Tuesday, September 15, 2026

 

Drug decriminalization in BC reduced police encounters for drug possession, with no changes in drug-related deaths

Canadian Medical Association Journal




British Columbia’s drug decriminalization policy was associated with a substantial decrease in police encounters for drug possession, while neither decriminalization nor the subsequent partial recriminalization was associated with detectable changes in deaths due to drug toxicity or drug-related hospitalizations, found new research in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.260038.

In January 2023, the Government of British Columbia introduced a time-limited initiative that decriminalized possession of up to 2.5 grams of opioids, cocaine, methamphetamine, and methylenedioxymethamphetamine (MDMA or ecstasy). The aim was to reduce overdose deaths and increase treatment engagement by reducing fear and stigma that lead to hiding substance use or using drugs alone and avoiding treatment and support. In May 2024, following concerns about drug use in public and public safety, the government partially recriminalized possession in most public spaces, while it remained decriminalized in designated spaces. In January 2026, the government of BC opted not to renew the decriminalization initiative.

“These regulatory shifts — the initial decriminalization and subsequent partial recriminalization — allow for the evaluation of changes in drug-related health and drug crime outcomes over time,” writes Dr. Daniel Myran, Gordon F. Cheesbrough Research Chair at North York General Hospital, and a scientist with the University of Toronto’s Department of Family Medicine, ICES, and the Bruyère Health Research Institute, with coauthors.

Over the 5-year study period from August 2020 to March 2025, the authors compared changes in police encounters for drug possession and trafficking and opioid- and stimulant-related hospitalizations and deaths from drug toxicity in BC to other parts of Canada before and after decriminalization and partial recriminalization. In total, 97 630 instances of police encounters for drug possession, 75 485 for drug trafficking, 161 278 opioid-related hospitalizations, 113 747 stimulant-related hospitalizations in Canada, and 29 730 drug toxicity deaths occurred in BC, Ontario and Alberta.

Decriminalization in BC was associated with a 39% decrease in police encounters for drug possession, which returned to pre-decriminalization levels after partial recriminalization. Decriminalization in BC was not associated with changes in drug-related hospitalizations or overdose deaths. The partial recriminalization period aligned with declines in both drug-related hospitalizations and overdose deaths in BC; however, similar declines occurred in the rest of Canada, suggesting that broader national trends likely accounted for these changes.

“The findings of this study reinforce that BC’s temporary decriminalization achieved the intended effect of reduced criminalization of drug possession among people who use drugs. The absence of changes in overdose outcomes highlights that there are no simple solutions to the overdose crisis in Canada and that other factors and interventions are urgently needed to improve key health outcomes related to drug use,” said Dr. Myran.

Although decriminalization was not associated with changes in hospitalizations or deaths from drug toxicity, the authors suggest it may have had positive benefit for people who use drugs.

“Decriminalization was intended to reduce the harms associated with criminalizing people who use drugs, and our findings suggest that it meaningfully reduced police-reported possession incidents,” said study coauthor Adrienne Gaudreault, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia. “At the same time, changing possession laws alone cannot make an unpredictable and highly toxic drug supply safer. Decriminalization should be understood as a component of a comprehensive public health response that must also address the toxicity of the drug supply.”

In a related commentary https://www.cmaj.ca/lookup/doi/10.1503/cmaj.261198, Dr. Alexis Crabtree, British Columbia Centre for Disease Control and the School of Population and Public Health, University of British Columbia, Vancouver, BC, with coauthor writes, “decriminalization may be best understood as a complex systems intervention, with myriad effects — and possible unintended consequences — emerging from interactions across institutions and sectors. The lesson from BC is not that decriminalization is irrelevant, but that such policies must be supported within prepared, trusted, and adequately resourced systems.”

 

Drug improves sexual function for patients with depression, study finds



Sexual side effects major reason patients stop taking depression medications




University of Virginia Health System

Anita H. Clayton, MD

image: 

Anita H. Clayton, MD, led a study that found patients with major depressive disorder and an inadequate response to standard antidepressants who received an add-on treatment with the drug lumateperone saw significantly improved sexual function.

