It’s possible that I shall make an ass of myself. But in that case one can always get out of it with a little dialectic. I have, of course, so worded my proposition as to be right either way (K.Marx, Letter to F.Engels on the Indian Mutiny)
Wednesday, March 12, 2025
Advancing biomedical breakthroughs: Science in One Health study draws insights from wild animals
— Researchers explore how Nature’s toughest creatures can pave the way for novel treatments against antimicrobial resistance and lifestyle diseases
Traditionally, biomedical research has focused on the use of conventional model organisms such as the mice and fruit flies for advancing our understanding of health and disease. However, of late, wild animals that live in the harshest places on the planet and thrive in extreme environmental conditions are garnering the attention of biomedical researchers. “Over the course of evolution, these animals have developed remarkable traits that could be of help for many health problems existing today,” says Dr. Yvon Le Maho, a Senior Researcher at the University of Strasbourg. However, biomedical investigations involving these wild animals have been few and far between.
With the goal of exploring the challenges that limit the use of wild animals in biomimetics and biomedical innovations, Dr. Le Maho of the Hubert Curien Pluridisciplinary Institute at the University of Strasbourg, along with Fabrice Bertile from the same institute and Aurélie Tasiemski from the University of Lille at the Pasteur Institute of Lille, Philippe Bulet from the University Grenoble Alpes, and Plateform BioPark of Archamps conducted a thorough review of different fieldwork involving wild animals from a biomedical perspective. The study was published online in Science in One Health on November 27, 2024. "We reviewed four research works that, at least at one stage, had requested the conduction of intensive fieldwork and were well documented. These four examples were connected to wild animals residing in completely distinct environments, ranging from aquatic to aerial life,” explains Dr. Le Maho.
One of the four studies reviewed focused on Alvinella pompejana, a deep-sea worm that inhabits regions near hydrothermal vents exposed to high pressure and temperature. These worms produce an antimicrobial peptide (AMP) called Alvinellacin, which effectively targets drug-resistant gram-negative bacteria, offering a promising solution against antibiotic-resistant infections even when conventional antibiotics are not suitable.
Bears in hibernation and their slow metabolism offered another intriguing perspective. Despite being inactive and fasting for several long months, bears tend to retain their muscular power due to specific proteins and signaling pathways that prevent muscle loss. Studies have demonstrated that serum of hibernating bears can make human muscle cells grow faster.
King penguins possess an interesting trait. For weeks during breeding when they do not eat, these birds retain food that is not strictly digested in their stomach, which is possible due to the production of antimicrobial peptides that defend them from foodborne germs. Such insights offer strategies to combat infections even in extremely saline conditions, like eye infections and cystic fibrosis, where antibiotics are generally poorly efficient.
While these findings are significant, there are very limited studies exploring such perspectives, primarily due to the lack of sufficient funding and limitations in fieldwork.
Discussing these limitations, Dr. Le Maho says, “Disturbance to wildlife and limited species-specific expertise were found to create roadblocks in fieldwork. The need of the hour is to focus on technological advancements for data collection and also interdisciplinary training to overcome these challenges.” Regulatory, ethical, and logistical hurdles faced by fieldwork being conducted in extreme and remote areas, including compliance with the Nagoya Protocol on genetic resources is yet another challenge. Navigating through this requires securing ethical approvals with collaboration with local experts.
Wild animals are unique in their biological and functional aspects, and the loss of biodiversity means losing out on biological breakthroughs. Climate warming, habitat loss, and excessive harvesting pose a threat to many species, and we may lose potential perspectives on treating human diseases in the absence of wildlife and environment conservation.
Lastly, the study calls for an expanded cross-disciplinary exploration of the adaptation of wild animals. By doing so, scientists can find new treatment strategies based on the most resistant species in the world. Wildlife is a repository of biological solutions and protecting it ensures not only conservation, but also future breakthroughs.
Results indicate the closer the Doomsday Clock ticks to midnight, the higher the rates are for mortality specific to Alzheimer’s disease, suicide, unintentional injuries, alcohol and substance-related disorders
Since 1947, the Bulletin of the Atomic Scientists (BAS) has used the metaphor of the Doomsday Clock as a means of communicating how close the human species is to self-imposed annihilation, represented as midnight. While early iterations of the clock focused more exclusively on the dangers of nuclear weapons, the BAS has also begun to consider other evolving existential dangers in recent decades, including climate change, disruptive technology and cyber risks, and political volatility. The Doomsday Clock is both famous and controversial. However, to date no known studies have explored the potential connection between the Doomsday Clock and health and mortality.
