Thursday, January 23, 2025

 

One of late laser pioneer Gisela Eckhardt’s legacies: A new endowed physics professorship at Goethe University


Olena Fedchenko appointed to new Gisela and Wilfried Eckhardt endowed professorship for experimental physics – Funding provided by the estate of former physics student Gisela Eckhardt – City of Frankfurt names central square after Raman laser’s invention


Grant and Award Announcement

Goethe University Frankfurt

Olena Fedchenko 

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As the incumbent to the new Gisela and Wilfried Eckhardt endowed professorship, Olena Fedchenko decisively strengthens the experimental competence in solid state physics at Goethe University’s Faculty of Physics. (Photo: Kateryna Fedorenko)

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Credit: Kateryna Fedorenko




Until a few years before her death, it was unthinkable that laser specialist Gisela Eckhardt, inventor of the Raman laser, would one day bequeath about 11.5 million to Goethe University Frankfurt. After all, Eckhardt had turned her back on the university with resentment after completing her doctorate here in 1958 and emigrating to the U.S. Sixty years later, however, the erstwhile physics student designated “her” Goethe University as her heir, thereby laying the foundations for an endowed professorship in experimental physics – to which solid-state physicist Prof. Olena Fedchenko was appointed this month. The city of Frankfurt has honored the late laser pioneer by naming one of the squares in its Bockenheim district after Gisela Eckhardt. Fedchenko will give her inaugural lecture as part of the honorary celebrations on January 30.

FRANKFURT. It is thanks to the legacy of late laser specialist Gisela Eckhardt that Goethe University was recently able to establish a professorship for experimental physics in the field of the solid-state spectroscopy of electronically correlated materials and now fill it with solid-state physicist Olena Fedchenko. A Frankfurt native, Gisela Eckhardt is the first alumna whose bequest – in addition to signifying a late reconciliation with her alma mater – has enabled the university to set up an endowed professorship. When Gisela Eckhardt, née Elsholtz, began her longed for physics studies in 1947, she was the only female student in her year, and soon experienced the everyday obstacles encountered by a woman in a male-dominated research environment. A delayed diploma exam, a delayed doctoral thesis – even decades later, Gisela Eckhardt still lamented the time she lost during her studies as a result of her doctoral supervisor. By that time, she had long since moved to the U.S.A., where she emigrated in 1958 with her husband – whom she had met during their common student days. In Malibu, California, the Mecca of physics research at the time, she was not only able to fulfill her dream of conducting research. Thanks to a discovery in laser research in 1962, her renown spread far beyond her own institute: Harvard University named her one of the early pioneers of laser physics.

A feature in Frankfurter Allgemeine Zeitung about precisely this discovery – the Raman laser, which is still widely used in medicine, chemistry and biology today – brought Gisela Eckhardt back in touch with her university in 2017. At age 90, at the invitation of Goethe University, she visited her former faculty – which meanwhile had three female professors and several female young researchers. Childless and already widowed, Gisela Eckhardt decided to leave to her university the funds for an endowed professorship in experimental physics. The laser physics pioneer passed away on January 30, 2020, at the age of 93. In her last will and testament, she bequeathed more than €11.5 million to Goethe University: The long-term financing of the new endowed professorship, which bears her name and that of her husband Wilfried Eckhardt, is made possible by an endowment fund’s earnings.

Goethe University President Prof. Enrico Schleiff is very grateful for the alumna’s late reconciliation with her alma mater, which was made possible by the initiative shown by Private Hochschulförderung [the Private University Funding Office] and the physics faculty. “There is one thing Gisela Eckhardt, donor of the new professorship for experimental physics, wanted all her life: to conduct research as a physicist, freely and without restrictions – something that was hardly possible for her as a woman in post-war Germany. I am certain it would give her twice the joy to see that not only were we able to fill the professorship with a woman, but we were able to specifically recruit Olena Fedchenko to it – a brilliant scientist who conducts research in a similar field to Gisela Eckhardt herself. Olena Fedchenko is a great asset to our physics faculty, where she strengthens our experimental expertise in solid state physics.”