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Credit: UVA Health





Patients with major depressive disorder (MDD) and an inadequate response to standard antidepressants who received an add- on treatment with the drug lumateperone saw significantly improved sexual function, found a new study led by a University of Virginia School of Medicine researcher. 

In a study of 480 patients, significant improvements in sexual function were seen in patients who were randomized to receive a daily 42 mg dose of lumateperone added to their antidepressant therapy compared with patients whose additional treatment was a harmless placebo. Improvements were seen across multiple patient groups including those with baseline sexual dysfunction, women, younger and older adults as well as across various aspects of sexual functioning (desire, arousal, orgasm and pleasure).  

Approximately 68% of patients with major depressive disorder have sexual dysfunction, and the sexual side effects of antidepressant medications are a leading reason patients stop treatment.

Lead researcher Anita H. Clayton, MD, a psychiatrist at UVA Health, hailed the findings as an important step forward in the management of sexual dysfunction in patients with depression.

Link Between Depression and Sexual Function

Major depressive disorder affects approximately 21 million American adults, according to the Anxiety & Depression Association of America. As the researchers note in a paper outlining their study results, sexual dysfunction increases the risk for major depressive disorder, while major depressive disorder and its treatments are also a common cause of sexual dysfunction.

The researchers wanted to see if lumateperone – an atypical antipsychotic medication approved by the federal Food and Drug Administration to treat schizophrenia, bipolar depression and as an add-on treatment to antidepressant therapy for major depressive disorder – could improve sexual function in patients with MDD already receiving treatment with standard antidepressant medications, but with a less than 50% reduction in depressive symptoms. 

The researchers found that participants who received the add-on lumateperone saw significant improvements in depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) and sexual function as measured by the Changes in Sexual Functioning Questionnaire (CSFQ-14) by the end of the 43-day treatment period. At the beginning of the trial, 82.5% had sexual dysfunction; by the end, more than a quarter reported regular sexual function. 

Women appeared to benefit more than men, but the researchers say more research is needed to verify that. Both sexes reported improvements in sexual pleasure and arousal.

In addition, study participants who did not have sexual dysfunction and received lumateperone did not report any worsening of their sexual function during the trial.

“While MDD is associated with sexual dysfunction in 68% of patients, common antidepressants like selective serotonin reuptake inhibitors (SSRIs) also contribute to sexual dysfunction in approximately 70% of patients. So if an individual taking an SSRI doesn’t see a significant reduction in MDD symptoms, they have a higher combined risk of sexual dysfunction,” Clayton said. “In this study, depressive symptoms and sexual functioning improved in patients randomized to receive lumateperone as an add-on treatment when compared with a placebo. This was particularly true in women although both sexes had improvement in pleasure, sexual desire and interest. This medication, recently approved by the FDA as an add-on treatment when antidepressants alone have had a limited benefit in patients with MDD, improves depressive symptoms and is not associated with medication-induced sexual dysfunction. For this reason, this treatment option may be preferable for some individuals with an inadequate MDD response who wish to avoid sexual dysfunction as a medication side effect.”  

Findings Published

Clayton and her team have published their findings in The Journal of Clinical Psychiatry. The research team who designed the plan to measure sexual function in the study and interpreted the results include Willie R. Earley, Susan G. Kozauer, Yifan Mo, John B. Edwards, Suresh Durgam and Clayton. The study was funded by Intra-Cellular Therapies. A full list of the authors’ disclosures is contained in the paper.

To keep up with the latest medical research news from UVA and UVA’s new Paul and Diane Manning Institute of Biotechnology, bookmark the Making of Medicine blog at https://www.uvahealth.com/making-of-medicine.


Forest fire smoke reduces bird diversity




ETH Zurich





When forests burn, the direct consequences are obvious: houses go up in flames and habitats are destroyed. The damage caused by the smoke that extends far beyond the fire area is less visible. Sarah Meier, an environmental economist at ETH Zurich, investigated this in relation to avian populations in the US together with Eric Strobl from the University of Bern.

