Wednesday, January 29, 2025

 

Crypto issues and voter outreach energized PolitiFi into relevance in 2024, according to Concordia researchers



Politically affiliated meme coins became a new and important tool in the just-concluded US elections



Concordia University

Juliane Proelss, Stéphane Sévigny, Denis Schweizer 

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Stéphane Sévigny (centre) with Juliane Proelss and Denis Schweizer: “These tokens initially were kind of a joke, but they were increasingly taken on as badges of honour to showcase political convictions.”

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Credit: Concordia University





The 2024 elections in the United States were memorable in several aspects, not least being the appearance of PolitiFi. It’s a new form of meme coin cryptocurrency inspired by internet culture and humour that is explicitly affiliated with a political candidate. Among the biggest were MAGA, supporting the Donald Trump campaign, and BODEN, linked to the Joe Biden / Kamala Harris team.

In a paper published in the journal Finance Research Letters, three Concordia scholars explore the growth of the PolitiFi phenomenon and how it helped shape narratives, enhance visibility and, critically, boost political engagement among voters in the cryptosphere.

“These tokens initially were kind of a joke, but they were increasingly taken on as badges of honour to showcase political convictions,” says lead author Stéphane Sévigny, a PhD candidate studying digital assets at the John Molson School of Business.

“This really ended up exploding in market capitalization, especially at the beginning of 2024, when the election campaigns were starting to ramp up.”

As the race progressed and cryptocurrency became a campaign issue, the politically affiliated tokens gained an unusual amount of attention from traders. It soon became clear that they were eclipsing the usual meme coins in value, and in some cases using that value to assist their respective campaigns financially. At its peak, the MAGA coin had a market capitalization of around USD $750 million.

“They started taking on a life of their own,” he says.

Politics drives trading

The researchers conducted event studies around two critical moments in the campaign that affected MAGA and BODEN coins in very different way. Their findings suggested that political opinion may have been at least somewhat expressed through trading behaviour.

“When Trump was shot in July, we saw the support for Republican-allocated tokens went up significantly while those that were allocated Democratic went down,” says co-author Juliane Proelss, associate professor in the Department of Finance. “The opposite happened when Biden was replaced by Harris just over a week later.”

According to their analyses, Republican-affiliated coins rose 15 per cent after the assassination attempt while Democratic-affiliated ones dropped around nine per cent. When Biden left the race, Republican tokens dropped one per cent but Democratic ones dropped 45 per cent.

“This suggests that these PolitiFi coins were used to express traders’ opinions and support of their respective candidates,” she says.

Sévigny says the Trump camp was more adept at using PolitiFi to help him reach demographics he and other Republicans have often struggled to interact with. As a result, he outperformed traditional Republicans among young, university-educated males, including relatively high proportions of Black and Hispanic voters.

“Being a very opportunistic candidate, he was able to see this gap and started addressing the lack of regulation in the area. That may have helped shift the tide in the election,” he says.

Worthless now, valuable soon

While PolitiFi began in the United States, Sévigny thinks it is unlikely to play a major role in Canada’s upcoming elections. However, it may catch on in larger democracies with looser rules around campaign financing, such as some in South America.

Even though the tokens from the 2024 campaign have lost roughly 90 per cent of their value since the election, the researchers believe PolitiFi will remain a factor in upcoming contests, as either a financing vehicle or a voter engagement tool. It is possible that both major US political parties may issue their own official coins that can be cyclically employed every two to four years.

“It could be like buying a cap or a flag,” says Proelss, the Jacques-Ménard-BMO Professor in Capital Markets. “After the election is over, you can still have these coins somewhere in your digital cupboard and not do anything until the next election, when you pull them out again.”

Professor of finance Denis Schweizer co-authored the article.

Read the cited paper: “PolitiFi: Just another meme, or instrumental for winning elections?”

 

First mouse with two male parents to reach adulthood



Cell Press
Imprinting modifications in sperm-derived haploid ESCs 

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Imprinting modifications in sperm-derived haploid ESCs

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Credit: Current Biology, Li et al.




