Saturday, August 28, 2021

US Hacker, 21, details how he breached T-Mobile in WSJ interview

‘Their security is awful,’ John Binns said of T-Mobile as he discussed hacking the personal details of 50 million users.

T-Mobile, which last week confirmed that more than 50 million customer records have been stolen, has also said that it had repaired the security hole that enabled the breach [File: Leonhard Foeger/Reuters]

By Al Jazeera Staff
26 Aug 2021

The 21-year-old American hacker who is taking responsibility for infiltrating T-Mobile’s systems said the wireless company’s weak security helped him access a trove of records with personal details on more than 50 million people, The Wall Street Journal (WSJ) reported Thursday.

John Binns, who grew up in Virginia in the United States but now lives in Turkey, told the WSJ that he managed to break through T-Mobile’s defences after discovering an unprotected router exposed. Binns has used several online aliases since 2017, and said he had been scanning T-Mobile’s internet addresses for vulnerabilities using a simple tool available to the general public.

“Their security is awful,” said Binns, who has been communicating with the WSJ via Telegram messages from an account that discussed details of the hack before they were widely known.

“I was panicking because I had access to something big,” he added.

Binns has not said whether he has sold any of the data or whether he was paid for the hack, the WSJ reported.

The August hack is the third major customer data leak that T-Mobile has made public in the past two years. According to the company, the latest attack stole an array of personal details from more than 54 million customers including their names, Social Security numbers and birth dates.

Many of the records reported stolen were from prospective clients or former customers that have switched to other carriers.

T-Mobile, which began informing customers of the breach last week, also reminded its users to update passwords and personal identification number (PIN) codes.

The Washington-based company is the second-largest US mobile carrier, with some 90 million mobile phones connecting to its networks.

The Seattle office of the Federal Bureau of Investigation (FBI) is looking into the T-Mobile hack, a person familiar with the matter told the WSJ.

Binns also told the WSJ that it took him about a week to get into the servers.


T-Mobile, which confirmed that more than 50 million customer records have been stolen, has also said that it had repaired the security hole that enabled the breach. It began informing customers of the breach last week.

It remains unclear whether Binns worked alone. In his communications with the WSJ, he described a collaborative effort to crack T-Mobile’s internal databases.

Binns also told the WSJ that he wanted to draw attention to his perceived persecution by the US government.

“Generating noise was one goal,” said Binns.

In his conversations with the WSJ, Binns described an alleged incident in which he says he was kidnapped in Germany and put into a fake mental hospital.

“I have no reason to make up a fake kidnapping story and I’m hoping that someone within the FBI leaks information about that,” he wrote to the WSJ.

Last year, Binns sued the Central Intelligence Agency, FBI and other federal agencies to push them to fulfil a federal records request he had made for information about FBI investigations of botnet attacks.

The complaint is still active in the US District Court for the District of Columbia.

SOURCE: AL JAZEERA



T-Mobile hack: Everything you need to know

More than 50 million T-Mobile customers were affected by the hack and about 48 million social security number were accessed



By Jonathan Greig | August 28, 2021 | Topic: Security


T-Mobile, one of the biggest telecommunications companies in the US, was hacked nearly two weeks ago, exposing the sensitive information of more than 50 million current, former and prospective customers.

Names, addresses, social security numbers, driver's licenses and ID information for about 48 million people were accessed in the hack, which initially came to light on August 16.

Here's everything we know so far.

What is T-Mobile?

T-Mobile is a subsidiary of German telecommunications company Deutsche Telekom AG providing wireless voice, messaging and data services to customers in dozens of countries.

In the US, the company has more than 104 million customers and became the second largest telecommunications company behind Verizon after its $26 billion merger with Sprint in 2018.
How many people are affected by the hack?

T-Mobile released a statement last week confirming that the names, dates of birth, social security numbers, driver's licenses, phone numbers, as well as IMEI and IMSI information for about 7.8 million customers had been stolen in the breach.

Another 40 million former or prospective customers had their names, dates of birth, social security numbers and driver's licenses leaked.

47% of respondents' organizations currently use the technology.
Research provided by TechRepublic Premium

More than 5 million "current postpaid customer accounts" also had information like names, addresses, date of births, phone numbers, IMEIs and IMSIs illegally accessed.

T-Mobile said another 667,000 accounts of former T- Mobile customers had their information stolen alongside a group of 850,000 active T-Mobile prepaid customers, whose names, phone numbers and account PINs were exposed.

The names of 52,000 people with Metro by T-Mobile accounts may also have been accessed, according to T-Mobile.
Who attacked T-Mobile?

A 21-year-old US citizen by the name of John Binns told The Wall Street Journal and Alon Gal, co-founder of cybercrime intelligence firm Hudson Rock, that he is the main culprit behind the attack.

His father, who died when he was two, was American and his mother is Turkish. He and his mother moved back to Turkey when Binns was 18.
How did the attack happen?

Binns, who was born in the US but now lives in Izmir, Turkey, said he conducted the attack from his home. Through Telegram, Binns provided evidence to the Wall Street Journal proving he was behind the T-Mobile attack and told reporters that he originally gained access to T-Mobile's network through an unprotected router in July.

According to the Wall Street Journal, he had been searching for gaps in T-Mobile's defenses through its internet addresses and gained access to a data center near East Wenatchee, Washington where he could explore more than 100 of the company's servers. From there, it took about one week to gain access to the servers that contained the personal data of millions. By August 4 he had stolen millions of files.