Experimental physicist Olena Fedchenko receives Gisela and Wilfried Eckhardt endowed professorship

The thematic proximity of experimental physicist Olena Fedchenko's area of expertise to laser pioneer Gisela Eckhardt would certainly have been in line with the wishes of the new Gisela and Wilfried Eckhardt endowed professorship’s donor. On January 1, 2025, this professorship was assumed by Olena Fedchenko, an expert who is particularly renowned in the field of electron spectroscopy, which holds great potential for use in modern solid-state research. “With this expertise, Olena Fedchenko strengthens one of our faculty’s three scientific research foci, that on 'condensed matter and quantum materials',” says Prof. Cornelius Krellner, managing director of the Institute of Physics. “Here in Frankfurt, we already have broad theoretical and experimental expertise when it comes to analyzing the complex problem of interacting particles in solids. With Olena Fedchenko's research group in experimental electron spectroscopy, we have now added a crucial link bridging theory and experiment – providing us with the key that is essential to unlocking important future technologies.”

Olena Fedchenko studied and completed her doctorate in physics and mathematics at Sumy State University (Ukraine), specializing in solid-state physics. After working as a research associate at that university’s Institute of Applied Physics, she moved to Johannes Gutenberg University Mainz in 2015. As a postdoctoral researcher here, she was involved in two collaborative research centers and several projects run by Germany’s Federal Ministry of Education and Research, contributing to the development of photoemission technology at DESY (Deutsches Elektronen-Synchrotron). In 2019 and 2024, her work was nominated as DESY Highlight of the Year; the latter year she was also nominated for the Charles S. Fadley Award for outstanding contributions to basic research in photoemission spectroscopy with hard X-rays.

Inauguration of Frankfurt’s new Gisela Eckhardt Square: Festive event held January 30 also features Prof. Olena Fedchenko’s inaugural lecture

Gisela Eckhardt will also receive a special honor in the city where she was born: At the suggestion of the Bockenheim local advisory council and the Physikalischer Verein, the City of Frankfurt is naming a previously nameless square on Ohmstraße after the Frankfurt native. Gisela Eckhardt Square will be officially inaugurated on January 30, the fifth anniversary of Gisela Eckhardt's death.

Prof. Dr. Olena Fedchenko will give her inaugural lecture during the subsequent festive event organized by the Physikalischer Verein, of which Gisela Eckhardt has been an honorary member since 2018 (time and place: 7 p.m., Robert-Mayer-Straße 2, 60325 Frankfurt; https://www.physikalischer-verein.de/veranstaltung/a-microscope-for-the-reciprocal-space.html).

Further information on the inauguration of the new Gisela Eckhardt Square is available here (in German): https://www.physikalischer-verein.de/veranstaltung/einweihung-des-gisela-eckhardt-platzes.html

You can find a more detailed account of how Goethe University came to endow a professorship for experimental physics here (in German): https://aktuelles.uni-frankfurt.de/forschung/wie-die-goethe-universitaet-zu-einer-stiftungsprofessur-fuer-experimentalphysik-kam/


 

New study finds social programs could reduce the spread of HIV by 29%



Although HIV was used as a case study, the UMass Amherst researchers say their assessment tool has applications for other diseases



University of Massachusetts Amherst

number of social factors 

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78% of people with diagnosed HIV (PWDH, blue line) are impacted by at least one of these social factors: 58% of PWDH have one or two of these social factors and another 20% have more than two. PWDH with no viral load suppression (VLS), i.e. likely not receiving HIV care and treatment, in green, have more social conditions than people who receive care to suppress the viral load (orange).  

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Credit: Chaitra Gopalappa




January 22, 2025 

 

New Study Finds Social Programs Could Reduce the Spread of HIV by 29% 

 

Although HIV was used as a case study, the UMass Amherst researchers say their assessment tool has applications for other diseases 

 

AMHERST, Mass. — Researchers at the University of Massachusetts Amherst have quantified the impacts of a constellation of social factors on the spread of HIV. Their study, published in Health Care Management Science, found that a hypothetical 100% effective intervention addressing barriers to HIV treatment and care from depression, homelessness, individual and neighborhood poverty, education disparities, lack of insurance and unemployment could reduce the national HIV incidence by 29% over 10 years. The mathematical model, a novel integration of machine learning, probability theory and simulation, is positioned to be an important tool for decision-makers to optimize social programs and will have applications for other diseases. 

