High-risk, disadvantaged groups face barriers to preventing spread of COVID-19

Researchers urge greater focus on ensuring access to vaccines and precautionary measures

AMERICAN COLLEGE OF CARDIOLOGY

Research News

 

Social factors such as education, financial stability, food security and the neighborhood where someone resides were strongly correlated with whether or not individuals with heart disease adopted measures to prevent the spread of COVID-19, including wearing masks and working from home, according to a study presented at the American College of Cardiology's 70th Annual Scientific Session. The researchers say the findings draw attention to longstanding challenges related to social determinants of health.

"Unless we look at COVID-19 through the lens of social determinants of health, we may not optimize our yield from interventions, and we might not be reaching the group of individuals who need these interventions the most," said Kobina Hagan, MD, a postdoctoral fellow at Houston Methodist Research Institute and the study's lead author.

The research is based on data from the COVID-19 Household Impact Survey, which assessed COVID-19 preventive strategies along with health and sociodemographic factors among more than 25,000 U.S. adults. The researchers analyzed responses from just over 2,000 survey respondents who reported a history of heart disease, heart attack or stroke. According to the U.S. Centers for Disease Control and Prevention, heart disease increases the risk of severe illness from COVID-19. The researchers grouped survey respondents into quartiles reflecting social risk factors based on income and financial security, employment, education, health insurance status, food insecurity and neighborhood quality.

The largest gap was seen in the degree to which respondents reported having flexibility in their work arrangements--defined as being able to work from home or cancel or postpone work activities. Compared to those with the most favorable social risk profile, those with the greatest social adversity were 46% less likely to report flexibility at work. Individuals with the greatest social adversity were also 31% less likely to engage in all social distancing measures (canceling or postponing social activities and avoiding crowded public places, restaurants and contact with high-risk people) and 17% less likely to engage in all personal protective measures (wearing a face mask, washing hands and keeping a 6-foot distance from those outside their household) compared to those with the most favorable social risk profile. These differences remained significant even after accounting for demographics and comorbidities.

The study was conducted before COVID-19 vaccines were available, at a time when public health experts primarily recommended social distancing and other measures to slow the disease's spread. However, similar trends are likely at play in the context of vaccine access, researchers said.

"I think we are repeating the same mistakes and expecting better results," Hagan said. "I hope we can come to a point where we as a society take social disparities into account in our decision making. We have to prioritize these socially disadvantaged individuals in our public policy programs, including vaccine delivery, to reduce the disparities in COVID-19 risk and outcomes."

Although the survey did not assess the reasons why respondents did or did not adopt COVID-19 mitigation measures, Hagan said many of the factors reflect circumstances that are often outside of a person's control, such as their ability to work from home. For measures that involve more personal choice, he suggested that low health literacy may play a role in the lower uptake of mitigation measures among disadvantaged groups.

"We as a society have ignored all the disparities and inequities that were happening during calmer times, even in cardiovascular disease," Hagan said. "2020 was a time when we could no longer ignore the disparities. We need to focus on holistic strategies to effectively fight this pandemic and ensure those not afforded the privilege of personal protection, social distancing and work flexibilities are prioritized with vaccine outreach to avoid further compounding existing health inequalities."

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For resources on managing heart disease and COVID-19, visit CardioSmart.org/coronavirus.

This study will be simultaneously published in Circulation: Cardiovascular Quality & Outcomes.

Hagan will present the study, "Social Determinants of Health Disparities for COVID-19 Mitigation Measures Among Adults with Cardiovascular Disease in the United States," on Saturday, May 15, at 9:30 a.m. ET / 13:30 p.m. UTC.

ACC.21 will take place May 15-17 virtually, bringing together cardiologists and cardiovascular specialists from around the world to share the newest discoveries in treatment and prevention. Follow @ACCinTouch, @ACCMediaCenter and #ACC21 for the latest news from the meeting.

The American College of Cardiology envisions a world where innovation and knowledge optimize cardiovascular care and outcomes. As the professional home for the entire cardiovascular care team, the mission of the College and its 54,000 members is to transform cardiovascular care and to improve heart health. The ACC bestows credentials upon cardiovascular professionals who meet stringent qualifications and leads in the formation of health policy, standards and guidelines. The College also provides professional medical education, disseminates cardiovascular research through its world-renowned JACC Journals, operates national registries to measure and improve care, and offers cardiovascular accreditation to hospitals and institutions. For more, visit ACC.org.

 

Achieving high COVID-19 vaccine coverage levels by summer can prevent millions of cases

New study finds if the United States vaccinates half its population by the summer vs fall, 5.8 million cases could be prevented and $7.8 billion in societal costs could be saved

CUNY GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

Research News

 

(MAY 6, 2021) New York, NY - With around 30 percent of the U.S. population now fully vaccinated, the rate of daily vaccinations has started to slow, raising concerns that greater efforts and investments may be needed to reach higher coverage levels. A study published in the Journal of Infectious Diseases on May 6 shows the lives, hospitalizations, and costs that can be saved by even relatively small increases in vaccination coverage and reaching higher vaccination coverage levels sooner (e.g., by the end of the summer versus fall/winter).

