Thursday, December 12, 2024

 

Unlocking the ‘black box’: scientists reveal AI’s hidden thoughts



Researchers introduce a new method to assess how deep neural networks interpret information, ensuring its reliability and robustness for real-world applications



Kyushu University

Comparison of k* distribution method to previous methods 

image: 

The k* distribution method, developed by researchers from Kyushu University, allows clear visualization and evaluation of how a neural network interprets data.

view more 

Credit: Danilo Vargas, Kyushu University





Fukuoka, Japan— Deep neural networks are a type of artificial intelligence (AI) that imitate how human brains process information, but understanding how these networks “think” has long been a challenge. Now, researchers at Kyushu University have developed a new method to understand how deep neural networks interpret information and sort it into groups. Published in IEEE Transactions on Neural Networks and Learning Systems, the study addresses the important need to ensure AI systems are accurate and robust and can meet the standards required for safe use.

Deep neural networks process information in many layers, similarly to humans solving a puzzle step by step. The first layer, known as the input layer, brings in the raw data. The subsequent layers, called hidden layers, analyze the information. Early hidden layers focus on basic features, such as detecting edges or textures—like examining individual puzzle pieces. Deeper hidden layers combine these features to recognize more complex patterns, such as identifying a cat or a dog—similar to connecting puzzle pieces to reveal the bigger picture.

“However, these hidden layers are like a locked black box: we see the input and output, but what is happening inside is not clear,” says Danilo Vasconcellos Vargas, Associate Professor from the Faculty of Information Science and Electrical Engineering at Kyushu University. "This lack of transparency becomes a serious problem when AI makes mistakes, sometimes triggered by something as small as changing a single pixel. AI might seem smart, but understanding how it comes to its decision is key to ensuring it’s trustworthy.”

Currently, methods for visualizing how AI organizes information rely on simplifying high-dimensional data into 2D or 3D representations. These methods let researchers observe how AI categorizes data points—for example, grouping images of cats close to other cats while separating them from dogs. However, this simplification comes with critical limitations.

“When we simplify high-dimensional information into fewer dimensions, it’s like flattening a 3D object into 2D—we lose important details and fail to see the whole picture. Additionally, this method of visualizing how the data is grouped makes it difficult to compare between different neural networks or data classes,” explains Vargas.

In this study, the researchers developed a new method, called the k* distribution method, that more clearly visualizes and assesses how well deep neural networks categorize related items together.

The model works by assigning each inputted data point a “k* value” which indicates the distance to the nearest unrelated data point. A high k* value means the data point is well-separated (e.g., a cat far from any dogs), while a low k* value suggests potential overlap (e.g., a dog closer to a cat than other cats). When looking at all the data points within a class, such as cats, this approach produces a distribution of k* values that provides a detailed picture of how the data is organized.

“Our method retains the higher dimensional space, so no information is lost. It’s the first and only model that can give an accurate view of the ‘local neighborhood’ around each data point,” emphasizes Vargas.

Using their method, the researchers revealed that deep neural networks sort data into clustered, fractured, or overlapping arrangements.  In a clustered arrangement, similar items (e.g., cats) are grouped closely together, while unrelated items (e.g., dogs) are clearly separated, meaning the AI is able to sort the data well. Fractured arrangements, however, indicate that similar items are scattered across a wide space, while overlapping distributions occur when unrelated items are in the same space, with both arrangements making classification errors more likely.

Vargas compares this to a warehouse system: “In a well-organized warehouse, similar items are stored together, making retrieval easy and efficient. If items are intermixed, they become harder to find, increasing the risk of selecting the wrong item.”

AI is increasingly used in critical systems like autonomous vehicles and medical diagnostics, were accuracy and reliability is essential. The k* distribution method helps researchers, and even lawmakers, evaluate how AI organizes and classifies information, pinpointing potential weaknesses or errors. This not only supports the legalization processes needed to safely integrate AI into daily life but also offers valuable insights into how AI “thinks”. By identifying the root causes of errors, researchers can refine AI systems to make them not only accurate but also robust—capable of handling blurry or incomplete data and adapting to unexpected conditions.

