Monday, March 24, 2025

 

Childhood brain injuries can affect educational attainment in adulthood – even a concussion can be enough




Tampere University




A study conducted at Tampere University shows that a blow to the head can significantly impact a child’s or adolescent’s future education and, consequently, their career. Even a mild concussion can have far-reaching consequences.

Childhood brain injuries can affect education in the long term, according to research by doctoral researcher Julius Möttönen at Tampere University. The study compared 0–17-year-old children and adolescents who had suffered brain injuries with those of the same age who had sustained limb injuries, such as ankle or wrist fractures.

The results indicate that those who had suffered brain injuries achieved a lower level of education over a 20-year follow-up period compared to those who had sustained limb injuries.

The study utilised data from the Finnish Institute for Health and Welfare's care register for health and education data register in the period of1998–2018. A total of 8,487 individuals diagnosed with brain injuries were chosen from the registers. They were compared with 15,552 individuals who had had an ankle or wrist fracture. At the end of the follow-up, participants had to be at least 26 years old to ensure that the impact on educational attainment was examined as reliably as possible.

Those who had suffered brain injuries were less likely to complete higher education degrees than the comparison group. Individuals with more specific internal brain injury diagnoses were more likely to have no higher education compared to those with milder concussions.

Even a single concussion can affect educational attainment. Patients who had suffered concussions were found to have significantly lower educational levels in the follow-up compared to those who had sustained limb injuries.

“A mild, single concussion is often considered a relatively harmless event, but our research suggests that it can have long-term effects on learning and cognitive abilities. This should get more attention in both healthcare and schools,” Möttönen points out.

The study highlights the need to provide better support and information to children and adolescents who have suffered brain injuries, as well as their parents. This would help to ensure equal opportunities for education and success in life.

The research article Impact of childhood traumatic brain injury on educational attainment in Finland from 1998 to 2018: A retrospective register-based nationwide cohort study was published in the European Journal of Epidemiology on 23 March 2025.

 

Childhood tuberculosis cases up by 26% in the EU/EE


Tuberculosis (TB) in children and adolescents serves as indicator for ongoing disease transmission. For the third year in a row, European Union and European Economic Area countries saw an uptick of TB diagnoses among children under the age of 15



European Centre for Disease Prevention and Control (ECDC)

Tuberculosis surveillance and monitoring in Europe 2025 - 2023 data 

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An estimated 225 000 people fell ill with tuberculosis (TB) in
2023 in the WHO European Region, equivalent to 24 cases
per 100 000 population. In the European
Union and European Economic Area (EU/ EEA), 38 993 cases of TB were reported, resulting in a notification rate of 8.6 per 100 000 population in the EU/ EEA.

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Credit: © Science Photo LibrarNew data published by ECDC and the World Health Organization (WHO) Regional Office for Europe [1] show that with almost 39 000 reported tuberculosis cases in 2023, the 29 European Union and European Economic Area (EU/ EEA) countries continue to see increases in TB notifications. Given that young children have an increased risk of developing tuberculosis disease during the first year after infection, childhood TB serves as a marker for ongoing transmission within a community. 




The new data for 2023 indicate that children and adolescents under the age of 15 accounted for 4.3% of all TB cases in the EU/EEA. And reported cases in this age group have gone up, even if only slightly, for the third year in a row. Between 2022 and 2023, notifications of paediatric TB rose from 1 341 to 1 689 cases. In addition, for one in five children with tuberculosis in the region it is unknown whether they completed their TB treatment. Incomplete treatment may result in deteriorating health outcomes such as the emergence of drug-resistant TB  and further transmission of the disease to others.

ECDC Director Pamela Rendi-Wagner stresses that [2]:

"The time to act to end TB is now. With just five years to meet our 2030 targets, it is critical that Europe renews its focus on prevention and timely, effective treatment. With the rise of drug-resistant TB, the cost of inaction today will be paid by us all tomorrow."