"I was panicking because I had access to something big. Their security is awful," Binns told the Wall Street Journal. "Generating noise was one goal."

Binns also spoke with Motherboard and Bleeping Computer to explain some dynamics of the attack.

He told Bleeping Computer that he gained access to T-Mobile's systems through "production, staging, and development servers two weeks ago." He hacked into an Oracle database server that had customer data inside.

To prove it was real, Binns shared a screenshot of his SSH connection to a production server running Oracle with reporters from Bleeping Computer. They did not try to ransom T-Mobile because they already had buyers online, according to their interview with the news outlet.

In his interview with Motherboard, he said he had stolen the data from T-Mobile servers and that T-Mobile managed to eventually kick him out of the breached servers, but not before copies of the data had already been made.

On an underground forum, Binns and others were found selling a sample of the data with 30 million social security numbers and driver licenses for 6 Bitcoin, according to Motherboard and Bleeping Computer.

T-Mobile CEO Mike Sievert explained that the hacker behind the attack "leveraged their knowledge of technical systems, along with specialized tools and capabilities, to gain access to our testing environments and then used brute force attacks and other methods to make their way into other IT servers that included customer data."

"In short, this individual's intent was to break in and steal data, and they succeeded," Sievert said.

Binns claimed he stole 106GB of data but it is unclear whether that is true.
Why did Binns do it?

The 21-year-old Virginia native told the Wall Street Journal and other outlets that he has been targeted by US law enforcement agencies for his alleged involvement in the Satori botnet conspiracy.

He claims US agencies abducted him in Germany and Turkey and tortured him. Binns filed a lawsuit in a district court against the FBI, CIA and Justice Department in November where he said he was being investigated for various cybercrimes and for allegedly being part of the Islamic State militant group, a charge he denies.

"I have no reason to make up a fake kidnapping story and I'm hoping that someone within the FBI leaks information about that," he explained in his messages to the Wall Street Journal.

The lawsuit includes a variety of claims by Binns that the CIA broke into his homes and wiretapped his computers as part of a larger investigation into his alleged cybercrimes. He filed the suit in a Washington DC District Court.

Before he was officially identified, Binns sent Gal a message that was shared on Twitter.

"The breach was done to retaliate against the US for the kidnapping and torture of John Erin Binns (CIA Raven-1) in Germany by CIA and Turkish intelligence agents in 2019. We did it to harm US infrastructure," the message said, according to Gal.
Was Binns alone in conducting the attack?

He would not confirm if the data he stole has already been sold or if someone else paid him to hack into T-Mobile in his interview with The Wall Street Journal.

While Binns did not explicitly say he worked with others on the attack, he did admit that he needed help in acquiring login credentials for databases inside T-Mobile's systems.

Some news outlets have reported that Binns was not the only person selling the stolen T-Mobile data.
When did T-Mobile discover the attack?

The Wall Street Journal story noted that T-Mobile was initially notified of the breach by a cybersecurity company called Unit221B LLC, which said their customer data was being marketed on the dark web.

T-Mobile told ZDNet on August 16 that it was investigating the initial claims that customer data was being sold on the dark web and eventually released a lengthy statement explaining that while the hack did not involve all 100 million of their customers, at least half had their information involved in the hack.
Is law enforcement involved?

T-Mobile CEO Mike Sievert said on August 27 that he could not share more information about the technical details of the attack because they are "actively coordinating with law enforcement on a criminal investigation."

It is unclear what agencies are working on the case and T-Mobile did not respond to questions about this.
What is T-Mobile doing about the hack?

Sievert explained that the company hired Mandiant to conduct an investigation into the incident.

"As of today, we have notified just about every current T-Mobile customer or primary account holder who had data such as name and current address, social security number, or government ID number compromised," he said in a statement

T-Mobile will also put a banner on the MyT-Mobile.com account login page of others letting them know if they were not affected by the attack.

Sievert admitted that the company is still in the process of notifying former and prospective customers, millions of whom also had their information stolen.

In addition to offering just two years of free identity protection services with McAfee's ID Theft Protection Service, T-Mobile said it was recommending customers sign up for "T-Mobile's free scam-blocking protection through Scam Shield."

The company will also be offering "Account Takeover Protection" to postpaid customers, which they said will make it more difficult for customer accounts to be fraudulently ported out and stolen. They urged customers to reset all passwords and PIN numbers as well.

Sievert also announced that T-Mobile had signed "long-term partnerships" with Mandiant and KPMG LLG to beef up their cybersecurity and give the telecommunications giant the "firepower" needed to improve their ability to protect customers from cybercriminals.

"As I previously mentioned, Mandiant has been part of our forensic investigation since the start of the incident, and we are now expanding our relationship to draw on the expertise they've gained from the front lines of large-scale data breaches and use their scalable security solutions to become more resilient to future cyber threats," Sievert added.

"They will support us as we develop an immediate and longer-term strategic plan to mitigate and stabilize cybersecurity risks across our enterprise. Simultaneously, we are partnering with consulting firm KPMG, a recognized global leader in cybersecurity consulting. KPMG's cybersecurity team will bring its deep expertise and interdisciplinary approach to perform a thorough review of all T-Mobile security policies and performance measurement. They will focus on controls to identify gaps and areas of improvement."

Both Mandiant and KPMG will work together to sketch out a plan for T-Mobile to address its cybersecurity gaps in the future.

Has this happened to T-Mobile before?

No attack of this size has hit T-Mobile before, but the company has been attacked multiple times.

