Monday, January 27, 2025

 

Will the U.S. have enough pain specialists?



New UC Davis study shows drop in applications to pain medicine fellowship programs



University of California - Davis Health

UC Davis Health Pain Specialists 

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Associate Professor Scott Pritzlaff, left, and Clinical Fellow Christine Kerr at the UC Davis Health Pain Intervention Center in Sacramento, California. (UC Davis Health courtesy photo)

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Credit: UC Davis Health




(SACRAMENTO) — Nearly a quarter of adults in the U.S. have chronic pain, but a new study from the UC Davis School of Medicine shows a concerning drop in residents applying to pain medicine fellowship programs.

The study was published in PAIN Practice. It found the number of anesthesiology residents applying for pain medicine fellowships — historically the key pool of applicants — dropped 45% between 2019 and 2023.

“While the demand for pain specialists is growing in the U.S., the pipeline of new doctors to fill these roles is drying up,” said Scott Pritzlaff, the study’s first author, an associate professor in the UC Davis Department of Anesthesiology and Pain Medicine and director of the Pain Medicine Fellowship program.

The study found fewer physicians overall are choosing to go into pain medicine. Female physicians applying to the specialty dropped 27.5%, and the number from all specialties dropped 14.2%.

report from the Centers for Disease Control and Prevention released in November showed 24.3% of adults report having chronic pain.

“Fewer doctors choosing pain medicine means longer wait times, rushed care and fewer treatment options for patients suffering from chronic pain,” Pritzlaff said. “In a country already grappling with an opioid crisis, this could leave millions without the specialized care they need to manage their pain safely and effectively.”

Opioid epidemic may have contributed to decline

The economic and societal impacts of the U.S. opioid epidemic have been enormous. But there may be another impact with far-reaching consequences: the practice of pain medicine itself.

Chinar Sanghvi is an assistant clinical professor in the UC Davis Department of Anesthesiology and Pain Medicine and associate director of the Pain Medicine Fellowship program. Among her many roles, she teaches courses at the UC Davis School of Medicine and mentors first- and second-year medical students.

She noted that although most of the lawsuits associated with the opioid epidemic targeted pharmaceutical companies, highly publicized cases involving physicians likely left an impression on medical students and residents.

“For trainees observing this during their formative years, it may have created a perception of pain medicine as a high-risk specialty — both legally and ethically,” Sanghvi said. “This fear of litigation, coupled with the stigma surrounding opioid prescribing, could discourage aspiring physicians from entering the field.”

Opioids are rarely a first-line treatment for chronic pain. Instead, pain specialists use a broad range of treatments. Conservative therapies include non-opioid medications, physical therapy, behavioral health intervention, biofeedback, acupuncture, nutrition counseling and many others. When conservative therapies fail, interventional procedures such as injections, radiofrequency ablation or spinal cord stimulation may be part of the treatment plan.

The authors note the widespread shortage of anesthesiologists in the U.S. is also likely playing a role in the declining interest in pain medicine.

Anesthesiologists currently rank at the top of Best-Paying Jobs (tied with obstetrics and gynecology). Specializing in pain medicine requires an additional year of training in a fellowship. With high demand and high salaries, many physicians are entering the workforce right after completing their anesthesiology residency.

Data show declining interest in pain medicine

The researchers analyzed data from the National Resident Matching Program and the Electronic Residency Application Service to look at the primary specialties of residents applying to pain medicine fellowship programs from 2019 to 2023. They also used a report from the American Association of Medical Colleges to view data on the number of applicants, specialty backgrounds, race and gender.

Their research found that between 2019 and 2023:

  • Applications from residents specializing in anesthesiology (historically the largest specialty) dropped 45%, from 351 to 193.
  • Applications from all specialties dropped 14.2%, from 520 to 446.
  • Applications from female physicians dropped 5%, from 131 to 95.
  • Applications from male physicians dropped 9.8%, from 389 to 351.

In addition to the overall concerns about the drop in numbers, the authors noted the specialty of pain medicine has a low number of female physicians, 18%, and the drop in applications raises concerns about the gender gap widening even more.

