Hope diamond it's characteristic blue color, originates from the bottom of the oceans. From there, plate tectonics drags it hundreds of kilometres down into the mantle, where it can be incorporated into diamond. It shows that there is a gigantic recycling route that brings elements from Earth's surface down into the Earth, and then occasionally returns beautiful diamonds to the surface, as passengers in volcanic eruptions".
Commenting, Dr Jeff Post, Curator-in-Charge of Gems and Minerals at the Smithsonian's National Museum of Natural History, said "This fascinating work confirms that the Hope Diamond is extraordinary and special, and truly one of Earth's rarest objects ".
Dr Christopher Beyer, of the Ruhr University, Bochum, Germany commented: "The discovery of remnants of bridgmanite break-down products in large gem-quality diamonds shows that inclusions in diamonds are capsules which come to us from otherwise inaccessible deep Earth. In addition, the unique signature of boron in type IIb diamonds supports the theory of whole mantle convection with subducting slabs descending into Earth's lower mantle. Diamonds crystallize from a fluid, so further studies are now needed to track down the fluid composition and the conditions that facilitate the growth of these rare large diamonds".
NOTE: Neither Dr Post nor Dr Beyer were involved in this work, these are independent comments.
The Goldschmidt Conference thanks the Smithsonian Museum of Natural History for their assistance in preparing this press notice.
The Goldschmidt Conference is the world's main geochemistry conference, hosted by the Geochemical Society and the European Association of Geochemistry. Held annually, it covers such material as climate change, astrobiology, planetary and stellar development and conditions, chemistry of Earth materials, pollution, the undersea environment, volcanoes, and many other subjects. For 2020 the scheduled Hawaii congress has been moved online, and takes place from 21-26 June, see https://goldschmidt.info/2020/index. Future congresses are in Lyon, France (2021) and the rescheduled Hawaii congress (2022).

NRL telescope onboard ESA, NASA SOHO discovers 4000th comet

NAVAL RESEARCH LABORATORY
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IMAGE: COURTESY PHOTO | THE 4,000TH COMET DISCOVERED BY ESA (EUROPEAN SPACE AGENCY) AND NASA'S SOHO OBSERVATORY IS SEEN HERE IN AN IMAGE FROM THE SPACECRAFT ALONGSIDE SOHO'S 3,999TH COMET DISCOVERY.... view more 
CREDIT: ESA/NASA/SOHO/KARL BATTAMS
WASHINGTON -- The U.S. Naval Research Laboratory's Large Angle Spectrometric Coronagraph (LASCO) instrument identified the 4000th comet discovered by the Solar and Heliospheric Observatory (SOHO), a joint mission between the European Space Agency and NASA on June 15.
LASCO, which is aboard SOHO, was developed in 1995 to see the extremely faint emission from the region around the Sun called the corona. Operating in space for nearly 25 years, the telescope has seen much more space action than researchers originally anticipated -- discovering well over half of all known comets.
"In less than 25 years SOHO has added this huge volume to the archives of our comet knowledge, and it comes from a telescope not designed to see comets," said Karl Battams, NRL computational scientist. "This is exciting for many reasons, but perhaps mostly because LASCO is discovering comets that are otherwise completely unobservable from Earth due to their proximity to the Sun."
The majority of the comet discoveries were made by amateur astronomers who participated in the NASA-funded and NRL-managed Sungrazer project, which encourages citizen scientists to peruse imagery from SOHO and the Sun-Earth Connection Coronal and Heliospheric Investigation (SECCHI) instrument suite on the NASA Solar Terrestrial Relations Observatory (STEREO) and search for previously unknown comets. New comet findings are reported through the website, and subsequently verified and measured by Battams, who has led this Project since 2003.
"The people who discovered these comets were not necessarily professional astronomers, they were people at home," Battams said. "People of all ages, backgrounds, and countries have volunteered their time to be a part of this citizen science project. The 4000th comet is a testament to the invaluable input from so many volunteers all around the world over the past two decades."
The Navy has a unique interest in the Sun and near -Sun environment. Much of the Navy's equipment, and equipment we use every day, such as GPS, is impacted by the Sun. Studying comets traveling near the Sun helps researchers gain a greater understanding of Earth's closest star, as they observe the comets reacting to its extreme environment.
Battams is a computational scientist and astrophysicist within the Solar and Heliospheric Physics Branch under the Space Sciences division at NRL. The mission of this Branch is to develop improved heliospace environment understanding, awareness, sensors, forecast capabilities, and monitoring tools that predict operational impacts and enable real-time threat warning; and transition these developments to support the Navy/Marine Corps and other agencies.
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About the U.S. Naval Research Laboratory
NRL is a scientific and engineering command dedicated to research that drives innovative advances for the Navy and Marine Corps from the seafloor to space and in the information domain. NRL is located in Washington, D.C., with major field sites in Stennis Space Center, Mississippi; Key West, Florida; and Monterey, California, and employs approximately 2,500 civilian scientists, engineers and support personnel.
MIGHT AS WELL TRY ANYTHING FOR AN 'INCURABLE' VERY PAINFUL DISEASE