The study was led by researchers from PHICOR (Public Health Informatics, Computational, and Operations Research) at CUNY Graduate School of Public Health & Health Policy, the National School of Tropical Medicine at Baylor College of Medicine, and Johns Hopkins Center for Health Security. The team developed a computer simulation model of the entire U.S. and the spread of the COVID-19 coronavirus throughout the country. Using the model, the team could simulate vaccinating different proportions of the population at different rates with different types of COVID-19 vaccines. Like real people, each of these virtual people could become infected with the virus and develop different symptoms over time and, depending upon the severity of those symptoms, visit clinics, emergency departments, or hospitals. These in turn would have associated costs, allowing the tracking of various medical costs and productivity losses.

The study showed that going from a 30 percent vaccination coverage to a 40 percent coverage could save 24.3 million cases and $33.1 billion in direct medical costs and productivity losses. Going from a 50 percent to 70 percent coverage could save 9.5 million cases and 10.8 billion in direct medical costs and productivity losses.

In fact, even relatively small increases in vaccine coverage can prevent thousands of cases and lives and hundreds of millions in costs. For example, results from the model showed each 1 percent increase between 40 and 50 percent of the U.S. population being vaccinated by the fall can prevent 1.6 million cases, 60,190 hospitalizations, and 7,100 deaths and save $674.2 million in direct medical costs and $1.5 billion in productivity losses. Each 1 percent increase between 50 and 70 percent can prevent 473,900 cases, 17,600 hospitalizations, 2,000 deaths, and 537 million in direct medical costs and productivity losses.

The study also emphasized the importance of reaching higher coverage levels as soon as possible. For example, speeding up vaccinations to reach a 50 percent coverage by July 2021 instead of October 2021 could save an additional 5.8 million cases, 215,790 hospitalizations, 26,370 deaths, $3.5 billion in direct medical costs, and $4.3 billion in productivity losses.

Results suggested that getting as many people fully vaccinated as possible before the early winter would be particularly important. The model incorporated changes in the transmission of the virus that occurred with the changing seasons in 2020, when surges occurred during the winter months, and projected what may happen in 2021. For example, when 50 percent of the U.S. population is vaccinated by October 2021 instead of the end of December 2021, 6.6 million cases, 252,260 hospitalizations, 29,380 deaths, $4.0 billion direct medical costs, and $8.0 billion productivity losses were saved.

"The results of this study can give policymakers, community leaders, and other decision makers a sense of how much can be invested into vaccinating those who may be harder to get vaccinated," explained Sarah Bartsch, MPH, the study's lead author and project director for PHICOR. "Such investments may end up paying for themselves. For example, the potential cost savings exceed the $1.5 billion Biden Administration community outreach and media campaign. Our results show that increasing total vaccination coverage by just one percent could cover the costs of this effort."

"The longer it takes to reach higher vaccination coverage levels and herd immunity thresholds, the more the virus can spread," said Bruce Y Lee, senior author of the study, executive director of PHICOR, and CUNY SPH professor. "It may be particularly important to reach higher coverage levels before the late fall to prevent another winter surge."

Additionally, the study showed how increasing vaccination coverage levels was more valuable than using vaccines with higher effectiveness. For example, we found that achieving a 70 percent coverage with a 70 percent effective vaccine can save 2.1 million cases and 5.5 billion in medical costs and productivity losses compared to achieving a 50 percent coverage with a 90 percent effective vaccine over the same period. This shows the value of using all Covid-19 vaccines that are available to get more people vaccinated as soon as possible, rather than focusing only on those with the highest effectiveness. Moreover, as more contagious variants circulate, potentially decreasing the effectiveness of the existing Covid-19 vaccines, this can help address concerns about continuing with the existing vaccines or waiting for an updated version.

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Media contact:

Sarah Rebbert
Sarah.Rebbert18@gmail.com

About CUNY SPH

The CUNY Graduate School of Public Health and Health Policy is committed to teaching, research, and service that creates a healthier New York City and helps promote equitable, efficient, and evidence-based solutions to pressing health problems facing cities around the world. Follow @CUNYSPH for updates.

About PHICOR

Since 2007, PHICOR has been developing computational methods, models, and tools to help decision makers better understand and address complex systems in health and public health. Follow @PHICORTeam for upda

Independent evolutionary origins of vertebrate dentitions, according to latest study

UNIVERSITY OF BRISTOL

Research News

 

IMAGE: SIDE AND ORAL VIEWS OF A VIRTUAL MODEL OF THE ISCHNACANTHID ACANTHODIAN JAW SHOWING THE TOOTH-ROWS AND RECONSTRUCTION OF THE TOOTH REPLACEMENT. view more 

CREDIT: MARTIN RÜCKLIN, NATURALIS BIODIVERSITY CENTER

The origins of a pretty smile have long been sought in the fearsome jaws of living sharks which have been considered living fossils reflecting the ancestral condition for vertebrate tooth development and inference of its evolution. However, this view ignores real fossils which more accurately reflect the nature of ancient ancestors.