The data also revealed some upward trends. Applications from physical medicine and rehabilitation increased almost 33%, from 101 to 134. And residents specializing in emergency medicine increased by 190%, with 10 applying in 2019 and 29 applying in 2023.

UC Davis School of Medicine focused on early outreach

To help attract new talent to the field, Pritzlaff, Sanghvi, and others in the UC Davis Health Division of Pain Medicine increased recruiting efforts with early outreach to medical students and residents. They've also become more active on social media channels. The efforts helped UC Davis fill its fellowship slots despite the national downturn.

David Copenhaver, senior author of the study, is a professor in the Department of Anesthesiology and Pain Medicine and chief of the Division of Pain Medicine.

“Pain medicine is caught in a strange paradox. On one hand, pain is one of the biggest public health problems in America, costing billions annually. On the other, the field is underappreciated and underfunded,” Copenhaver said. “This decline isn’t just about numbers — it’s a wake-up call for the future of pain care in America.”

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COVID-19 infection associated with nearly eightfold increase in chronic fatigue syndrome





University of Utah Health
Rachel Hess 

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Rachel Hess, MD, one of the senior authors on the paper.

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Credit: Charlie Ehlert / University of Utah Health




A new study published in the Journal of General Internal Medicine, “Incidence and Prevalence of Post‑COVID‑19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER‑Adult Study,” reveals that infection with SARS-CoV-2, the virus that causes COVID-19, significantly increases the rate of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among COVID-19 survivors.
 
“This analysis provides the first substantive estimate of the incidence of post-viral ME/CFS,” said Rachel Hess, MD, associate vice president for research in health sciences at University of Utah Health and one of the senior authors on the paper.
 
Suzanne D. Vernon, PhD, research director at the Bateman Horne Center, is the lead author on this study of post-COVID-19 ME/CFS to analyze adult participants in the NIH’s RECOVER (Researching COVID to Enhance Recovery) Initiative. Included in the analysis were 11,785 participants who had been infected by SARS-CoV-2 and 1,439 participants who had not been infected by the virus. The results found that 4.5% of SARS-CoV-2 infected RECOVER participants met Institute of Medicine (IOM) ME/CFS clinical diagnostic criteria—nearly eight times higher than uninfected controls.
 
"These findings highlight the urgent need for healthcare providers to recognize and address ME/CFS as a diagnosable and treatable condition in the wake of COVID-19," Vernon said.

Key findings:

  • New incident cases of ME/CFS are 15 times higher than pre-pandemic levels.
  • ME/CFS occurred in 4.5% of infected RECOVER participants compared to 0.6% of uninfected individuals.
  • Nearly 90% of the post-COVID-19 ME/CFS participants were also identified as the most symptomatic long COVID patients.

“This research underscores the urgency for healthcare providers to recognize post-COVID-19 ME/CFS,” Vernon said. “Early diagnosis and proper management can transform lives. At Bateman Horne Center, we are dedicated to equipping providers with the knowledge and tools to meet this critical need.”
 
Hess added that she hopes that the new publication will help lead the way for more studies into ME/CFS. “This condition, which predominantly impacts women, has often been dismissed,” Hess said. “This paper will hopefully change the trajectory of research into this understudied condition.”

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Original release published by the Bateman Horne Center.

The study was supported by the NIH (OT2HL161841, OT2HL161847, and OT2HL156812). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About University of Utah Health
University of Utah Health provides leading-edge and compassionate care for a referral area that encompasses Idaho, Wyoming, Montana, and much of Nevada. A hub for health sciences research and education in the region, U of U Health has a $492 million research enterprise and trains the majority of Utah’s physicians, and more than 1,670 scientists and 1,460 health care providers at its Colleges of Health, Nursing, and Pharmacy and Schools of Dentistry and Medicine. With more than 20,000 employees, the system includes 12 community clinics and five hospitals. U of U Health is recognized nationally as a transformative health care system and provider of world-class care.

