Friday, November 07, 2025

 

Death Valley plant reveals blueprint for building heat-resilient crops




Michigan State University

Collecting T. oblongifolia 

image: 

Dr. Karine Prado collecting T. oblongifolia seeds in Death Valley, California.

view more 

Credit: Jennifer Johnson





In California’s Death Valley, where summer temperatures regularly soar above 120 degrees Fahrenheit, life seems almost impossible. Yet among the cracked earth and blinding sunlight, one native plant not only survives — it thrives. 

That plant, Tidestromia oblongifolia, has helped Michigan State University scientists uncover how life can flourish in extreme heat, revealing a potential blueprint for engineering crops that can adapt to our changing climate. 

In a new paper published in Current Biology, Research Foundation Professor Seung Yon “Sue” Rhee and Research Specialist Karine Prado report that T. oblongifolia grows faster in Death Valley’s summer conditions by rapidly adjusting its photosynthetic system to withstand the heat. 

A heat-defying growth spurt 

For Prado, the study began with a simple but searing question: how can this plant remain green and vigorous where most others would wither in hours? 

“When we first brought these seeds back to the lab, we were fighting just to get them to grow,” Prado said. “But once we managed to mimic Death Valley conditions in our growth chambers, they took off.” 

Working with colleagues from the Rhee lab at MSU’s Plant Resilience Institute, Prado used custom-built plant growth chambers to recreate the intense light and temperature swings of a real Death Valley summer. What happened next stunned them: T. oblongifolia tripled its biomass in just 10 days. In contrast, closely related species often praised for their heat tolerance stopped growing altogether. 

Within only two days of exposure to extreme heat, the plant raised its photosynthetic comfort zone, enabling it to keep producing energy. Within two weeks, its optimal photosynthetic temperature reached 45 degrees Celsius (113 degrees Fahrenheit), higher than any major crop species known. 

“This is the most heat-tolerant plant ever documented,” Rhee said. “Understanding how T. oblongifolia acclimates to heat gives us new strategies to help crops adapt to a warming planet.” 

Inside a plant built for extremes 

By pairing physiological measurements with live imaging and genomic analysis, the researchers discovered that T. oblongifolia’s remarkable resilience comes from coordinated changes across multiple layers of biology. 

Under Death Valley-like heat, the plant’s mitochondria, its energy-producing organelles, reposition next to its chloroplasts, where photosynthesis takes place. The chloroplasts themselves change shape, forming distinctive “cup-like” structures never before seen in higher plants. These may help capture and recycle carbon dioxide more efficiently, stabilizing energy production under stress. 

Meanwhile, thousands of genes switch their activity within 24 hours. Many are involved in protecting proteins, membranes, and photosynthetic machinery from heat damage. The plant also boosts production of a key enzyme called Rubisco activase, which may help keep photosynthesis running smoothly at high temperatures. 

A model for agriculture in a hotter world 

With global temperatures projected to rise by up to 5 degrees Celsius by the end of the century, heat waves are already cutting yields for major crops like wheat, maize and soybeans. As the world's population continues to grow, scientists are searching for ways to increase food production. 

“T. oblongifolia shows us that plants have the capacity to adapt to extreme temperatures,” Rhee said. “If we can learn how to replicate those mechanisms in crops, it could transform agriculture in a hotter world.”

For decades, most plant biology has focused on model species that are easy to grow such as Arabidopsis or crop plants like rice and maize. But Rhee argues that extreme survivors like T. oblongifolia represent a new frontier for improving resilience. 

“Desert plants have spent millions of years solving the challenges we’re only beginning to face,” she said. “We finally have the tools, such as genomics, high-resolution live imaging and systems biology, to learn from them. What we need now is broader support to pursue this kind of research.” 

Her lab is already putting those insights to work, exploring how the genes and cell structures that give T. oblongifolia its heat resilience could be harnessed to make staple crops more robust. 

“This research doesn’t just tell us how one desert plant beats the heat,” Prado said. “It gives us a roadmap for how all plants might adapt to a changing climate.” 

By Morgan Koetje Magilligan  

C.R.T. / B.L.M.