 

Although 100% suppression of the virus — and consequently a 0% spread of the disease — is feasible through medication, there were still 31,800 new cases in 2022. Furthermore, the lifetime HIV cost per person in America is $420,285.  

 

“HIV strikes me as something that we should be able to eliminate, but it’s really the social vulnerability that is driving the epidemic,” says Chaitra Gopalappa, associate professor of mechanical and industrial engineering at UMass Amherst and corresponding author on the paper. For instance, 44% of people with HIV have some kind of disability and 43% have a household income at or below the poverty line.  

 

While previous work has focused on behavioral risk factors of HIV spread — sexual behavior and needle sharing — less has been done to quantify the association of social factors with HIV risk behaviors.  

 

“Just having behavioral interventions is not going to be sufficient, so what are those additional interventions that are needed?” says Gopalappa. “What our work did was to develop a model that helps us determine what the joint social burden is and how is that related to behavioral mechanisms that increase the risk of HIV?” 

 

Gopalappa, with doctoral candidate Amir Khosheghbal and Manning College of Information and Computer Science professor Peter Haas, first identified the proportion of people with diagnosed HIV (PWDH) who are also affected by depression, homelessness, individual and neighborhood poverty, education disparities, lack of insurance or unemployment. They found that 78% of PWDH are impacted by at least one of these social factors: 58% of PWDH have one or two of these social factors and another 20% have more than two. (It is important to note that the model looked at association and not causality and assumed an idealistic hypothetical intervention that is 100% effective.) 

 

The model takes into consideration that different social factors present different-sized barriers to HIV care and treatment. Compare unemployment and lacking insurance. More PWDH are unemployed than lack insurance — 14% versus 3% of PWDH. However, previous research indicates that insurance has a greater effect on HIV care access than unemployment.  

 

There is a certain chance that an individual faces one or both of these social factors. The disparity gap in HIV care for someone with only one social factor may be different than with the gap for someone with both. The complexity of estimating these disparity gaps increases as more social factors come into play. The model, a novel integration of probability theory with machine learning, is built to quantify this. Followed by a simulation to do a what-if analysis to estimate the impact of a hypothetical intervention that can completely close these disparity gaps i.e., all persons will receive the same higher level of HIV care as that of people with no social burden.  

 

“The likely interventions that we need, like food and housing assistance, are likely to involve some cost but we’re going to be reducing the percent of cases,” says Gopalappa. “The cost of treatment itself is very high. Could investing in prevention avert those future costs for treatment?” 

 

With this perspective, this model can help decision-makers optimize the most cost-effective combination of social programs. If each intervention is like a lever, you may not need to pull every lever to 100% if you can find the optimal combination, she explains. “This tool helps analyze those resource allocation decisions.” 

 

She also highlights that the impacts of social programs extend beyond HIV. “Diseases don’t occur in silos,” she says. “What we’re seeing is that the same social determinants are associated with other diseases from HIV and STIs to mental health, cardiovascular disease and diabetes to maternal morbidity and mortality. The decision-making process for each of these diseases occurs by different entities, but it is in the same people. So, how do we integrate all of these interventions for decision analysis? This is one part of a long-term goal to develop a tool that helps resource allocation strategies.” 

 

This research was supported by the U.S. National Science Foundation

 

Advancing surgical sutures: The promise of cellulose-based materials


A comprehensive review of cellulose-based sutures: Innovation and future outlook



Journal of Bioresources and Bioproducts

Cellulose-based suture: State of art, challenge, and future outlook 

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Advancing Surgical Sutures: The Promise of Cellulose-Based Materials

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Credit: CAS Key Laboratory of Biobased Materials, Qingdao New Energy Shandong Laboratory, System Integration Engineering Center, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China




A recent review published in the Journal of Bioresources and Bioproducts examines the state of cellulose-based sutures, focusing on materials, fabrication methods, and application performance. The study underscores the potential of these sutures as eco-friendly alternatives to traditional synthetic sutures, with significant advancements in biocompatibility and biodegradability.

