It’s possible that I shall make an ass of myself. But in that case one can always get out of it with a little dialectic. I have, of course, so worded my proposition as to be right either way (K.Marx, Letter to F.Engels on the Indian Mutiny)
Friday, December 12, 2025
Indoor tanning makes youthful skin much older on a genetic level
Tanning bed users are known to have a higher risk of skin cancer, but for the first time researchers have found that young indoor tanners undergo genetic changes that can lead to more mutations in their skin cells than people twice their age.
The study, which was led by UC San Francisco and Northwestern University, appears Dec. 12 in Science Advances.
“We found that tanning bed users in their 30s and 40s had even more mutations than people in the general population who were in their 70s and 80s,” said Bishal Tandukar, PhD, a UCSF postdoctoral scholar in Dermatology who is the co-first author of the study. “In other words, the skin of tanning bed users appeared decades older at the genetic level.”
Such mutations can lead to skin cancer, which is the most common cancer in the U.S., according to the American Cancer Society. Among those skin cancers is melanoma, which accounts for only about 1% of skin cancers but causes most of the deaths. About 11,000 Americans die annually from melanoma, primarily from exposure to ultraviolet radiation.
UV radiation occurs naturally in sunlight, as well as in artificial light sources like tanning beds. Rates of melanoma have risen along with the use of tanning beds in recent years, disproportionately affecting young women, who are the main clients of the tanning industry.
Numerous countries effectively ban tanning beds, and the World Health Organization classifies them as a group 1 carcinogen, the same category as tobacco smoke and asbestos, but tanning beds remain legal and popular in the U.S.
In their study, the authors looked at the medical records of more than 32,000 dermatology patients including their tanning bed usage, history of sunburn, and family history of melanoma. They also obtained skin samples from 26 donors and sequenced 182 cells.
The young tanning bed users had more skin mutations than people twice their age, especially in their lower backs, an area that does not get much damage from sunlight but has a great deal of exposure from tanning beds.
“The skin of tanning bed users was riddled with the seeds of cancer — cells with mutations known to lead to melanoma,” said senior author A. Hunter Shain, PhD, associate professor in the UCSF Department of Dermatology.
“We cannot reverse a mutation once it occurs, so it is essential to limit how many mutations accumulate in the first place,” said Shain, whose laboratory focuses on the biology of skin cancer. “One of the simplest ways to do that is to avoid exposure to artificial UV radiation.”
Authors: From UCSF, authors include Delahny Deivendran; Limin Chen, PhD; Jessica Tang, PhD; Tuyet Tan; Harsh Sharma, PhD; Aravind K. Bandari, PhD; Noel Cruz-Pacheco, MS; Darwin Chang; Annika L. Marty, MS; Adam Olshen, PhD; Natalia Faraj Murad, PhD; and Iwei Yeh, MD, PhD. Co-first author Pedram Gerami, MD, is with Northwestern University, Chicago.
Funding: The study was supported by the National Cancer Institute (R01 CA265786); the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR080626); the Department of Defense Melanoma Research Program (ME210014); and the Melanoma Research Alliance. Please see the paper for additionalfunders.
Disclosures: None reported.
About UCSF: The University of California, San Francisco (UCSF) is exclusively focused on the health sciences and is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. UCSF Health, which serves as UCSF’s primary academic medical center, includes top-ranked specialty hospitals and other clinical programs, and has affiliations throughout the Bay Area. UCSF School of Medicine also has a regional campus in Fresno. Learn more at https://ucsf.edu or see our Fact Sheet.
Study analyzed thousands of medical records to compare melanoma rates in tanning bed users vs. non-users, and sequenced 182 skin biopsies from tanning bed users and controls
Tanning bed users carried double the mutation burden of controls
In users, mutations appeared even in body areas that don’t get much sun exposure
CHICAGO ---Tanning bed use is tied to almost a threefold increase in melanoma risk, and for the first time, scientists have shown how these devices cause melanoma-linked DNA damage across nearly the entire skin surface, reports a new study led by Northwestern Medicine and University of California, San Francisco.
Melanoma, the deadliest skin cancer, kills about 11,000 in the U.S. each year. Despite decades of warnings, the precise biological mechanism behind tanning beds’ cancer risk remained unclear. The indoor tanning industry, which is making a comeback, has used that uncertainty to argue that tanning beds are no more harmful than sunlight.
