Monday, February 03, 2025

 

MIT engineers help multirobot systems stay in the safety zone


New research could improve the safety of drone shows, warehouse robots, and self-driving cars.




Massachusetts Institute of Technology

Multiagent control 

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MIT engineers developed a training method for multiagent systems, such as large numbers of drones, that can guarantee their safe operation in crowded environments. 

 

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Credit: Image courtesy of Chuchu Fan, Songyuan Zhang and Oswin So, et al




Drone shows are an increasingly popular form of large-scale light display. These shows incorporate hundreds to thousands of airborne bots, each programmed to fly in paths that together form intricate shapes and patterns across the sky. When they go as planned, drone shows can be spectacular. But when one or more drones malfunction, as has happened recently in Florida, New York, and elsewhere, they can be a serious hazard to spectators on the ground. 

Drone show accidents highlight the challenges of maintaining safety in what engineers call “multiagent systems” — systems of multiple coordinated, collaborative, and computer-programmed agents, such as robots, drones, and self-driving cars. 

Now, a team of MIT engineers has developed a training method for multiagent systems that can guarantee their safe operation in crowded environments. The researchers found that once the method is used to train a small number of agents, the safety margins and controls learned by those agents can automatically scale to any larger number of agents, in a way that ensures the safety of the system as a whole. 

In real-world demonstrations, the team trained a small number of palm-sized drones to safely carry out different objectives, from simultaneously switching positions midflight to landing on designated moving vehicles on the ground. In simulations, the researchers showed that the same programs, trained on a few drones, could be copied and scaled up to thousands of drones, enabling a large system of agents to safely accomplish the same tasks. 

“This could be a standard for any application that requires a team of agents, such as warehouse robots, search-and-rescue drones, and self-driving cars,” says Chuchu Fan, associate professor of aeronautics and astronautics at MIT. “This provides a shield, or safety filter, saying each agent can continue with their mission, and we’ll tell you how to be safe.”

Fan and her colleagues report on their new method in a study appearing in the journal IEEE Transactions on Robotics.The study’s co-authors are MIT graduate students Songyuan Zhang and Oswin So as well as former MIT postdoc Kunal Garg, who is now an assistant professor at Arizona State University. 

Mall margins

When engineers design for safety in any multiagent system, they typically have to consider the potential paths of every single agent with respect to every other agent in the system. This pair-wise path-planning is a time-consuming and computationally expensive process. And even then, safety is not guaranteed. 

“In a drone show, each drone is given a specific trajectory — a set of waypoints and a set of times — and then they essentially close their eyes and follow the plan,” says Zhang, the study’s lead author. “Since they only know where they have to be and at what time, if there are unexpected things that happen, they don’t know how to adapt.”

The MIT team looked instead to develop a method to train a small number of agents to maneuver safely, in a way that could efficiently scale to any number of agents in the system. And, rather than plan specific paths for individual agents, the method would enable agents to continually map their safety margins, or boundaries beyond which they might be unsafe. An agent could then take any number of paths to accomplish its task, as long as it stays within its safety margins. 

In some sense, the team says the method is similar to how humans intuitively navigate their surroundings. 

“Say you’re in a really crowded shopping mall,” So explains. “You don’t care about anyone beyond the people who are in your immediate neighborhood, like the 5 meters surrounding you, in terms of getting around safely and not bumping into anyone. Our work takes a similar local approach.” 

Safety barrier

In their new study, the team presents their method, GCBF+, which stands for “Graph Control Barrier Function.” A barrier function is a mathematical term used in robotics that calculates a sort of safety barrier, or a boundary beyond which an agent has a high probability of being unsafe. For any given agent, this safety zone can change moment to moment, as the agent moves among other agents that are themselves moving within the system.  

When designers calculate barrier functions for any one agent in a multiagent system, they typically have to take into account the potential paths and interactions with every other agent in the system. Instead, the MIT team’s method calculates the safety zones of just a handful of agents, in a way that is accurate enough to represent the dynamics of many more agents in the system. 

“Then we can sort of copy-paste this barrier function for every single agent, and then suddenly we have a graph of safety zones that works for any number of agents in the system,” So says. 