Racial disparities in premature mortality and unrealized Medicare benefits across US states



JAMA Health Forum






About The Study: 

Between 2012 and 2022, premature mortality among adults ages 18 to 64 in the U.S. increased by over 27%. During this period, racial disparities in premature mortality widened substantially, with Black individuals experiencing persistently higher and worsening rates compared with white individuals across most states. These results raise concerns about structural inequities within the Medicare entitlement and financing system. Despite contributing to Medicare throughout their working lives, Black individuals in the U.S. are less likely to live long enough to reach the qualifying age for coverage.



Corresponding Author: To contact the corresponding author, Irene Papanicolas, PhD, email irene_papanicolas@brown.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamahealthforum.2025.4916)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

Embed this link to provide your readers free access to the full-text article 

 https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.4916?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=110725

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

Heat- and cold-related mortality burden in the US from 2000 to 2020



JAMA Network Open





About The Study:

 In this case series, nonoptimal temperatures were critical environmental contributors associated with mortality burden, with differential vulnerability by geographic location, cause of death, and demographic factors. These findings highlight the need for urgent actions against temperature-related health burdens through tailored climate and public health strategies, considering the local context and demographic profiles. 



Corresponding Author: To contact the corresponding author, Kai Chen, PhD, email kai.chen@yale.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.42269)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

Embed this link to provide your readers free access to the full-text article 

 'https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.42269?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=110725

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

Research hints at the potential of pain relief with CBD



University of Rochester Medical Center

Could CBD Be Used to Treat Pain? 

video: 

Del Monte Institute for Neuroscience at the University of Rochester | https://doi.org/10.1016/j.chembiol.2025.10.005

view more 

Credit: Del Monte Institute for Neuroscience at the University of Rochester





Reaching for CBD-infused lotion or oil may seem like a low-risk way to find pain relief, but little is actually known about the impact that CBD has on the nervous system.

Over the past decade, the use of cannabis products for pain management has increased, in part because in 2018 Congress signed a law removing hemp from the federal Controlled Substances Act, thereby legalizing hemp-derived CBD. Today, it is most commonly found in oil form, as well as in lotions and cosmetics, and it is widely understood that CBD does not cause a ‘high’. However, what CBD does in the human body and brain is not well understood. Currently, the Food and Drug Administration has only approved CBD as an adjunctive treatment for certain forms of epilepsy, and it is not recommended for use during pregnancy.

“We need to understand more about this compound, what mechanisms it interacts with in the brain, its impact on the body, and whether it is a potentially safer solution for treating the chronic pain epidemic,” said Kuan Hong Wang, PhD, professor of Neuroscience and member of the Del Monte Institute for Neuroscience at the University of Rochester, whose lab in collaboration with researchers at Harvard Medical School and Boston Children’s Hospital, recently discovered that in mice, they could effectively deliver CBD to the brain for neuropathic pain relief with no adverse side effects. This research was published today in the journal Cell Chemical Biology.

Devising a Delivery Method

The first hurdle researchers had to cross was the blood-brain barrier. This part of our anatomy does an incredible job of keeping our brain healthy, as it essentially acts as a protective force field around the brain. Because of this barrier and the fact that CBD does not dissolve well in water, very little CBD reaches the brain when taken in its common oil form. Staff scientist Jingyu Feng, PhD, in the Wang Lab, and the first author of the study, helped develop the delivery mechanism: inclusion-complex-enhanced nano-micelle formulation or CBD-IN. CBD-IN is a method that encapsulates CBD molecules within nano-micelles or water-soluble spheres that are considered safe in food and drugs.

Researchers found that when CBD-IN was given to mice, it provided pain relief within 30 minutes, and with none of the common adverse side effects, like loss of movement, balance, or memory, that often occur when taking conventional pain drugs. “The pain relief also lasted through repeated use,” said Feng. “We did not see its effect wear off over time.”

Impact on the Brain

Using imaging and genetic mapping tools, researchers revealed that when CBD-IN is ingested by mice, it calms overactive nerve circuits in the areas of the brain and spinal cord responsible for sensing touch and pain. This calming effect only occurs where abnormal activation is present, like after a nerve injury. Importantly, CBD-IN does not affect healthy neurons.