“Our ultimate goal is to create AI systems that maintain precision and reliability, even when faced with the challenges of real-world scenarios,” concludes Vargas.

Written by Science Communicator Intern, Negar Khalili

###

For more information about this research, see “k* Distribution: Evaluating the Latent Space of Deep Neural Networks Using Local Neighborhood Analysis,” Shashank Kotyan; Tatsuya Ueda; Danilo Vasconcellos Vargas, IEEE Transactions on Neural Networks and Learning Systemshttps://doi.org/10.1109/TNNLS.2024.3446509

About Kyushu University 
Founded in 1911, Kyushu University is one of Japan's leading research-oriented institutes of higher education, consistently ranking as one of the top ten Japanese universities in the Times Higher Education World University Rankings and the QS World Rankings. The university is one of the seven national universities in Japan, located in Fukuoka, on the island of Kyushu—the most southwestern of Japan’s four main islands with a population and land size slightly larger than Belgium. Kyushu U’s multiple campuses—home to around 19,000 students and 8000 faculty and staff—are located around Fukuoka City, a coastal metropolis that is frequently ranked among the world's most livable cities and historically known as Japan's gateway to Asia. Through its VISION 2030, Kyushu U will “drive social change with integrative knowledge.” By fusing the spectrum of knowledge, from the humanities and arts to engineering and medical sciences, Kyushu U will strengthen its research in the key areas of decarbonization, medicine and health, and environment and food, to tackle society’s most pressing issues.

 

Diagnosing and managing blast injuries



Boston University School of Medicine




(Boston)—The prevalence of armed conflicts, terrorist attacks and industrial accidents necessitates clinician understanding of blast injuries in both civilian and military settings. Blast injuries are a complex form of trauma, resulting from the explosive release of energy. The severity and types of injury depend on the proximity to the blast, blast pressure and the presence of other elements like fragments and heat.

 

In a new video published in the New England Journal of Medicine’s “Video in Clinical Medicine” section, authors from Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center (BMC), in collaboration with the department of anesthesiology at Walter Reed National Military Medical Center, focus on the mechanisms and classifications of blast injuries and present essential knowledge for initial diagnosis and management.

 

“Blast injuries present a unique challenge in trauma medicine due to their complex mechanisms and varied presentations. A comprehensive understanding and approach to managing these injuries is essential to improve patient outcomes,” explains corresponding author Rafael Ortega, MD, FASA, chair & professor of anesthesiology at the school.

 

The video provides a review on blast injury types including: primary injuries to the lungs, ears and bowels due to the blast wave; secondary injuries caused by trauma from propelled debris; tertiary injuries due to blast wind impacts on the body; quaternary injuries like burns, asphyxiation and exposure to toxic substances; and quinary injuries, clinical repercussions of chemical, radiologic or biologic contaminants occurring post-detonation. Also considered are  the types of explosives, such as dynamite and Molotov cocktails.  

 

The authors point out that explosions can inflict injuries on many organ systems and that the diagnosis of blast injuries requires a high index of suspicion to identify silent blunt injuries. They suggest initial assessment should follow advanced trauma life support (ATLS) protocols including imaging methods, such as radiographs, CT scans, and ultrasonography, which are critical for detecting internal injuries. Injuries to the pulmonary, gastrointestinal system, along with neurological, cardiovascular, facial and auditory, musculoskeletal systems are also reviewed. 

 

In terms of diagnosis, the authors˙ indicate that ATLS guidelines offer a structured approach to trauma care after explosions. “However, their application should be tailored to the specific situation and patient needs, with the order of interventions potentially varying based on clinical judgment and immediate life threats,” says Ortega who also is chief of anesthesiology at BMC.

 

According to the authors, blast injuries should be managed using a multidisciplinary approach tailored to the individual patient’s injuries. “When possible, involve different specialties such as emergency medicine, trauma surgery, neurosurgery, orthopedic surgery, maxillofacial surgery, otolaryngology and anesthesiology to ensure the best possible patient outcomes,” he adds.