To calculate an agent’s barrier function, the team’s method first takes into account an agent’s “sensing radius,” or how much of the surroundings an agent can observe, depending on its sensor capabilities. Just as in the shopping mall analogy, the researchers assume that the agent only cares about the agents that are within its sensing radius, in terms of keeping safe and avoiding collisions with those agents. 

Then, using computer models that capture an agent’s particular mechanical capabilities and limits, the team simulates a “controller,” or a set of instructions for how the agent and a handful of similar agents should move around. They then run simulations of multiple agents moving along certain trajectories, and record whether and how they collide or otherwise interact. 

“Once we have these trajectories, we can compute some laws that we want to minimize, like say, how many safety violations we have in the current controller,” Zhang says. “Then we update the controller to be safer.”

In this way, a controller can be programmed into actual agents, which would enable them to continually map their safety zone based on any other agents they can sense in their immediate surroundings, and then move within that safety zone to accomplish their task. 

“Our controller is reactive,” Fan says. “We don’t preplan a path beforehand. Our controller is constantly taking in information about where an agent is going, what is its velocity, how fast other drones are going. It’s using all this information to come up with a plan on the fly and it’s replanning every time. So, if the situation changes, it’s always able to adapt to stay safe.”

The team demonstrated GCBF+ on a system of eight Crazyflies — lightweight, palm-sized quadrotor drones that they tasked with flying and switching positions in midair. If the drones were to do so by taking the straightest path, they would surely collide. But after training with the team’s method, the drones were able to make real-time adjustments to maneuver around each other, keeping within their respective safety zones, to successfully switch positions on the fly. 

In similar fashion, the team tasked the drones with flying around, then landing on specific Turtlebots — wheeled robots with shell-like tops. The Turtlebots drove continuously around in a large circle, and the Crazyflies were able to avoid colliding with each other as they made their landings. 

“Using our framework, we only need to give the drones their destinations instead of the whole collision-free trajectory, and the drones can figure out how to arrive at their destinations without collision themselves,” says Fan, who envisions the method could be applied to any multiagent system to guarantee its safety, including collision avoidance systems in drone shows, warehouse robots, autonomous driving vehicles, and drone delivery systems.

This work was partly supported by the U.S. National Science Foundation, MIT Lincoln Laboratory under the Safety in Aerobatic Flight Regimes (SAFR) program, and the Defense Science and Technology Agency of Singapore.

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Written by Jennifer Chu, MIT News

Paper: “GCBF+: A Neural Graph Control Barrier Function Framework for Distributed Safe Multi-Agent Control”

https://ieeexplore.ieee.org/document/10842511

 

Bipartisan state of the nation report reveals where US is excelling — and falling behind


The project provides a consensus-based “progress report” for the nation that rises above polarizing headlines and campaign speeches to candidly assess the current state of the country.



Tulane University




The State of the Nation Project, a bipartisan collaboration of former appointees and advisors from the past five presidential administrations, released its first comprehensive "State of the Nation" report to shed light on how the United States is doing in key areas — the economy, education, health, the environment, civic engagement, trust in major institutions — compared to historical trends and peer countries. 

The report, which tracks 37 measures across 15 topics, found stark contrasts in the nation’s global standing in key indicators. The United States excels economically and is improving in poverty reduction. Yet it lags other high-income nations in mental health, life satisfaction, citizenship and democracy, income inequality, trust in institutions, and rates of violence. The country is doing extremely well in some areas and extremely poorly in many others.

The report, funded by Tulane University’s Murphy Institute, provides a consensus-based “progress report” for the nation that rises above polarizing headlines and campaign speeches to candidly assess the current state of the country.

“Ultimately, the goal of the work is to foster progress,” said State of the Nation Project Director Douglas Harris, professor and chair of economics at Tulane University. “Without a clear and accurate diagnosis of the most pressing issues facing the nation, there can be little hope for sensible solutions.”