A new study by researchers at Mass General Brigham investigated the mortality and mental health correlates of the iconic Bulletin of the Atomic Scientists’ Doomsday Clock, using data published by the United States Centers for Disease Control and Prevention (CDC) and the University of Washington’s Institute for Health Metrics and Evaluation’s (IHME 2023) Global Burden of Disease project. The authors describe the work as an initial approach to understanding the connection between the Doomsday Clock and human and mental health, opening the door for more conversations around how social determinants of health (SDOH) may influence people’s wellbeing, which in turn may influence broader events. Results are published in The Bulletin of the Atomic Scientists.
“This study represents a first step, with the inherent limitations thereof, but it suggests a bridge between the fate of the world, our psychology, and our health,” said first author Samuel Justin Sinclair, PhD, director of the Psychological Assessment and Research Service (PARSe) and a faculty member in the Department of Psychiatry at Brigham and Women's Hospital (BWH), a founding member of Mass General Brigham. “This may sound intuitive, but it’s something that no one has looked at before. We hope it opens the door to further discussion.”
The study’s results indicate that Doomsday Clock settings closer to midnight (indicating greater risk) are associated with higher mortality from Alzheimer’s disease, suicide, unintentional injuries, and alcohol and substance-related disorders. Conversely, the researchers also observed lower mortality rates for malignant neoplasms, HIV, and diabetes mellitus as the clock ticked closer to midnight.
According to the authors, the findings indicate that during periods of greater risk to society, there may also be corresponding variations in mortality and health and that socio-political indicators such as the Doomsday Clock may be useful in capturing aspects of social determinants of health on a macro level.
“The wellbeing and functioning of individuals, societies, nations, international affairs, our species, and our planet are interrelated,” says senior author David Silbersweig, MD, chairman emeritus of the BWH Department of Psychiatry. “Further studies can address the complex, multi-directional interactions so as to address large-scale challenges and inform policy.”
Authorship: Samuel Justin Sinclair and David A. Silbersweig.
Disclosures: Silbersweig is a co-founder and SAB chair for Ceretype Neuromedicine (unrelated to this submission).
Funding: None
Paper cited: Sinclair JS et al. “Apocalypse now? Mortality and mental health correlates of the Doomsday Clock” Bulletin of the Atomic Scientists DOI: /10.1080/00963402.2024.2439762
###
About Mass General Brigham
Mass General Brigham is an integrated academic health care system, uniting great minds to solve the hardest problems in medicine for our communities and the world. Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services. Mass General Brigham is a nonprofit organization committed to patient care, research, teaching, and service to the community. In addition, Mass General Brigham is one of the nation’s leading biomedical research organizations with several Harvard Medical School teaching hospitals. For more information, please visit massgeneralbrigham.org.
Apocalypse now? Mortality and mental health correlates of the Doomsday Clock
Article Publication Date
12-Mar-2025
COI Statement
Silbersweig is a co-founder and SAB chair for Ceretype Neuromedicine (unrelated to this submission
CIVILIZATION HO!
Marine litter has already reached the deepest point in the Mediterranean Sea
The bottom of the Calypso Deep, a 5,112-metre deep depression in the Ionian Sea, contains one of the highest concentrations of marine debris in the deep ocean
The bottom of the Calypso Deep, a 5,112-metre deep depression in the Ionian Sea, contains one of the highest concentrations of marine debris in the deep ocean: it is yet another testimony to the increasingly worrying human footprint that has turned seas and oceans into a vast waste dump.
Waste generated by human activities has now reached the deepest point in the Mediterranean: the 5,112-metre-deep Calypso Deep in the Ionian Sea. A total of 167 objects — mainly plastics, glass, metal and paper — have been identified at the bottom, of which 148 are marine debris and 19 others are of possible anthropogenic origin. These results represent one of the highest concentrations of marine litter ever detected at great depths.
These findings are presented in an article published in Marine Pollution Bulletin. The article’s main authors are Miquel Canals, from the University of Barcelona’s Faculty of Earth Sciences; Georg Hanke, from the European Commission’s Joint Research Centre (JRC); François Galgani, from the French Research Institute for Exploitation of the Sea (IFREMER), and Victor Vescovo, from the American company Caladan Oceanic.
To reach the bottom of the trench — the most critical aspect of the entire study — the team used a high-tech manned submarine, the Limiting Factor, a deep-submergence vehicle (DSV). The images provided by the Limiting Factor confirm that, in addition to accumulating on coasts, surface waters and shallower bottoms, marine litter also reaches the deepest and most remote points of the Mediterranean, a sea that is particularly affected by human activities.
The debris identified by the international team in the Calypso Deep warns of the need to implement global policy actions to reduce ocean waste, as well as to encourage changes in citizens’ consumption habits and waste reduction in order to protect seas and oceans around the world.