New research led by the University of Bristol and the Naturalis Biodiversity Center published in Nature Ecology and Evolution reveals that the dentitions of living shark relatives are entirely unrepresentative of the last shared ancestor of jawed vertebrates.

The study reveals that while teeth evolved once, complex dentitions have been gained and lost many times in evolutionary history and tooth replacement in living sharks is not the best model in the search for therapeutic solutions to human dental pathologies.

Lead author Martin Rücklin from Naturalis Biodiversity Center in Leiden, The Netherlands said: "We used high energy x-rays at the TOMCAT beamline of the Swiss Light Source at the Paul Scherrer Institut in Switzerland, to study tooth and jaw structure and development among shark ancestors. These ischnacanthid acanthodians possessed marginal dentitions composed of multiple, successional tooth rows, that are quite unlike the tooth whorls that occur in front of the jaw in acanthodians and across the jaws of crown-chondrichthyans."

Co-author Professor Philip Donoghue from the University of Bristol's School of Earth Sciences said: "Dentitions of vertebrates are characterized by an organised arrangement to enable occlusion and efficient feeding over the lifetime of an animal. This organisation and pattering of teeth is thought to originate in a universal development mechanism, the dental lamina, seen in sharks. The condition we see in the successional tooth rows cannot be explained by this mechanism."

Co-author Benedict King from Naturalis Biodiversity Center said: "Using state of the art probabilistic ancestral state estimation methods, we build on this discovery to show that teeth existed in the crown-ancestor of gnathostomes, whereas complex dentitions, tooth whorls, a dental lamina and coordinated replacement, have all evolved independently and been lost several times in the early evolution of jawed vertebrates."

This work was supported by the Dutch Research Council NWO (Vidi grant), the Natural Environment Research Council, the Paul Scherrer Institut, EU Horizon2020 and the Naturalis Biodiversity Center.

Paper

'Acanthodian dental development and the origin of gnathostome dentitions' by Martin Rücklin, Benedict King, John A. Cunningham, Zerina Johanson, Federica Marone and Philip C. J. Donoghue in Nature Ecology & Evolution

Open source tool can help identify gerrymandering in voting maps

WASHINGTON STATE UNIVERSITY

Research News

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IMAGE: VISUALIZATION OF SAMPLED COUNTY-PRESERVING VIRGINIA CONGRESSIONAL VOTING DISTRICTS, CREATED WITH THE RECOM METHOD IN GERRYCHAIN. view more 

CREDIT: DARYL DEFORD, WASHINGTON STATE UNIVERSITY

PULLMAN, Wash. -- With state legislatures nationwide preparing for the once-a-decade redrawing of voting districts, a research team has developed a better computational method to help identify improper gerrymandering designed to favor specific candidates or political parties.

In an article in the Harvard Data Science Review, the researchers describe the improved mathematical methodology of an open source tool called GerryChain. The tool can help observers detect gerrymandering in a voting district plan by creating a pool, or ensemble, of alternate maps that also meet legal voting criteria. This map ensemble can show if the proposed plan is an extreme outlier--one that is very unusual from the norm of plans generated without bias, and therefore, likely to be drawn with partisan goals in mind.

An earlier version of GerryChain was used to analyze maps proposed to remedy the Virginia House of Delegates districts that a federal court ruled in 2018 were unconstitutional racial gerrymanders. The updated tool will likely play a role in the upcoming redistricting using new census data.

"We wanted to build an open-source software tool and make that available to people interested in reform, especially in states where there are skewed baselines," said Daryl DeFord, assistant mathematics professor at Washington State University and a co-lead author on the paper. "It can be an impactful way for people to get involved in this process, particularly going into this year's redistricting cycle where there are going to be a lot of opportunities for pointing out less than optimal behavior."

The GerryChain tool, first created by a team led by DeFord as a part of the 2018 Voting Rights Data Institute, has already been downloaded 20,000 times. The new paper, authored by Deford along with Moon Duchin of Tufts University and Justin Solomon of the Massachusetts Institute of Technology, focuses on how the mathematical and computational models implemented in GerryChain can be used to put proposed voting districting plans into context by creating large samples of alternative valid plans for comparison. These alternate plans are often used when a voting plan is challenged in court as being unfair as well as to analyze potential impacts of redistricting reform.