The report found:

  • Economic Strength: The U.S. economy remains a global powerhouse, maintaining its position as one of the world's largest and fastest-growing economies for over a century. This success is underpinned by consistently high worker productivity, improving education levels relative to competitors, and a culture of innovation and entrepreneurship. While labor force participation has slightly declined, population growth through immigration continues to expand the workforce.
  • Gains at Home, Declines Abroad:  While the trends within the country show improvement in more areas than decline, international standings in key areas faltered. U.S. trends since 1990 show domestic improvement in the economy, education, environment, health and violence reduction, but the nation is declining in citizenship, democracy, life satisfaction, mental health and trust. Internationally, America's position is weakening in environmental protection, physical health and civil liberties, with gains only in economy and education. This suggests that while the U.S. is advancing domestically, it's falling behind global peers. 
  • Disconnect Between Wealth and Well-being: As material wealth and income levels rise, measures of perceived well-being are declining. Mental health indicators and life satisfaction are deteriorating despite economic gains. Social connections are also fraying, with increasing social isolation and eroding trust. This suggests either that other factors are outweighing the positive effects of rising income, or that the current approach to pursuing material prosperity might be directly undermining psychological and social well-being.

The group also polled 1,000 Americans from various regions and political spectrums to gather additional perspectives on the best indicators of national progress. While there were some differences of opinion, the overall findings from both the report’s author are largely consistent with the public’s views. So, while the report shows growing dislike for opposing political parties, the various sides actually agree on more than they think. This realization provides hope for the potential to make tangible progress, Harris said. 

"We embarked on this project to provide a more realistic assessment of how the country is doing," Harris said. “It's noteworthy that such a wide-ranging group could find common ground on how we should gauge our progress. The first step toward moving the nation forward is to gain broad agreement on the real state of the nationThe State of the Nation Project is committed to monitoring these critical measures and engaging the public in dialogues that shape America's future.”

The full report and a detailed breakdown of the findings are available at https://stateofnation.org/

 

Nearly half of adults mistakenly think benefits of daily aspirin outweigh risks



Annenberg Public Policy Center of the University of Pennsylvania

Public knowledge of the risks vs. benefits of a daily low-dose aspirin 

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Among people with no personal or family history of stroke or heart attack, younger adults (18-39) are more aware that for most adults, the risks of taking a daily low-dose aspirin outweigh the benefits. Nearly 3 in 10 (29%) young adults know the risks outweigh the benefits, compared with 7% of adults 60+. Source: Annenberg Public Policy Center's ASAPH survey, November 2024.

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Credit: Annenberg Public Policy Center




For years, healthy older adults were advised by doctors to take a low-dose aspirin daily as a way to reduce the risk of heart attack. But in March 2019, the American College of Cardiology and the American Heart Association (AHA) announced new guidelines and no longer routinely recommended a daily dose of aspirin for healthy adults over the age of 70 because the risk of gastrointestinal bleeding outweighs the benefits.

Nearly five years later, many Americans still have not received the message.

The Annenberg Public Policy Center (APPC) of the University of Pennsylvania finds in a new health survey that nearly half (48%) of U.S. adults incorrectly think that for most adults, the benefits of taking a low-dose aspirin every day to reduce the chance of heart attack or stroke outweigh the risks. In all, nearly 1 in 5 U.S. adults who say they have no personal or family history of heart attack or stroke report routinely taking a low-dose aspirin, with 10% saying they take it “basically every day,” 2% “a few times a week,” and 6% “a few times a month.”

The past rationale for routine low-dose aspirin use was that aspirin acts as a blood thinner and reduces the clotting that can clog arteries and lead to heart attack or stroke. Low-dose aspirin is still considered an important strategy for preventing heart attack in people who have been diagnosed with cardiovascular disease and are not at risk of increased bleeding.

But doctors’ recommendations for healthy adults have shifted on the risks and benefits of taking a low-dose (typically 81 mg.) aspirin. In 2022, three years after the publication of the new AHA guidelines, the U.S. Preventative Services Task Force recommended against starting a new regimen of low-dose aspirin use for the primary prevention of cardiovascular disease for an even larger group of older adults – those 60 and older without a history of cardiovascular disease (including heart failure and stroke) or signs or symptoms of cardiovascular disease.

