Friday, December 12, 2025

 

Could AI help primary care clinics spot risky drinking habits?




Having a natural language processing tool scan the full text of health records identified more potential cases of unhealthy alcohol use



Michigan Medicine - University of Michigan






On any given day in a busy primary care clinic, doctors and others often ask patients about their alcohol use, and try to gauge if it falls into healthy or problematic range.

Patients might even complete an alcohol use questionnaire on a clipboard or their smartphone while they wait for their appointment.

But a new study suggests that artificial intelligence might help increase the chance that people with risky drinking patterns or signs of alcohol use disorder (AUD) will get the outreach and help they need.

That’s important, because only about 10% of people who qualify for the diagnosis of AUD have actually gotten help in the past year. Many may not realize that their drinking habits suggest signs of addiction or that they’re consuming more alcohol than recommended, which can raise the risk of everything from injuries to cancer to sleep problems.

The study, published in the journal Drug and Alcohol Dependence by a University of Michigan Addiction Center team, used a natural language processing tool to analyze the full text of notes, comments and screening tool scores in anonymous electronic health records from more than 133,000 primary care patients at U-M Health.

Going by just the formal parts of the record like diagnosis codes and alcohol use questionnaire scores, 820 of the patients had risky alcohol use or AUD. The NLP tool did almost as well as human reviewers in finding these.

But the natural language processing tool also identified more than 47,500 other patients whose notes showed some sign of risky drinking.

Identifying alcohol issues

Anne Fernandez, Ph.D., the addiction psychologist who helped lead the study, says the findings suggest the majority of people drinking at risky levels are overlooked, and automated tools could help identify them.

This is important because alcohol use causes health problems, interacts with medications, and makes some common medical conditions worse, she said. These are things that doctors want to know, so they can provide the best care possible.

“Doctors can’t read every clinical note from every provider and appointment in a patient’s chart, but automated tools can do this quickly and easily,” she explained. “Our study shows that these notes contain useful information about alcohol use that we hope can improve clinical care in the long term.” Fernandez is an associate professor in the U-M Medical School Department of Psychiatry and clinical psychologist at the U-M Addiction Treatment Service.

She and colleagues, including first author and Psychiatry research assistant Celeste Xintong Ju, applied the same NLP tool that has previously been shown to identify signs of risky drinking in patients scheduled to have surgery.

For the new study, they went a step further, by contacting a sample of those identified by the natural language processing tool as drinking at risky levels, and a matched sample of those identified by standard means.

They asked them to answer questions about their drinking habits and symptoms of alcohol use disorder and used this information to check the accuracy of the electronic health record and natural language processing tool.

In this group of 170 people, the natural language processing tool found 17 more cases of alcohol use disorder that standard data had missed, and 23 more cases of risky alcohol use that standard screening had missed.

The people identified through standard screenings were more likely to have depression or anxiety, and to have sought some form of help for their alcohol use, whether in a self-help group, an outpatient therapy setting or residential care.

Potential implications

Fernandez notes that if the new study is borne out in larger samples using the natural language processing tool, the use of AI could eventually complement what primary care providers already do to identify risking drinking and signs of AUD. 

Despite national recommendations calling for universal screening of adults for risky alcohol use, and insurance coverage under the Affordable Care Act for such screening, many patients aren’t screened.

There’s also the issue of patients not being completely forthcoming or accurate with their health care providers about their alcohol use, especially when they’re filling out standardized questionnaires.

That’s another reason that using natural language processing to scan the text of notes that primary care providers make about a patient’s visit may reveal more than screening tools.

However, natural language processing can’t replace standard alcohol screening. Clinicians still need to do their own screening to check accuracy, because AI can make errors, the electronic health record can be inaccurate, and alcohol use changes over time.

Many patients, and even some providers, may not know that there are prescription medications available to help patients recover from AUD. These are covered by Medicaid, Medicare and most other insurance programs. So is an approach called SBIRT, for screening, brief intervention and referral to treatment.