Persistent challenge: treatment success rates lag behind

Similar to previous years, the treatment success rate in 2023 was lower in the EU/EEA countries than in the rest of the WHO European Region (67.9% versus 77.2%, respectively). This represents a substantial gap between the current treatment success rates and the global targets set by the WHO, which aim for successful outcomes in at least 90% of patients.

Multidrug-resistant tuberculosis (MDR-TB) remains a significant challenge: only roughly every second (56%) MDR-TB patient successfully finished their treatment regimen according to the released data. This clearly shows consistent problems to effectively manage and treat drug-resistant tuberculosis across the region. Possible reasons for this could be lack of treatment adherence, delays in diagnosis, and insufficient access to appropriate therapies.

Despite improvements in TB diagnostics and care, the persistence of MDR-TB and other drug-resistant forms of TB underscores the urgent need for more effective treatment strategies and better patient management, such as new and shorter injection-free oral treatment regimes. [3]

 

----Ends---- 

References/notes to editors: 

[1] Tuberculosis surveillance and monitoring in Europe 2025 - 2023 data.
European Centre for Disease Prevention and Control, WHO Regional Office for Europe. Tuberculosis surveillance and monitoring in Europe 2024 – 2022 data. Copenhagen: WHO Regional Office for Europe and Stockholm: European Centre for Disease Prevention and Control; 2024.
Available from: https://www.ecdc.europa.eu/en/publications-data/tuberculosis-surveillance-and-monitoring-europe-2025-2023-data 

[2] The Sustainable Development Goals Target 3.3 as part of goal 3 on ‘Good Health and Well-Being to ensure healthy lives and promote well-being for all at all ages. It outlines for communicable diseases: By 2030, end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases. Available from: https://sdgs.un.org/goals/goal3

[3] A recent study from 13 countries in the European Region showed they had a treatment success rate over 80%.

[4] The WHO European Region covers 53 countries from Europe and Central Asia, along with Israel.

[5] World Tuberculosis Day is observed on 24 March each year. Its overall goal is to raise awareness about the burden of TB worldwide and the status of TB prevention and control efforts. TB elimination is defined as less than one case of TB disease per 1 million population per year. You can find more materials around World TB Day here: https://www.ecdc.europa.eu/en/news-events/world-tuberculosis-day-2025

UK

Study shows almost all people claiming Universal Credit struggle to afford to eat properly



University of Nottingham




A new study has shown that almost all people claiming Universal Credit aren’t able to eat properly, with many never eating fruit or vegetables, and a significant proportion regularly not eating for whole days at a time, leading to deficiencies in vital nutrients.

The Benefits and Nutrition Study (BEANS) was led by the University of Nottingham’s Division of Food, Nutrition and Dietetics to examine food insecurity among people who claim Universal Credit. Their findings, published in the European Journal of Nutrition, show that 85% of those in receipt of Universal Credit are food insecure and struggle to eat properly, with 73% reporting that they go whole days without food and 39% never eating fruit and 16% never eating vegetables.

The researchers also found that the loss of the £20 per week uplift in Universal Credit added during covid resulted in an almost doubling of reported reliance on food banks.

Household food insecurity is defined by having limited and uncertain access to adequate food and is currently a significant health concern. Food insecurity is associated with a range of adverse health conditions including; childhood stunting, respiratory disease and, paradoxically, obesity and diabetes. 

For this study, data was collected from 328 adults aged 16-65 from across the UK who were in receipt of Universal Credit, with the household equivalised income ranging from £135.58-£300.67 per household per week depending on the number of adults and children. Those households on less than £200 per week were found to be the most at risk of food insecurity.

Study participants completed an online survey that asked them a range of questions about their food and shopping habits. They were also asked to provide details of their food intake over a four day period. 