This involved the researchers factoring in data from the North American Breeding Bird Survey, a long-term programme running since 1966 to monitor bird populations in North America. Each year, trained volunteers count all the birds they see or hear along fixed routes, each around 40 kilometres long, at some 50 stops. Meier and Strobl analysed data from around 2,800 such routes in the US over a 15-year period, from 2008 to 2022, and combined it with high-resolution data on particulate matter pollution from wildfires. 

In addition to the number of species, they also examined how evenly the birds were distributed across different species and how much these species differed from one another in evolutional terms. 

Smoke from wildfires leaves its marks into the subsequent year 

The result: if an area had been more heavily affected by wildfire smoke the previous year, bird diversity there was lower in the following breeding season. If smoke levels rose from an average year to a significantly smokier one, the number of species dipped by around three percent. On an average survey route with 55 species, this equates to roughly one to two fewer species. At the most heavily affected monitoring sites, however, the number of species fell much more significantly. 

“I wasn’t sure whether we would see any effect at all across such a large and ecologically diverse area,” ETH researcher Meier relates. This makes it all the more remarkable that the correlation is evident across the US as a whole. 

“The effect isn’t huge, but it is measurable. And we never know which species will disappear and which of these are particularly important for an ecosystem. Therefore, even a small decline can, in the worst-case scenario, cause an ecosystem to become unbalanced.”

Is smoke really to blame? 

Forest fires often occur during periods of heat and drought – conditions that can also have a direct impact on birds. Applying a method from econometrics, the researchers therefore isolated the effect of smoke from other factors. They compared the same areas over many years, taking into account factors such as weather, land use and differences in how the bird counts were conducted. 

In addition, they examined two particularly obvious explanations. Firstly, the lower bird diversity could be a direct consequence of destroyed habitats. However, even on survey routes where no areas had burned within a five-kilometre radius, the effects of the smoke persisted. Secondly, birds might simply have moved to neighbouring areas to avoid the smoke. Even after the researchers had taken such local shifts into account in their analysis, reduced avian diversity was still evident. 

The study does not reveal exactly what happens to the birds. Other research suggests that smoke can weaken birds, possibly causing loss of weight and respiratory damage. Their behaviour may also change during the breeding season.

What is the impact on the economy and ecosystems? 

For Meier, the study findings highlight a consequence of forest fires that is decidedly difficult to capture in traditional damage assessments. Birds perform important functions in many ecosystems: they disperse seeds, pollinate plants and help to control pests. 

A decline in avian diversity can therefore also affect other animal and plant species – and ultimately sectors such as agriculture and forestry.

The study intentionally does not quantify the extent of the economic damage caused by a decline in avian diversity. Meier focuses initially on demonstrating individual impacts as reliably as possible.

“In the case of burned-out buildings, we can relatively easily quantify the cost of the damage. With biodiversity, things are far more complex,” says Meier. “There are other consequences of forest fires that we have barely taken into account to date, even though they have an impact on society.”

References 

Meier S, Strobl E: The impact of wildfire smoke on local avian biodiversity. Journal of Environmental Economics and Management, 139, 103379 (2026). DOI: 10.1016/j.jeem.2026.103379  

 

Bacteria in airway shape air pollution health risk


Wellcome Trust Sanger Institute





Air pollution leads to different risk of bacterial pneumonia, sepsis, and meningitis, depending on the subtype of bacteria a person has, new research suggests.

The new study comes from the Wellcome Sanger Institute, the National Institute for Communicable Diseases in Johannesburg, South Africa, the Barcelona Supercomputing Center – Centro Nacional de Supercomputación (BSC-CNS), and collaborators. The team suggests that the subtype of the bacterium, Streptococcus pneumoniae (S. pneumoniae), together with air pollution exposure impacts the rate and timing of invasive disease — with some strains linked to immediate infection after air pollution exposure, and some taking several weeks.

Published today (14 September) in Nature Microbiology, the researchers also found that older adults and young children are more vulnerable during periods of high air pollution, and that improving air quality could lower disease risk. They also suggest that understanding what type of bacterial strains are circulating and how environmental factors shape infection rates could inform future public health policies, protect those most at risk, and prepare hospitals for outbreaks.  