In addition to Fernandez and Ju, the study’s authors are Jake Solka, Katherine Weber, VG Vinod Vydiswaran, Lewei Allison Lin and Erin E. Bonar.  Fernandez, Lin and Bonar are members of the Michigan Innovations in Addiction Care through Research & Education (MI-ACRE) group, and the U-M Institute for Healthcare Policy and Intervention.

Lin is also a member of the VA Center for Clinical Management Research at the VA Ann Arbor Healthcare System, which is also taking part in the clinical trial of alcohol treatment in primary care.

The research was funded by the U-M Medical School Office of Research Pandemic Research Recovery Program and the National Institute of Alcohol Abuse and Alcoholism of the National Institutes of Health (R01AA029400 and R33AA028315).

The researchers used the U-M Medical School Data Office for Clinical and Translational Research for secure, anonymous access to patient records.

Citation: Unhealthy alcohol use detection in electronic health records: A comparative study using natural language processing, Drug and Alcohol Dependence, DOI: 10.1016/j.drugalcdep.2025.112920https://www.sciencedirect.com/science/article/pii/S0376871625003734

 

UC3M and INCIBE promote a new metric that allows for more accurate assessment of user privacy in digital databases




Universidad Carlos III de Madrid
UC3M and INCIBE promote a new metric that allows for more accurate assessment of user privacy in digital databases 

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Cibersecurity

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Credit: UC3M



Universidad Carlos III de Madrid (UC3M), in collaboration with the National Cybersecurity Institute (INCIBE), an entity under the Ministry for Digital Transformation and Public Administration through the Secretariat of State for Telecommunications and Digital Infrastructure, have promoted the development of a new probabilistic metric designed to more accurately measure the level of privacy and protection that users have in different databases.

The research, recently published in the scientific journal Array, involved reviewing the metric commonly used in the field of data privacy (K-anonymity) before proposing a new system with the intention of improving it.

“K-anonymity has been used for years, but it only measures how many people are like you within a database, so it doesn't reflect whether a user is actually well protected or not,” explains Rubén Cuevas Rumín, deputy director of the UC3M–Banco Santander Joint Institute in Financial Big Data. “What our metric proposes is an alternative measure that incorporates probabilistic information rather than simply indicating how many users match others.”

This new method estimates the probability that one individual resembles another user based on the data set within the system (e.g., age, gender, interests, etc.), thus providing much more useful information for evaluating and comparing the privacy of its users.

“This approach allows us to examine in greater detail the level of anonymity offered by different digital platforms and understand how small changes in the way data is stored can have a major impact on privacy,” says Rubén Cuevas.

A metric tested through practical use cases

The researchers have applied this metric to platforms such as LinkedIn, X and Meta, and the results show significant differences between them. “We have seen that LinkedIn and X provide greater privacy protection than Meta. We have also found that, with very simple changes, such as replacing a user's exact age with an age range, Meta could improve its privacy level more than tenfold,” explains Rubén Cuevas.

The researchers emphasise the importance of users being aware of the level of privacy provided by the digital services they use in order to reduce the risks associated with leaks or misuse of personal information.

“People should be aware of which databases are storing their information and what protection they provide, as leaks can lead to dangerous practices if the systems are not well designed,” concludes Rubén Cuevas.  

ANTICIPA Project

This project is part of the agreement between INCIBE and UC3M entitled ANTICIPA, included in the Strategic Projects in Spain, within the framework of the Recovery, Transformation, and Resilience Plan, with funding from the Next Generation-EU Funds. These initiatives are part of the Global Security Innovation Program, included in the Recovery, Transformation, and Resilience Plan (PRTR), through Component 15. Investment 7 Cybersecurity: Strengthening the capabilities of citizens, SMEs, and professionals and promoting the sector.

The National Cybersecurity Institute is an entity under the Ministry for Digital Transformation and Public Administration through the Secretariat of State for Telecommunications and Digital Infrastructure, consolidated as a benchmark entity for the development of cybersecurity and digital trust among citizens and businesses. It is also a driver of social transformation and an opportunity for innovation, promoting R&D&I and talent.