About Bateman Horne Center
The Bateman Horne Center (BHC) is a leading non-profit 501(c)(3) Center of Excellence committed to improving access to informed healthcare for individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long COVID ME/CFS and other infection chronic conditions (IACCs). Through its clinical expertise, BHC drives medical education, research, and patient outreach, while actively supporting the community with educational resources, learning opportunities, and advocacy efforts.

About RECOVER
The National Institutes of Health Researching COVID to Enhance Recovery (NIH RECOVER) Initiative brings together clinicians, scientists, caregivers, patients, and community members to understand, diagnose, prevent, and treat Long COVID. RECOVER has created the world’s largest and most diverse cohort of Long COVID patients. In addition, RECOVER clinical trials are testing potential interventions across five symptom focus areas. For more information, please visit recoverCOVID.org.

 

Significant rise in mental health admissions for young people in last decade



Peer-reviewed | Observational study | People


University College London




There was a 65% increase in the number of children and young people being admitted to general acute medical wards in hospitals in England because of a mental health concern between 2012 and 2022, finds a new study led by UCL researchers.

The study, published in The Lancet Child and Adolescent Health journal and funded by the National Institute for Health and Care Research (NIHR) and the NIHR Great Ormond Street Hospital Biomedical Research Centre (NIHR GOSH BRC), analysed data on all admissions of five- to 18-year-olds to medical wards in England from April 1st 2012 to March 31st 2022.

General acute medical wards are specialised hospital wards designed to provide rapid assessment, treatment, and care for patients. These units serve as a bridge between the emergency department, general practitioners, and other hospital wards and are separate to specialised mental health wards such as eating disorder units.

Children and young people are most commonly admitted to general wards from Accident and Emergency because they are too unwell, or it is not safe, for them to go home.

The researchers found that over the course of 10 years, mental health admissions increased from 24,198 to 39,925 (a 65% increase). This was in comparison to just a 10.1% increase in all cause admissions – which rose from 311,067 to 342,511.

Increases in admissions were greatest among girls aged 11-15, rising from 9,091 to 19,349 (112.8% increase), and for eating disorders, rising from 478 to 2,938 (514.6% increase).

This study is the first to analyse national trends in mental health admissions of children and young people to acute medical wards. As the study looked at admissions of up to 18 years of age, the acute medical wards included both children’s wards and adult wards.

Senior author, Dr Lee Hudson (UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital) said: “Over the past decade, we've observed a significant rise in mental health admissions among children and young people to acute medical wards. Although there has been attention paid to increased referrals to community mental health services and inpatient mental health settings, admissions to general acute medical settings feels like a piece of the jigsaw missing in the story.

“Acute medical wards are important places for caring for young people with mental health concerns – especially those with co-existing physical health problems like starvation from an eating disorder.

“However, the increased intensity we describe is presenting real challenges for acute wards, both for patients and their families and the staff supporting them. They may not be set up with an appropriate ward environment for this care, and sometimes staff working there need more training and support with relevant skills. This calls for better co-working between physical and mental health professionals across hospital and community teams, including, for example, adequate provision of psychiatrists and mental health trained nurses to support physical medical care on the actual ward.”

The researchers were unable to pinpoint the reasons behind the dramatic increase in mental health admissions in their study from this national level data, but are now in the process of collating more detailed data on reasons for admissions from a selection of children’s wards in England, alongside interviewing young people, their families and staff working on wards.

From this, they hope to better understand the needs and problems for these admissions to guide appropriate and effective interventions and improvements.

Dr Hudson said: “At a bigger level, we are all currently grappling with and trying to figure out why more and more young people are suffering with their mental health but it’s likely the bigger background prevalence of mental health problems, and possibly increased severity of individual cases, leading to increased presentations to hospitals that require an emergency admission to a general ward because it is not safe for the patient to go home.

“Our findings also show that these increases are not solely down to the COVID-19 pandemic, as there have been year on year increases in numbers of admissions since 2012. This is an issue that appears to now be core business for acute wards, and isn’t going to go away, so a focus on improving care is essential. We hope this study and our future work will help with this.

“Beyond that, it is of course crucial to understand the factors driving these presentations to better support the mental health of young patients.”