S. pneumoniae is found in the respiratory microbiome, the collection of microbes that live in the human nose and throat, in almost 20 per cent of adults globally1. While many adults and children carry the bacteria without any symptoms, when S. pneumoniae gets into the lower respiratory tract, or blood stream, it can lead to invasive pneumococcal disease (IPD)2.

IPD includes bacterial sepsis, pneumonia and meningitis. It is a major cause of disease and death globally and often peaks during colder months2. In South Africa, there were over 1,800 reported cases of IPD in 20223. In England, the UK Health Security Agency reports that there are more than 5,000 cases per year, particularly impacting children under the age of five, people over 65 years old, and those with underlying conditions2. There are currently over 100 different serotypes, which are specific subtypes of S. pneumoniae4.

While it is known that different subtypes of S. pneumoniae can lead to varying infection rates in different populations, important gaps remain in our collective understanding of how things such as humidity, temperature, and air pollution impact the timing of disease, and how risks vary by individual age and bacterial subtype.

This new study examined around 59,000 cases of IPD across 19 years from South Africa’s national GERMS-SA surveillance programme.  In South Africa, between 40-60 per cent of children carry S. pneumoniae,5,6.

The researchers found that different subtypes of S. pneumoniae responded differently to higher air pollution exposure, noting three subtypes (14, 19A, and 8) were linked to the greatest risk of IPD following exposure.  

Additionally, they found that different subtypes were linked to differences in the timing of disease risk. While the highest risk of IPD peaked roughly two weeks after air pollution exposure, in areas where subtypes 4, 8, 23F, and 19F were common, there was an immediate increase in disease risk, occurring within the same week.

Importantly, the team accounted for other factors including temperature, humidity, and population density to ensure that the effects were measured as accurately as possible. They also noted that high temperatures were associated with an immediate increase in disease risk, and cold temperatures led to a delayed rise in cases. The team suggests that cold weather slows bacterial transmission or that damage from seasonal viruses could make it easier for bacterial infections to follow.  

The authors suggest that integrating environmental monitoring with genomic surveillance of S. pneumoniae could help predict infection spikes, inform vaccination strategies, and support healthcare providers prepare during periods of poor air quality. The study also provides further evidence that reducing air pollution may yield important benefits for infectious disease prevention, particularly in areas with high levels of exposure, such as cities.

Professor Anne von Gottberg, co-senior author at the National Institute for Communicable Diseases in Johannesburg, South Africa, said: “Invasive pneumococcal diseases are a significant public health issue in South Africa and globally. This research adds to the ongoing evidence that air quality greatly impacts our health and shows that it has different effects depending on the strain of bacteria that is found in an area. We need to focus on monitoring and improving air quality in areas with high disease risk to prevent or reduce some of these infections.”

Professor Rachel Lowe, co-senior author at the Barcelona Supercomputing Center and the Catalan Institution for Research & Advanced Studies, said: “Climate change and rapid urbanisation are fundamentally altering the environmental conditions that influence risk of infectious disease. By linking long-term climate and air quality monitoring with health outcomes, this work highlights how shifting environmental patterns can amplify public health risks. Protecting communities most at risk will require cross-sector collaboration and adaptive health strategies that can keep pace with a changing environment.” 

Dr Sophie Belman, first author previously at the Wellcome Sanger Institute, and Barcelona Supercomputing Center, currently Assistant Professor at Yale School of Public Health, said: “While we found that temperature and air pollution generally increase the risk of invasive pneumococcal diseases, such as bacterial meningitis, our research also suggests that it is the bacterial subtypes a person is carrying that modulate infection rates. The strain of bacteria impacts the timing of disease and who might be more at risk depending on their respiratory microbiome, meaning that the risk is not the same in every situation or for every person. By extending our findings to other parts of the globe, we will better understand who has the highest health risk from environmental exposures, and what factors need to be addressed in different regions, such as improving air quality in cities."