A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse—a mouse with two male parents—that lived until adulthood. Their results, publishing on January 28, 2025, in the Cell Press journal Cell Stem Cell, describe how targeting a particular set of genes involved in reproduction allowed the researchers to overcome previously insurmountable challenges in unisexual reproduction in mammals.  

Scientists have attempted to create bi-paternal mice before, but the embryos developed only to a certain point and then stopped growing. Here, the investigators, led by corresponding author Wei Li of the Chinese Academy of Sciences (CAS) in Beijing, focused on targeting imprinting genes, which regulate gene expression in a number of ways. “This work will help to address a number of limitations in stem cell and regenerative medicine research,” says Li. 

“The unique characteristics of imprinting genes have led scientists to believe that they are a fundamental barrier to unisexual reproduction in mammals,” says co-corresponding author Qi Zhou, also of CAS. “Even when constructing bi-maternal or bi-paternal embryos artificially, they fail to develop properly, and they stall at some point during development due to these genes.” 

Earlier attempts to make a bi-paternal mouse used ovarian organoids to derive oocytes from male pluripotent stem cells; those ooctyes were then fertilized with sperm from another male. However, when the homologous chromosomes—the chromosomes that divide during meiosis to create oocytes and sperm—originated from the same sex, imprinting abnormalities arose, leading to severe developmental defects.  

In this study, the researchers modified 20 key imprinting genes individually using a number of different techniques, including frameshift mutations, gene deletions, and regulatory region edits. They found that not only did these edits allow the creation of bi-paternal animals that sometimes lived to adulthood, but they also led to stem cells with more stable pluripotency. 

“These findings provide strong evidence that imprinting abnormalities are the main barrier to mammalian unisexual reproduction,” says co-corresponding author Guan-Zheng Luo of Sun Yat-sen University in Guangzhou. “This approach can significantly improve the developmental outcomes of embryonic stem cells and cloned animals, paving a promising path for the advancement of regenerative medicine.” 

The researchers note several limitations that their work still needs to address. For one thing, only 11.8% of the viable embryos were capable of developing until birth, and not all the pups that were born lived to adulthood due to developmental defects. Most of those that did live to adulthood had altered growth and a shortened lifespan. Also, the mice that lived to adulthood were sterile, although they did exhibit increased cloning efficiency.  

“Further modifications to the imprinting genes could potentially facilitate the generation of healthy bi-paternal mice capable of producing viable gametes and lead to new therapeutic strategies for imprinting-related diseases,” says co-corresponding author Zhi-Kun Li of CAS. 

The team will continue to study how modifying imprinting genes may lead to embryos with higher developmental potential. They also aim to extend the experimental approaches developed in mice to larger animals, including monkeys. However, they note that this will require considerable time and effort because the imprinting gene combinations in monkeys differ significantly from those in mice. Whether this technology will ultimately be applied towards solving human disease remains unclear. The International Society for Stem Cell Research's ethical guidelines for stem cell research does not allow heritable genome editing for reproductive purposes nor the use of human stem cell-derived gametes for reproduction because they are deemed as currently unsafe. 

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Cell Stem Cell, Li et al. “Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals.” https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00005-0

Cell Stem Cell (@CellStemCell), published by Cell Press, is a monthly journal that publishes research reports describing novel results of unusual significance in all areas of stem cell research. Each issue also contains a wide variety of review and analysis articles covering topics relevant to stem cell research ranging from basic biological advances to ethical, policy, and funding issues. Visit: http://www.cell.com/cell-stem-cell. To receive Cell Press media alerts, contact press@cell.com. 

Largest study ever done on cannabis and brain function finds impact on working memory

The study looked at the effect of cannabis use on young adults who are recent or heavy users




University of Colorado Anschutz Medical Campus

Dr. Gowin looking at brain scans in his office. 

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Dr. Gowin looking at brain scans in his office.