Surgical sutures are critical in wound closure and healing, with traditional materials like cotton and synthetic polymers dominating the market. However, the rise of sustainable and biocompatible materials has led researchers to explore cellulose-based sutures as a viable alternative. A comprehensive review published in the Journal of Bioresources and Bioproducts provides an in-depth look at the current state of cellulose-based sutures, their fabrication methods, and potential applications.

Cellulose, the most abundant natural polymer on Earth, offers several advantages for surgical sutures, including non-toxicity, biocompatibility, and mechanical strength. The review covers various types of cellulose-based sutures, including natural cellulose, nanocellulose, and regenerated cellulose. Each type offers unique properties, with nanocellulose showing particular promise due to its high strength and flexibility. For instance, cellulose nanofibrils (CNF) have been used to create sutures with tensile strengths comparable to traditional materials, while maintaining excellent biocompatibility.

The review also highlights innovative fabrication methods such as wet spinning and interfacial polyelectrolyte complexation (IPC) spinning. Wet spinning is a traditional method used to create strong and flexible fibers, while IPC spinning allows for the creation of composite fibers with enhanced properties. These methods enable the production of sutures with tailored mechanical properties, biodegradability, and antibacterial characteristics.

One of the key challenges identified in the review is the need for consistent quality and improved biocompatibility in cellulose-based sutures. While natural cellulose fibers like cotton have been used historically, their quality can vary, leading to inconsistent performance. In contrast, nanocellulose and oxidized regenerated cellulose (ORC) offer more uniform properties and can be engineered for specific applications. For example, ORC sutures have demonstrated significant biodegradability, losing over 50% of their strength within 14 days, making them suitable for absorbable sutures.

The review also emphasizes the importance of multifunctional sutures that integrate antibacterial properties and growth factors to enhance wound healing. For instance, CNF/chitosan composite sutures have shown excellent antibacterial activity against common pathogens like Escherichia coli and Staphylococcus aureus, while maintaining high cell viability in vitro and in vivo.

Looking ahead, the review suggests that cellulose-based sutures could become the next generation of high-end medical sutures, driven by advancements in materials science and a growing focus on sustainability. Future research should focus on optimizing fabrication processes, enhancing mechanical properties, and conducting clinical trials to validate their performance.

 

Global research on hydrothermal pre-treatment: A green leap for biorefineries



Bibliometric analysis reveals growing interest and advancements




Journal of Bioresources and Bioproducts

Global evolution of research on autohydrolysis (hydrothermal) pretreatment as a green technology for biorefineries: A bibliometric analysis 

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Global Research on Hydrothermal Pretreatment: A Green Leap for Biorefineries

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Credit: Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China




A bibliometric analysis of 6,403 articles on hydrothermal pretreatment reveals a steady increase in global research over the past two decades. China is the most active country, with 36.5% of publications. The study highlights advancements in using this technology for sustainable biomass conversion in biorefineries.


Hydrothermal pretreatment, a green technology that uses hot water or steam to break down lignocellulosic biomass, has gained significant attention in recent years as a sustainable solution for bioenergy production. A new study published in the Journal of Bioresources and Bioproducts provides a comprehensive bibliometric analysis of research on this topic, revealing a steady increase in global interest and advancements.

The study analyzed 6,403 research articles published between 2000 and 2023, sourced from the Web of Science database. The results show that the number of publications related to hydrothermal pretreatment has increased annually, with China leading the global research output at 36.5%, followed by the United States (14.6%) and Japan (8.2%). This trend indicates a growing recognition of hydrothermal pretreatment as a key technology for sustainable biomass conversion.

The analysis also identified key research hotspots, including the optimization of pretreatment conditions, the development of integrated biorefinery processes, and the application of hydrothermal pretreatment for producing biofuels and high-value chemicals. The study highlights the Chinese Academy of Sciences as the most prolific institution in this field, with 245 publications. Other leading institutions include Universidade de Vigo in Spain and the United States Department of Energy.

