Thursday, January 01, 2026

 SCI-FI-TEK 70 YRS IN THE MAKING

EAST Tokamak experiments exceed plasma density limit, offering new approach to fusion ignition




Chinese Academy of Sciences Headquarters
Schematic illustration of the EAST tokamak operation during ECRH-assisted Ohmic start-up 

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Schematic illustration of the EAST tokamak operation during ECRH-assisted Ohmic start-up

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Credit: YAN Ning




Researchers working on China's fully superconducting Experimental Advanced Superconducting Tokamak (EAST) have experimentally accessed a theorized "density-free regime" for fusion plasmas, achieving stable operation at densities well beyond conventional limits. The results, reported in Science Advances on January 1, provide new insights into overcoming one of the most persistent physical obstacles on the path toward nuclear fusion ignition.

The study was co-led by Prof. ZHU Ping from Huazhong University of Science and Technology and Associate Prof. YAN Ning from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences. By realizing a novel high-density operating scheme on EAST, the team demonstrated that plasma density, long constrained by empirical limits in tokamak operation, can be substantially extended without triggering disruptive instabilities.

Nuclear fusion is widely regarded as a promising source of clean and sustainable energy. For deuterium-tritium fusion reactions, plasmas must be heated to an optimal temperature of around 13 keV (150 million kelvin). Under these conditions, thermonuclear power scales with the square of fuel density. However, in conventional tokamak operation, plasma density has long been restricted by an empirical upper limit. Exceeding this limit often leads to instabilities that disrupt plasma confinement and endanger tokamak operation, posing a major challenge to improving fusion performance.

The recent development of the plasma–wall self organization (PWSO) theory provides a novel perspective on understanding the disruptive density limit. PWSO was originally proposed by D.F. Escande et al. from the French National Center for Scientific Research and Aix-Marseille University. The theory predicts that a new density-free regime could be accessed by achieving a delicate balance between the plasma and the metallic walls of the device, which are dominated by physical sputtering.  

The physical concept on the density-free regime has been verified for the first time on EAST in this work. The EAST experiments combine control of the initial fuel gas pressure with electron cyclotron resonance heating during the startup phase, allowing effective optimization of plasma–wall interactions from the very beginning of the discharge. Through this approach, plasma–wall interactions, impurity accumulation and energy losses were significantly reduced, plasma is eventually pushed into a high enough density at the end of start-up. The researchers successfully accessed the PWSO theoretical density-free regime, in which the plasma can remain stable even when operating at densities that far exceeded empirical limits.  

These experimental achievements provide new physical insights into breaking through the long-standing density limit in tokamak operation in pursuit of fusion ignition.

"The findings suggest a practical and scalable pathway for extending density limits in tokamaks and next-generation burning plasma fusion devices," said Prof. ZHU.

Associate Pro. YAN added that the research team plans to apply the new method during high-confinement operation on EAST in the near future in an attempt to access the density-free regime under high-performance plasma conditions.

 

Global spread of tigecycline-resistant bacteria: a growing public health concern




Higher Education Press
Schematic diagram of the research workflow. 

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The flowchart illustrates the selection and analysis process of tmexCD1-toprJ1-positive isolates in this study. SRA: Sequence Read Archive.

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Credit: Luchao Lv, Xun Gao, Chengzhen Wang, et al.




A recent study published in Engineering has shed light on the transmission and epidemiological trends of tmexCD1-toprJ1-positive Klebsiella pneumoniae across various ecological niches, highlighting the potential threat this antibiotic-resistant bacterium poses to global public health. The research, conducted by a team of scientists from multiple institutions in China, utilized whole-genome sequencing (WGS) to analyze strains from humans, animals, food, and the environment, revealing significant insights into the spread and characteristics of these resistant bacteria.

 

The study found that tmexCD1-toprJ1-positive strains, which confer resistance to the critical antibiotic tigecycline, are predominantly identified in Klebsiella pneumoniae from chicken feces in China. However, the presence of these strains has expanded beyond chickens to other ecological niches and countries, including Japan, Vietnam, Kenya, and others. The researchers noted that the majority of these strains exhibited resistance to nearly all antimicrobials, including colistin, another last-resort antibiotic, with a resistance rate of 42.13%.