Survey: Alternative medicine is widespread among people with MS

Oregon survey finds growing acceptance of complementary and alternative medicine
OREGON HEALTH & SCIENCE UNIVERSITY

A new survey of more than 1,000 people with multiple sclerosis finds that an overwhelming majority use complementary and alternative medicine, with many using cannabis.
Researchers at Oregon Health & Science University conducted the survey of people in Oregon and Southwest Washington in 2018. The results were published recently in the journal Multiple Sclerosis and Related Disorders.
The survey found that patients are nine times more likely to talk with their neurologist about the use of alternative therapies than patients in a similar survey conducted in 2001, a sign of broader societal acceptance of treatments beyond conventional medications. In the years since the first survey, several conventional medications have become available to manage MS-related disease activity.
Even so, patients appear to be more inclined to use alternatives such as dietary supplements, despite limited evidence of their effectiveness.
"The use of these alternative supplements has remained high even though we have all these other treatment modalities," said lead author Elizabeth Silbermann, M.D., a fellow in neurology in the OHSU School of Medicine.
Key findings:
  • 81% used dietary supplements such as vitamins, minerals and herbs, up from 65% in the same survey conducted almost two decades ago.
  • 39% used mind-body therapies such as mindfulness and massage, up from 14% in the earlier survey.
  • 81% used exercise to help manage their symptoms - an increase from 67% in 2001.
The use of cannabis was common among respondents in the new survey, with about 30% reporting that they've used it in a variety of forms. Although cannabis remains an illegal substance under federal law, voters in recent years legalized it in both Oregon and Washington state.
Even though traditional uses of alternative therapies such as botanical supplements dates back hundreds of years, scientific research generally has been limited. Silbermann said it's a positive sign that patients are more open to discussing their use of alternatives with their neurologist because it's important to manage interactions with conventional medications.
"There's been a change in culture between patients and providers over the past 20 years," Silbermann said. "It's less paternalistic and more of a partnership."
More research is needed so that neurologists can tell patients what does and doesn't help their MS, she said. About 85% of the respondents reported mild or moderate disability.
Senior author Rebecca Spain, M.D., M.S.P.H., associate professor of neurology in the OHSU School of Medicine, said she was gratified the survey reflected patients' comfort and openness in sharing their full experience with their doctors. She said that may be due in part to OHSU's well-established reputation as an academic health center that supports patients' use of complementary and alternative medicine, or CAM.
"Patients' openness in sharing the whole picture of what CAM they're taking has allowed us to better understand and effectively care for our patients with MS," Spain said.
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This research was supported by the National Multiple Sclerosis Society, award R-1705-27,628, and the National Center for Advancing Translational Sciences of the National Institutes of Health, through grant award number UL1TR002369

Maryland offshore wind farm could become stop-over for migrating sturgeon, striped bass