For instance, the enacted 2010 House of Delegates plan in Virginia had 12 voting districts with a Black voting age population at or above 55%. By comparing that plan against an ensemble of alternate plans that all fit the legal criteria, advocates showed that map was an extreme outlier of what was possible. In other words, it was likely drawn intentionally to "pack" some districts with a Black voter population to "crack" other districts, breaking the influence of those voters.

One of the biggest challenges to creating voting maps are the sheer number of possibilities, DeFord said. Many states like Virginia have hundreds of thousands of census blocks. They also have many rules and goals for structuring voting districts: such as keeping them geographically contiguous and compact with units like counties and cities intact. Many states also want to protect "communities of interest" an often undefined term, but the federal Voting Rights Act explicitly aims to protect minority voters, since historically, gerrymanders have sought to weaken the effect of their vote. In addition, multiple states require that voting maps be drawn with an attempt at political neutrality.

Even with all these rules, voting maps can still be drawn in a myriad of different ways.

"There are more feasible plans in a lot of states than there are molecules in the universe," Deford said. "That's why you want this kind of mathematical tool."

Since the advent of computers, models have provided the ability to make an array of maps. Before the current version of Gerrychain, many models used a data method called a "Flip walk" to create alternatives, which involves changing just one assignment at time, such as a precinct or census block. Every change has a ripple effect on other districts, resulting in a different map.

The tool developed by DeFord and his colleagues uses a method called a spanning tree recombination or "ReCom" for short. To create an alternative voting map, the method involves taking two districts, merging them together before splitting them apart again in a different way. This creates a greater change with multiple voting blocks changing at a time.

The computational tool can create many alternative voting plans within a matter of hours or days, and it is freely available for use by voting reform groups or anyone who has knowledge of Python, the data software behind it.

The authors emphasize, however, that computers alone shouldn't create the voting plan that is ultimately adopted for use. Rather the ensemble method provides a tool for analyzing baselines and evaluating potential alternatives.

"This is not some sort of magic black box where you push the button, and you get a collection of perfect plans," said Deford. "It really requires serious engagement with social scientists and legal scholars. Because the rules are written and implemented by people, this is a fundamentally human process."

CAPTION

Visualization of sampled population-shifted Washington Congressional districts, created with the ReCom method in Gerrychain.

CREDIT

Daryl DeFord, Washington State University

CAPTION

Visualization of sampled Pennsylvania Congressional districts, created with the ReCom method in Gerrychain.

CREDIT

Daryl DeFord, Washington State University

 

We need to build more EV fast-charging stations, researchers say

UNIVERSITY OF CALIFORNIA - SAN DIEGO

Research News

IMAGE: THE UNIVERSITY OF CALIFORNIA SAN DIEGO IS HOME TO ONE OF THE LARGEST, MOST DIVERSE RANGE OF ELECTRIC VEHICLE CHARGING STATIONS AT ANY UNIVERSITY IN THE WORLD. view more 

CREDIT: UNIVERSITY OF CALIFORNIA SAN DIEGO

A team of engineers recommends expanding fast-charging stations for electric vehicles as campuses and businesses start planning for a post-pandemic world.

The recommendation is based on a study of charging patterns for electric vehicles on the University of California San Diego campus from early January to late May of 2020, after the university moved most of its operations online. Researchers say the findings can be applied to a broader range of settings.

"Workplace charging is a critical enabler of carbon-free transportation as the electrons consumed primarily come from solar power plants, as opposed to at-home charging, which occurs at night and relies more on fossil fuel power plants," said Jan Kleissl, the paper's senior author and a professor of environmental engineering at UC San Diego.

It's the first time that a research team gathered information on workplace charging patterns for electric vehicles during the COVID-19 pandemic. As expected, charging declined dramatically once most campus operations became remote. Also as expected, charging at the campus' medical center was less impacted as medical facilities continued most in-person operations and healthcare workers and patients kept using those charging stations.

This reflects nationwide trends. Vehicle travel in the United States declined by about 40 percent from mid-March to mid-April 2020, according to the National Bureau of Economic Research.

But DC fast chargers that provide a full charge in about half an hour were less affected than what is known as Level 2 chargers, which provide a full charge over eight hours. Energy dispatched at Level 2 chargers on the main UC San Diego campus decreased by 84 percent. DC fast charging initially dropped by 67 percent. These stations quickly returned to near-normal usage in a short period of time, unlike Level 2 charging stations.

"This finding reinforces ongoing efforts to deploy at least an additional 20 DCFCs primarily on the perimeter of campus in order to serve both UC San Diego commuters as well as the general public in need of recharging," said Byron Washom, the UC San Diego director of strategic energy initiatives and one of the paper's coauthors.

The team details their findings in the March 23 issue of the Journal of Renewable and Sustainable Energy.

Only four out of 100 stations in the study were fast-charging. More broadly, in the United States, only a tiny fraction of charging stations are fast-charging, and most of those only serve Tesla vehicles. For example, California has about 31,800 EV charging stations. Of those, almost 3000 are Tesla supercharging stations, only available to Tesla vehicles. An additional 470 are DCFC stations managed by California-based Chargepoint.