“Habits backed by conventional wisdom and the past advice of health care providers are hard to break,” noted Kathleen Hall Jamieson, director of the Annenberg Public Policy Center and director of the survey. “Knowing whether taking a low-dose aspirin daily is advisable or not for you is vital health information.” 

Who takes a daily low-dose aspirin?

In the survey, 45% of respondents report that they or someone in their family has had a heart attack or stroke, while 49% do not have a family history of heart attack or stroke (6% are not sure). A 2024 AHA report estimates that 3.1% of Americans age 20 and older have had a heart attack and 3.3% have had a stroke, and over 48% of adults 20 and older have cardiovascular disease, including coronary heart disease, heart failure, stroke or hypertension.

Those with a personal history of heart attack or stroke may be directed to take a low-dose daily aspirin by their doctors. Those 40- to 59-year-olds who have a 10% or greater 10-year cardiovascular risk also may be directed to take aspirin, in line with the recommendations. Still, the survey finds that 18% of those with no history of heart attack or stroke report regularly taking a daily low-dose aspirin and 43% of this no-history group say that for most adults, the benefits of doing so outweigh the risks.

Among the group with no history, younger survey respondents are more likely to correctly report that the risks outweigh the benefits – possibly because older respondents are more familiar with the earlier guidance. Twenty-nine percent of respondents with no relevant medical history who are 18 to 39 years old correctly say that the risks of a daily aspirin outweigh the benefits, compared with 11% of those 40 to 59 years old and 7% of those 60 and older.


Among U.S. adults with no personal or family history of heart attack or stroke, over 1 in 4 people age 60 and up report regulary taking low-dose aspirin to reduce their risk of heart attack or stroke. Source: Annenberg Public Policy Center's ASAPH survey, November 2024.

Credit

Annenberg Public Policy Center

APPC’s Annenberg Science and Public Health knowledge survey

The survey data come from the 22nd wave of a nationally representative panel of 1,771 U.S. adults conducted for the Annenberg Public Policy Center by SSRS, an independent market research company. Most have been empaneled since April 2021. To account for attrition, small replenishment samples have been added over time using a random probability sampling design. The most recent replenishment, in September 2024, added 360 respondents to the sample. This wave of the Annenberg Science and Public Health Knowledge (ASAPH) survey was fielded Nov. 14-24, 2024. The margin of sampling error (MOE) is ± 3.3 percentage points at the 95% confidence level. All figures are rounded to the nearest whole number and may not add to 100%. Combined subcategories may not add to totals in the topline and text due to rounding.

Download the topline and the methods report.

The policy center has been tracking the American public’s knowledge, beliefs, and behaviors regarding vaccination, Covid-19, flu, RSV, and other consequential health issues through this survey panel over the past two-and-a-half years. APPC’s team on the survey includes research analysts Laura A. Gibson and Shawn Patterson Jr., Patrick E. Jamieson, director of the Annenberg Health and Risk Communication Institute, and Ken Winneg, managing director of survey research.

The Annenberg Public Policy Center was established in 1993 to educate the public and policy makers about communication’s role in advancing public understanding of political, science, and health issues at the local, state, and federal levels.

 

Research aims to standardize rock climbing route difficulty through machine learning techniques



UNH reviews three methods to address grading bias in rock climbing




University of New Hampshire




DURHAM, N.H. – [January 31, 2025] – A recent study conducted by University of New Hampshire researchers explored how integrating machine and deep learning techniques can create a standardized system for evaluating rock climbing routes to provide a difficulty grading scale that promotes inclusivity, accuracy and accessibility for all experience levels. The study, published in the journal Frontiers in Sport and Active Living, found that the most successful approach for determining the difficulty of a rock-climbing route used route-centric, natural language processing methods.

As the sport of rock climbing continues to gain popularity and international recognition since making its debut in the 2020 Tokyo Olympics, the demand for a consistent method of determining route difficulty has become increasingly important as there is no official standard. Whereas commercial climbing gyms require objectivity in creating routes that are attainable for climbers of all levels, difficulty scales often rely on personal judgment and remain a subjective process, leading to inconsistencies and bias.