Before the attack two weeks ago, the company had announced four data breaches in the last three years. The company disclosed a breach in January after incidents in August 2018, November 2019, and March 2020.

The investigation into the January incident found that hackers accessed around 200,000 customer details such as phone numbers, the number of lines subscribed to an account, and, in some cases, call-related information, which T-Mobile said it collected as part of the normal operation of its wireless service.

The previous breaches included a March 2020 incident where T-Mobile said hackers gained access to both its employees' and customers' data, including employee email accounts, a November 2019 incident where T-Mobile said it "discovered and shut down" unauthorized access to the personal data of its customers, and an August 2018 incident where T-Mobile said hackers gained access to the personal details of 2 million of its customers.

Before it merged with T-Mobile in 2020, Sprint also disclosed two security breaches in 2019 as well, one in May and a second in July.

What happens now?

Binns has not said if he has sold the data he stole, but he told Bleeping Computer that there were already multiple prospective buyers.

Research finally reveals ancient universal equation for the shape of an egg


Peer-Reviewed Publication

UNIVERSITY OF KENT

Researchers from the University of Kent, the Research Institute for Environment Treatment and Vita-Market Ltd have discovered the universal mathematical formula that can describe any bird’s egg existing in nature, a feat which has been unsuccessful until now.

Egg-shape has long attracted the attention of mathematicians, engineers, and biologists from an analytical point of view. The shape has been highly regarded for its evolution as large enough to incubate an embryo, small enough to exit the body in the most efficient way, not roll away once laid, is structurally sound enough to bear weight and be the beginning of life for 10,500 species that have survived since the dinosaurs. The egg has been called the “perfect shape”.

Analysis of all egg shapes used four geometric figures: sphere, ellipsoid, ovoid, and pyriform (conical), with a mathematical formula for the pyriform yet to be derived.

To rectify this, researchers introduced an additional function into the ovoid formula, developing a mathematical model to fit a completely novel geometric shape characterized as the last stage in the evolution of the sphere-ellipsoid, which it is applicable to any egg geometry.

This new universal mathematical formula for egg shape is based on four parameters: egg length, maximum breadth, shift of the vertical axis, and the diameter at one quarter of the egg length.

This long sought-for universal formula is a significant step in understanding not only the egg shape itself, but also how and why it evolved, thus making widespread biological and technological applications possible.

Mathematical descriptions of all basic egg shapes have already found applications in food research, mechanical engineering, agriculture, biosciences, architecture and aeronautics. As an example, this formula can be applied to engineering construction of thin walled vessels of an egg shape, which should be stronger than typical spherical ones.

This new formula is an important breakthrough with multiple applications including:

  1. Competent scientific description of a biological object.
    Now that an egg can be described via mathematical formula, work in fields of biological systematics, optimization of technological parameters, egg incubation and selection of poultry will be greatly simplified.
  2. Accurate and simple determination of the physical characteristics of a biological object.
    The external properties of an egg are vital for researchers and engineers who develop technologies for incubating, processing, storing and sorting eggs. There is a need for a simple identification process using egg volume, surface area, radius of curvature and other indicators for describing the contours of the egg, which this formula provides.
  3. Future biology-inspired engineering.
    The egg is a natural biological system studied to design engineering systems and state-of-the-art technologies. The egg-shaped geometric figure is adopted in architecture, such as London City Hall’s roof and the Gherkin, and construction as it can withstand maximum loads with a minimum consumption of materials, to which this formula can now be easily applied.

Darren Griffin, Professor of Genetics in the University of Kent and PI on the research, said: ‘Biological evolutionary processes such as egg formation must be investigated for mathematical description as a basis for research in evolutionary biology, as demonstrated with this formula. This universal formula can be applied across fundamental disciplines, especially the food and poultry industry, and will serve as an impetus for further investigations inspired by the egg as a research object.’

Dr Michael Romanov, Visiting Researcher at the University of Kent, said: ‘This mathematical equation underlines our understanding and appreciation of a certain philosophical harmony between mathematics and biology, and from those two a way towards further comprehension of our universe, understood neatly in the shape of an egg.’

Dr Valeriy Narushin, former visiting researcher at the University of Kent, said: ‘We look forward to seeing the application of this formula across industries, from art to technology, architecture to agriculture. This breakthrough reveals why such collaborative research from separate disciplines is essential.’

###

The paper ‘Egg and math: introducing a universal formula for egg shape’ is published in Annals of the New York Academy of Sciences (Valeriy G. Narushin, Research Institute for Environment Treatment and Vita-Market Ltd, Ukraine; Dr Michael N. Romanov, University of Kent; Professor Darren K. Griffin, University of Kent).

URL: https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/nyas.14680

DOI: https://doi.org/10.1111/nyas.14680

 

The physics behind a water bear's lumbering gait


Peer-Reviewed Publication

ROCKEFELLER UNIVERSITY

Walking tardigrades 

IMAGE: TARDIGRADES WALK IN A MANNER CLOSELY RESEMBLING THAT OF INSECTS 500,000 TIMES THEIR SIZE. view more 

CREDIT: JASMINE NIRODY

Plump and ponderous, tardigrades earned the nickname "water bears" when scientists first observed the 0.02-inch-long animals' distinctive lumbering gaits in the 18th century. Their dumpy plod, however, raises the question of why tardigrades evolved to walk at all.