The data showed that participants were consuming an extremely limited diet containing few protein sources and minimal or, in some cases, zero fruit and vegetables. There was also a reliance on bread, something respondants referred to as a ‘beige’ diet. The experts analysed the micronutrient content of participants’ diets and found them to have very low intakes of vitamin A, iron, selenium, potassium, iodine and magnesium which, for many, was considerably below dietary requirements to support health.

Dr Simon Welham from the University of Nottingham who led the study, said: “Although we know that there is a link between food insecurity and poverty we were surprised by the results as it showed clearly that nearly everyone claiming Universal Credit faced food insecurity over the period of the study. It was also starkly apparent that the choices people are having to make about food will have an effect on their health, with a lack of fruit and vegetables and limited food diversity leading to micronutrient deficiencies.

“Selenium in particular stood out as one of the micronutrients people weren’t getting enough of, with the majority consuming below a level known as the lower reference nutrient intake. The lower reference nutrient intake defines an intake that is adequate for only the 2.5% of the population with very lowest requirements (typically the smallest and least metabolically active). Everyone else (97.5%) requires more. In this study, almost 70% of Universal Credit recipients consumed below this lower reference nutrient intake level. Selenium is essential as plays an indispensable role as an antioxidant to protect against damage from oxidative stress. If we can’t do this then significant tissue injury occurs and the prevalence of age associated diseases such as heart disease and cancer is far greater.”

Additionally, the study showed that people who lived further away from the shops were also more likely to experience food insecurity as they would have to make more trips on public transport to get their shopping and were limited to what they could carry, so they may have to rely on more expensive local shops with a much reduced variety of products.

Dr Welham continues: “We would expect that, as the cost of living has risen significantly since we carried out this study, the situation for people on Universal Credit today is even bleaker. This is a complex issue to solve and there are many reasons why people can’t access better food, but this study shows that interventions are needed to ensure that everyone can obtain an appropriate diet at an affordable price, or large numbers of society’s very poorest people will experience a rapid decline in health.”

 

Northernmost record of toxic pufferfish in Mediterranean raises alarm



Pensoft Publishers
Specimen of Lagocephalus sceleratus from Medulin Bay, Croatia. 

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Specimen of Lagocephalus sceleratus from Medulin Bay, Croatia.

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Credit: Iveša et al.




Researchers have documented the northernmost record of the highly invasive silver-cheeked toadfish, Lagocephalus sceleratus, in the Mediterranean, raising concerns about its impact on marine biodiversity, fisheries, and coastal tourism. 

In a study published in the open-access journal Acta Ichthyologica et Piscatoria, a team of researchers from the Faculty of Natural Sciences at Juraj Dobrila University of Pula and the Institute of Oceanography and Fisheries in Split detail the May 13, 2024 discovery. 

Captured in the Bay of Medulin in the northern Adriatic at a depth of 19.7 m, the 522 mm male weighing 1330 g is the fourth confirmed record of the species in the Adriatic and the first from its northernmost waters.  

The pufferfish poses a threat to local marine life, fisheries, and public safety. Recent evidence from the southern and eastern Mediterranean shows that bites from its powerful beak-like jaws can result in severe injuries such as partial amputations of fingers. Its flesh and organs contain a potent neurotoxin, tetrodotoxin, which is potentially lethal  if consumed.  

In Mediterranean coastal regions, Lagocephalus sceleratus has become an increasingly significant portion of small-scale fishing catches, often causing damage to fishing gear with its bite. The study’s stomach analysis revealed a diet consisting of bivalves, gastropods, and sea urchins, suggesting potential disruptions to the Adriatic’s ecological balance. 

The species is a Lessepsian migrant, meaning it migrated through the artificially created Suez Canal. Originating from the Indo-Pacific, it has spread aggressively through the Mediterranean since its first sighting in 2003. 