ENDS

Contact details:

Rachael Smith

Press Office

Wellcome Sanger Institute

Cambridge, CB10 1SA

07827979492

Email: press.office@sanger.ac.uk

Notes to Editors:

  1. D. Rosdiana, AM. Simanjuntak, NC. Ediwi, et al. (2025) Prevalence of Streptococcus pneumoniae carriage among adults: Should we raise a concern? A systematic review and meta-analysis with geospatial analysis. Exploration of Medicine. DOI:  10.37349/emed.2025.1001354
  2. Pneumococcal disease: guidance, data and analysis. UK Health Security Agency. Available at: https://www.gov.uk/government/collections/pneumococcal-disease-guidance-data-and-analysis [Accessed August 2026]
  3. C. Lekhuleni, K. Ndlangisa, R.A. Gladstone, et al.(2024) Impact of pneumococcal conjugate vaccines on invasive pneumococcal disease-causing lineages among South African children. Nature Communications. DOI: 10.1038/s41467-024-52459-3
  4. F. Ganaie, et al. (2020) A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large cps Fragment from an Oral Streptococcus. mBio. DOI: 10.1128/mbio.00937-20
  5. F. S. Dube, et al. (2018) Longitudinal characterization of nasopharyngeal colonization with Streptococcus pneumoniae in a South African birth cohort post 13-valent pneumococcal conjugate vaccine implementation. Scientific Reports. DOI: 10.1038/s41598-018-30345-5
  6. S.L. Downs, et al. (2023) Streptococcus pneumoniae and other bacterial nasopharyngeal colonization seven years post-introduction of 13-valent pneumococcal conjugate vaccine in South African children. International Journal of Infectious Diseases. DOI: 10.1016/j.ijid.2023.05.016

Publication:

S. Belman, C. Lekhuleni, J. Kleynhans, et al. (2026) ‘Pneumococcal population structure influences the effects of air pollution on invasive disease risk in South Africa’. Nature Microbiology. DOI: 10.1038/s41564-026-02458-5

Funding:

Sophie Belman conducted this research as part of her Schmidt Science Fellowship at Barcelona Supercomputing Center (BSC). Surveillance for IPD in South Africa is funded by the National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg, South Africa. This research was supported in part by the Fogarty International Center, the Gates Foundation, Wellcome, and the Department of Health and Social Care. A full acknowledgement list can be found in the publication.  

Selected websites:

The Wellcome Sanger Institute

The Wellcome Sanger Institute is a world leader in genomics research. We apply and explore genomic technologies at scale to advance understanding of biology and improve health. Making discoveries not easily made elsewhere, our research delivers insights across health, disease, evolution and pathogen biology. We are open and collaborative; our data, results, tools, technologies and training are freely shared across the globe to advance science.

Funded by Wellcome, we have the freedom to think long-term and push the boundaries of genomics. We take on the challenges of applying our research to the real world, where we aim to bring benefit to people and society.

Find out more at www.sanger.ac.uk or follow us on Bluesky, X, Instagram, Facebook, LinkedIn and on our Blog.

About Wellcome

Wellcome supports science to solve the urgent health challenges facing everyone. We support discovery research into life, health and wellbeing, and we’re taking on three worldwide health challenges: mental health, infectious disease and climate and health. https://wellcome.org/

National Institute for Communicable Diseases

The National Institute for Communicable Diseases (NICD) is South Africa’s leading public health institute responsible for disease surveillance, outbreak response, reference laboratory services, and public health research. GERMS-SA is its national laboratory-based surveillance programme that monitors invasive bacterial diseases, including invasive pneumococcal disease across South Africa. More information: https://www.nicd.ac.za

Barcelona Supercomputing Center
Barcelona Supercomputing Center (BSC) is one of the leading supercomputing centers in Europe and houses one of the most powerful supercomputers in the world, MareNostrum 5. The center specializes in High Performance Computing (HPC) and artificial intelligence (AI), serving a dual purpose: providing supercomputing infrastructure and services to Spanish and European scientists, and generating knowledge and technology to transfer to society.

BSC’s research focuses on the fields of computer science, life sciences, Earth sciences, computer applications in science and engineering, and computational social sciences and humanities.

Within BSC’s Earth Sciences Department, the Global Health Resilience (GHR) group works to strengthen preparedness for and response to emerging climate-sensitive health threats worldwide. GHR develops approaches to anticipate how climate extremes, environmental degradation and social inequalities interact to shape disease risk across regions and populations. More information: https://www.bsc.es/discover-bsc/organisation/research-departments/global-health-resilience