Animals as small and soft as tardigrades seldom have legs and almost never bother walking. For example, round worms of similar size and body type thrash about, slithering their doughy forms over unpredictable substrates. Yet the water bear, a micro-animal so distinct that scientists were forced to assign it to its own phylum, uses eight stubby legs to improbably propel itself through marine and freshwater sediment, across desert dunes, and beneath the soil.

Now, a new study in PNAS analyzes tardigrade gaits and finds that water bears walk in a manner most closely resembling that of insects 500,000 times their size. The discovery implies the existence of either a common ancestor or an evolutionary advantage that explains why one of the smallest and squishiest creatures evolved to walk just like larger, hard-bodied insects.

"Tardigrades have a robust and clear way of moving—they're not these clumsy things stumbling around in the desert or in leaf litter," says Jasmine Nirody, a fellow in Rockefeller's Center for Studies in Physics and Biology. "The similarities between their locomotive strategy and that of much larger insects and arthropods opens up several very interesting evolutionary questions."

Smooth runners

Nirody and colleagues first determined how water bears walk and run. "If you watch tardigrades under a light microscope for long enough, you can capture a wide range of behavior," Nirody says. "We didn't force them to do anything. Sometimes they would be really chill and just want to stroll around the substrate. Other times, they'd see something they like and run towards it."

Nirody found that, at their most leisurely, water bears lumber about half a body length per second. At full throttle, their loping strides carried them two body lengths in the same amount of time. But the surprise came when she observed how a water bear’s feet contact the ground as it gains momentum. Unlike vertebrates, which have distinct gaits for each speed—picture a horse's hooves as it transitions from a walk to a gallop—tardigrades run more like insects, scurrying at increasing speeds without ever changing their basic stepping patterns.

"When vertebrates switch from walking to running, there is a discontinuity," Nirody says. "With arthropods, all stepping patterns exist along the same continuum."

Ancient coordination

Why do tardigrades share a locomotive strategy with much larger, hard-bodied insects?

One possible explanation is that tardigrades, long assumed to fit neatly into no existing taxonomy, may share common ancestors—and even a common neural circuit— with insects such as fruit flies, ants, and other segmented scurrying creatures. In fact, some scientists advocate classifying tardigrades within the proposed panarthropod clade, a catchall group that would assign common shelf space to insects, crustaceans, velvet worms, and water bears.

Another possibility is that there is no ancestral connection between tardigrades and arthropods, but that the unrelated groups of organisms independently arrived at the same walking and running strategies because they were evolutionarily advantageous. Perhaps the best way to navigate unpredictable terrain with a microscopic body is to plod like a water bear.

Nirody is equally fascinated by both possibilities. "If there is some ancestral neural system that controls all of panarthropod walking, we have a lot to learn," she says. "On the other hand, if arthropods and tardigrades converged upon this strategy independently, then there's much to be said about what makes this strategy so palatable for species in different environments."

Beyond the implications for evolutionary biology and the study of animal locomotion, the findings may have ramifications for the burgeoning fields of soft and microscale robotics.

By studying how small animals evolved to move across challenging environments, scientists may be able to design robots that can more efficiently squeeze into small spaces or operate at the microscale. "We don't know much about what happens at the extremes of locomotion—how to make an efficient small walker, or how soft-bodied things should move," Nirody says.

"Tardigrades are an important porthole into soft-bodied, microscale locomotion."

DEWORMER 
Doctor who promoted ivermectin as a COVID-19 treatment has advised Florida’s governor

Steve Contorno, Kirby Wilson
Sat., August 28, 2021




A California psychiatrist who has advised Gov. Ron DeSantis on the coronavirus pandemic recently promoted a drug for COVID-19 patients that federal disease experts have strongly warned against after a spike in calls to poison control centers.

The surge of interest in the parasite drug, ivermectin, prompted the Centers for Disease Control and Prevention on Thursday to issue a national alert advising against its use to treat coronavirus. The maker of the drug, Merck, has also said there is “no scientific basis” to claim that ivermectin is effective against COVID-19.

Dr. Mark McDonald of Los Angeles is among a fringe group of outspoken medical professionals who have pushed ivermectin as an alternative to widespread vaccination against coronavirus. McDonald called ivermectin an “effective, safe, inexpensive treatment” in a Aug. 5 Twitter post, and he shared an article by the Jerusalem Post citing a recent study of the drug in Israel.

A wave of online misinformation about ivermectin has led to increased demand, and some people have turned to a version of the drug meant for farm animals. That sparked the U.S. Food and Drug Administration to tweet: “You are not a horse. You are not a cow. Seriously, y’all. Stop it.”

Florida’s Poison Control Center, a state-funded non-profit, has treated 27 ivermectin-related cases in August, with most involving drugs made for livestock. That’s more cases tied to the drug than the center saw in all of last year.

McDonald called people who think ivermectin is a drug for horses “ignoramuses” in a tweet posted Monday. (The drug can treat parasites in both humans and animals like horses.)

In a phone interview, McDonald made clear Friday that people “should not get (ivermectin) from a feed lot.” But he said people are ingesting livestock medicine out of desperation because the federal government was preventing doctors from making the drug available.

McDonald accused the Food and Drug Administration of sidelining ivermectin because it already has spent billions of dollars to “mass vaccinate the population.”

“If the goal of these people is to advance public health and make the public well, why have none of them spoke a single word about prevention and making one healthy to prevent an infection or hospitalization or death?” McDonald said. “I think there is a lot of dishonesty here and cancellation of people who support truth.”

