Monday, August 25, 2025

Tiny waves, big impact: study finds new way to control fluid in space



Researchers use water’s shape, behavior to control liquid in new study



University of Mississippi

Likun Zhang and Zhengwu Wang 

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The shape of water can help researchers manipulate how much energy flows through a barrier. Likun Zhang (right) senior scientist at the National Center for Physical Acoustics, and Zhengwu Wang, a doctoral student in physics, take photos of the water passing through a barrier while manipulating the angle of the water’s meniscus, the curve caused by surface tension near barriers.

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Credit: Photo by Clara Turnage/University Marketing and Communications




OXFORD, Miss. – Liquids can provide some especially tricky challenges for space travelers, but new research from the University of Mississippi could help engineer smarter, more efficient fluid control in zero- and low-gravity environments. 

Likun Zhang, senior scientist at the National Center for Physical Acoustics and associate professor in the Department of Physics and Astronomy, led a research team studying how liquid waves move through barriers in low-gravity environments. Their results were published in Physical Review Letters.  

“In low-gravity cases like the space station, surface tension dominates everything,” said Zhengwu Wang, a fourth-year Ole Miss doctoral student in physics and co-author of the study. “The curvature of the water – the meniscus – is going to appear around structures, and we wanted to know how that meniscus would affect how waves move across barriers.” 

When water meets a partially submerged barrier – think of a leaf on a pond – the surface tension of the liquid causes the liquid to curve upward where it meets the barrier; in this case, the leaf. Zhang and Wang’s research shows that this curve, called the meniscus, can be manipulated to reduce or increase the amount of energy that passes through that barrier.  

If the meniscus’ curve is slight, more energy passes through. But as the meniscus curves more steeply, it reduces the energy conveyed by the fluid.  

“Our common sense tells us a barrier should block waves, but here we found certain meniscus shapes can make waves pass through more easily,” Zhang said. “Only a tiny, 1.5-millimeter change in the meniscus shape caused the transmission to drop from about 60% to just a few percent. Tiny meniscus, huge impact.” 

Space travelers use liquids for all manner of applications: from fuel and water-recycling systems to life support and cooling systems. Being able to better control the fluid in these systems can make them more efficient and lighter – a key for space travel. 

“These are really tiny effects in daily life, but they can have a huge impact in microgravity environments,” Wang said.   

To conduct the experiment, the researchers simulated low gravity by generating small, frequent surface waves. Then, they placed a partial barrier in the path of those waves and used acoustics to measure the meniscus' movement.  

By changing the barrier’s height and using a surface coating to make it water-attracting or water-repelling, the researchers controlled the meniscus – and how much energy passed through the barrier.  

“As physicists, we are looking at very fundamental problems – the like problem of wave dynamics and barriers,” Zhang said. “But being able to control fluid behavior in low gravity is crucial – whether you’re talking about water recycling systems or fuel tanks – because you can’t rely on gravity to separate liquids and gases.” 

The applications could prove useful in earthbound manufacturing and biomedical engineering, too, where microfluidic devices move fluids through channels just millimeters wide, Zhang said. These devices range from printers to DNA chips to lab-on-a-chip technology.  

“This is the first experiment studying this behavior in fluid, but it opens the door to new phenomena and new physics,” he said. “This work is valuable because it shows a new way to control fluid for the first time.”  

This material is based on work supported by the National Science Foundation grant no. 2306106.  

WHY D.E.I.

Including more females in cardiac device trials benefits all patients



University of Rochester Medical Center




A cardiac device trial published in eClinicalMedicine shows that improving enrollment of females in such trials can better guide care for all patients.

The BIO-LIBRA study investigated how well implantable cardiac defibrillators work for patients with non-ischemic cardiomyopathy, a weakening of heart muscle that is more common in females. Because nearly 48 percent of study participants were assigned female at birth—a number that is unheard-of in cardiac device trials—the one-year interim study results revealed that participants assigned male at birth were twice as likely to die or experience life-threatening heart rhythm abnormalities.

“This is the first study that had a large enough number of females enrolled to show this difference,” said Valentina Kutyifa, MD, PhD, professor of Medicine, Cardiology Heart Research at the University of Rochester Medical Center and co-lead of BIO-LIBRA. “We learned that patients with non-ischemic cardiomyopathy do well with these devices, but they still have a residual risk of developing life-threatening ventricular arrhythmias or dying, and this risk is lower in females. Our data will help clinicians identify patients at higher risk and potentially intensify their treatment.”

