Tuesday, May 20, 2025

 

Two out of five patients with heart failure do not see a cardiologist even once a year and these patients are more likely to die




European Society of Cardiology





If you have cancer, you expect to see an oncologist, but if you have heart failure you may or may not see a cardiologist. According to research published in the European Heart Journal [1] today (Sunday), only around three out of five heart failure patients see a cardiologist at least once a year.

 

The study, also presented at Heart Failure Congress 2025, shows that patients who do see a cardiologist once a year are around 24% less likely to die in the following year. It also shows which patients could benefit from seeing a cardiologist once a year and which patients should be seen more often.

 

The research suggests that if cardiologists did see heart failure patients at least once a year, one life could be saved for every 11–16 patients seen.

 

The study is by a team of French researchers led by Dr Guillaume Baudry and Professor Nicolas Girerd from the Clinical Investigation Centre of Nancy University Hospital.

 

Dr Baudry said: “In patients with heart failure, the heart is unable to normalise blood flow and pressure. Heart failure can’t usually be cured, but with the right treatment, symptoms can often be controlled for many years. At the moment, depending on the patient and their condition, for example whether they have chronic or acute heart failure, they may or may not be seen by a cardiologist.

 

“We conducted this study to see whether some simple criteria could be used to divide patients into high or lower risk categories and to assess whether an appointment with a cardiologist is linked with deaths or hospitalisation in heart failure patients at the national level, based on these categories.”

 

The study included all French patients living with heart failure in January 2020 who had been diagnosed in the previous five years – 655,919 people in total. These patients were found using French national medical administrative data. Researchers broke the group down according to whether they had been hospitalised with heart failure in the last year or the last five years, and whether or not they were taking diuretics as a treatment. Diuretics help the body eliminate excess sodium through urine, which reduces the build-up of fluid in the body.

 

Among all groups of patients, researchers found that around two out of every five patients did not see a cardiologist over the course of a year. Those who did see a cardiologist were less likely to die of any cause and less likely to be hospitalised with heart failure in the following year.

 

Taking into account the number of cardiology consultations available at a national level, the researchers created a model to show how often patients should see a cardiologist, based on recent hospitalisation and diuretic use, to reduce the risk of death as much as possible.

 

According to the model, patients who had not recently been hospitalised and were not taking diuretics, one visit per year would be optimal to minimise the risk of death. This would reduce their risk of dying in the following year from 13% to 6.7%.

 

Those who had not recently be hospitalised but were taking diuretics, should be seen two to three times per year. This would reduce their risk of death from 21.3% to 11.9%.

 

In patients who had been hospitalised in the last five years, but not in the last year, being seen two to three times per year appears optimal. This would reduce the risk from 24.8% to 12.9%.

 

For patients who had been hospitalised in the last year, four appointments with a cardiologist were optimal. This reduced the risk from 34.3% to 18.2%

 

The researchers caution that the design of the study (a retrospective observational study) means they cannot be certain that seeing a cardiologist leads to a lower risk of death, only that the two are associated. Although they made every attempt to account for other factors, it could be that patients under the care of cardiologists have had a lower risk of dying for some other reason.

 

Dr Baudry said: “Although there are inherent limitations in observational research, our findings highlight the potential value of specialist follow-up, even in patients who appear clinically stable. Patients should feel encouraged to ask for a cardiology review, particularly if they have recently been in hospital or they are taking diuretics.”

 

Professor Girerd added: “There could be many reasons why heart failure patients do not see a cardiologist, for example, we know that older people and women are less likely to see a cardiologist. We found that patients with another chronic condition, such as diabetes or a lung condition, were also less likely to see a cardiologist. These differences have been found in many countries around the world.

 

“Our findings suggest that referrals to cardiology could be made more systematically in heart failure care, in the same way that an oncology referral is part of routine cancer care.

 

“We have also found that that two very simple criteria – recent hospitalisation and diuretic use – can easily stratify patient risk. These criteria don’t involve any expensive tests, so can be used by anyone, in any setting, in any country. These results could help redesign health systems to reduce deaths while preserving resources.”

 

The researchers are now planning to test their findings in an interventional clinical trial. They also hope to study the impact of seeing a cardiologist for heart failure in other countries with different healthcare systems.

 

In an accompanying editorial [2] Professor Lars Lund from the Karolinska Institutet, Stockholm, Sweden said: “Since the first heart transplantation in 1967, drug discovery, technology advances, and rigorous randomised clinical trials have delivered extensive and highly effective evidence-based and guideline-directed medical therapy and other interventions for heart failure. Yet patients are not receiving and benefiting from these treatments. Consequently, outcomes in heart failure are not improving.