Dr. John Sinnott, the chairman of internal medicine at University of South Florida’s Morsani College of Medicine and an epidemiologist at Tampa General Hospital, said it was “evil” for people to promote ivermectin as a COVID-19 treatment “because it detracts from appropriate care.”

”Any physician who espouses this should be reported to their state medical association,” Sinnott added.

McDonald was one of several doctors summoned by DeSantis for a July closed-door discussion on mask policies in schools. In his comments, he argued that “masking children is child abuse,” according to video of the meeting later released by the governor’s office. He also likened mask mandates to apartheid, South Africa’s racist system of segregation during the 20th century.

At this week’s trial in Tallahassee over the governor’s ban on school mask mandates, attorneys for the state included McDonald’s comments as evidence. But in his ruling against DeSantis on Friday, Leon County Circuit Judge John Cooper was dismissive of McDonald’s opinion.

McDonald is one of several medical professionals from outside the state’s network of public health experts who DeSantis has leaned on for guidance throughout the pandemic. DeSantis has also regularly turned to Dr. Scott Atlas, a Stanford neuroradiologist favored by former President Donald Trump. Atlas reportedly clashed with other White House coronavirus task force members last year for urging Trump to let the virus run its course without government interventions.

And at the mask trial, Florida attorneys called on Stanford University professor Dr. Jay Bhattacharya to defend DeSantis’ order — not state Surgeon General Scott Rivkees. Bhattacharya, an early opponent of business restrictions aimed at curbing the virus’ spread, testified he has been an “informal advisor” to the governor since last September.

In a Friday statement to the Times/Herald, DeSantis spokeswoman Christina Pushaw said McDonald’s inclusion on the school mask panel “does not imply that Governor DeSantis endorses (or opposes) any of Dr. McDonald’s opinions on other subjects.”

“The panel was not about ivermectin,” she said. “It was about forced masking of schoolchildren.”

McDonald has a history of comments that defy the consensus of the greater medical and public healthy community. He shared on social media a graphic that called people who wear masks “retarded,” and he has posted comments skeptical of vaccines.

McDonald has ties to America’s Frontline Doctors, a political organization that medical experts have accused of spreading misinformation about coronavirus and treatments. McDonald spoke at a summit organized by America’s Frontline Doctors, and a picture of him with the group is featured at the top of his Twitter feed.

On Friday, NBC News reported that America’s Frontline Doctors is one of the leading purveyors of ivermectin as a false cure. The organization has built a business around prescribing the drug, the network reported.

Prescriptions for ivermectin jumped to 88,000 in the week ending August 13, up from just a few thousand a week prior to the pandemic and a four-fold increase since July, the CDC said. Meanwhile, ivermectin-related calls to poison control centers are up 400 percent, the agency said.

Dr. Asim Tarabar, an assistant professor of emergency medicine at the Yale School of Medicine and a medical toxicologist, said the poison control figures likely underestimate the problem because many who are taking ivermectin may be experiencing no side effects. Or, they are getting sick from the medicine, but they’re reluctant to pick up the phone, he said.

Ivermectin has been successfully used in developing countries to treat parasites for decades. In the United States, it is approved by the U.S. Food and Drug Association as an oral drug against roundworm and a topical treatment for lice, among other uses. It’s side effects are minor when used correctly, but overdoses can lead to vomiting, confusion, seizures and death, the Centers for Disease Control and Prevention said.

Studies have not demonstrated that ivermectin is effective in treating coronavirus patients and the Centers for Disease Control and Prevention has advised against off-label use. The National Institutes of Health said in February that clinical studies on ivermectin have varied, with some suggesting some benefits while others showed little or worsening change in patients.

Tarabar said some people’s trust in ivermectin could be explained by a misunderstanding of the scientific process. The drug has been shown in some studies to limit the virus’ ability to reproduce in a laboratory setting, the physician said. But there’s no proof the medicine works that way in the human body.

“Regardless what we believe — left, right, center — scientific rigor has to be followed,” Tarabar said.

 

Study finds mobile telemedicine unit as effective as traditional clinics to treat opioid addiction during COVID-19 pandemic


Research could pave the way for broader use of innovative RV clinic

Peer-Reviewed Publication

UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE

Rural regions in the U.S. have been disproportionately affected by the opioid epidemic, while also having the fewest number of programs to treat opioid use disorder. In an effort to remedy this dire health issue, University of Maryland School of Medicine (UMSOM) researchers reconfigured a recreational vehicle (RV) as a telemedicine mobile treatment unit to determine whether it could provide effective screening and treatment to individuals with opioid use disorder in rural areas. Their research, published today in the Journal of the American Medical Association (JAMA) Network Open, found that the innovative approach to be as successful as traditional brick-and-mortar treatment clinics. The study also found a significant reduction in illicit opioid use among the majority of patients treated on the mobile unit, as well as sustained success in these patients continuing therapy to avoid relapse. 

[Check out this video showing RV unit in action.]

“We are very encouraged by our findings and hope that our model can be replicated throughout the country in places where patients have limited access to health care providers who can treat opioid use disorder,” said study lead author Eric Weintraub, MD, Professor of Psychiatry and Division Head of Addiction Research and Treatment at UMSOM. 