Marine debris in the deepest Mediterranean Sea
The Calypso Deep is a depression located 60 kilometres west of the Peloponnese coast in Greece, within the so-called Hellenic Trench, with several similar but shallower depressions. Located in an area of high seismicity due to active faults, it is surrounded by fairly steep, stepped relief and has slopes of thousands of metres, and a virtually flat bottom. The inner part of the trench, more than 5,000 metres deep, is kidney-shaped and measures approximately 20 km by 5 km.
But how did the rubbish get so deep? The debris at the bottom of the Calypso Deep “comes from various sources, both terrestrial and marine. It could have arrived by various routes, including both long-distance transport by ocean currents and direct dumping”, explains Miquel Canals, professor at the Department of Earth and Ocean Dynamics and director of the UB Chair on Sustainable Blue Economy. “Some light waste, such as plastics, comes from the coast, from where it escapes to the Calypso Deep, just 60 kilometres away. Some plastics, such as bags, drift just above the bottom until they are partially or completely buried, or disintegrate into smaller fragments” he says.
“We have also found evidence of the boats’ dumping of bags full of rubbish, as revealed by the pile-up of different types of waste followed by an almost rectilinear furrow. Unfortunately, as far as the Mediterranean is concerned, it would not be wrong to say that “not a single inch of it is clean”, warns the expert. The Calypso Trench traps and accumulates the anthropogenic materials that reach it at the bottom: “It is a closed depression, which favours the accumulation of debris inside it. The weak currents in the trench — about two centimetres per second and, exceptionally, 18 — also facilitate the deposition of light debris at the bottom”.
The currents carry floating debris mainly from the southern Ionian Sea and from marine areas further south. Surface eddies also tend to form, concentrating the debris inland. “When these eddies are located over the Calypso Trench, some debris tends to fall slowly to the bottom, aided by degradation mechanisms and ballasting processes that increase its density. Surface currents can also transport debris from the Adriatic Sea to the north, through the Strait of Otranto, and from the waters off north-western Greece”.
The Limiting Factor: cutting-edge technology for deep-sea exploration
Accessing the deepest sea basins is a huge challenge that requires the use of cutting-edge technology. In this case, the innovation is the Limiting Factor submarine, built by Triton Submarines. This vehicle, which is deployed from specially prepared mother ships, is capable of carrying two passengers to the deepest ocean trenches. During the inspection of the seabed, this unique technological device moves slowly — about 1.8 kilometres per hour — to obtain good quality images.
In the Calypso Deep, the Limiting Factor was able to cover a distance equivalent to 650 metres in a straight line, during a 43-minute stay near the bottom. “On each dive, more time is usually spent descending and ascending the vehicle back to the surface than inspecting the bottom. Each complete dive usually takes a few hours”, Canals notes.
This technology has made it possible to calculate the density of marine litter at the bottom of the trench, although no significant impacts on marine life have been detected, as it is particularly impoverished in this chasm of the Ionian Sea. The images only revealed the presence of the species Coryphaenoides mediterraneus, a fish of the macrouridae family, and the decapod Acanthephyra eximia.
“However, in places with more biodiversity, there are different types of interaction between the debris deposited on the bottom and the organisms, such as ghost fishing, burial, hooking or ingestion, but also the use of debris as a substrate where animals can grow, hide or lay their eggs”, Canals notes.
The Mediterranean is one of the most polluted seas by marine debris
The first evidence of debris on the world’s seabed dates back to 1975, in the Skagerrak Strait in the North Atlantic. Canyons and seamounts are the major accumulation points for debris, which can be buried, crumbled or moved by gravity, ocean currents and other oceanographic factors.
Today, the Mediterranean is a marine region particularly affected by this environmental problem. In 2021, a study already identified the Strait of Messina as the area with the highest known density of marine litter in the world (Miquel Canals et al., Environmental Research Letters). This is a real hotspot where large quantities of waste accumulate.
“The Mediterranean is an enclosed sea, surrounded by humanity, with intense maritime traffic and widespread fishing activity. The evidence provided by our research should shake up global efforts, and in particular in the Mediterranean, to mitigate waste dumping, especially plastics, in the natural environment and ultimately in the sea, in line with the UN Global Plastics Treaty against plastic pollution, which is still pending approval. Even the papal encyclical Laudato si’ of May 2015 goes in this direction, as well as some declarations of the G7 world summits, although we are still far from achieving a great social echo in terms of seabed litter”, Canals notes.
Unlike other popular places, such as beaches or the coastline, “the ocean floor is still largely unknown to society as a whole, which makes it difficult to raise social and political awareness about the conservation of these spaces”, the expert continues. “It is necessary to make a joint effort between scientists, communicators, journalists, the media, influencers and other people with social impact. The problem is there, and it has an enormous scope, even if it is not directly visible. We should not forget about it”, concludes Miquel Canals.