 

“…the present French study adds important evidence that for patients with heart failure, regardless of severity, access to cardiology follow-up is associated with improved use of guideline-directed medical therapy and improved outcomes. Yet, in many countries, there is a continued push to triage patients with heart failure away from cardiology and toward primary care which is often overburdened and cannot be expected to master the complexities of heart failure treatment selection and optimisation. Heart failure is common and serious, but treatable. What good is 50 years of discovery, innovation, and rigorous randomised-controlled trials delivering highly effective therapy, if this therapy is not used?”

 

In a second presentation at Heart Failure Congress 2025 on the same cohort [3], the researchers discussed sex differences in outcome and healthcare utilisation. After adjusting for demographic differences, they found that 33.8% of women did not see a cardiologist within a year while in men, the proportion was 27.9%. Women were also less likely to be prescribed RAS inhibitors, which act to lower blood pressure. Despite these differences, women had better outcomes than men in term of mortality and heart failure events.

 

First human bladder transplant performed at UCLA


Historic surgery, the result of years of research by UCLA and USC surgeons, opens the door for improved treatment of non-functioning bladders


University of California - Los Angeles Health Sciences




B-roll and stills available at link below

Surgeons from UCLA Health and Keck Medicine of USC have performed the world’s first-in-human bladder transplant.

The surgery was successfully completed at Ronald Reagan UCLA Medical Center on May 4, 2025. It was a joint effort by Dr. Nima Nassiri, a urologic transplant surgeon and director of the UCLA Vascularized Composite Bladder Allograft Transplant Program, and Dr. Inderbir Gill, founding executive director of USC Urology.

"Bladder transplantation has been Dr. Nassiri's principal academic focus since we recruited him to the UCLA faculty several years ago," said Dr. Mark Litwin, UCLA Urology Chair, "It is incredibly gratifying to see him take this work from the laboratory to human patients at UCLA, which operates the busiest and most successful solid-organ transplant program in the western United States."

“This surgery is a historic moment in medicine and stands to impact how we manage carefully selected patients with highly symptomatic ‘terminal’ bladders that are no longer functioning,” said Gill, who is also chair and Distinguished Professor of Urology and Shirley and Donald Skinner chair in Urologic Cancer Surgery with the Keck School of Medicine of USC. “Transplantation is a lifesaving and life-enhancing treatment option for many conditions affecting major organs, and now the bladder can be added to the list.”

“This first attempt at bladder transplantation has been over four years in the making,” Nassiri said. “For the appropriately selected patient, it is exciting to be able to offer a new potential option.”

The patient had lost most of his bladder during a tumor removal, leaving the remainder too small and compromised to work. Both of his kidneys were also subsequently removed due to renal cancer in the setting of pre-existing end-stage kidney disease. As a result, he was on dialysis for seven years.

The biggest risks of organ transplantation are the body’s potential rejection of the organ and side-effects caused by the mandatory immune suppressing drugs given to prevent organ rejection.

“Because of the need for long-term immunosuppression, the best current candidates are those who are already either on immunosuppression or have an imminent need for it,” Nassiri said.

Nassiri, formerly a urology resident with the Keck School and now assistant professor of urology and kidney transplantation at UCLA, and Gill worked together for several years at the Keck School to develop the new surgical technique, design clinical trials and secure the necessary regulatory approvals.

Nassiri and Gill collaborated for several years to develop the surgical technique. Numerous pre-clinical procedures were performed at USC and OneLegacy, Southern California’s organ procurement organization, to prepare for the first human bladder transplant.

The recovery of the kidney and bladder from the donor was performed at OneLegacy.  All parts of the procedure, including surgery and post-surgical monitoring during the transplantation, were aligned with the highest current clinical and research standards.

During the complex procedure, the surgeons transplanted the donated kidney, following that with the bladder. The new kidney was then connected to the new bladder using the technique that Nassiri and Gill pioneered. The entire procedure lasted approximately eight hours.

“The kidney immediately made a large volume of urine, and the patient’s kidney function improved immediately,” Nassiri said. “There was no need for any dialysis after surgery, and the urine drained properly into the new bladder.”

“Despite the complexity of the case, everything went according to plan and the surgery was successful,” Gill added. “The patient is doing well, and we are satisfied with his clinical progress to date.”

Millions of people around the globe experience some degree of bladder disease and dysfunction. Some develop terminal bladders that are either non-functioning and/or cause constant pain, repeated infections and other complications. Current treatment for severe terminal cases of bladder dysfunction or a bladder that has been removed due to various conditions includes replacement or augmentation of the urinary reservoir. These surgeries use a portion of a patient’s intestine to create a new bladder or a pathway for the urine to exit the body.