 

Phylogenetic analysis revealed that the tmexCD1-toprJ1 gene cluster is primarily carried by narrow host-range plasmids specific to Klebsiella species, which may limit its spread across different bacterial species. However, the study also identified instances where the gene cluster had been captured by broad-host-range plasmids, suggesting a potential for wider dissemination. Notably, the gene cluster has been found in hypervirulent carbapenem-resistant K. pneumoniae (hvCRKP) strains, which are known to cause severe infections in healthcare settings.

 

The research highlighted a significant decline in the prevalence of tmexCD1-toprJ1-positive strains in food animals and humans in China following the withdrawal of antibiotics as growth promoters in animal feed in 2020. This finding underscores the importance of antimicrobial stewardship policies in controlling the spread of resistance genes. The study also pointed out that the frequent use of tetracyclines in chicken farming likely contributes to the high detection rate of tmexCD1-toprJ1, suggesting that targeted interventions in the poultry industry could be effective in mitigating the spread of these resistant strains.

 

In addition to the epidemiological findings, the study provided detailed genomic insights into the tmexCD1-toprJ1 gene cluster. The researchers identified various genetic environments surrounding the gene cluster, with the type II structure being the most prevalent. This structure is characterized by the presence of insertion sequences such as IS26, which facilitate the mobility and dissemination of the resistance genes. The study also highlighted the role of specific plasmid types, such as IncFIB(Mar)–IncHI1B and IncFIB(K)–IncHI1B, in the spread of tmexCD1-toprJ1.

 

The findings of this study emphasize the need for continuous monitoring of tmexCD1-toprJ1 across different ecological niches and the enforcement of strict antimicrobial policies in animal husbandry. The global spread of tmexCD1-toprJ1-positive Klebsiella pneumoniae poses a significant challenge to the treatment of infections caused by multidrug-resistant bacteria, highlighting the importance of a One Health approach to address the growing threat of antimicrobial resistance.

 

The paper “Transmission of tmexCD1-toprJ1-Positive Klebsiella pneumoniae Across Multiple Ecological Niches: A Global Epidemiological and Genomic Analysis,” is authored by Luchao Lv, Xun Gao, Chengzhen Wang, Guolong Gao, Jie Yang, Miao Wan, Zhongpeng Cai, Sheng Chen, Jing Wang, Chuying Liang, Chao Yue, Litao Lu, Zhiyong Zong, Jian-Hua Liu. Full text of the open access paper: https://doi.org/10.1016/j.eng.2025.03.038. For more information about Engineering, visit the website at https://www.sciencedirect.com/journal/engineering.

Tiny magnetic bacteria show big potential for fighting lead pollution



Hefei Institutes of Physical Science, Chinese Academy of Sciences
Tiny Magnetic Bacteria Show Big Potential for Fighting Lead Pollution 

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Magnetotactic bacteria antagonized lead toxicity through distinct enrichment mechanisms in magnetosome-containing/deficient bacteria.

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Credit: LIU Yun





Recently, a research team led by Prof. XU An from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has discovered that magnetotactic bacteria (MTB) — tiny microorganisms that can sense and move along magnetic fields — have remarkable abilities to resist and detoxify lead (Pb), one of the most toxic heavy metals in the environment.

The research results were published in Journal of Environmental Sciences.

Lead, a highly toxic heavy metal pollutant with a long biological half-life and environmental persistence, has posed serious threats to global health. However, efficient and safe detoxification methods for Pb poisoning remain lacking. Studies have shown that MTB have efficient heavy metal recovery ability and favorable biosafety.

In this study, the researchers compared two types of Magnetospirillum magneticum bacteria — one with magnetosomes (tiny magnetic particles inside the cells) and one without. 

The results showed that both could significantly detoxify Pb(Ⅱ)-induced various adverse effects even after 6 h of Pb(Ⅱ) pre-treatment, including cell damage, oxidative stress, and DNA injury. 

Interestingly, the team discovered that the two types of bacteria used different strategies to handle lead. The magnetosome-containing bacteria mainly adsorbed lead on their cell surfaces, trapping the metal externally. The bacteria without magnetosomes, on the other hand, absorbed lead into their cells, likely through pathways usually used for transporting iron.

These differences seem to be linked to the iron content in the cells — a higher iron level may help block lead from entering the bacteria.

These findings might not only offer novel intervention strategies for Pb(Ⅱ) poisoning, but also expand the application of MTB in the field of environmental health, according to the team.