UNIVERSITY OF MARYLAND CENTER FOR ENVIRONMENTAL SCIENCE
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IMAGE: RESEARCHER ELLIE ROTHERMEL CONFIGURES AN ACOUSTIC RECEIVER OFF COAST OF OCEAN CITY, MARYLAND, TO MONITOR TO THE MOVEMENT OF ATLANTIC STURGEON AND STRIPED BASS OFF THE DELMARVA COASTLINE. view more 
CREDIT: UNIVERSITY OF MARYLAND CENTER FOR ENVIRONMENTAL SCIENCE/MIKE O'BRIEN
SOLOMONS, MD (June 23, 2020)--For the endangered Atlantic sturgeon and the commercially and recreationally important striped bass, the Delaware-Maryland-Virginia coastal shelf serves as an important spring and fall "flyway." Typically thought of as an established aerial route used by migratory birds to travel between feeding and breeding grounds, a recent study by scientists at the University of Maryland Center for Environmental Science applies the term to fish species of concern. Authors suggest that the development of wind farms on the Delmarva coastal shelf, 17-26 miles from Ocean City's shoreline, may alter the migratory behavior of these fish as new wind turbines in this otherwise featureless region could create habitat around which fish linger.
Studies within the Maryland Wind Energy Area--the coastal shelf waters leased by the Bureau of Ocean Energy Management for offshore wind farms--prior to construction activities reveal that Atlantic sturgeon and striped bass are frequent visitors. Seasonal trends lead scientists to believe that the wind energy area lies within an important migration corridor for both species. Atlantic sturgeon were most commonly observed moving through the area during the spring and fall, while striped bass had an increased migratory presence in spring and winter. The Atlantic sturgeons' "flyway" tended to favor shallower, warmer waters, while striped bass were more likely to be found at great depths and cooler conditions.
Both species spent longer periods of time in the corridor during the autumn and winter. This trend was particularly strong for striped bass, with many individuals prolonging their presence on the outer shelf during winter. However, during the summer, Atlantic sturgeon were rarely detected and striped bass were absent.
The construction of an off-shore wind farm creates loud noises and increased activity that can disrupt typical animal behaviors. The low occurrence of these important fish species during the summer months suggests a potential window for wind turbine construction, when impacts could be minimized.
"Scientists have learned a lot about the Atlantic sturgeon and striped bass' seasonal patterns of habitat selection within spawning rivers, estuaries, and shelf foraging habitats," says study author Ellie Rothermel, who recently received her master's degree from the University of Maryland Center for Environmental Science. "During these times, we know where the fish are likely to be and when to expect them there, but information on the location and timing of key coastal migrations is limited. Coastal waters have been largely inaccessible to scientists. Our study uses acoustic telemetry to understand the critical migratory periods in the lives of these fish species."
Rothermel compares acoustic telemetry to the E-ZPass system used for vehicles. When a car with E-ZPass is driven over the Bay Bridge, a toll booth collects its identification number, along with the time and date. Just like toll booths and the E-Z Pass system, scientists use acoustic receivers and tags to track where fish go, and when they go there.
After catching and determining the size, weight and sex of a striped bass, scientists surgically implanted an acoustic tag into the fish prior to releasing it. An acoustic tag is a small device, about the size of a thumb, that has a unique ID and makes a "ping" sound every few seconds.
Scientists also deployed 20 acoustic receivers in the Maryland Wind Energy Area. When a tagged fish swims past a receiver, a listening device about the size of a liter soda bottle, the receiver records the "ping" sent out by the tag. Each "ping" transmits its unique ID and the depth at which the fish was swimming to the receiver, which also records the time and date. The array of receivers allows scientists to monitor the movements of tagged fish. During the study, "pings" from 352 individual Atlantic sturgeon and 315 individual striped bass were recorded by receivers.
Scientists believe that Maryland's future offshore wind farm could become a stop-over region where striped bass and sturgeon might linger longer. The DelMarVa coastal shelf is a fairly barren area. The development of high relief wind turbines would provide structure around which fish may gather and linger during migrations.
"To extend the highway travel metaphor, the wind farm that will be built in the area off-shore from Ocean City may become a 'rest stop' where fish and sharks can grab a bite to eat and take a break before resuming their travels," says study co-author Dave Secor of the University of Maryland Center for Environmental Science.
As wind farms are developed and operated offshore of the Mid-Atlantic and Southern New England regions, which together comprises a multispecies "flyway," scientists could use the telemetry array design to monitor potential impacts. Cooperation among researchers, expanded scale of acoustic telemetry arrays, and increased incorporation of oceanographic data will improve understanding of how fishes will respond to wind energy development in the northwest Atlantic Ocean.
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Project funding was provided by U.S. Department of the Interior's Bureau of Ocean Energy Management (BOEM), Office of Renewable Energy Programs.
The study "Comparative migration ecology of striped bass and Atlantic sturgeon in the US Southern mid-Atlantic bight flyway" was published in PLOS ONE.
UNIVERSITY OF MARYLAND CENTER FOR ENVIRONMENTAL SCIENCE
A globally eminent research and graduate institution focused on advancing scientific knowledge of the environment, the University of Maryland Center for Environmental Science provides sound advice to help state and national leaders manage the environment and prepares future scientists to meet the global challenges of the 21st century.