In terms of preventive strategies, the authors recommend public education, improved safety regulations for handling explosives, and the use of personal protective equipment which can help reduce the impact of blast injuries and designing public spaces to minimize the impact of blasts.

 

As wildfires intensify, prolonged exposure to pollution linked to premature death


New study assesses how natural events are shaping human lifespans


Ohio State University




WASHINGTON – Researchers have found evidence that living in areas prone to wildfire smoke may negatively impact an individual’s life expectancy. 

In many parts of the contiguous United States, wildfires are rapidly growing more intense, endangering the humans and wildlife that live in the region. Even once fires are doused, serious health risks remain because of the many adverse effects caused by wildfire smoke and the airborne pollution that the blaze releases into the atmosphere. 

Now, scientists at The Ohio State University have found that not only is wildfire smoke linked to a shortened lifespan, it also greatly diminishes the positive health impacts of local greenspaces, like forests or parks. 

“When considering the environment’s effect on human life expectancy, we have to account for all kinds of factors,” said Yanni Cao, lead author of the study and a postdoctoral researcher in environmental health services at Ohio State. “Forests, for example, provide essential ecosystem services to mitigate the impact of wildfire smoke because they can purify the air.” 

Generally, greenspaces benefit human health by helping to regulate the local ecosystem and climate through capturing carbon dioxide, oxygen production and air filtration as well as by providing open spaces to foster social and community connection. It’s why higher levels of greenspaces are usually correlated with higher life expectancies. 

But because these lush areas can essentially act as fuel for wildfires, their presence is also tightly correlated with higher wildfire smoke emissions, said Cao. Due to its high toxicity, human exposure to this smoke has been known to cause respiratory issues, cardiovascular disease, and an increase in the risk of dementia and hospitalization. 

The research was presented this week at the annual meeting of the American Geophysical Union.

To better understand the complex role these factors play in determining the average number of years an individual might live, researchers analyzed more than 66,000 pieces of U.S. census data collected between 2010 and 2015. 

Their findings concluded that for every additional day of smoke exposure, a person’s life expectancy could be expected to decrease by about 0.02 years – or about one week. 

Conversely, living in a green neighborhood can be beneficial, as even a 1% increase in these spaces can lead to a slight life expectancy increase. While wildfire smoke can negate the benefits of greenspace, the team’s results suggest that sociodemographic factors such as income, population density, age and race also significantly impact future life expectancies. 

“Families with higher average household income have better living conditions, more comprehensive nutritional intake, and tend to have better sanitary conditions and living habits,” said Cao. Widespread inequality for minorities means they are less likely to have those protective factors. 

People living in areas with extensive greenspaces should carefully consider appropriate health protection measures if they are exposed to wildfire smoke, said Jianyong Wu, co-author of the study and an assistant professor in environmental health sciences at Ohio State. 

“Our findings contribute to a deeper understanding of how environmental factors influence public health,” he said. “We want our research to offer valuable guidance for future urban planning and public health policies that are aimed at improving life expectancy across the country.”

Although this study focuses on the U.S. as a whole, researchers note that future work will aim to discover if wildfires have a similar effect on adult and child mortality in regions like Ohio, where the populace often deals with other kinds of environmental extremes, like drought. 

“The goal of this work is to raise awareness about the health impacts of wildfire,” said Cao. “To do that, we need to enhance risk communication with the public and further strengthen research on the effects of these disasters.” 

#

Contact: Yanni Cao, Cao.1637@osu.edu

Written by: Tatyana Woodall, Woodall.52@osu.edu 

 

Barn swallow research offers real-time insight on how new species form



University of Colorado at Boulder
Barn swallows 

image: 

A Hirundo rustica erythrogaster from Colorado. 

view more 

Credit: Matt Wilkins




Beauty is in the eye of the beholder—even if that beholder is a barn swallow. 

Depending on where the birds live, some of them may favor mates with a paler chest color while others find a redder chest more attractive. The difference in what these birds prefer when it comes to choosing a mate is helping scientists unlock one of biology’s greatest mysteries: How do new species originate?