This new study “irrefutably” challenges those claims by showing how tanning beds, at a molecular level, mutate skin cells far beyond the reach of ordinary sunlight, according to the authors.
“Even in normal skin from indoor tanning patients, areas where there are no moles, we found DNA changes that are precursor mutations that predispose to melanoma,” said study first author Dr. Pedram Gerami, professor of skin cancer research at Northwestern University Feinberg School of Medicine. “That has never been shown before.”
Melanoma survivors with histories of tanning bed use, who donated their biopsies for this study, are available for interviews upon request.
The findings will publish Dec. 12 in Science Advances.
A clinical mystery
Gerami, who also directs the melanoma program in dermatology at Northwestern, has been treating melanoma patients for 20 years. Over the years, he noticed an unusually high number of women under 50 with a history of multiple melanomas, and suspected the linking factor was tanning bed usage. So, along with his research team, he designed the epidemiologic part of the study and compared the medical records of roughly 3,000 tanning bed users with 3,000 age-matched controls with no history of indoor tanning.
The team found that melanoma was diagnosed in 5.1% of tanning bed users compared with 2.1% of non-users. After adjusting for age, sex, sunburn history and family history, tanning bed use remained associated with a 2.85-fold increase in melanoma risk.
Tanning bed users were also more likely to develop melanoma on sun-shielded body sites, such as the lower back and buttocks. These findings supported the idea that tanning beds may cause broader DNA injury than sun exposure.
DNA sequencing
To test that hypothesis, the scientists used new genomic technologies to perform single-cell DNA sequencing on melanocytes (the pigment-producing skin cells where melanoma begins) from three skin donor groups.
The first group included 11 patients from Gerami with long histories of indoor tanning. The second group consisted of nine patients who had never used tanning beds but were otherwise matched for age, sex and cancer risk profiles. A third group of six cadaver donors supplied additional skin tissue to round out the control samples.
The scientists sequenced 182 individual melanocytes and found skin cells from tanning bed users carried nearly twice as many mutations as those from controls and were more likely to contain melanoma-linked mutations. In indoor tanners, the mutations also appeared in body areas that typically remain protected from the sun, confirming that tanning beds create a broader field of DNA injury.
“In outdoor sun exposure, maybe 20% of your skin gets the most damage,” Gerami said. “In tanning bed users, we saw those same dangerous mutations across almost the entire skin surface.”
Cancer survivor donates skin biopsy
The study would not have been possible without the generosity of Gerami’s patients who donated their biopsies. One of them, 49-year-old Heidi Tarr from the Chicago area, used tanning beds heavily during high school — two to three sessions a week — because friends and celebrities at the time were also doing it and “it felt like that's what made you beautiful.”
Decades later, as a mother in her thirties, she noticed a mole on her back and immediately feared the worst. Her melanoma diagnosis led to surgery, years of frequent follow-up visits and more than 15 additional biopsies as new moles appeared. “The biopsies can be painful, but the mental anxiety is worse,” she said. “You’re always waiting for the call that it’s melanoma again.”
When Gerami explained the study, she volunteered more biopsies without hesitation. “I value science, and I wanted to help,” she said. “If what happened to my skin can help others understand the real risks of tanning beds, then it matters.”
‘Wronged by the industry’
After seeing the biological and clinical evidence side by side, Gerami said the need for policy change is clear. “At the very least, indoor tanning should be illegal for minors,” he said.
“Most of my patients started tanning when they were young, vulnerable and didn’t have the same level of knowledge and education they have as adults,” he said. “They feel wronged by the industry and regret the mistakes of their youth.”
Gerami also said tanning beds should carry warnings similar to those on cigarettes. “When you buy a pack of cigarettes, it says this may result in lung cancer,” he said. “We should have a similar campaign with tanning bed usage. The World Health Organization has deemed tanning beds to be the same level of carcinogen as smoking and asbestos. It’s a class one carcinogen.”
Gerami suggests that anyone who frequently tanned earlier in life should have a total-body skin exam by a dermatologist and be evaluated for whether they need routine skin checks.
The study, titled “Molecular effects of indoor tanning,” was funded by the National Institutes of Health (grants R01 CA265786 and AR080626), the Department of Defense Melanoma Research Program (grant ME210014), the Melanoma Research Alliance Team Science Award, the Melanoma Research Alliance Dermatology Fellows Award, the LEO Foundation Region Americas Award, Cancer Center Support (grant P30CA082103), the IDP Foundation Award and the Greg and Anna Brown Family Foundation Award.
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