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Credit: CU Anschutz Medical Campus




A new study published today in JAMA Network Open explores the effects of both recent and lifetime cannabis use on brain function during cognitive tasks.

The study, the largest of its kind ever to be completed, examined the effects of cannabis use on over 1,000 young adults aged 22 to 36 using brain imaging technology. The researchers found that 63% of heavy lifetime cannabis users exhibited reduced brain activity during a working memory task, while 68% of recent users also demonstrated a similar impact.

This decline in brain activity was associated with worse performance on working memory - the ability to retain and use information to perform tasks. For example, working memory allows a person to follow instructions they’ve just been given or to mentally visualize and manipulate information, like solving a math problem.

“As cannabis use continues to grow globally, studying its effects on human health has become increasingly important. By doing so, we can provide a well-rounded understanding of both the benefits and risks of cannabis use, empowering people to make informed decisions and fully comprehend the potential consequences," said the study’s first author Joshua Gowin, PhD, assistant professor of radiology at the University of Colorado School of Medicine on the University of Colorado Anschutz Medical Campus.

In the study, heavy users are considered young adults who’ve used cannabis more than 1000 times over their lifetime. Whereas, using 10 to 999 times was considered a moderate user and less than 10 times was considered a nonuser.

The researchers studied the neural response of participants during a magnetic resonance imaging (MRI) session and gave them seven cognitive tasks to complete. The tasks tested working memory, reward, emotion, language, motor skills – such as tapping a finger to map brain control, relational assessment and theory of mind.

The researchers found that cannabis had a statistically significant effect on brain function during working memory tasks, meaning the observed impact is very unlikely to be due to random chance. This effect was seen in both recent and lifetime cannabis users. The impact was less significant for the other tasks.

"We applied the highest standards to our research, setting rigorous thresholds for statistical significance across all seven cognitive function tests. To minimize the risk of false positives, we employed false discovery rate (FDR) correction. While some of the other tasks indicated potential cognitive impairment, only the working memory task showed a statistically significant impact,” adds Gowin.

During working memory tasks, the researchers found heavy cannabis use appeared to reduce brain activity in certain areas of the brain (dorsolateral prefrontal cortex, dorsomedial prefrontal cortex and anterior insula). These regions of the brain are involved in important cognitive functions such as decision-making, memory, attention and emotional processing.

However, Gowin mentions their research also suggests that abstaining from using cannabis before doing a cognitive task could help to improve performance. “People need to be aware of their relationship with cannabis since abstaining cold turkey could disrupt their cognition as well. For example, heavy users may need to be more cautious,” Gowin says.

He adds, “There are a lot of questions we still need answers to regarding how cannabis impacts the brain. Large, long-term studies are needed next to understand whether cannabis use directly changes brain function, how long these effects last and the impact on different age groups.”

About the University of Colorado Anschutz Medical Campus

The University of Colorado Anschutz Medical Campus is a world-class medical destination at the forefront of transformative science, medicine, education and patient care. The campus encompasses the University of Colorado health professional schools, more than 60 centers and institutes and two nationally ranked independent hospitals - UCHealth University of Colorado Hospital and Children's Hospital Colorado – which see more than two adult and pediatric patient visits yearly. Innovative, interconnected and highly collaborative, the CU Anschutz Medical Campus delivers life-changing treatments, patient care and professional training and conducts world-renowned research fueled by $910 million in annual research funding, including $757 million in sponsored awards and $153 million in philanthropic gifts. 

Journal

Article Title

Brain function outcomes of recent and lifetime cannabis use


JAMA Network Open



About The Study:

 Lifetime history of heavy cannabis use was associated with lower brain activation during a working memory task in this study of young adults. These findings identify negative outcomes associated with heavy lifetime cannabis use and working memory in healthy young adults that may be long lasting. 