In a new study led by the University of Colorado Boulder, biologists used genetic sequencing from barn swallows around the globe to provide real-time evidence that sexual selection, in which organisms choose mates based on traits they find attractive, drives the emergence of new species. 

The study was published Dec 12 in the journal Science

“This is one of the very first papers to comprehensively show the role of mate selection decisions in the evolution of new species,” said Rebecca Safran, the paper’s senior author and professor in the Department of Ecology and Evolutionary Biology. The new findings shed light on how new species form, a fundamental but elusive process for all life on Earth.

Proving Darwin right

Charles Darwin proposed the theory of sexual selection in 1875. It suggests that organisms evolve showy traits, like extravagant plumage or eye-catching dance moves, to attract mates. When organisms of the same species develop preferences for different traits and no longer breed with each other, new species could emerge over time, a process known as speciation.

For the past 150 years, researchers of sexual selection have primarily studied organisms that already diverged into distinct species. For example, orchids, which now encompass more than 25,000 species, originated from a common ancestor. Their remarkable diversity often leads to the assumption that they evolved different looks to attract different pollinators, said Drew Schield, the paper’s first author and assistant professor at the University of Virginia.

“It’s logical to think this way and it could totally be the case,” said Schield, who did the research while a postdoctoral researcher at CU Boulder. “But with speciation already having occurred, it’s impossible to know for certain.” As a result, it has been difficult to find direct evidence that sexual selection drives the emergence of new species.

Barn swallows provide a unique opportunity to explore the speciation process as it unfolds. 

These birds are one of the most common and widespread species on our planet. Currently, there are six subspecies of barn swallow each looking slightly different in some traits critical to the mate choice decisions depending on where they are. 

For example, the East Asian group, Hirundo rustica gutturalis, has a pale chest and shorter tail streamers—the elongated outer tail feathers. Hirundo rustica tytleri, found in Siberia, has long tail streamers and red chest feathers. The subspecies in Europe and western Asia, Hirundo rustica rustica, has a pale chest and long tail streamers.

Reuniting after isolation

Evidence suggests that the bird’s ancestors left the Nile River valley in northern Africa about 11,000 years ago and spread out across the Northern Hemisphere. For thousands of years, different populations barely interacted and developed diverse traits, forming subspecies.

Some 800 to 2000 years ago, certain subspecies expanded their territories, and habitats began to overlap. In some parts of the world, subspecies now interact with each other, producing hybrid offspring. 

Safran and her team set out to investigate whether sexual selection in these birds was driving the speciation process.

The team, including Elizabeth Scordato, associate professor at the California State Polytechnic University, sequenced the genomes of 336 barn swallows from around the globe, encompassing all subspecies and three hybrid zones, where subspecies interbreed, in Eurasia. 

The researchers found a dozen regions in the barn swallow genome associated with the birds’ two sexually selected traits: Ventral coloration—the plumage color of their chest and belly— and tail streamer length.

When individuals reproduce, the genes from both parents reshuffle and combine to form the genes of their offspring. When two populations encounter one another, the flow of genetic material from one to another is a marker of how similar the populations are. If the rate of gene flow is low, it means the two populations are breeding with each other at a lower rate than they would if they are the same species. 

The study found that in barn swallow hybrid zones much of their genes flows freely across groups. But the genetic regions coding for ventral coloration and tail streamer length hardly transfer to other populations.

It suggests that among the hybrid individuals with parents from different subspecies, a small number of lucky birds that inherit a favorable combination of tail streamer and ventral color genes are able to attract mates. Hybrids that receive less favorable combinations tend to be less successful in reproduction.  

“These genes are hitting a boundary due to divergent sexual selection, and they stop moving from one population to the other,” Schield said. 

The different preferences for tail feather length and chest color across subspecies make barn swallows more likely to mate within their own group, Schield added. If the trend continues, these groups could no longer interbreed or produce offspring, markers for the formation of separate species.   

Next, the team plans to sample more birds and study whether being a hybrid affects reproductive success.  