The study looked at 100 charging stations in 28 parking structures. Specifically, researchers found that from March 11 to May 20, 2020:

• Charging on the main campus dropped by 84 percent from pre-pandemic levels
• Charging dropped by 50 percent at the parking structures at the UC San Diego medical center locations
• Charging at DC fast charging stations initally dropped by 67 percent before going back up to near pre-pandemic levels

Charging will likely not resume back to normal even after the pandemic ends, researchers say.

"Commuting patterns based on five days a week in the office are unlikely to resume, however, as employers may allow more telecommuting even after the end of the pandemic," Kleissl said. .

That may be good news as the anticipated dramatic increase in EV adoption over the coming years would otherwise strain the existing charging infrastructure, he added.

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Impact of the Coronavirus Pandemic on Electric Vehicle Workplace Charging
Graham McClone, Jan Kleissl, Byron Washom, Sushil Silwal, University of California San Diego

Temperature explains why aquatic life more diverse near equator

Findings indicate global warming could reduce biodiversity in tropics

UNIVERSITY OF NEBRASKA-LINCOLN

Research News

 

IMAGE: A MAP ILLUSTRATING THE OCCURRENCE OF MOLLUSKS IN MARINE SHELF ENVIRONMENTS BETWEEN 1700 AND 2020, WITH DARKER HEXAGONS INDICATING FEWER AND LIGHTER INDICATING MORE. BY COMPILING AND ANALYZING MOLLUSK FOSSIL... view more 

CREDIT: ADAPTED FROM FIGURE IN CURRENT BIOLOGY / CELL PRESS

The bulging, equator-belted midsection of Earth currently teems with a greater diversity of life than anywhere else -- a biodiversity that generally wanes when moving from the tropics to the mid-latitudes and the mid-latitudes to the poles.

As well-accepted as that gradient is, though, ecologists continue to grapple with the primary reasons for it. New research from the University of Nebraska-Lincoln, Yale University and Stanford University suggests that temperature can largely explain why the greatest variety of aquatic life resides in the tropics -- but also why it has not always and, amid record-fast global warming, soon may not again.

Published May 6 in the journal Current Biology, the study estimates that marine biodiversity tends to increase until the average surface temperature of the ocean reaches about 65 degrees Fahrenheit, beyond which that diversity slowly declines.

During intervals of Earth's history when the maximum surface temperature was lower than 80 degrees Fahrenheit, the greatest biodiversity was found around the equator, the study concluded. But when that maximum exceeded 80 degrees, marine biodiversity ebbed in the tropics, where those highest temperatures would have manifested, while peaking in waters at the mid-latitudes and the poles.

Marine life that could travel considerable distances likely migrated north or south from the tropics during periods of extreme heat, said co-author Will Gearty, a postdoctoral researcher of biological sciences at Nebraska. Stationary or slower-moving animals, such as sponges and sea stars, may have instead faced extinction.

"People have always theorized that the tropics are a cradle of diversity -- that it pops up and then is protected there," Gearty said. "There's also this idea that ... there's lots of migration toward the tropics, but not away from it. All of that centers around the idea that the highest diversity will always be in the tropics. And that's not what we see as we go back in time."

Gearty, Yale's Thomas Boag and Stanford's Richard Stockey went back about 145 million years, compiling estimated temperatures and fossil records of mollusks -- snails, clams, cephalopods and the like -- from 24 horizontal bands of Earth that were equal in surface area. The trio chose mollusk records for multiple reasons: They live (and lived) around the globe, in large enough numbers to accommodate statistical analyses, with hard enough shells to yield identifiable fossils, with enough variation that their diversity trends might generalize to fish, corals, crustaceans and an array of other marine animals.

That data allowed the team to derive the temperature-diversity relationship across 10 geologic intervals that covered most of the elapsed time from the Cretaceous period through the modern day.

"Temperature seems to account for a lot of the trend that we see in the fossil record," Gearty said. "There are certainly other factors, but this seems to be the first-order predictor of what's going on."

To investigate why temperature might be so influential and predictive, Stockey took the lead in developing a mathematical model. The model accounts for the fact that higher temperatures generally increase the amount of energy in an ecosystem, theoretically raising the ceiling on the biodiversity an ecosystem can sustain, at least to a point.

But it also factors in metabolism and the small matter of oxygen, which, by dissolving in water, makes aquatic life possible in the first place. Colder waters dissolve more oxygen, meaning that elevated temperatures naturally reduce the amount available to marine life and, by extension, potentially limit the biodiversity an ecosystem can support. Higher temperatures also raise the metabolic demands of organisms, increasing the minimum oxygen needed to sustain active marine animals.

"That means you require more oxygen in warmer waters," Gearty said. "And if the amount of oxygen available is not satisfying that increase in metabolism, you won't survive in that environment. So, to survive, you'll need to move to another environment where the temperature is lower."