The study, funded by BIOTRONIK, enrolled 1,000 patients with non-ischemic cardiomyopathy and investigated how well they did with devices commonly used to treat the disease. Patients received either an implantable cardioverter defibrillator (ICD) or a cardiac resynchronization therapy defibrillator (CRT-D) to monitor heart rhythm and deliver impulses to correct irregular beats and/or coordinate heart contraction.

One year after device implantation, 13 percent of males in the study had experienced a life-threatening heart rhythm abnormality or died, compared to just six percent of females. While the rate of arrythmias or death among female participants is clinically meaningful, it amounts to a 52 percent lower risk.

The trial will continue to monitor patients to evaluate the differences in rates of arrhythmias and death between male and female patients at three years after device implantation.

Representation Matters

Despite making up roughly half of the global population, females have historically been underrepresented in research generally, and particularly in medical device trials. The original trials testing ICDs and CRT-Ds focused on ischemic cardiomyopathy, which is more common in males, and only15-29 percent of participants were female.

This gap in the data may have contributed to the fact that females are less likely to be treated with ICDs or CRT-Ds.

When Kutyifa and Jeanne Poole, MD, professor of Medicine at UW Medicine, designed the BIO-LIBRA study, they set out to fill this data gap. To enroll more females and better reflect the demographics of patients impacted by non-ischemic cardiomyopathy, they had to address multiple barriers that prevent females from enrolling in studies.

“Clinical trials might be too much of a time demand, too much to juggle with family, because females are still more likely to be caregivers,” said Kutyifa. “Females may not know about studies, and doctors and study staff may assume females are at low risk or ineligible for a study.”

To address those barriers, Kutyifa and Poole designed the study visits to coincide with regular care appointments and used remote monitoring to reduce the study time demands. Unlike previous studies, they did not exclude patients based on age or comorbidities, which can inadvertently disproportionately exclude females. They educated study teams about the importance of increasing female participation in clinical trials and provided practical guidance to help teams enroll more females.

That extra effort was well worth it. Not only did Kutyifa and Poole blow past their goal of enrolling 40 percent females, but they also enrolled greater proportions of several other groups that are typically underenrolled.

“As we’ve shown in this study, enrolling participants that better reflect the actual patient population benefits everyone, not just those who have been left out in the past,” Kutyifa said.

 

Erasing the seams between the virtual and physical worlds




Princeton University, Engineering School
Abtahi, Kari with Robot 

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Computer scientists Parastoo Abtahi, center, and Mohamed Kari, left, are are working to bring virtual reality into the physical world by pairing mixed reality headsets with robots. Doctoral student Lauren Wang, right, assists in demonstrating how the robot operates. 

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Credit: Nick Donnoli/Orangebox Pictures





Computer scientists at Princeton are working to bring virtual reality into the physical world, with the potential to enhance a variety of experiences, including remote collaboration, education, entertainment and gaming.

Someday virtual and augmented reality technology will likely be commonplace, said Parastoo Abtahi, assistant professor of computer science. It will be important that users of this technology are able to seamlessly interact with the physical world.

Abtahi and postdoctoral research associate Mohamed Kari are working to make this possible by pairing virtual reality technology with a physical robot that the user can control. Their research will be presented next month at the ACM Symposium on User Interface Software and Technology in Busan, Korea.

Someone using this system can, while wearing a mixed reality headset, select a drink from a list of options and then place it, virtually, on the desk in front of them. Or, more fantastically, they can ask an animated bee to deliver a bag of chips to them on the sofa.

At first, the drink and the chips might be only pixels. But after a minute or so, they will physically materialize, as if by magic. But it’s not magic — it’s a robot, rendered invisible to the user, that has delivered the snack. “Visually, it feels instantaneous,” said Abtahi.

By removing “all unnecessary technical details, even the robot itself,” said Kari, the experience appears seamless. The goal is to make the technology disappear and have the interaction between human and computer feel intuitive.

A key technical challenge in this system is communication. The user must be able to communicate their desires simply — selecting a pen across the room, for example, and moving it to the table in front of them. Kari and Abtahi created an interaction technique where a simple hand gesture allows the user to select an object, even from far away.

These gestures are then translated into commands for the robot to execute. The robot is outfitted with its own mixed reality headset, so it knows where to place objects within the virtual environment.

Another technical challenge is adding and erasing physical objects from the user’s field of view. Using a technology called 3D Gaussian splatting, Abtahi and Kari create a realistic digital copy of the physical space. Once everything in the room has been scanned, it allows the system to erase something from view, like a moving robot, or add something, like an animated bee.