A recent report from the Health Services Safety Investigations Body (HSSIB), an independent patient safety organisation, highlighted multiple concerns associated with these admissions. For example, 13 out of 18 paediatric units surveyed by the HSSIB described their ward environment as “not safe” for caring for children and young people with high-risk behaviours related to mental health concerns.

Issues raised included a lack of resources to provide therapeutic engagement for children and young people, challenges related to the physical ward space, difficulties managing children and young people who require sedation, and concerns regarding the impact of these admissions on other patients and staff morale. Work is ongoing around the country to address these issues, and researchers hope that their study will highlight the urgent need for better integration of acute, mental health, and social care services to support children and young people admitted with mental health concerns.

By improving coordination and planning, they hope it will be possible to ensure that young patients receive the comprehensive care they need, both in hospital and in the community.

Study limitations

The study's limitations include potential underestimation of mental health admissions due to variations in diagnostic coding and the inability to describe the level of care or use of the Mental Health Act. Additionally, the study could not differentiate between admissions to paediatric or adult wards, nor account for changes in admission criteria during the pandemic.

Further research in the MAPS project currently collecting more detailed information on admissions in a set of hospitals in England, and interviews with children, families and staff experiences aims to address some of this missing information.


Association between surgeon stress and major surgical complications



 News Release 

JAMA Surgery




About The Study: 

In this cohort study including 38 attending surgeons and 793 patients, increased surgeon stress at the beginning of a procedure was associated with improved clinical patient outcomes. The results are illustrative of the complex relationship between physiological stress and performance, identify a novel association between measurable surgeon human factors and patient outcomes, and may highlight opportunities to improve patient care. 



Corresponding Author: To contact the corresponding author, Jake Awtry, MD, email jawtry@bwh.harvard.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamasurg.2024.6072)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time

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Changes in microbiome predict risk for sexually transmitted disease




Albert Einstein College of Medicine




January 15, 2025—(BRONX, NY and BUFFALO, NY)—Women who develop bacterial vaginosis (BV) often later acquire chlamydia, a common and potentially serious sexually transmitted bacterial infection. Now, researchers at Albert Einstein College of MedicineRoswell Park Comprehensive Cancer Center, and the Icahn School of Medicine at Mount Sinai have found that BV actually consists of two subtypes—one of which significantly increases the risk of developing chlamydia infections. The findings were made in a population of young Black and Hispanic women, who are disproportionately affected by both BV and chlamydia, but are historically understudied. The study, one of the largest and most comprehensive of its kind, was published online today in the journal Cell.

It was already known that BV raises a womans risk for acquiring chlamydia, but it wasn’t clear how the microbiome imbalances seen in BV contribute to that risk,” said study co-leader Robert Burk, M.D., professor of pediatrics, of microbiology & immunology, of obstetrics & gynecology and womens health, and of epidemiology & population health at Einstein and vice chair for translational research in the department of pediatrics at Montefiore EinsteinThis research shows that specific changes in the cervicovaginal microbiome set the stage for chlamydia. And it shows that targeting treatment against the more-dangerous BV subtype could potentially prevent many women from developing chlamydia, which is particularly prevalent in historically underserved communities.”

BV affects at least 30% of women at any given time and up to 50% of Black and Hispanic women. Black and Hispanic adolescent and young adult females have a five-fold higher risk of acquiring chlamydia compared with their white counterparts.

“This study was made possible by the participation of young women of color, who are at highest risk for this infection and most likely to experience its negative impact,” said study co-author Angela Diaz, M.D., Ph.D., MPH, dean of Global Health, Social Justice, and Human Rights at the Icahn School of Medicine at Mount Sinai. “We hope that our research and future studies continue to address disparities in healthcare, improve access to treatment, and enhance our approach to personalized care.”

Discovering two types of BV infection
BV is caused by imbalances in the cervicovaginal microbiome—the collection of bacteria naturally found in the genital tract. Common symptoms include vaginal discharge, itching or irritation, and burning sensation during urination, although many cases are asymptomatic. BV can be readily treated with antibiotics.