Last year, more than 92,000 Americans died from drug overdoses, a nearly 30 percent increase from 2019, according to a recent report from the Centers for Disease Control and Prevention. Most of these deaths were caused by illicit opioid drugs like fentanyl and heroin. While effective medication-based treatments are available, only 1 in 4 people with opioid use disorder receive such treatments. FDA-approved medications including buprenorphine and methadone are able to prevent withdrawal symptoms and reduce cravings in those who stop using illicit drugs and are reported to significantly decrease overdose deaths. Treatment also can include counseling techniques to encourage motivation to change and prevent relapse.

In the new study, the UMSOM researchers used the mobile health unit to evaluate and treat 94 patients with opioid use disorder, all of whom lived in rural areas along the Eastern Shore region of Maryland. These patients accessed the unit for treatment within 10 miles of their respective homes from June to October 2020 – during the height of the COVID-19 pandemic. The mobile unit was staffed with a nurse, a substance use counselor, and a peer recovery specialist. Patients were provided with in-person screening and counseling as well as access to a physician via a secure videoconferencing link. Buprenorphine or naloxone were electronically prescribed and sent to a patient’s local pharmacy.

The researchers wanted to measure how effective the mobile unit was at maintaining patients in buprenorphine therapy and decreasing their use of illicit opioids. They found nearly 64 percent of patients remained in treatment after two months and 58 percent after three months, rates that are similar to those seen in traditional in-person substance use treatment programs. Opioid use was reduced, on average, by about one-third, which was also similar to what researchers have seen in traditional clinical settings.

“To our knowledge, this is the first of its kind mobile telemedicine unit to treat opioid use disorders in rural communities,” said Annabelle (Mimi) Belcher, PhD, Assistant Professor of Psychiatry at UMSOM. “We have demonstrated that the model works as well as traditional clinics situated in more populated areas, which is an exciting finding.”

Sarah Kattakuzhy, MD; Aaron Greenblatt, MD; Christopher Welsh, MD; and Alexander Pappas, MD were co-authors on this study. The research was funded by a federal grant from the Health Resources and Services Administration. The telemedicine mobile treatment unit was funded by the Maryland Department of Health’s Behavioral Health Administration.

“Providing patients with access to healthcare via telemedicine and mobile health units has become increasingly important during the COVID-19 pandemic, and our UMSOM faculty continue to innovate in this area,” said E. Albert Reece, MD, PhD, MBA, Executive Vice President for Medical Affairs, UM Baltimore, the John Z. and Akiko K. Bowers Distinguished Professor, and Dean, University of Maryland School of Medicine. "This new study provides evidence that telemedicine and mobile health units really work to provide patients with access to the lifesaving services they need. We will continue to explore other ways to provide mobile healthcare to patients in underserved communities.”

About the University of Maryland School of Medicine

 

Now in its third century, the University of Maryland School of Medicine was chartered in 1807 as the first public medical school in the United States. It continues today as one of the fastest growing, top-tier biomedical research enterprises in the world -- with 46 academic departments, centers, institutes, and programs, and a faculty of more than 3,000 physicians, scientists, and allied health professionals, including members of the National Academy of Medicine and the National Academy of Sciences, and a distinguished two-time winner of the Albert E. Lasker Award in Medical Research.  With an operating budget of more than $1.2 billion, the School of Medicine works closely in partnership with the University of Maryland Medical Center and Medical System to provide research-intensive, academic and clinically based care for nearly 2 million patients each year. The School of Medicine has nearly $600 million in extramural funding, with most of its academic departments highly ranked among all medical schools in the nation in research funding.  As one of the seven professional schools that make up the University of Maryland, Baltimore campus, the School of Medicine has a total population of nearly 9,000 faculty and staff, including 2,500 student trainees, residents, and fellows. The combined School of Medicine and Medical System (“University of Maryland Medicine”) has an annual budget of over $6 billion and an economic impact of nearly $20 billion on the state and local community. The School of Medicine, which ranks as the 8th highest among public medical schools in research productivity (according to the Association of American Medical Colleges profile) is an innovator in translational medicine, with 606 active patents and 52 start-up companies.  In the latest U.S. News & World Report ranking of the Best Medical Schools, published in 2021, the UM School of Medicine is ranked #9 among the 92 public medical schools in the U.S., and in the top 15 percent (#27) of all 192 public and private U.S. medical schools.  The School of Medicine works locally, nationally, and globally, with research and treatment facilities in 36 countries around the world. Visit medschool.umaryland.edu

 

 

 

 

 

Common pesticide may contribute to global obesity crisis


Chlorpyrifos slows down the burning of calories in the brown adipose tissue of mice 

Peer-Reviewed Publication

MCMASTER UNIVERSITY

Hamilton, ON (Aug. 27, 2021) – A commonly-used pesticide could be partially responsible for the global obesity epidemic, says a study led by McMaster University scientists.

Researchers discovered that chlorpyrifos, which is banned for use on foods in Canada but widely sprayed on fruits and vegetables in many other parts of the world, slows down the burning of calories in the brown adipose tissue of mice. Reducing this burning of calories, a process known as diet-induced thermogenesis, causes the body to store these extra calories, promoting obesity.

Scientists made the discovery after studying 34 commonly used pesticides and herbicides in brown fat cells and testing the effects of chlorpyrifos in mice fed high calorie diets. Their findings were published in Nature Communications and could have important implications for public health.

“Brown fat is the metabolic furnace in our body, burning calories, unlike normal fat that is used to store them. This generates heat and prevents calories from being deposited on our bodies as normal white fat. We know brown fat is activated during cold and when we eat,” said senior author Gregory Steinberg, professor of medicine and co-director of the Centre for Metabolism, Obesity, and Diabetes Research at McMaster.