The debris at the bottom of the Calypso Deep comes from various sources, both terrestrial and marine.
The debris identified by the international team in the Calypso Deep warns of the need to implement global policy actions to reduce ocean waste, as well as to encourage changes in citizens’ consumption habits and waste reduction in order to protect seas and oceans around the world.
The Limiting Factor submarine is capable of carrying two passengers to the deepest ocean trenches.
Pollution by marine litter of anthropogenic origin –that comes from human activity– is currently one of the biggest environmental concerns given its increasing magnitude, especially due to the considerable amount of plastics present in the marine environment.
A study carried out by the University of Malaga and the Oceanographic Centre of the Balearic Islands (COB-IEO/CSIC) highlights the importance of making accurate estimates of the amount of these contaminants to face this challenge, which not only affects the scientific community but also the general public.
“The Mediterranean Sea, characterized by being a semi-enclosed basin with intense demographic pressure, is one of the world’s most vulnerable regions with respect to this type of pollution, with direct effects on its very high biodiversity”, says Javier Soto Navarro, researcher of the Department of Applied Physics II of the University of Malaga, one of the authors of this study.
Inadequate results
Together with the scientist of the Oceanographic Center of the Balearic Islands of the Spanish Institute of Oceanography (COB-IEO/CSIC) Gabriel Jordá, they have found that the monitoring strategies commonly implemented in the observational campaigns undertaken so far are inadequate for obtaining average values of marine litter concentration within an acceptable uncertainty range (20-30%). The results of this research have been published in the scientific journal Marine Pollution Bulletin.
“It is, without a doubt, a very complex task, as it requires scarce and very expensive resources and, additionally, it depends on factors that are out of researchers’ control, such as meteorological factors,” explains Soto Navarro.
Experts point out that uncertainty in the results obtained can be largely attributed to the sampling techniques and strategies employed.
Simulation experiments
This study led by the University of Malaga has analyzed the spatial and temporal requirements for the marine litter sampling in the Mediterranean Sea. For this purpose, experiments have been carried out with a simulated observation system (OSSE), which are based on using synthetic or simulated reality.
To obtain this synthetic reality, a high-resolution numerical modeling system has been used that simulates the circulation of the basin and the dispersion of litter in it. In this way, according to the UMA scientist, a representation of the distribution and variability of marine litter concentrations is achieved as realistically as possible.
“The different sampling strategies are evaluated on this simulated reality, performing a series of virtual experiments. For example, what values of the temporal average of concentration we obtain if we measure over a one-month period, with a daily sampling frequency. By varying the period and frequency, the temporal average errors are estimated. As for spatial averages, we proceed in a similar way, but studying the variability of the results based on the target area at a specific moment,” he clarifies.
“Since this is a simulated reality, we have all necessary information to estimate and compare the errors of plastics concentration averages, based on the strategy used in the different experiments. This analysis enables the identification of the most appropriate sampling strategies”, explains the researcher of the Physical Oceanography Group of the UMA.
The most appropriate sampling strategies
Therefore, it has been shown that the magnitude of errors in the average concentration, both spatial and temporal, can be quantified based on the strategy used. Specifically, with regard to temporal averages, it is evident that it is much more efficient to extend campaigns over time than increase the number of observations in shorter campaigns.
As for spatial averages, on the other hand, it is determined that characterizing synoptically, in a schematic way, the entire basin or even smaller sub-basins would require a considerable increase in the number of observations.
“It is necessary to rethink the strategies used so far to monitor marine litter. With the same sampling strategy, it is feasible to achieve significantly more accurate results by better planning the campaigns, coordinating the different groups involved and establishing standardized protocols to integrate the measures made by different teams into a unified database”, concludes the researcher at the University of Malaga.
The study is part of the Project of Excellence of the Government of Andalusia ‘Origin and evolution of marine litter on the Andalusian coast’ (OBASMARAN), in which researchers from the UMA, the COB-IEO/CSIC and the Mediterranean Institute of Advanced Studies (IMEDEA) collaborate. Planned to be conducted in three years, it ends in December 2025.
Bibliography:
Javier Soto-Navarro, Gabriel Jordà, (2025) Observational requirements for marine litter concentration characterization in the Mediterranean Sea, Marine Pollution Bulletin, Volume 211,117434,ISSN 0025-326X, https://doi.org/10.1016/j.marpolbul.2024.117434.
Observational requirements for marine litter concentration characterization in the Mediterranean Sea
Javier Soto Navarro, researcher of the Department of Applied Physics II of the University of Malaga, and with the scientist of the Oceanographic Center of the Balearic Islands of the Spanish Institute of Oceanography (COB-IEO/CSIC) Gabriel Jordá, authors of this study.