In the new study, the researchers used advanced DNA-sequencing technology to analyze the cervicovaginal microbiomes of 560 adolescent and young adult Black and Hispanic females. The analyses were performed before infection with chlamydia, at the time of infection, and following antibiotic treatment, allowing the researchers to identify which combination of cervicovaginal bacteria is associated with subsequent chlamydia infections.

The analysis detected two distinct subtypes of BV. One subtype—a collection of ten different interconnected bacterial types that account for about 40% of all BV cases—contributed to increased risk for acquiring chlamydia, subsequent reinfection with chlamydia, and complications such as pelvic inflammatory disease.

“This study adds to the growing evidence of the impact of BV on the risk of clinically significant infections, including chlamydia and human papillomaviruses, that can cause cervical cancer,” said Nicolas Schlecht, Ph.D., M.Sc., professor of oncology at Roswell Park Comprehensive Cancer Center, noting in particular work published by this group of collaborators in Nature Communications in 2022. “It’s our hope that this work to reveal the connections between the cervicovaginal microbiome, common infections like chlamydia and HPV, and cancer might help advance the larger effort to prevent more cancers and other resulting conditions.” Dr. Schlecht, who was co-lead and co-author of the study, also serves as an adjunct faculty member at Einstein.

Treating One Infection to Prevent Another
These results are particularly significant for communities of color and could lead to a wholly new approach for clinically managing BV and chlamydia,” said Dr. Burk, who is also a clinical geneticist at the Childrens Hospital at Montefiore and a member of the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center We can now determine which BV cases are most worrisome and should be closely monitored. Detecting and treating these infections could substantially reduce the incidence of chlamydia and its serious consequences including pelvic inflammatory disease, infertility, and miscarriage. The findings also suggest that altering the cervicovaginal microbiome could be a strategy for both treating BV and preventing chlamydia.”

Dr. Burk likens BV to high blood pressure. High blood pressure is silent, but its not harmless,” he said. We routinely screen for high blood pressure because its a major risk factor for cardiovascular disease. By the same token, BV is more or less silent but is a major risk factor for chlamydia. Regularly screening for and treating BV would go a long way toward preventing chlamydia.”

At present, advanced cervicovaginal microbiome analysis is not available to most clinicians. But, said Dr. Burk, I can envision a scenario where it would be readily accessible to most doctors and perhaps even incorporated into home tests, like we have now for COVID-19.”

“This study represents a breakthrough by showing that the risk posed by a relatively benign bacterial condition such as BV can be assessed through microbiome analysis,” said Mykhaylo Usyk, Ph.D., research assistant professor of pediatrics and of microbiology & immunology and first author of the paper. “Our findings suggest that only a subset of BV cases may require treatment to prevent subsequent infections with chlamydia.”

The study is titled Cervicovaginal Microbiome and Natural 1 History of Chlamydia Trachomatis in Adolescents and Young Women.” Additional Einstein authors include Mykhaylo Usyk, Nicolas Schlecht (also at Roswell Park Comprehensive Cancer Center), Christopher Sollecito, Evan Grassi, Fanua Wiek, Shankar Viswanathan, and Howard Strickler. Other authors include Anne Nucci-Sack (deceased), and Angela Diaz both at Icahn School of Medicine at Mount Sinai in New York.

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Albert Einstein College of Medicine
Albert Einstein College of Medicine is one of the nation’s premier centers for research, medical education and clinical investigation. During the 2024-25 academic year, Einstein is home to 712 M.D. students, 226 Ph.D. students, 112 students in the combined M.D./Ph.D. program, and approximately 250 postdoctoral research fellows. The College of Medicine has more than 2,000 full-time faculty members located on the main campus and at its clinical affiliates. In 2024, Einstein received more than $192 million in awards from the National Institutes of Health. This includes the funding of major research centers at Einstein in cancer, aging, intellectual development disorders, diabetes, clinical and translational research, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. For more information, please visit einsteinmed.edu, follow us on TwitterFacebook, InstagramLinkedIn, and view us on YouTube