Carlos III University of Madrid (UC3M) is a Spanish public university that excels in research, teaching, and innovation. It ranks as the best Spanish public university in employability according to The Global University Employability Ranking and Survey 2026; among the top universities in Spain for its overall performance in the latest edition of the U-Ranking; and among the best universities in the world in the QS World University Rankings 2026. It is also the first university in Europe to achieve dual ACEEU accreditation for its contribution and impact on the industrial and social fabric. It also has other accreditations and quality distinctions, such as the EUR-ACE seal in the field of engineering and AACSB accreditation in business and finance programs.

Bibliographic reference: A. Merino, A. Cuevas, R. Cuevas. KPN-anonymity: Extension of K-anonymity for user anonymity evaluation on web applications. Array. 

https://doi.org/10.1016/j.array.2025.100499.

 

Video: https://youtu.be/dPLtN_d73QE?si=HjO3ECYHgpJa1bvk

 

CRISPR primes goldenberry for fruit bowl fame



Cold Spring Harbor Laboratory
Goldenberry 

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Goldenberries have been eaten for at least several centuries in Colombia and Peru, dating back to the days of the Incan Empire. As shown here, the fruit is comparable in size to many of the most popular berries consumed today.

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Credit: Lippman lab/CSHL





Since the dawn of agriculture around 10,000 years ago, our ancestors have saved seeds from the tastiest, largest, and most resilient crops to plant in the following season. Today, most fruits and vegetables we buy are the result of hundreds to thousands of years of selective breeding.

Now, Cold Spring Harbor Laboratory (CSHL) plant biologists may have found a “shortcut” to this tedious breeding process using the gene-editing tool CRISPR on a tiny tomato relative called goldenberry. This method could make the fruit easier to grow, opening it up for large-scale farming in the U.S. and abroad. The CRISPR-edited crops could be key to quickly breeding plants that are resistant to new diseases, pests, or drought.

“By using CRISPR, you open up paths to new and more resilient food options,” said Blaine Fitzgerald, the greenhouse technician in CSHL’s Zachary Lippman lab. “In an era of climate change and increasing population size, bringing innovation to agricultural production is going to be a huge path forward.”

The Lippman lab studies plants in the nightshade family, which includes major crops such as tomatoes, eggplants, and potatoes, and lesser-known species like goldenberries. Primarily grown in South America, goldenberries are gaining popularity due to their nutritional value and unique mix of sweet and tart flavors. You might’ve seen them in your local supermarket. Yet, goldenberry growers still rely on bushy crops that are “not really domesticated,” said Miguel Santo Domingo Martinez, the Lippman lab postdoc who led this study.

“These massive, sprawling plants in an agricultural setting are cumbersome for harvest,” Fitzgerald explained.

Previously, the Lippman lab used CRISPR to target genes in tomatoes and another lesser-known relative called groundcherry to make the plants more compact for urban farming. Building off this work, the team edited similar genes in goldenberries. The resulting crops grew 35% shorter, making planting in denser areas possible and maintenance easier. Next, Lippman’s lab searched for goldenberries with the tastiest fruits. This involved eating “hundreds of them, walking a field, and trying fruit off every plant in the row,” Fitzgerald said with a laugh.

After breeding several generations of the most delicious and compact goldenberry crops, the team had two distinct lines ripe for production. While these plants produced slightly smaller fruits, the next steps will involve using CRISPR to emphasize other desirable traits.

“We can try to target fruit size or disease resistance,” Santo Domingo said. “We can use these modern tools to domesticate undomesticated crops.” The team now hopes to seek additional regulatory approval for growers to get seeds and start producing the newly developed varieties.


Mutating the ERECTA gene with CRISPR caused goldenberry plants to grow 35% shorter (as shown on the left). Although each goldenberry was smaller, overall fruit productivity did not decrease as a result.

Credit

Lippman lab/CSHL