While these surgeries can be effective, they come with many short-and long-term risks that compromise a patient’s health such as internal bleeding, bacterial infection and digestive issues.

“A bladder transplant, on the other hand, results in a more normal urinary reservoir, and may circumvent some short- and long-term issues associated with using the intestine,” Nassiri said.

As a first-in-human attempt, there are naturally many unknowns associated with the procedure, such as how well the transplanted bladder will function immediately and over time, and how much immunosuppression will ultimately be needed.

“Despite the unknowns, our goal is to understand if bladder transplantation can help patients with severely compromised bladders lead healthier lives,” Gill said.

Bladder transplants have not been done previously, in part because of the complicated vascular structure of the pelvic area and the technical complexity of the procedure. As part of the research and development stage, Nassiri and Gill successfully completed numerous practice transplantation surgeries at Keck Medical Center of USC, including the first-ever robotic bladder retrievals and successful robotic transplantations in five recently deceased donors with cardiac function maintained on ventilator support.

The two surgeons also undertook several non-robotic trial runs of bladder recovery at OneLegacy, allowing them to perfect the technique while working closely with multi-disciplinary surgical teams.

The bladder is strictly within the domain of urologists. At UCLA, kidney transplantation is also housed within the department of urology. This is why the combined kidney and bladder transplant was ultimately performed at UCLA, which has the necessary infrastructure, clinical expertise, and multidisciplinary support to carry out the procedure and manage the patient from pre-transplant evaluation through post-transplant care, all  within the one department.

The procedure was performed as part of a UCLA clinical trial. Nassiri and Gill hope to perform more bladder transplants in the near future.

UCLA Urology has long been at the frontier of urologic transplantation, with pioneering research in kidney transplantation and now, bladder transplantation.

 

Credits for Bladder Transplant B-Roll and Stills

Photos: Nick Carranza/UCLA Health

Videos: Cesar Sarmiento Blanco/UCLA Health

https://downloads.uclahealth.org/mediarelease/PressKit-BladderTransplant.zip


\The Keck Medicine of USC surgical team evaluates the integrity of a bladder during the research and development stage of bladder transplantation.

Credit

Photo courtesy of USC Urology


USC, UCLA team up for the world’s first-in-human bladder transplant



Historic surgery, the result of years of research at Keck Medicine of USC and UCLA Health, opens the door for improved treatment of non-functioning bladders



University of Southern California - Health Sciences

Inderbir Gill, MD (L) and Nima Nassiri, MD (C) perform the world’s first-in-human bladder transplant. 

image: 

Inderbir Gill, MD (L) and Nima Nassiri, MD (C) perform the world’s first-in-human bladder transplant.

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Credit: Photo courtesy of Nick Carranza, UCLA Health




LOS ANGELES — Surgeons from Keck Medicine of USC and UCLA Health have performed the world’s first-in-human bladder transplant. The surgery was successfully completed at Ronald Reagan UCLA Medical Center on May 4, 2025, in a joint effort by Inderbir Gill, MD, founding executive director of USC Urology, and Nima Nassiri, MD, urologic transplant surgeon and director of the UCLA Vascularized Composite Bladder Allograft Transplant Program. 

Groundbreaking moment in medical history  

“This surgery is a historic moment in medicine and stands to impact how we manage carefully selected patients with highly symptomatic ‘terminal’ bladders that are no longer functioning,” said Gill, who is also Chair and Distinguished Professor of Urology and Shirley and Donald Skinner Chair in Urologic Cancer Surgery with the Keck School of Medicine of USC. “Transplantation is a lifesaving and life-enhancing treatment option for many conditions affecting major organs, and now the bladder can be added to the list.”  

“This first attempt at bladder transplantation has been over four years in the making,” Nassiri said. “For the appropriately selected patient, it is exciting to be able to offer a new potential option.”  

Nassiri, formerly a urology resident with the Keck School and now assistant professor of urology and kidney transplantation at UCLA, and Gill worked together for several years at the Keck School to develop the new surgical technique, design a clinical trial and secure the necessary regulatory approvals.  

Numerous pre-clinical procedures were performed both at Keck Medical Center of USC and OneLegacy, Southern California’s organ procurement organization, to prepare for this first-in-human bladder transplant.  

A complicated yet successful surgery  

The patient had been dialysis-dependent for seven years. He lost the majority of his bladder during surgery to resect cancer over five years ago, leaving the remainder of his bladder too small and compromised to function appropriately. Both of his kidneys were subsequently removed due to renal cancer.  