“Rock climbing’s popularity as a recreational sport is growing dramatically,” says Blaise O’Mara, a graduate student at UNH and lead author of the study. “Reporting the objective grade of a climbing route is critical in the climbing community but the challenge has been in how to set a uniform grade that applies to all skill levels.”

Route difficulty relies on multiple factors such as climbing environment, rock hold types and the movements of the climber. The researchers looked at how these factors play a role in the determination of route difficulty. The survey conducted by UNH categorized machine learning techniques into route-centric, climber-centric and path-finding approaches and highlighted the potential use of natural language processing to offer a more objective method for rating route difficulty.

“Through our research, we seek to address how climbing gyms can integrate machine and deep learning systems to streamline route setting and eliminate route difficulty bias,” said MD Shaad Mahmud, associate professor of electrical and computer engineering at UNH. “During our study, the route-centric approach focused on analyzing route features such as hold types, movements between holds and sequences, while the climber-centric approach involved using wearable sensors to track metrics like electromyography and acceleration and looked at past climbing performances. The path-finding approach combined qualities from the other approaches. In the end, the most successful of these approaches was the route-centric and path-finding data with natural language processing methods.”

The survey found that accuracy and granularity are the key outputs to optimize, and the route-centric method was able to achieve the greatest granularity accuracy of 84.7%. According to UNH researchers, future success in determining rock climbing difficulty in chaotic environments will likely rely on route-centric data extracted with computer vision and then fed through a Natural Language Processing algorithm. Additionally, they expect machine learning and deep learning methods to keep evolving to solve route problems like climbers. With further evolution, these methods may solve the pervading grading bias problem in determining rock climbing route difficulty.

This work was supported by N.H. Agricultural Experiment Station CREATE grant (11HN37). 

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The University of New Hampshire inspires innovation and transforms lives in our state, nation and world. More than 16,000 students from 50 states and 87 countries engage with an award-winning faculty in top-ranked programs in business, engineering, law, health and human services, liberal arts and the sciences across more than 200 programs of study. A Carnegie Classification R1 institution, UNH partners with NASA, NOAA, NSF, and NIH, and received over $250 million in competitive external funding in FY24 to further explore and define the frontiers of land, sea and space.

 

Cardiovascular disease medications underused globally


Study shows lack of progress managing future adverse health events in patients with cardiovascular disease, largely due to patients not receiving recommended medications



American College of Cardiology




Secondary prevention medications for cardiovascular diseases (CVD) are underused globally and additional strategies to increase their use are needed to improve CVD management and reduce premature mortality rates, according to study published today in JACC, the flagship journal of the American College of Cardiology. The study observed participants with CVD from 17 countries over 12 years and found that medication use remains low with little improvement.

Secondary prevention of CVD focuses on preventing further health problems in people already diagnosed with CVD. This includes managing risk factors through lifestyle changes, medications and treatments. Without intervention, these patients are at a higher risk of death, future heart attacks, strokes and heart failure. Leading international organizations, such as the World Health Organization (WHO) and the United Nations (UN), have issued targets over the last decade to reduce premature mortality from CVD through improved treatments and medications.

“After examining the progress of medication use for secondary cardiovascular (CVD) prevention, our research indicates that there continues to be substantial under-utilization of these medications with little improvement over time, and that global targets are unlikely to be reached,” said Dr. Philip Joseph, lead author of the study and scientist at the Population Health Research Institute (PHRI) – a joint institute of McMaster University and Hamilton Health Sciences, Canada.

The PHRI Prospective Urban Rural Epidemiology (PURE) study, a multi-national, community-based, prospective cohort study, analyzed over 11,000 participants with diagnosed CVD between 30-70 years of age over 12 years. Participants were from communities in countries at different income levels and were selected based on criteria representing urban and rural areas.

Participating countries include: (income level based on their World Bank classification at their time of starting the study)

  • High-income: Canada, Sweden, United Arab Emirates
  • Upper-middle-income: Argentina, Brazil, Chile, Malaysia, Poland, South Africa, Türkiye
  • Lower-middle-income: China, Colombia, Iran
  • Low-income: Bangladesh, India, Pakistan, Zimbabwe

Research results showed that medication use for secondary CVD prevention varied by country income level and was lower at the last study visit compared to the first visit in every income level except for upper-middle-income countries.