“The presence of Lagocephalus sceleratus in the northern Adriatic is a clear warning sign of the species’ expanding range and potential ecological and economic consequences. Proactive monitoring and management strategies are important to mitigating its impact on local marine biodiversity, fisheries, and public safety.” said Dr. Neven Iveša, the study’s  co-author. 

Increased monitoring, regulatory measures, and public awareness campaigns are recommended to address the threats posed by the species. The research team proposes targeted removal efforts, public education on handling and reporting sightings, and further research into its ecological impact. Finally, they urge local fishers to report sightings of Lagocephalus sceleratus to support early detection and management efforts. 

Original source

Iveša N, Buršić M, Dulčić J (2025) Northernmost Mediterranean record of the silver-cheeked toadfish, Lagocephalus sceleratus (Actinopterygii, Tetraodontiformes, Tetraodontidae). Acta Ichthyologica et Piscatoria 55: 77-81. https://doi.org/10.3897/aiep.55.146945

The area in the northern Adriatic Sea where Lagocephalus sceleratus was caught, Medulin Bay, southern Istria, Croatia. Red dot indicates the exact location (44°47′24′′N, 13°55′43′′E).

Different types of prey found in the stomach of the captured individual of Lagocephalus sceleratus in Medulin Bay. a = bivalve shells, b = gastropod shells, c = fragments of sea urchin skeletons, d = particles of inorganic material.

Credit

Iveša et al.


 

Generative artificial intelligence: a historical perspective




Science China Press
Timeline of the development of Generative AI methods and applications. 

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The timeline shows representative Generative AI technologies that were developed and refined during different historical periods. The color of each bullet point indicates the specific stage in the development of Generative AI.

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Credit: ©Science China Press




This study is led by Dr. Ran He (Institute of Automation, Chinese Academy of Sciences). His research team has conducted a comprehensive review of the development of Generative Artificial Intelligence (Generative AI) over the past half-century. Their work systematically traces the evolution of Generative AI, identifying key milestones such as the rise of deep learning, transformer architectures, and foundation models. To provide a structured understanding, they organized the development of Generative AI into four distinct stages:

  1. Rule-based Generative Systems: They highlighted that early methods for autonomous content generation emerged in the 1950s. These systems were built on predefined rules crafted by human experts and achieved notable success in specific tasks, particularly through expert systems.
  2. Model-based Generative Algorithms: They summarized the development of generative algorithms based on statistical or physical models, which expanded Generative AI to include fields such as machine learning, neural networks, computer graphics, and computer vision. Practical applications like computer animation became reliable tools, significantly reducing the need for manual content creation.
  3. Deep Generative Methodologies: With advances in computational power and data availability, deep generative models demonstrated exceptional capabilities. They summarized the technologies such as autoregressive and diffusion-based models, which have become foundational for numerous applications.
  4. Foundation Models: They emphasized that foundation models, such as GPT and deepSeek, now dominate the forefront of Generative AI development. These models, characterized by their large scale in terms of size and training data, offer unparalleled advantages, including high-quality content generation, natural interactions, and versatility across tasks. Foundation models have become the cornerstone of various applications, driving innovation across multiple industries.

They also compiled a representative timeline illustrating the development trajectory of Generative AI methods and applications (see the below figure titled 'Evolution of Design Principles in Generative AI'). Their work delves into representative approaches, evaluates the strengths and limitations of different generative technologies, and highlights successful applications in various fields. Additionally, they identify open challenges in the field, emphasizing that issues such as safety concerns and breakthroughs in theoretical paradigms urgently require further attention and development.

 

Evolution of design principles in Generative AI. 

The figure illustrates the design principles behind rule-based and model-based Generative AI technologies. The design principles of rule-based approaches are depicted in part (a), while the unified design principles behind generative methods based on classical models and deep models are shown in part (b). Part (c) highlights the design principles of foundation model-based approaches.

Credit

©Science China Press


See the article:

Generative Artificial Intelligence: A Historical Perspective

https://doi.org/10.1093/nsr/nwaf050