To address these deficits, Drs. Gill and Nassiri performed a combined kidney and bladder transplant, allowing the patient to immediately stop dialysis and produce urine for the first time in seven years. First the kidney, then the bladder, were transplanted. The new kidney was then connected to the new bladder. The entire procedure took approximately eight hours.  

“The kidney immediately made a large volume of urine, and the patient’s kidney function improved immediately,” Nassiri added. “There was no need for any dialysis after surgery, and the urine drained properly into the new bladder.” 

“Despite the complexity of the case, everything went according to plan and the surgery was successful,” said Gill. “The patient is doing well, and we are satisfied with his clinical progress to date.”  

The recovery of the kidney and bladder from the donor was performed at OneLegacy’s Transplant Recovery Center in Azusa, Calif. All parts of the procedure, including surgery and post-surgical monitoring during the transplantation, were aligned with the highest current clinical and research standards.  

How a bladder transplant may benefit patients 

Millions of people around the globe experience some degree of bladder disease and dysfunction. Some develop terminal bladders that are either non-functioning and/or cause constant pain, repeated infections and other complications. Current treatment for severe terminal cases of bladder dysfunction or a bladder that has been removed due to various conditions includes replacement or augmentation of the urinary reservoir. These surgeries use a portion of a patient’s intestine to create a new bladder or a pathway for the urine to exit the body.  

“While these surgeries can be effective, they come with many short-and long-term risks that compromise a patient’s health such as recurrent infections, compromised kidney function and digestive issues,” said Gill.  

“A bladder transplant, on the other hand, delivers a more ‘normal’ urinary reservoir and may circumvent some of the challenges associated with using the intestine,” said Nassiri.  

The biggest risks of organ transplant are the body’s potential rejection of the organ and side-effects caused by the mandatory immunosuppressive drugs given to prevent organ rejection. 

“Because of the need for long-term immunosuppression, the best current candidates are those with a pre-existing organ transplant or those who need a combined kidney and bladder transplant,” said Nassiri.  

As a first-in-human attempt, there are naturally many unknowns associated with the procedure, such as how well the transplanted bladder will function immediately and over time, and how much immunosuppression will ultimately be needed.  

“Despite the unknowns, our goal is to understand if bladder transplantation can help patients with severely compromised bladders lead healthier lives,” said Gill.  

Collaborative research and development leading to the transplant  

Bladder transplants have not been done previously, in part because of the complicated vascular structure of the pelvic area and the technical complexity of the procedure. As part of the research and development stage, Gill and Nassiri successfully completed numerous practice transplantation surgeries at Keck Medical Center of USC, including the first-ever robotic bladder retrievals and successful robotic transplantations in five recently deceased donors with cardiac function maintained on ventilator support. 

Several non-robotic trial runs of bladder recovery were performed at OneLegacy by Gill and Nassiri, allowing them to perfect the technique while working alongside multidisciplinary surgical teams.  

The bladder transplant was done as part of a UCLA clinical trial. Gill and Nassiri hope to perform more bladder transplants together in the near future.  

Under Gill’s leadership, USC Urology has rapidly established itself as a pioneer and world leader in the most advanced robotic urologic oncologic surgeries for kidney, bladder, prostate, testicular and penile cancers, and has achieved important milestones leveraging machine learning and artificial intelligence to optimize patient outcomes. 

UCLA Urology has long been at the frontier of urologic transplantation, with pioneering research in kidney transplantation and, now, bladder transplantation.  

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For more information about Keck Medicine of USC, please visit news.KeckMedicine.org.

Nima Nassiri, MD (L) and Inderbir Gill, MD (R) collaborated on years of clinical research to prepare for the historic surgery. 

Credit

Photo courtesy of Nick Carranza, UCLA Health

 

Climate change increases severity of obstructive sleep apnea



American Thoracic Society

Bastien Lechat, PhD 

image: 

Bastien Lechat, PhD, is a senior research fellow at FHMRI: Sleep Health at Flinders University.

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Credit: Bastien Lechat, PhD




Session:  A109—Smoke, Snooze, and ICU Blues: The Influence of Environmental Exposures and Critical Care Conditions on Sleep

Rising Temperatures Are Associated with Increased Burden of Obstructive Sleep Apnea

ATS 2025, San Francisco – Rising temperatures increase the severity of obstructive sleep apnea (OSA), according to a large new study published at the ATS 2025 International Conference. The study also found that, under the most likely climate change scenarios, the societal burden of OSA is expected to double in most countries over the next 75 years.