Overall, the use of at least one medication for secondary prevention started at 41.3% at the baseline study visit, peaked at 43.1%, and dropped to 31.3% at the last study visit. In high-income countries, use declined from 88.8% to 77.3%. In upper-middle-income countries, it rose from 55% to 61.1%. In lower-middle-income countries, it began at 29.5%, peaked at 31.7%, and fell to 13.4%. In low-income countries, it increased from 20.8% to a peak of 47.3%, then declined to 27.5%. Use of three or more proven medication classes for secondary prevention was substantially lower in all country income levels.

“Our findings suggest that current secondary prevention strategies continue to leave the majority of people with CVD either untreated or undertreated and highlight the general lack of progress being made to increase the use of secondary CVD prevention medications in most parts of the world,” Joseph said.

“This landmark study underscores an immense opportunity to improve global cardiovascular health,” said Harlan M. Krumholz, MD, SM, Harold H. Hines Jr. Professor at Yale School of Medicine and Editor-in-Chief of JACC. “It is unacceptable that so many individuals worldwide who have already experienced heart disease are not receiving readily available and inexpensive treatments that could save lives and prevent further events. We have the tools to bridge this gap in care now—and we must act urgently.”

Limitations of the study include the analysis of only seventeen countries, although they were from a broad range of geographical areas as well as levels of economic development.  The potential for participants to have underestimated their medication use may have caused limitations, including the unknown extent to which changes in cohort demographics, CVD duration or severity impacted variations in medication use over time. Lastly, the COVID-19 pandemic restricted the ability to conduct research in some countries during part of the last follow up visit cycle.

For an embargoed copy of the study, please contact Olivia Walther, American College of Cardiology Media Relations Manager for JACC, at owalther@acc.org.

The American College of Cardiology (ACC) is the global leader in transforming cardiovascular care and improving heart health for all. As the preeminent source of professional medical education for the entire cardiovascular care team since 1949, ACC credentials cardiovascular professionals in over 140 countries who meet stringent qualifications and leads in the formation of health policy, standards and guidelines. Through its world-renowned family of JACC Journals, NCDR registries, ACC Accreditation Services, global network of Member Sections, CardioSmart patient resources and more, the College is committed to ensuring a world where science, knowledge and innovation optimize patient care and outcomes. Learn more at www.ACC.org or follow @ACCinTouch.

The ACC’s JACC Journals rank among the top cardiovascular journals in the world for scientific impact. The flagship journal, the Journal of the American College of Cardiology (JACC) — and specialty journals consisting of JACC: Advances, JACC: Asia, JACC: Basic to Translational Science, JACC: CardioOncology, JACC: Cardiovascular ImagingJACC: Cardiovascular InterventionsJACC: Case Reports, JACC: Clinical Electrophysiology and JACC: Heart Failure — pride themselves on publishing the top peer-reviewed research on all aspects of cardiovascular disease. Learn more at JACC.org.

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 SPAGYRIC HERBALISM

Could lycopene—a tomato plant extract—be an effective antidepressant?



Wiley




Emerging evidence suggests that lycopene—a natural plant extract—may have antidepressant properties. New research in Food Science & Nutrition reveals the mechanisms behind its antidepressant effects.

In mice with depressive-like behaviors, brain analyses revealed impairments in the hippocampus. Lycopene treatment lessened these impairments and reversed the animals’ depressive-like traits.

Lycopene treatment boosted the expression of brain-derived neurotrophic factor (BDNF), a protein with roles in many aspects of brain function. Experiments indicated that a signaling pathway involving BDNF (called the BDNF-TrkB pathway, which helps regulate learning, memory, and communication between neurons) is inhibited in mice with depression, and that lycopene treatment alleviates this inhibition.

The study “offers an effective avenue for the development of novel antidepressant therapies,” the authors wrote. “We plan to conduct further verification in future studies and include multiple brain regions in our research.”

URL upon publication: https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70003

 

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