Researchers were surprised to discover that the pain-relieving effect did not rely on the typical cannabinoid receptors (CB1 and CB2) that THC and other cannabis compounds target in the body. “Instead, CBD-IN seems to influence broader electrical and calcium signaling in nerve cells, offering a new way to control nerve hyperactivity without triggering the 'high' or dependency risks associated with traditional cannabinoids or opioids,” Feng said.

“The broader implication of this research is that nanotechnology can make natural compounds like CBD more effective and precise,” said Wang, co-senior author of this research. “By enhancing brain delivery and targeting only disease-related neural overactivity, this strategy could open new doors for treating chronic pain and possibly other neurological disorders, such as epilepsy or neurodegenerative diseases, where abnormal nerve activity plays a central role.”

This research was a collaboration between the University of RochesterHarvard Medical School, and Boston Children’s Hospital. Other authors include Jessica Page, PhD, and Leeyup Chung, PhD, both co-first authors, and Zhigang He, PhD, co-senior author, of Harvard Medical School. The research was supported by the National Institutes of Health and the Del Monte Institute for Neuroscience.

 

Swedish parliament votes to allow uranium mining

The Swedish parliament has voted to pass legislative changes that will come into effect on 1 January, lifting the country's ban on uranium mining and extraction.
 
The Riksdagen (Image: Arild VÃ¥gen)

"The Riksdag has voted in favour of the Government's proposal on uranium mining in Sweden," a statement from the parliament said. "The decision states that it will be allowed to mine uranium in Sweden and that uranium is to be classed as a concession mineral, that is a mineral which is especially useful for society.

"The decision also means that activities in which small amounts of uranium are handled will not be subject to a permit requirement and will not be subject to a municipal veto. A municipal veto means that municipalities can, by means of a local political decision, determine whether or not to allow such activities in the municipality."

Sweden's Environmental Code was amended to ban uranium exploration and mining in 2018. Earlier this year the government announced the draft law, proposing amendments that would allow the extraction of uranium in the country.

Australian mineral company Aura Energy said the change will mean that from 1 January uranium will now be regulated as a concession mineral under the Minerals Act, embedding it within the conventional permit process for mining in Sweden and potentially adding substantial value to polymetallic projects like the company's 100%-owned Häggån vanadium, potash and uranium project.

"This vote means that from now on uranium has the potential to be an important contributor to Sweden's economy and energy security, and to support the region's intention to triple nuclear power," Aura Executive Chairman Phil Mitchell said. "Given that Sweden has 27 percent of Europe's known uranium within its bedrock, the commercial potential is significant."

A scoping study for Häggån published in September 2023 was "constrained" by the uranium mining prohibition, Aura said, but the company will now "examine options to include uranium in its future plans" and increase its investment in exploration activity in Sweden.

"We have been consistently open about the fact that we would like to extract uranium in a safe and environmentally friendly manner from the Häggån deposit. It is economically sensible, more resource efficient and less environmentally wasteful to use Swedish uranium to support the country's nuclear ambitions and a global nuclear renaissance, rather than treat it as a waste component to the Häggån polymetallic deposit as currently required," Mitchell added.

Sweden-focused Canadian polymetallic exploration and development company District Metals Corp's Viken project contains an estimated 1.5 billion pounds U3O8 (577,000 tU) along with significant mineral resource estimates of vanadium, molybdenum, nickel, copper, zinc, and other important and critical raw materials.

The company's CEO Garrett Ainsworth said he was "very pleased" with the historic vote, which "positions Sweden to unlock its vast uranium resources in support of the green energy transition amid growing global geopolitical uncertainty".

The company updated its mineral resource estimate for Viken earlier this year, in anticipation of this decision, as well as completing airborne geophysical surveys across its uranium polymetallic properties in Sweden, he said. "Looking ahead to 2026, we are now eager to further advance exploration programmes at our uranium properties in Sweden that we anticipate will include fieldwork, additional airborne geophysics, drilling, and an economic study of the Viken Deposit."