In addition to highlighting the critical importance of limiting global warming, the findings also emphasize the immediate need for strategies to alleviate the health and economic impacts of OSA as it becomes more common and severe, researchers said.

“This study really highlights the societal burden associated with the increase in OSA prevalence due to rising temperatures,” said Bastien Lechat, PhD, a senior research fellow at FHMRI: Sleep Health at Flinders University.

Previous cross-sectional studies identified a link between ambient temperature and OSA severity. However, this is the first to explain and describe that connection in detail.

For the study, researchers analyzed a consumer database of more than 116,000 worldwide users of an under-mattress sensor validated to estimate OSA severity. The dataset included around 500 repeat measurements per user. Researchers then analyzed this data against 24-hour ambient temperatures extracted from climate models.

Overall, higher temperatures were associated with a 45 percent increased likelihood of a sleeper experiencing OSA on a given night. However, these findings varied by region, with people in European countries seeing higher rates of OSA when temperatures rise than those in Australia and the United States.

“We were surprised by the magnitude of the association between ambient temperature and OSA severity,” Dr. Lechat said.

Researchers then sought to estimate how burdensome the increase in OSA prevalence due to rising temperature is to society in terms of wellbeing and economic loss. They conducted modeling including disability-adjusted-life-years, productivity losses, and health economics to estimate the OSA burden under several climate scenarios.

They found that any scenario that involved temperatures rising 2 degrees Celsius or higher would result in a 1.5-fold to 3-fold increase to the OSA burden by the year 2100. They estimated that climate change has already increased the OSA burden by 50 percent to 100 percent since the year 2000.

In addition to providing further evidence of the major threat of climate change to human health and wellbeing, Dr. Lechat said the study highlighted the importance of developing effective interventions to diagnose and manage OSA.

“The high prevalence undiagnosed and untreated OSA amplifies the effect of global warming on the societal burden associated with OSA,” he said. “Higher rates of diagnosis and treatment is likely to reduce the health and productivity burden due to rising temperature and increased OSA prevalence.”

Next, the team plans to develop intervention studies looking at strategies to mitigate the effects of temperature on OSA. They also hope to study the physiological mechanisms linking OSA severity to temperature.

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VIEW ABSTRACT

You may also be interested in these abstracts.

 

 

Waitlist deaths dropped under new lung transplant allocation system




American Thoracic Society
Mary Raddawi, MD 

image: 

First author Mary Raddawi, MD.

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Credit: Mary Raddawi, MD





 

ATS 2025, San Francisco – Two years ago the United Network for Organ Sharing implemented new allocation guidelines for lung transplants that prioritize medical urgency. Now new research published at the 2025 ATS International Conference shows that waitlist outcomes significantly improved under the new system.

Waitlisted patients had a lower risk of death or delisting under the new Composite Allocation Score (CAS) than they did before the guidelines were implemented, researchers said. They also found that the sickest patients on the waitlist saw the largest benefit.

“We always want to make sure that any time we make a change to the allocation system that we’re improving outcomes, especially for our sickest patients,” said first author Mary Raddawi, MD. “This provides confirmation that we’re on the right track.”

Donor lungs were previously allocated based on geographical proximity, with local patients receiving priority access. After a lawsuit in 2017 the allocation radius was expanded to a wider area, and UNOS began working on new guidelines.

Implemented in 2023, the CAS system is based on a compilation of points that prioritizes medical urgency, along with other patient factors.

For the new study, researchers compared outcomes for waitlisted patients before 2017, after the geographic radius was expanded in 2017, and after the CAS was implemented in 2023.

Across the board, they found that 11.2 percent of patients died or were delisted while waiting for a transplant before 2017. That number declined slightly to 8.4 percent when the geographical area was extended in 2017 but dropped to 4.1 percent after CAS.

Improvements were even more dramatic for the patients with the top 5 percent of waitlist urgency scores. These patients were three times more likely to die on the waitlist before 2017 than they were after the implementation of CAS.

Dr. Raddawi said the results were encouraging, but not surprising. “When you think about the fact that now we’re focusing on many different factors, including medical urgency, it makes sense that the waitlist mortality would go down for our sicker patients — but it is nice to see the actual numbers,” she said.

The findings highlight the importance of providers advocating for their sickest patients and ensuring that their medical urgency is reflected in their scores, she added. “We’re seeing that it really does make a difference for them,” she said.

Researchers plan to follow up on the study by looking at outcomes in greater detail, such as analyzing whether certain biological factors considered in CAS scores are linked to better outcomes among the critically ill. 

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VIEW ABSTRACT

You may also be interested in these abstracts.