The team applied its model to numerous marine species with varying metabolisms. As expected, metabolism influenced how the population of a given species would respond to a rise in temperature, along with the temperature threshold beyond which that population would decline. When the researchers averaged the effects of metabolism and oxygen availability across those species, they discovered that the resulting temperature-diversity relationship resembled -- and, in doing so, supported -- the one they derived from the fossil record.

"It shows a similar trend of this (biodiversity) increase and then decrease," Gearty said. "After many a day at the whiteboard just trying to figure out how to make it work, it all just came together very nicely at the end -- you know, a nice little bow on top."

Collectively, the study indicates that human-driven global warming could hit the inhabitants of tropical waters especially hard. The average surface temperature of tropical waters could jump by as many as 6 degrees Fahrenheit by the year 2300, according to one projection. And according to the fossil records analyzed for the study, similar temperature increases during the past 145 million years have sometimes permanently driven mollusk species from tropical waters. There are worrying signs that the expected trend is already underway, Gearty said.

Though the team had difficulty narrowing down the projected magnitude of the decline in biodiversity, Gearty said the worst-case projection called for the tropics losing up to 50% of their marine species by 2300. Some of the loss will take the form of migration. Yet the warming could spell doom for, say, corals and the thousands of marine species that they support, he said, as seen in the oft-fatal bleaching of the Great Barrier Reef off the coast of Australia.

"This (biodiversity loss) is already happening, and it will only keep happening unless we do something," Gearty said. "We can't really take back the buildup of carbon dioxide (in the atmosphere) that's already happened, so it's going to keep happening for some amount of time. But it's up to us to determine how long until it'll stop."

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Ice core data show why, despite lower sulfur emissions in US and Western Europe, air pollution is dropping more slowly

TOKYO INSTITUTE OF TECHNOLOGY

Research News

 

IMAGE: THIS STUDY IS BASED ON THE 90.45-M-DEEP ICE CORE OBTAINED AT A SOUTHEASTERN GREENLAND DOME SITE (67.18°N, 36.37°W, 3170 M A.S.L., SE-DOME HEREAFTER).... view more 

CREDIT: HOKKAIDO UNIVERSITY

The air in the United States and Western Europe is much cleaner than even a decade ago. Low-sulfur gasoline standards and regulations on power plants have successfully cut sulfate concentrations in the air, reducing the fine particulate matter that harms human health and cleaning up the environmental hazard of acid rain.

Despite these successes, sulfate levels in the atmosphere have declined more slowly than sulfur dioxide emissions, especially in wintertime. This unexpected phenomenon suggests sulfur dioxide emission reductions are less efficient than expected for cutting sulfate aerosols. A new study led by Tokyo Institute of Technology (Tokyo Tech), Hokkaido University and the University of Washington explains why.

The open-access paper was published on May 5 in Science Advances.

When concentrations of acidic sulfate from fossil fuel emissions decrease while the concentration of more basic ammonium molecules in the atmosphere stay constant, liquid water droplets in clouds become less acidic. This makes conversion of sulfur dioxide to sulfate more efficient. So, even though air quality regulations have reduced the supply of sulfur dioxide from power plants and shipping, the total amount of sulfate particulates that harm human health has dropped more slowly.

"This does not mean that the emissions reductions aren't working. It's just that there is a reaction which partially mitigates the reductions," said co-author Becky Alexander, a UW professor of atmospheric sciences. "We need to understand this multiphase chemistry in the atmosphere to design an efficient strategy to manage air pollution and accurately predict future air pollution and climate change impacts."

During most of the 20th century, sulfur dioxide emissions increased with industrialization in many parts of the world. But recently that trend has reversed in response to regulations, while ammonium emissions from animals and agriculture continue at the same rate. These trends are expected to continue.

Data from an ice core in Greenland that preserves past years' atmospheres show that the proportion of sulfate containing oxygen with one extra neutron, or oxygen-17, increased in the 1980s after countries began to regulate emissions. The authors' analysis shows this is due to faster sulfate formation in the liquid phase in the atmosphere, which occurs largely within clouds, under less-acidic conditions.

"After the SO2 emission control, relatively lower atmospheric acidity promotes the efficiency of sulfate production in the atmosphere, which weakens the response of sulfate level to the SO2 reduction," said lead author Shohei Hattori at Tokyo Tech. "Our unique isotopic techniques applied for the Greenland ice core records identify the key process of the weakened response of sulfate to SO2 emissions reduction."

The data came from an ice core drilled in southeast Greenland (SE-Dome) as part of a project led by Hokkaido University. The oxygen trapped in this ice provided evidence of sulfate composition from 1959 to 2015, without contamination from local pollution.