“Lifestyle changes around diet and exercise rarely lead to sustained weight loss. We think part of the problem may be this intrinsic dialling back of the metabolic furnace by chlorpyrifos.”

Steinberg said chlorpyrifos would only need to inhibit energy use in brown fat by 40 calories every day to trigger obesity in adults, which would translate to an extra five lbs of weight gain per year.

He said that while several environmental toxins including chlorpyrifos have been linked to rising obesity rates in both humans and animals, most of these studies have attributed weight gain to increases in food intake and not the burning of calories.

While the use of chlorpyrifos on foods is banned in Canada, imported produce may still be treated with it.

“Although the findings have yet to be confirmed in humans, an important consideration, is that whenever possible consume fruits and vegetables from local Canadian sources and if consuming imported produce, make sure it is thoroughly washed,” said Steinberg.

External funding for the study was provided by the Canadian Institutes of Health Research. 

 

-30-

Editors:

The article can be found here: https://www.nature.com/articles/s41467-021-25384-y

 

For information, please contact:

Veronica McGuire

Media Relations

Faculty of Health Sciences

McMaster University

289-776-6952

vmcguir@mcmaster.ca

 


Light-to-moderate coffee drinking associated with health benefits


Reports and Proceedings

EUROPEAN SOCIETY OF CARDIOLOGY

Sophia Antipolis, France – 28 Aug 2021:  Up to three cups of coffee per day is associated with a lower risk of stroke and fatal heart disease, according to research presented at ESC Congress 2021.1,2

“To our knowledge, this is the largest study to systematically assess the cardiovascular effects of regular coffee consumption in a population without diagnosed heart disease,” said study author Dr. Judit Simon, of the Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.

“Our results suggest that regular coffee consumption is safe, as even high daily intake was not associated with adverse cardiovascular outcomes and all-cause mortality after a follow-up of 10 to 15 years,” she continued. “Moreover, 0.5 to 3 cups of coffee per day was independently associated with lower risks of stroke, death from cardiovascular disease, and death from any cause.”

Even though coffee is among the most consumed beverages in the world, little is known about the long-term impact of regular consumption on cardiovascular health.

This study investigated the association between usual coffee intake and incident heart attack, stroke and death. The study included 468,629 participants of the UK Biobank with no signs of heart disease at the time of recruitment. The average age was 56.2 years and 55.8% were women.

Participants were divided into three groups according to their usual coffee intake: none (did not consume coffee on a regular basis, 22.1%), light-to-moderate (0.5 to 3 cups/day, 58.4%) and high (more than 3 cups/day, 19.5%).

The researchers estimated the association of daily coffee consumption with incident outcomes over a median follow-up of 11 years using multivariable models. The analyses were adjusted for factors that could influence the relationship including age, sex, weight, height, smoking status, physical activity, high blood pressure, diabetes, cholesterol level, socioeconomic status, and usual intake of alcohol, meat, tea, fruit and vegetables.

Compared to non-coffee drinkers, light-to-moderate consumption was associated with a 12% lower risk of all-cause death (hazard ratio [HR]=0.88, p<0.001), 17% lower risk of death from cardiovascular disease (HR=0.83, p=0.006), and 21% lower risk of incident stroke (HR=0.79; p=0.037).

To examine the potential underlying mechanisms, the researchers analysed the association between daily coffee intake and heart structure and function over a median follow-up of 11 years. For this, they used data from 30,650 participants who underwent cardiac magnetic resonance imaging (MRI), which is considered the gold standard for the assessment of cardiac structure and function.

Dr. Simon said: “The imaging analysis indicated that compared with participants who did not drink coffee regularly, daily consumers had healthier sized and better functioning hearts. This was consistent with reversing the detrimental effects of ageing on the heart.”

She concluded: “Our findings suggest that coffee consumption of up to 3 cups per day is associated with favourable cardiovascular outcomes. While further studies are needed to explain the underlying mechanisms, the observed benefits might be partly explained by positive alterations in cardiac structure and function.”

 

ENDS

 

Notes to editors

Authors: ESC Press Office

Mobile: +33 (0)7 85 31 20 36
Email: press@escardio.org

The hashtag for ESC Congress 2021 is #ESCCongress.

Follow us on Twitter @ESCardioNews 

 

Funding: P.B.M and S.E.P acknowledge support from the National Institute for Health Research (NIHR) Barts Biomedical Research Centre. S.E.P. acknowledges support from the ‘SmartHeart’ EPSRC programme grant (www.nihr.ac.uk; EP/P001009/1) and also from the CAP-AI programme, London’s first AI enabling programme focused on stimulating growth in the capital’s AI Sector. CAP-AI is led by Capital Enterprise in partnership with Barts Health NHS Trust and Digital Catapult and is funded by the European Regional Development Fund and Barts Charity. S.E.P. and S.N. acknowledge the British Heart Foundation for funding the manual analysis to create a cardiovascular magnetic resonance imaging reference standard for the UK Biobank imaging resource in 5000 CMR scans (www.bhf.org.uk; PG/14/89/31194). S.N and SKP supported by the Oxford NIHR Biomedical Research Centre and S.N. by the Oxford British Heart Foundation Centre of Research Excellence. N.A. recognize the National Institute for Health Research (NIHR) Integrated Academic Training programme which supports their Academic Clinical Lectureship posts. N.C.H acknowledges support from the UK Medical Research Council (MRC #405050259 and #U105960371), NIHR Southampton Biomedical Research Centre, University of Southampton, and University Hospital Southampton. Z.R.E was supported by a British Heart Foundation Clinical Research Training Fellowship (FS/17/81/33318). Project no. NVKP_16-1–2016-0017 (’National Heart Program’) has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the NVKP_16 funding scheme. The research was financed by the Thematic Excellence Programme (2020-4.1.1.-TKP2020) of the Ministry for Innovation and Technology in Hungary, within the framework of the Therapeutic Development and Bioimaging thematic programmes of the Semmelweis University.