New data reveals even low levels of air pollution triggers gene expression

MONASH UNIVERSITY
New data from a landmark study by Monash University researchers raises concerns that even short-term exposure to low level air pollution can affect gene expression, leaving us at risk of diseases such as cancer, cardiovascular and respiratory diseases.
It has long been known that exposure to air pollution, including the widespread smoke events of the last Summer in Australia, can lead to short term health problems such as respiratory distress. It is also known that, longer term, exposure to air pollutants leads to oxidative stress and issues like an increased risk of cardiovascular disease. Now the American Lung Association has warned that there is a risk of increased infections if and when a region's pollution spikes - as happened when the Summer bushfires occurred in Australia.
The study, published in the PLOS Medicine, provides the first evidence that exposure to even very low levels of air pollution can change gene expression that are the hallmark of diseases such as cancer.
Led by Associate Professor Yuming Guo from the Monash School of Public Health and Preventive Medicine, and colleagues at Nagasaki University in Japan and Cambridge University in the UK, the study involved blood samples from 266 pairs of twins (192 identical and 74 non identical) as well as 165 parents in Brisbane over periods from 2005 to 2010. The volunteers are part of the Brisbane System Genetics Study.
The periods when the blood samples were taken were matched to data from seven air quality monitoring stations around Brisbane at that time, to measure the levels of exposure to PM2.5 (the main particulate matter in smoke) and sulphur dioxide (the main gaseous pollutant).
The researchers studied expression in six genes associated with oxidative stress and inflammation, which have long been considered important features of disease processes initiated by pollutants and found that even the low levels of air pollution experienced in Brisbane led to change of gene expression associated with morbidity and mortality in the longer term.
The latest study is further evidence that exposure to air pollutants, even at low levels, has long term health consequences, which has real life implications for the current the COVID-19 pandemic according to Associate Professor Guo. "This is the first evidence as to how exactly exposure to low levels of air pollution actually alters our gene expression which in turn impacts our health," he said.
"Combined with the global consequences of COVID-19 and its impact on respiratory health there is even a greater need to be conscious of limiting our exposure to air pollution."
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Countries with early adoption of face masks showed modest COVID-19 infection rates