Corresponding Author: To contact the corresponding author, Joshua L. Gowin, PhD, email joshua.gowin@cuanschutz.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.57069)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

Ambitious projects to tackle invasive alien species launched in Europe



Two new European projects just kicked off aiming to tackle invasive alien species across marine, freshwater and terrestrial habitats



Pensoft Publishers

GuardIAS and OneSTOP participants at the kick-off meeting 

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GuardIAS and OneSTOP participants at the kick-off meeting

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Credit: GuardIAS and OneSTOP projects




Two ambitious multi-stakeholder projects that aim to tackle the threat of invasive alien species have been launched at a conference in Europe last week (20-23 January 2025). GuardIAS and OneSТOP — covering marine and freshwater, and terrestrial habitats respectively — will work in tandem to alleviate the adverse impacts of invasive alien species on endangered species, natural sites and human health, providing comprehensive coverage of Europe’s ecosystems.

Invasive alien species — animals and plants that are introduced accidentally or deliberately into a natural environment where they are not normally found — are major threats worldwide, contributing to 60% of plant and animal extinctions and costing over $400 billion annually to global economies [1]. The challenges associated with invasive alien species are likely to intensify with climate change and ongoing globalisation.

The GuardIAS and OneSTOP projects will use advanced scientific research, cutting-edge technology, and artificial intelligence to develop new tools and methods that will prevent, detect, prioritise, eradicate, and manage invasive alien species — covering all steps of the biological invasion process.

In addition, a significant aspect of both projects is public engagement and wider community involvement, including Citizen Science initiatives, outreach and art events, and the development of interactive games to gain support and promote action in addressing the threats of invasive alien species.

“We have created a multi-disciplinary approach, which I am very excited about”, said GuardIAS Project Coordinator Professor Stelios Katsanevakis, University of the Aegean, Greece.

“We have brought together public research institutes, universities, non-profit associations, small/medium enterprises and the EU’s Joint Research Centre to work on the issue. Through this, we will create a far-reaching outreach programme that involves the wider community in addressing the challenges posed to society by invasive alien species.”

Prof Katsanevakis continued, “The GuardIAS project aims to improve the detection and prevent the spread of invasive alien species in both marine and freshwater habitats using a range of novel methods — such as artificial intelligence (AI), environmental DNA, satellite imagery, underwater robotics and monitoring systems, and the development of an early alert system. Information gained from the research will be used to increase public awareness regarding threats from invasive species spread, enhance public engagement, and enable decision makers to prioritise where and when to act.”

GuardIAS and OneSTOP will develop solutions for the management of invasive alien species at multiple governance levels, from local to international — and will also conduct analyses to assess invasion risks under various future scenarios, including climate change.

“It has been an incredible week at the Joint Research Centre in Ispra, hearing the scope of both projects and being with the different partners and stakeholders, discussing and collaborating, said Professor Helen E. Roy from the UK Centre for Ecology & Hydrology and University of Exeter, who is co-leading OneSTOP.

“We have been aware for many years that there are datasets in many different places, with different people doing different things in different ways, and we knew there had to be a way to bring it all together. And now, we are launching initiatives to build on the incredible progress of the last decade. It is an exciting and significant moment for all involved”.

OneSTOP’s coordinator Doctor Quentin Groom from Meise Botanic Garden, Belgium, shared the reasoning behind the project,

“To comprehensively address the issue of invasive alien species, OneSTOP is working around four main objectives. We are developing new tools allowing us to detect invasive alien species better. We are connecting these tools to systems which send information to the interested stakeholders faster. Based on the obtained data, we are also developing a system which allows policymakers to prioritise action on invasive alien species. Throughout all of this, we are working closely with people on a regional level through Living Labs and on an international level with a policy forum.”

A key part of both projects are work packages that will use Artificial Intelligence (AI) to systematically query different biodiversity databases for information about invasive alien species — for example, species distribution, environmental tolerances, biological traits, and genetic information, streamlining multiple datasets.

To complement the EU efforts for an official reporting system and the European Alien Species Information Network (EASIN), the projects will be co-developing an Alert System on invasive alien species.

Funded by Horizon Europe, the projects have been hailed as not just a response to current environmental challenges but also a proactive step towards sustainable management and conservation of aquatic and terrestrial ecosystems in Europe.