 

Disclosures: No conflict of interest.

 

References and notes

1Abstract title: Association of daily coffee consumption with cardiovascular health - Results from the UK Biobank.

2Press conference: “Heart health made easy” on Thursday 26 August from 17:00 to 18:00 CEST.

 

About the European Society of Cardiology

The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.

About ESC Congress 2021 - The Digital Experience

It is the world’s largest gathering of cardiovascular professionals, disseminating ground-breaking science in a new digital format. Online each day – from 27 to 30 August. Explore the scientific programme. More information is available from the ESC Press Office at press@escardio.org.

 

Ultra-processed food is associated with cardiovascular disease

Reports and Proceedings

EUROPEAN SOCIETY OF CARDIOLOGY

Sophia Antipolis, France – 28 Aug 2021:  Weekly consumption of ultra-processed food is linked with an increased risk of heart disease, according to research presented at ESC Congress 2021.1,2

Ultra-processed food refers to a wide range of products such as mass produced bread, ready meals, fast foods, sweets and desserts, salty snacks, breakfast cereals, reconstituted meat including chicken and fish nuggets, instant noodles and soups, tinned vegetables with added salt, sugar-coated dried fruit, sodas and sweetened beverages.

Limited information exists on the relationship of these products with heart attacks and strokes. This study examined the association between consumption of ultra-processed foods and developing, or dying from, cardiovascular disease over a 10-year period.

The analysis used data from the ATTICA prospective study, which was conducted during 2001-2012 in Greece. The study enrolled adults free of cardiovascular disease at baseline who were asked about the frequency and portion sizes of a range of foods and beverages consumed during the previous seven days. The researchers also used a questionnaire to assess level of adherence to a heart healthy dietary pattern, i.e. the Mediterranean diet, which emphasises fruit, vegetables, and whole grains. Participants were assigned a score of 0 to 55 (higher values mean better adherence).

Participants were followed up for 10 years for the occurrence of fatal and non-fatal cardiovascular events including heart attack, unstable angina, stroke, heart failure and heart rhythm disorders (arrhythmias).

The study included 2,020 participants, of whom 1,014 were women and 1,006 were men. The average age was 45 years. On average, participants consumed approximately 15 servings of ultra-processed foods per week. During the 10-year follow up there were 317 cardiovascular events. The incidence of cardiovascular events was progressively higher as ultra-processed food consumption rose. With an average weekly consumption of 7.5, 13, and 18 servings, the incidence of cardiovascular disease was 8.1%, 12.2%, and 16.6%, respectively.

Each additional weekly serving of ultra-processed food was associated with a 10% higher likelihood of cardiovascular disease within the decade (hazard ratio [HR] per additional weekly serving=1.10; 95% confidence interval [CI] 1.02–1.21; p=0.04).

The association was reassessed according to adherence to a Mediterranean diet. The aggravating role of ultra-processed foods became even stronger in participants with a low level of adherence to this dietary pattern. In those with a Mediterranean diet score less than 27, each additional weekly serving of ultra-processed food was associated with a 19% higher likelihood of cardiovascular disease within the decade (HR per additional weekly serving=1.19; 95% CI 1.12–1.25; p=0.02).

In those with a moderate to high level of adherence to the Mediterranean diet (score above 27), each additional weekly serving of ultra-processed food was associated with an 8% higher likelihood of cardiovascular disease within 10 years – but the association was no longer significant (HR per additional weekly serving=1.08; 95% CI 0.98–1.19; p=0.09).

Study author Dr. Matina Kouvari of Harokopio University of Athens, Greece said: “Evidence is accumulating for an association between ultra-processed foods and increased risks of several chronic diseases. Our study suggests that the detrimental relationship with cardiovascular disease is even stronger in those with a generally unhealthy diet. Public health initiatives and nutrition policies are needed to promote nutritious food choices while for individuals, limiting ultra-processed food intake seems sensible.”

 

ENDS

 

Notes to editors

Authors: ESC Press Office
Mobile: +33 (0)7 85 31 20 36
Email: press@escardio.org

The hashtag for ESC Congress 2021 is #ESCCongress.

Follow us on Twitter @ESCardioNews 

 

Funding: The ATTICA study is supported by research grants from the Hellenic Cardiology Society [HCS2002] and the Hellenic Atherosclerosis Society [HAS2003].

Disclosures: None to declare.

 

References and notes

1Abstract title: Ultra-processed foods and ten-year cardiovascular disease incidence in a Mediterranean population: results from a population-based cohort study.

2Press conference: “Heart health made easy” on Thursday 26 August from 17:00 to 18:00 CEST.

 

About the European Society of Cardiology

The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.

About ESC Congress 2021 - The Digital Experience

It is the world’s largest gathering of cardiovascular professionals, disseminating ground-breaking science in a new digital format. Online each day – from 27 to 30 August. Explore the scientific programme. More information is available from the ESC Press Office at press@escardio.org.