AMERICAN THORACIC SOCIETY
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IMAGE: EARLY FACE MASK ADOPTION LINKED TO MODEST INFECTION RATES. view more 
CREDIT: ATS
June 24, 2020 - Regions with an early interest in face masks had milder COVID-19 epidemics, according to a new letter-to-the-editor published in the American Journal of Respiratory and Critical Care Medicine.
In "COVID-19 and Public Interest in Face Mask Use," researchers from the Chinese University of Hong Kong shared findings from their analysis of how public interest in face masks may have affected the severity of COVID-19 epidemics and potentially contained the outbreak in 42 countries in 6 continents.
The authors noted that "In many Asian countries like China and Japan, the use of face masks in this pandemic is ubiquitous and is considered as a hygiene etiquette, whereas in many western countries, its use in the public is less common."
There was a clear negative correlation between the awareness or general acceptance of wearing a face mask and its infection rates. "One classic example is seen in Hong Kong," said Sunny Wong, MD, associate professor, Department of Medicine and Therapeutics, The Chinese University of Hong Kong.
"Despite [Hong Kong's] proximity to mainland China, its infection rate of COVID-19 is generally modest with only 1,110 cases to-date. This correlates with an almost ubiquitous use of face masks in the city (up to 98.8 percent by respondents in a survey). Similar patterns are seen in other Asian areas, such as Taiwan, Thailand and Malaysia. To date, there are more than two million cases in the U.S. and more than one million cases in Brazil.
While, the authors acknowledge that face masks are seen as important in slowing the rise of COVID-19 infections, it is difficult to assess whether it is more effective than handwashing or social distancing alone.
As cities in the U.S. and elsewhere put re-opening plans into effect, Dr. Wong said the use of face masks should be encouraged: "Face masks can help slow the spread of COVID-19, and have a relatively low cost compared to the health resources and death toll associated with the pandemic".
He added, "We believe that face mask use, hand washing and social distancing are all important components of the non-pharmaceutical measures against COVID-19."
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About the American Journal of Respiratory and Critical Care Medicine
The AJRCCM is a peer-reviewed journal published by the American Thoracic Society. The Journal takes pride in publishing the most innovative science and the highest quality reviews, practice guidelines and statements in pulmonary, critical care and sleep medicine. With an impact factor of 16.494, it is one of the highest ranked journals in pulmonology. Editor: Jadwiga Wedzicha, MD, professor of respiratory medicine at the National Heart and Lung Institute (Royal Brompton Campus), Imperial College London, UK.
About the American Thoracic Society
Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy. The ATS publishes four journals, the American Journal of Respiratory and Critical Care Medicine, the American Journal of Respiratory Cell and Molecular Biology, the Annals of the American Thoracic Society, and ATS Scholar.
BIOPHAGES VS COVID-19

Bacterial predator could help reduce COVID-19 deaths

UNIVERSITY OF BIRMINGHAM
A type of virus that preys on bacteria could be harnessed to combat bacterial infections in patients whose immune systems have been weakened by the SARS-CoV-2 virus that causes the COVID-19 disease, according to an expert at the University of Birmingham and the Cancer Registry of Norway.
Called bacteriophages, these viruses are harmless to humans and can be used to target and eliminate specific bacteria. They are of interest to scientists as a potential alternative to antibiotic treatments.