The comprehensive approach of the projects, encompassing science, technology, and community engagement, positions them as key players in the EU's efforts to preserve biodiversity and protect ecosystems from the growing threat of invasive species in alignment with the EU Biodiversity Strategy for 2030 and the Invasive Alien Species (IAS) Regulation.

[1] IPBES Invasive Alien Species Assessment: Summary for Policymakers (2023) IPBES 2023. doi:10.5281/zenodo.7430692

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GuardIAS and OneSTOP receive funding from the European Union’s Horizon Europe Research and Innovation Programme (ID Numbers respectively 101181413 and 101180559). Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency (REA). Neither the EU nor REA can be held responsible for them.

WOKE, CSR, DEI, ESG, PAYES

Strategic corporate social responsibility can create social, economic value



Penn State




UNIVERSITY PARK, Pa. — Strategic corporate social responsibility (CSR) efforts that are directly related to a hospitality company’s core business operations and competencies can help companies create both social and business value, according to researchers in the Penn State School of Hospitality Management.

Led by Penn State Professor of Hospitality Management Seoki Lee, the research team developed a strategic framework to help hospitality companies optimize their CSR activities — like environmental and social initiatives — to obtain greater social and business value. The researchers published their work in the journal Tourism Economics.

“When it comes to strategic CSR, it is a company’s core business operations and competencies that matter most,” Lee said, pointing to a restaurant participating in food donation programs as an example of strategic CSR matching with a company’s core business operations and competencies. “If a business is participating in CSR activities, those activities must be directly related to the company’s core business operations and competencies. When they do that, they can create not only social value but also business value for the company itself.”

The research team’s strategic CSR framework consists of four components: shared value, enlightened stakeholder theory, resource-based theory and CSR-fit perspective.

Shared value relates to the need for companies to ensure CSR activities create both social and business value, such as a coffee shop working with local farmers to cultivate plants and harvest coffee beans in an environmentally friendly manner. By doing so, the company would add social value through supporting environmentally friendly practices and business value by gaining access to a key product.

Enlightened stakeholder theory centers around a company’s ability to maximize long-term value from strategic CSR. Enlightened stakeholder theory shows that the economic return a business may receive from strategic CSR practices are generally long-term in nature, as it takes time for businesses to inform stakeholders about the benefits of CSR investments and the financial market to understand and recognize the true value of CSR investments, according to Lee.

The final two components of the framework consist of CSR fit and resource-based theory. CSR fit ensures a company's CSR positioning is aligned with its operations or competencies. Resource-based theory demonstrates how strategic CSR can improve a company’s relationship with various stakeholders, such as when CSR engagement improves brand image and thus enhances the company’s relationship with its consumer base.

“Companies must take care of social and environmental issues,” Lee said. “When they know they must tackle those issues, they must ask, ‘What is the best way to do that? What is the best way to create the most value?’ Companies should aim to optimize the social and business value of CSR at the same time.”

To understand perceptions of this strategic CSR framework, the researchers surveyed 310 participants recruited via a Qualtrics panel list. The survey asked participants how they perceived inclusion of business value in CSR and how people perceive CSR activities that relate to a company’s core operations and competencies. Participants were also asked to rate both a restaurant and hotel company on how effective they were in implementing different CSR practices, some of which coincided closely with each respective industry, and others that did not.

Lee said the survey results indicate people perceive CSR to be more effective when a company’s activities strategically relate back to its core operations and competencies, which supports the researchers’ four-component framework.

“Many large corporations may try to do everything or a lot of things, as they have the interests of many stakeholders to take care of,” Lee said. “However, if these corporations focus on a more limited number of CSR activities that are aligned with their core competencies, they can create increased business value while also creating greater social value. Creating business value is equally as important as creating social value because businesses may struggle to continue their CSR efforts if they do not generate economic value in return.”

Penn State doctoral student Samantha Hwang, Minjung Shin of the University of Houston and Kyung Ho Kang of Kyung Hee University collaborated on this research.