To achieve this, every inch of the room and every object within it must be scanned and rendered digitally. Right now, the process is somewhat tedious, said Abtahi. Streamlining it, perhaps by assigning the task to a robot, is a subject for future research in her lab.


Bee carrying Pringles [VIDEO] |

A virtual bee delivers a real package of chips via a robot. The robot is made invisible to the viewer by advanced digital rendering techniques. 

Credit

Video by Mohamed Kari

 

What can prairie dogs teach us about wildfire management?






University of Arizona

Prairie Dogs and Fire 

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Black-tailed prairie dogs eat vegetation, create burrows and clear ground. Do those habits impact the spread of wildfires? Researchers from the University of Arizona are calling for more investigations into the small mammal's role in fire management and mitigation strategies.

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Credit: Courtney Duchardt/College of Agriculture, Life and Environmental Sciences





In the battle to manage wildfires, experts often turn to advanced technologies and evolving techniques for help, but could the next breakthrough in fire management be found right under their feet?

If those experts are standing in the Great Plains, then the answer might be yes, said Courtney Duchardt, assistant professor in the University of Arizona College of Agriculture, Life and Environmental Sciences.

Duchardt is the lead author of a new paper published in the journal BioScience arguing that historical fire patterns, current fire management strategies and unpublished data strongly suggest that black-tailed prairie dogs are likely to reduce wildfire spread and intensity.

"Black-tailed prairie dogs are eating vegetation, creating burrows and bare ground," Duchardt said. "But they are not only eating vegetation. They are actively clipping it and keeping it short so that they can see predators, and their long-term occupancy leads to a shift in the types of vegetation that grows. You see a kind of shift from more grass to smaller, flowering plants and a lot barer ground that can act as a kind of fire stop."

Duchardt discovered the impact prairie dogs have on their environment while researching fire, grazing and bird behavior across the Great Plains. Over time, she noticed a consistent factor across many of her sites: the presence of prairie dog colonies that appeared to alter the landscape in ways that made fire behave differently.

Intrigued, she and other researchers asked a simple question: do prairie dog colonies actually affect wildfire behavior? When Duchardt and her colleagues began a review of previous research, only one of the 34 studies they found directly examined the effect of prairie dogs on wildfire.

This newly observed connection between prairie dogs and wildfire places the small mammals in a larger discussion of something called "disturbance regimes," Duchardt said.

Disturbance regimes are events like fires and floods that have shaped the Great Plains for millennia. It also includes more recent human activities like logging, mining and agriculture that have further transformed ecosystems. These disturbance regimes can sometimes degrade the environment, but in many cases, they play a vital role in maintaining ecosystem health.

"While there are real conflicts when it comes to prairie dog management, this species and a lot of other wildlife species may be providing ecosystem services that we really haven't quantified yet," Duchardt said. "We want to really think about the potential ecosystem services of these species, because we might lose them and then run into problems that we didn't think about ahead of time."

Different species of prairie dogs also manage the growth of mesquite trees and invasive lovegrass throughout Arizona, Duchardt added, potentially slowing the spread of wildfires.

Duchardt collaborated with Jacob Hennig, assistant professor in the School of Natural Resources and the Environment, along with researchers from the U.S. Department of Agriculture, the Smithsonian's Migratory Bird Center, Oklahoma State University, the University of Wyoming, Northern Illinois University and the City of Boulder. The group is calling for more research and an integrated approach to fire management. By incorporating prairie dog activity into fire behavior models, land managers could develop more effective strategies for fire prevention and mitigation, particularly in vulnerable grassland ecosystems.



Prairie Dogs and Fire Gif 



Trail camera footage shows a wildfire burning across the Great Plains but stopping short of a prairie dog colony, leaving the area around the burrows unburned.

Credit

Courtney Duchardt/College of Agriculture, Life and Environmental Sciences


 

Polysubstance involvement in youth opioid overdoses increases with age




A new study found that youth as young as 15 are using multiple substances combined with opioids, and by age 21, youth opioid overdoses more commonly involve other substances—primarily stimulants—rather than opioids alone




Boston University School of Public Health



Most research suggests that opioid overdoses involving multiple substances in the United States typically occur among people ages 25-54. However, a new study led by Boston University School of Public Health (BUSPH) and Mass General Brigham for Children indicates that polysubstance-involved opioid overdoses are also prevalent among youth.