In a new systematic review, published in the journal Phage: Therapy, Applications and Research, two strategies are proposed, where bacteriophages could be used to treat bacterial infections in some patients with COVID-19.
In the first approach, bacteriophages would be used to target secondary bacterial infections in patients' respiratory systems. These secondary infections are a possible cause of the high mortality rate, particularly among elderly patients. The aim is to use the bacteriophages to reduce the number of bacteria and limit their spread, giving the patients' immune systems more time to produce antibodies against SARS-CoV-2.
Dr Marcin Wojewodzic, a Marie Sk?odowska-Curie Research Fellow in the School of Biosciences at the University of Birmingham and now researcher at the Cancer Registry of Norway, is the author of the study. He says: "By introducing bacteriophages, it may be possible to buy precious time for the patients' immune systems and it also offers a different, or complementary strategy to the standard antibiotic therapies."
Professor Martha R.J. Clokie, a Professor of Microbiology at the University of Leicester and Editor-in-Chief of PHAGE journal explains why this work is important: "In the same way that we are used to the concept of 'friendly bacteria' we can harness 'friendly viruses' or 'phages' to help us target and kill secondary bacterial infections caused by a weakened immune system following viral attack from viruses such as COVID-19".
Dr Antal Martinecz, an expert in computational pharmacology at the Arctic University of Norway who advised on the manuscript says: "This is not only a different strategy to the standard antibiotic therapies but, more importantly, it is exciting news relating to the problem of bacterial resistance itself."
In the second treatment strategy, the researcher suggests that synthetically altered bacteriophages could be used to manufacture antibodies against the SARS-CoV-2 virus which could then be administered to patients via a nasal or oral spray. These bacteriophage-generated antibodies could be produced rapidly and inexpensively using existing technology.
"If this strategy works, it will hopefully buy time to enable a patient to produce their own specific antibodies against the SARS-CoV-2 virus and thus reduce the damage caused by an excessive immunological reaction," says Dr Wojewodzic.
Professor Martha R.J. Clokie's research focuses on the identification and development of bacteriophages that kill pathogens in an effort to develop new antimicrobials: "We could also exploit our knowledge of phages to engineer them to generate novel and inexpensive antibodies to target COVID-19. This clearly written article covers both aspects of phage biology and outlines how we might use these friendly viruses for good purpose."
Dr Wojewodzic is calling for clinical trials to test these two approaches.
"This pandemic has shown us the power viruses have to cause harm. However, by using beneficial viruses as an indirect weapon against the SARS-CoV-2 virus and other pathogens, we can harness that power for a positive purpose and use it to save lives. The beauty of nature is that while it can kill us, it can also come to our rescue." adds Dr Wojewodzic.
"It's clear that no single intervention will eliminate COVID-19. In order to make progress we need to approach the problem from as many different angles and disciplines as possible." concludes Dr Wojewodzic.
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Notes to editor:
* The University of Birmingham is ranked amongst the world's top 100 institutions. Its work brings people from across the world to Birmingham, including researchers, teachers and more than 6,500 international students from over 150 countries.
* Wojewodzic (2020). '' Bacteriophages could be a potential game changer in the trajectory of coronavirus disease (COVID-19). PHAGE: Therapy, Applications, and Researchhttps://www.liebertpub.com/doi/10.1089/phage.2020.0014