“It’s very cool that we could capture a real-time evolutionary portrait of this common animal and understand how and why the populations are diverging,” Safran said. “Our understanding of the process is fundamentally important for addressing a wide range of questions related to biodiversity, evolution and conservation.” 

Hirundo rustica rustica (left) and Hirundo rustica tytleri (right) have different sexually selected traits, so they prefer to mate within their own group. 

Credit

Matt Wilkins

 

Policy Forum: Considering risks of “mirror life” before it is created



Summary author: Meagan Phelan






American Association for the Advancement of Science (AAAS)



In a Policy Forum, scientists discuss lifeforms composed of mirror-image biological molecules – also known as “mirror life” – and say creation of such lifeforms, which could evade immune mechanisms and predators, warrants careful consideration. The hallmark of mirror organisms is reversed chirality – a feature that would render them resistant to normal forms of biological degradation, making them useful for applications like long-lasting therapies. While these organisms haven’t yet been observed in nature, and the capability to create them is likely at least a decade away, requiring large investments and major technical advances, now is the moment, say the authors, to consider and preempt risks. The authors – an interdisciplinary researcher group, including researchers who have held the creation of mirror life as a long-term aspirational goal – call for broader discussion amongst the global research community, policymakers, research funders, industry, civil society, and the public, to chart an appropriate path forward. The detailed analysis on mirror life they present is perhaps the most comprehensive assessment to date. It qualitatively assesses the feasibility and risks of creating mirror bacteria, considering factors including the nature, magnitude, and likelihood of potential harms, the ease of accidental or deliberate misuse, and the effectiveness of potential countermeasures. The authors focus on mirror bacteria in this analysis but note that many of the considerations might also apply to other forms of mirror life. Among concerns, the authors say their analysis suggests that mirror bacteria would likely evade many immune mechanisms, potentially causing lethal infection in humans, animals, and plants. Such bacteria are likely to evade predation from phages and many other predators, facilitating spread in the environment. The authors explain that though they were initially skeptical that mirror bacteria could pose such major risks, they have since become deeply concerned. They call for additional scrutiny of their findings and further research to improve understanding of these risks. However, they note, in the absence of compelling evidence for reassurance, their view is that mirror bacteria and other mirror organisms should not be created. They believe that this can be ensured with minimal impact on beneficial research.

 

The findings of these researchers – summarized in the Policy Forum – are available in more detailed form in a separate, in-depth technical report that can be accessed at a link in the related press release.

Breakthrough of the Year: A drug that prevents HIV infection, providing six months of protection per shot



Summary author: Walter Beckwith



American Association for the Advancement of Science (AAAS)




As its 2024 Breakthrough of The Year, Science has named the development of lenacapavir – a promising new injectable drug that prevents HIV infection. The award also recognizes related work surrounding gaining a new understanding of the structure and function of HIV’s capsid protein. Despite decades of advancements, HIV continues to infect more than a million people annually, with a vaccine remaining elusive. However, a new injectable drug, lenacapavir, offers hope by providing six months of protection per shot. Clinical trials have demonstrated the drug’s remarkable efficacy, achieving 100% protection in African adolescent girls and women and 99.9% in gender-diverse groups across continents. Lenacapavir’s success stems from groundbreaking research on HIV’s capsid protein, which shields the virus's genetic material. By rigidifying this protein, the drug blocks key stages of viral replication. This capsid-targeting mechanism, once deemed impractical, could inspire treatments for other viral diseases. Initially developed as a rescue therapy for patients resistant to other drugs, lenacapavir’s long-lasting injectable form now positions it as a game-changer in HIV prevention. It overcomes adherence issues seen with daily oral pre-exposure prophylaxis (PrEP) and bimonthly injections like cabotegravir, particularly for populations facing stigma and access challenges. However, global rollout depends on affordability, manufacturing agreements, and robust health infrastructure, with regulatory approval expected by 2025. Nevertheless, its potential to drastically reduce infections in high-risk populations underscores its significance. Combined with previous biomedical advances, lenacapavir represents a pivotal step toward diminishing HIV/AIDS as a global health crisis.