"Based on a continuous and high-resolution ice core record from SE-Dome, we could obtain reliable records for atmospheric aerosols without second modification after deposition," said co-author and leader of SE-Dome ice core project Yoshinori Iizuka at Hokkaido University. "We plan to drill a second ice core at the same location this year, and try to reconstruct the aerosol history back to the 1750s."

The ice core does not contain separate data for summer and winter, but models show that other, gas-phase chemical reactions for sulfur dioxide become more important in summer, reducing the summertime impact of changing cloud acidity. Knowing how these molecules react will help improve the atmospheric models used to forecast air quality and project climate change.

CAPTION

Sulfur dioxide from anthropogenic activities follow various chemical paths to form hazardous sulfate particulates. The multiphase path (inside the shaded box) becomes more important under less acidic conditions, resulting in a weaker response of sulfate to SO2 emission reduction.

CREDIT

University of Washington, Tokyo Tech, Hokkaido University

Zero to hero: Overlooked material could help reduce our carbon footprint

Scientists report hitherto unobserved high-performance CO2 adsorption in zeolites at room temperature, opening doors to applications in air purification

OKAYAMA UNIVERSITY

Research News

 

IMAGE: A NEW AVENUE FOR SELECTIVE AND EXCELLENT CO2-DESORPTION AT ROOM TEMPERATURE AND IN THE LOWER PRESSURE REGION BY UTILIZING A-TYPE ZEOLITE; THE CO2 MOLECULE ADSORBED IS SIMULTANEOUSLY PINNED BY TWO... view more 

CREDIT: 2021 OKAYAMA UNIVERSITY-INORGCHEM

It is now well known that carbon dioxide is the biggest contributor to climate change and originates primarily from burning of fossil fuels. While there are ongoing efforts around the world to end our dependence on fossil fuels as energy sources, the promise of green energy still lies in the future. Can something be done in the meantime to reduce the concentrations of CO2 in the atmosphere?

It would, in fact, be great if the CO2 in the atmosphere could simply be adsorbed! Turns out, this is exactly what direct air capture (DAC), or the capture of CO2 under ambient conditions, aims to do. However, no such material with the ability to adsorb CO2 efficiently under DAC conditions has so far been developed. "It is well known that CO2 is acidic in nature. Therefore, materials with basic nature are generally utilized as adsorbents for CO2. However, that often leads to corrosion of the system and is also not suitable for recycling the adsorbed CO2," explains Professor Yasushige Kuroda from Okayama University, Japan, who conducts research on surface chemistry.

Against this backdrop, in a recent study published in the Journal of Materials Chemistry A, scientists from Okayama University and Japan Synchrotron Radiation Research Institute (JASRI) led by Prof. Kuroda explored the adsorption properties of a material that has so far remained an "underdog": zeolites (minerals containing mainly aluminum and silicon oxides). "Zeolite materials have received little attention as adsorbents owing to their low CO2 adsorption capacity at room temperature and in the lower pressure adsorption region, as well as their poor selectivity over nitrogen," says Prof. Kuroda.

In their study, Prof. Kuroda and his team designed an ion-exchanging method of zeolite with alkaline-earth ions and achieved a remarkably high CO2 adsorption under ambient conditions. The team specifically chose an A-type zeolite (silicon/aluminum ratio of 1) because of its appropriate pore size for adsorbing CO2, while the alkaline-earth ion exchange imparted a large electric field strength that, supposedly, acted as a driving force for the adsorption. Scientists chose a doubly charged calcium ion (Ca2+) as the exchange ion since it allowed for the greatest amount of adsorption. In fact, the adsorbed volume noted was the largest amount of CO2 to have ever been adsorbed by any zeolite system, surpassing that for other materials under similar conditions!

To investigate the underlying adsorption mechanism, the scientists carried out far-infrared (far-IR) measurements and backed them up with density functional theory (DFT) calculations. The far-IR spectra, which detected the vibrational modes due to Ca2+-zeolite vibration, showed a distinct shift towards longer wavelengths following CO2 adsorption, a feature scientists could not recognize in other samples, e.g. Na-ion exchanged A-type zeolite. They further verified their observation with a model that showed good agreement with DFT calculations.

Moreover, the scientists were able to completely desorb the adsorbed CO2 and recover the original sample and its specific adsorption properties. In addition, the sample showed a superior selective adsorption of CO2 from other gases after the scientists examined the separation of CO2 using a model gas that emulated ambient air in its composition.

The findings thus bring zeolites to the forefront as an efficient adsorbent of CO2 under ambient conditions, a feat previously thought unachievable with these systems. "Our work can open doors to potentially novel applications of zeolites, such as in the cleaning of air inside semi-closed spaces including space shuttles, submarines, and concert halls, and as an adsorbent material in the anesthetic process," speculates Prof. Kuroda excitedly.

One thing is for sure, though: chemists will never look at zeolite in the same way again.