Published in the journal Pediatrics, the study examined trends in overdose mortality and found that, among youth, opioid overdoses more commonly involved multiple substances than opioids alone, starting at age 21. Polysubstance-involved overdose deaths occurred among youth as young as 15 years old, and rose steadily with age. The findings also demonstrated that fentanyl and other synthetic opioids were involved in more than 93% of overdose deaths, while stimulants such as methamphetamine and cocaine were the primary contributors to polysubstance-involved deaths.

“These findings indicate that overdose fatalities among youth under 25 are unfortunately mirroring trends seen in the general adult population, indicating the youth overdose crisis has entered a fourth wave,” says study lead and corresponding author Connor Buchholz, PhD student in health services and policy research at BUSPH. 

This latest wave of the decades-long opioid epidemic centers on the combined use of stimulants and synthetic opioids, and follows previous waves driven by prescription opioids in the 1990s, heroin in 2010, and fentanyl and other synthetic opioids since 2013. In 2023, 48.5 million people aged 12 or older had a substance use disorder in the past year, and drug overdose deaths more than doubled among adolescents from 2018 to 2022. As drug overdose deaths in the U.S. remain alarmingly high despite a decline in 2024 from 2023, the new findings underscore the need for tailored treatment strategies among youth to address rising overdoses involving synthetic opioids combined with stimulants.

The study analyzed federal overdose mortality data for youth ages 15–24 from 2020 to 2023, comparing opioid overdoses involving multiple substances with opioid-only fatalities. Polysubstance use drove nearly half of the 23,000 youth opioid overdose deaths during this period. Stimulants were involved in 65 percent of polysubstance opioid overdose deaths and 33 percent of all opioid overdose fatalities.

Among the approximately 23,000 opioid overdose deaths that occurred in youth during this period, polysubstance-involved overdoses contributed to 25 percent of opioid overdose deaths among 15-year-olds, 40 percent among 18-year-olds, nearly 53 percent of these deaths among 21-year-olds, and 58 percent among 24-year-olds. Other than opioids, stimulants were the most common substance involved in overdose deaths, and were used in approximately 12 percent of opioid overdose deaths among 15-year-olds, 21 percent among 18-year-olds, 34 percent among 21-year-olds, and 41 percent among 24-year-olds. 

Although the study did not directly analyze the specific factors that are driving age-related increases in polysubstance-involved overdose deaths, the researchers point to several likely factors: wider availability of illicit drugs, rising potency of drugs, and worsening mental health challenges.

“Despite a reduction in opioid prescriptions, youth remain at risk of unintentionally encountering counterfeit pills that resemble medications such as oxycodone, benzodiazepines, and other prescription drugs, which can be contaminated with fentanyl,” Buchholz says. Rising rates of mental health conditions may also be driving youth to turn to substances as a way to cope with difficult emotions,” he adds. “Rates of attention-deficit/hyperactivity disorder [ADHD] have increased in recent years, and symptoms of ADHD and other mental health conditions were likely exacerbated during the COVID-19 pandemic.”

The forthcoming funding cuts to Medicaid under the recently passed federal tax and spending bill may further complicate this crisis by reducing access to medications for opioid use disorder (OUD), including buprenorphine, methadone, and naltrexone. 

“Medicaid is a primary source of coverage for youth with OUD, and many youth and their families rely on this lifesaving treatment, which has been proven to substantially reduce the risk of opioid overdose,” says study senior author Dr. Scott Hadland, chief of the Division of Adolescent and Young Adult Medicine at Mass General Brigham for Children/Harvard Medical School. “Early intervention, particularly among youth, is critical to preventing overdoses, avoiding serious long-term health consequences, and reducing the risk of decades-long addiction." The budget cuts will also reduce funding for programs that provide the overdose reversal medication Narcan (naloxone) to first responders, which could jeopardize recent progress in combating the opioid crisis, he adds.

Despite these challenges, clinicians can continue to promote substance use recovery by promoting nonstigmatizing and developmentally appropriate care, Buchholz says, citing treatment guidelines from U.S. medical organizations for youth with OUD and stimulant use disorders (StUD). 

“To mitigate overdose risk, comprehensive education on overdose prevention, including the administration of Narcan, should be widely implemented for all clinicians treating youth with OUD,” Buchholz says. For youth with StUD, “recommended treatments include off-label medication use, contingency management, and behavioral therapies.”

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About Boston University School of Public Health 

Founded in 1976, Boston University School of Public Health is one of the top ten ranked schools of public health in the world. It offers master's- and doctoral-level education in public health. The faculty in six departments conduct policy-changing public health research around the world, with the mission of improving the health of populations—especially the disadvantaged, underserved, and vulnerable—locally and globally.