First comparison of dangers of tobacco cigarettes, e-cigarettes and waterpipes

Any smoking and vaping technique may increase risk of COVID-19 infection and death
EUROPEAN SOCIETY OF CARDIOLOGY


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IMAGE: IMAGE SHOWS TOXIC COMPOUNDS, DISEASE MECHANISMS, CLINICAL OUTCOMES AND ADVERSE HEALTH EFFECTS ASSOCIATED WITH TOBACCO CIGARETTES, E-CIGARETTES AND WATERPIPES. view more 
CREDIT: EUROPEAN HEART JOURNAL
Smoking and vaping, whether by means of tobacco cigarettes, e-cigarettes or waterpipes, stiffens the arteries, causes inflammation and damages DNA, leading to a variety of health problems, according to a study published today (Friday) in the European Heart Journal [1].
In addition, smoking and vaping may increase the risk of people being infected by COVID-19, suffering worse symptoms and dying from it, say the researchers. They join the World Health Organization (WHO), the US Centers for Disease Control and Prevention, the Food and Drug Administration and the European Society of Cardiology in urging smokers to try to give up the habit, regardless of which smoking method they use.
The study is the world's first comparison of the effects of the three forms of smoking and vaping on human health and the function of cells that line blood vessels (the endothelium). It provides an overview of the available evidence about the harmful chemicals produced and the mechanisms by which smoking and vaping affect the body. The researchers also looked at the effects of each on medical conditions ranging from stroke to heart attacks and lung cancer.
The researchers found there were multiple good studies showing that, overall, tobacco cigarettes were more harmful than e-cigarettes. However, there were few good, large studies about the adverse effects of waterpipes (often referred to as hookahs, shisha or narghile) and e-cigarettes on endothelial dysfunction and so the evidence was more variable. The researchers say the long-term effects of water pipes and e-cigarettes need to be investigated more thoroughly. In the meantime, they write, "waterpipe smoking is not less harmful than tobacco smoking and thus cannot be considered a healthy alternative".
The researchers reviewed a range of studies, which they graded as providing strong, good or medium levels of evidence on the harmfulness of the three types of smoking and vaping [2]. Compared to non-smokers, tobacco cigarettes increased the risk of chronic obstructive pulmonary disease (COPD) by 704% (good level of evidence), waterpipes by 218% (strong) and e-cigarettes by 194% (good); tobacco cigarettes and waterpipes increased the risk of lung cancer by 1210% (strong) and 122% (strong) respectively, while the level of evidence for e-cigarettes was not sufficient to draw reliable conclusions.
They also looked at how much the three smoking techniques stiffened the arteries, an important prognostic indicator for the risk of heart problems and stroke. Compared to non-smokers, tobacco cigarettes increased arterial stiffness by 10%, waterpipes by 9% and e-cigarettes by 7% (medium level of evidence for all three).
The first author of the review, Professor Thomas Münzel, of the Department of Cardiology of the University Medical Centre Mainz in Mainz, Germany, said: "Our review focuses primarily on the adverse effects of these three smoking and vaping techniques on endothelial dysfunction and the relation to oxidative stress and, secondly, on clinical disease. All three forms of smoking and vaping lead to increased production of oxygen-derived free radicals in blood vessel tissue, such as superoxide. This breaks down nitric oxide, which is released by the endothelium, and is important for helping blood vessels to dilate and for protecting against inflammation and clogging of the arteries."
The researchers say the main toxic chemicals in e-cigarette vapour include formaldehyde and acrolein, as well as traces of chemicals called transition metals and volatile organic compounds (VOCs), all of which are known to damage cells. In contrast, tobacco cigarettes and waterpipe smoke contain a much more complex mixture of harmful chemicals and other substances. Waterpipe smoke contains solid particulate matter, originating mainly from the charcoal used to burn the tobacco; this is also present in lower concentrations in cigarette smoke. Nicotine is present in all three tobacco products, is addictive and is responsible for harmful biological effects as well as, to a minor extent, some beneficial effects.
Prof. Münzel said: "These different as well as overlapping profiles of toxic compounds may be a key to understand the similarities and differences in the adverse health effects of smoking and vaping, and should be further investigated in detail by future studies."
The researchers looked at the effects of smoking and vaping on COVID-19 infections. In the EHJ paper, they write: "As outlined by the WHO, tobacco cigarette and waterpipe smoking may contribute to increased burden of symptoms due to COVID-19 compared to non-smoking, including being admitted to intensive care, requiring mechanical ventilation, and suffering severe health consequences."
They conclude: "There is no doubt...that smoking cessation is and will remain the most powerful approach to prevent smoking-induced cardiovascular and respiratory disease. This may be even more important in light of the...COVID-19 pandemic as the use of tobacco products likely increases the risk for COVID-19 associated cardiovascular and other severe complications in smokers and vapers."
Prof. Münzel said: "Given the well-established harms associated with tobacco use and second-hand smoke exposure, the WHO recommends that tobacco users should quit. Proven interventions to help users give up include toll-free quit lines, mobile text-messaging cessation programmes, nicotine replacement therapies and other approved medications, particularly if you have smoked for a long time, and especially if you use tobacco cigarettes and water pipes.
"The WHO also warns that although e-cigarettes appear to be less harmful than tobacco cigarettes, there is growing evidence that they also may cause side effects in the lungs, heart and blood vessels and that e-cigarette use may increase the risk of COVID-19 infection."
The authors also address the issue of tobacco advertising. In the EU, TV and radio advertising of cigarettes, and tobacco products is not permitted. Some countries, such as Slovenia and Norway, have strict laws that ban all types of advertising, even at the point of sale. Germany is the only EU country where tobacco products, including e-cigarettes, can be advertised in public spaces via billboards. In the US, advertising of both tobacco products and e-cigarettes on billboards is allowed. The EHJ study includes maps to show where in the world e-cigarette sales are legal, and where in Europe advertising permitted.
Prof. Münzel said: "E-cigarettes are mostly considered as tobacco products, but the regulations on their advertising are not always clear."
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Notes:
[1] "Effects of tobacco cigarettes, e-cigarettes and waterpipe smoking on endothelial function and clinical outcome", by Thomas Münzel et al. European Heart Journal. doi:10.1093/eurheartj/ehaa460
[2] Examples of studies that provided strong evidence (shown as +++ in Figure 1 in the paper) were large meta-analyses; studies providing "good" evidence (++) were single studies with over 1,000 participants; and studies providing "medium" evidence (+) were single studies with fewer than 1,000 participants.