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Alcohol in moderation may help the heart by calming stress signals in the brain

Findings should spur the search for new therapies that help lower stress and impact the heart without the drawbacks of alcohol

AMERICAN COLLEGE OF CARDIOLOGY

Research News

 

Moderate alcohol intake--defined as no more than one alcoholic drink for women and two for men per day--has been associated with a lower risk of dying from cardiovascular disease when compared with individuals who abstain from drinking or partake in excessive drinking, according to a new study being presented at the American College of Cardiology's 70th Annual Scientific Session. It's also the first study to show that drinking moderate amounts of alcohol may be heart protective, in part, by reducing stress-related brain signals based on a subset of patients who underwent brain imaging.

"We found that stress-related activity in the brain was higher in non-drinkers when compared with people who drank moderately, while people who drank excessively (more than 14 drinks per week) had the highest level of stress-related brain activity," said Kenechukwu Mezue, MD, a fellow in nuclear cardiology at Massachusetts General Hospital and the study's lead author. "The thought is that moderate amounts of alcohol may have effects on the brain that can help you relax, reduce stress levels and, perhaps through these mechanisms, lower the incidence of cardiovascular disease."

While Mezue was quick to caution that these findings should not encourage alcohol use, he said they could open doors to new therapeutics or prescribing stress-relieving activities like exercise or yoga to help minimize stress signals in the brain.

"The current study suggests that moderate alcohol intake beneficially impacts the brain-heart connection. However, alcohol has several important side effects, including an increased risk of cancer, liver damage and dependence, so other interventions with better side effect profiles that beneficially impact brain-heart pathways are needed," Mezue said.

In a related study by the same research team (which is also being presented at ACC.21), exercise was found to have a similar effect on brain activity as well as on the incidence of cardiovascular disease and events. The authors said exercise is associated with decreased stress-associated brain activity in a dose-dependent manner. While the connection between stress and heart disease is widely accepted, the authors said relatively little research has been done on how modifying stress may help protect heart health.

Data were obtained from the Mass General Brigham Biobank health care survey of 53,064 participants, of which 59.9% were women and the average age was 57.2 years. Alcohol intake was based on self-report and was classified as low (<1 drink/week), moderate (1-14 drinks/week) or high (>14 drinks/week). Major adverse cardiovascular events, including heart attack, stroke or related hospitalizations, were determined using diagnostic (ICD) codes.

Of the patients included, 752 underwent 18F-fluorodeoxyglucose positron emission tomography, or PET imaging, which is often used as part of cancer screening but can also show areas in the brain that have increased activity. The scans allowed researchers to objectively measure activity in regions of the brain known to be associated with stress. Researchers assessed stress-related brain activity by measuring the activity of the amygdala (the part of the brain associated with fear and stress) and dividing it by activity in the frontal cortex (the part of the brain involved in executive functions). They then grouped patients based on the extent of brain stress activity.

Of the 53,064 participants, 7,905 (15%) experienced a major adverse cardiovascular event: 17% in the low alcohol intake group and 13% in the moderate alcohol intake group. People who reported moderate alcohol intake were found to have a 20% lower chance of having a major event compared to low alcohol intake (in adjusted analysis), and also had lower stress-related brain activity. This remained significant even after controlling for demographic variables, cardiovascular risk factors, socioeconomic variables and psychological factors.

"Previous studies by our group and others have shown a robust association between heightened amygdalar activity and a higher risk of major adverse cardiovascular outcomes, such as heart attack, stroke or death. In the current study, path analyses showed that the link between moderate alcohol intake and lowered cardiovascular event risk is significantly mediated though reductions in amygdalar activity," Mezue said.

The study is limited due to the self-reporting of alcohol intake based on the average consumption of drinks per week. The data is also from a single center, and each participant in the imaging sub-study only received a single brain scan. Further study would be needed to show that the observed reductions in brain activity are the direct result of moderate alcohol intake through repeated brain scans and more detailed alcohol intake assessments over time.

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Mezue will present the study, "Alcohol's Beneficial Effect on Cardiovascular Disease is Partially Mediated through Modulation of Stress-Associated Brain Activity," on Monday, May 17, at 8 a.m. ET / 12:00 UTC.

ACC.21 will take place May 15-17 virtually, bringing together cardiologists and cardiovascular specialists from around the world to share the newest discoveries in treatment and prevention. Follow @ACCinTouch, @ACCMediaCenter and #ACC21 for the latest news from the meeting.

The American College of Cardiology envisions a world where innovation and knowledge optimize cardiovascular care and outcomes. As the professional home for the entire cardiovascular care team, the mission of the College and its 54,000 members is to transform cardiovascular care and to improve heart health. The ACC bestows credentials upon cardiovascular professionals who meet stringent qualifications and leads in the formation of health policy, standards and guidelines. The College also provides professional medical education, disseminates cardiovascular research through its world-renowned JACC Journals, operates national registries to measure and improve care, and offers cardiovascular accreditation to hospitals and institutions. For more, visit ACC.org.