The findings suggest that hydrothermal pretreatment is not only effective in breaking down lignocellulosic biomass but also environmentally friendly, avoiding the use of harsh chemicals and reducing waste generation. The technology has shown promise in enhancing the enzymatic hydrolysis of biomass, leading to higher yields of fermentable sugars and biofuels. As the world seeks sustainable alternatives to fossil fuels, hydrothermal pretreatment could play a crucial role in the future of biorefineries.

In conclusion, the study underscores the potential of hydrothermal pretreatment as a green technology for sustainable biomass conversion. With continuous advancements and increasing global collaboration, this technology is poised to contribute significantly to the development of bio-based economies and the circular economy.

 

Overlooking a low-hanging fruit in climate mitigation: Biochar is much better than its reputation


A new study shows biochar to be far more effective at long-term carbon storage than previously thought. The study reveals critical flaws in the models used by the IPCC and European climate policymakers.



Aarhus University

A handful of biochar 

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A small handful of biochar in pellet form, produced by pyrolysis

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Credit: GEUS




Biochar – a carbon-rich material produced by pyrolyzing biomass – has long been recognized for its ability to improve soil health and sequester carbon. But its potential as a permanent CO₂ removal solution has been underestimated in conventional models. As a result, biochar has not been prioritized as a key tool in global and European climate strategies.

Now, a transformative new study led by Professor Hamed Sanei from Aarhus University and recently published in Biochar (Springer), challenges the outdated perceptions of biochar and reveals its enormous potential as a shovel-ready, long-term carbon dioxide removal (CDR) solution.

“Our study shows that biochar is not just a promising technology – it is an essential one,” said Professor Hamed Sanei, head of the Lithospheric Organic Carbon Lab at Aarhus University in Demark.

The research identifies significant shortcomings in the carbon modelling frameworks upon which the IPCC and European climate policies have relied, and it provides a path to fully unlock biochar's promise for climate mitigation.

“The previous models underestimated the stability of carbon stored in biochar. By correcting these inaccuracies, we can elevate biochar to its rightful place as a highly reliable carbon storage option.”

This study builds on previous research by Hamed Sanei and Henrik Ingermann Petersen et. al., who last year showed that biochar can store carbon for millions of years. The new study highlights how current models used by the IPCC and other climate organizations fail to reflect this long-term stability accurately.

A revised narrative on biochar

The research, supported by Innovation Fund Denmark and the EU's NextGenerationEU program, documents how outdated assumptions have sidelined biochar in climate discussions.

By addressing these misconceptions, the study establishes a foundation for biochar to be recognized as an effective, scalable, and permanent carbon storage technology.

“Biochar has been a missed opportunity in the fight against climate change,” said Professor Henrik Ingermann Petersen from the Geological Survey of Denmark and Greenland (GEUS), who also co-authored the new study. “Our work corrects the narrative and highlights biochar’s exceptional capacity for long-term carbon storage. It’s a ready-to-implement technology that can make an immediate impact.”

Denmark as a frontrunner

Denmark in particular stands to benefit significantly from this research. As a leader in innovative climate initiatives, Denmark has already identified biochar as a critical component of its strategy to achieve carbon neutrality by 2050.

“This study provides policymakers and stakeholders with the tools they need to integrate biochar into carbon markets with confidence,” said Professor Ondrej Masek from the University of Edinburgh, a co-author of the paper.

A call to action

The authors hope their findings will drive immediate action among policymakers, industry leaders, and researchers. With accurate models now available, supported by latest experimental findings, biochar and slow pyrolysis can take center stage as a trusted and scientifically validated solution for carbon dioxide removal.

“This isn’t just a story about biochar—it’s about the future of carbon removal,” said Professor David Chiaramonti from Politecnico di Torino. “By improving the accuracy of our models, we unlock the potential of technologies like biochar that are ready to scale today.”

Durian, a fruit from Southeast Asia, is seen here before (left) and after (right) pyrolysis.

Credit

GEUS