SO I HAVE TO ASK THE RHETORICAL QUESTION, IF THIS IS THE FIRST SUCH STUDY ON WHAT BASIS DID THE CITY OF EDMONTON DECIDE TO PASS A BYLAW BANNING WATER PIPE BARS AN LOUNGES, SHISHA BARS, POPULAR AMONG LEBANESE AND SYRIANS IN THE CITY.

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Edmonton looks at banning shisha lounges as early as July 2020. Edmonton will be following several Canadian cities in its clampdown on smoking shisha in lounges. In 2016, Toronto passed a bylaw banning the use of water pipes in all licensed establishments.Aug 27, 2019
Edmonton's ban on indoor shisha smoking to come into effect ...
https://www.thestar.com › edmonton › 2019/08/27 › edmontons-ban-on-in...


City proposes full ban on shisha lounges by 2021 | Edmonton ...
https://edmontonjournal.com › news › local-news › city-recommends-regu...

Jun 22, 2019 - Hookah bar business owners advocated for a transition period of four to five years before the ban is put in place, to recover costs associated with ...

Shisha lounges and city reach 12-month compromise on ...
https://edmontonjournal.com › news › local-news › it-will-be-detrimental-t...


Jun 26, 2019 - City council will vote to ban shisha lounges in Edmonton effective July ... Wednesday as shisha lounges offered to end hookah and water pipe ...
European police used racial discrimination when enforcing coronavirus lockdowns: Amnesty International

Amnesty International has said police in Europe demonstrated racial discrimination when implementing lockdowns.


Police forces across Europe were marred by systemic racism when implementing coronavirus lockdown measures, Amnesty International said in a report published on Wednesday.

The non-governmental organization which focuses on human rights said that while enforcing lockdowns, police across 12 European countries "disproportionately targeted ethnic minority and marginalized groups with violence, discriminatory identity checks, forced quarantines and fines."

Read more: Activists call for amnesty as COVID-19 spreads in Russian jails

The investigation revealed "a disturbing pattern of racial bias which is linked to concerns about institutional racism within police forces, and echoes wider concerns raised in the ongoing Black Lives Matter protests."

The death of George Floyd on May 25 while in police custody in Minneapolis sparked protests around the world and "highlighted the pervasiveness of discriminatory policing and impunity in Europe as well," the report added.


"THEY AREN'T PROTESTERS THEY ARE ANARCHISTS 
OR, OR WORSE" 
DONALD TRUMP 23/6/2020

PROTESTS AGAINST RACISM, POLICE BRUTALITY AROUND THE WORLD
Washington, DC
One of the largest rallies in the United States was held in the capital, Washington, DC, where thousands of people of all colors took to the streets near the White House, which was barricaded with black metal grates.  PHOTOS 12345678910

Read more: Blacks in the US targeted by an unfair justice system

Poorer areas subjected to greater crackdowns

The enforcement of lockdowns meant poorer communities were more likely to suffer greater crackdowns, according to Amnesty, and these zones often have a higher proportion of people from ethnic minorities.

In Seine-Saint-Denis, the poorest area of mainland France where the majority of inhabitants are Black or of North African origin, the number of fines handed out for breaching lockdown measures was three times higher than in the rest of the country, Amnesty said. Furthermore, poorer areas were often subjected to longer overnight curfews.

In the UK, police in London registered a 22% rise in stop and searches between March and April of this year. During that same period the proportion of Black people who were searched increased by almost a third.


Roma settlements imposed with militarized quarantines

Meanwhile, discrimination against Roma minorities in Bulgaria and Slovakia was evident during lockdown, the report said. Governments from both countries brought in mandatory quarantines on Roma settlements, for example.

In Slovakia they also tasked the military with enforcing quarantines while Amnesty considers that this option "is not suitable to carry out public health measures."

During mandatory quarantines in Bulgaria, over 50,000 Roma citizens were cut off from the rest of the country and suffered severe food shortages, according to Amnesty's investigations.

The 12 countries covered in the report were Belgium, Bulgaria, Cyprus, France, Greece, Hungary, Italy, Serbia, Slovakia, Romania, Spain and the UK


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