Does air pollution affect mental health later in life?
In a study of women aged 80 years and older, living in locations with higher exposures to air pollution was associated with increased depressive symptoms. The findings are published in the Journal of the American Geriatrics Society.
When looking at individual air pollutants, a team led by investigators from of the University of Southern California found that long-term exposure to nitrogen dioxide or fine particulate air pollution was associated with increased depressive symptoms, but with only a small effect. Results also suggested that depressive symptoms might play a role in linking long-term air pollution exposure to memory decline more than 10 years after the exposure.
"This is the first study showing how air pollution exposures affect depressive symptoms as well as the interrelationship between the symptoms and subsequent memory decline that had not been found in older people aged less than 80 years," said lead author Andrew Petkus, PhD.
Senior author Jiu-Chiuan Chen, MD, ScD, added, "We know late-life exposures to ambient air pollutants accelerate brain aging and increase the dementia risk, but our new findings suggest the oldest-old populations may respond to air pollution neurotoxicity in a different way that needs to be investigated further."
Does air pollution increase women's risk of dementia?
Study finds high levels associated with brain shrinkage patterns common in Alzheimer's
MINNEAPOLIS - Older women who live in locations with higher levels of air pollution may have more brain shrinkage, the kind seen in Alzheimer's disease, than women who live in locations with lower levels, according to a new study published in the November 18, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study looked at fine particle pollution and found that breathing in high levels of this kind of air pollution was linked to shrinkage in the areas of the brain vulnerable to Alzheimer's disease.
Fine particle pollution consists of microscopic particles of chemicals, smoke, dust and other pollutants suspended in the air. They are no larger than 2.5 micrometers, 30 times smaller than the width of a human hair.
"Smaller brain volume is a known risk factor for dementia and Alzheimer's disease, but whether air pollution alters brain structure is still being researched," said study author Diana Younan, Ph.D., of the University of Southern California in Los Angeles. "Our study found that women in their 70s and 80s who were exposed to the higher levels of air pollution had an increased risk of brain changes linked to Alzheimer's disease over five years. Our research suggests these toxins may disrupt brain structure or connections in the brain's nerve cell network, contributing to the progression toward the disease."
The study involved 712 women with an average age of 78 who did not have dementia at the start of the study. Participants provided health histories as well as information on race/ethnicity, education, employment, alcohol use, smoking and physical activity. All women received MRI brain scans at the start of the study and five years later.
Researchers used the residential addresses of each participant to determine their average exposures to air pollution in the three years before the first MRI scan. They then divided participants into four equal groups. The lowest group was exposed to an average of 7 to 10 micrograms of fine particle pollution per cubic meter of air (μg/m3). The highest group was exposed to an average of 13 to 19 μg/m3. The U.S. Environmental Pollution Agency (EPA) considers average yearly exposures up to 12 μg/m3 to be safe.
Researchers used a machine learning tool to measure signs of Alzheimer's disease in the brain, a tool that had been trained to identify patterns of brain shrinkage specific to an increased risk of Alzheimer's disease by reading the brain scans of people with the disease.
Participants' MRI brain scans at the start of the study and five years later were assigned scores based on how similar they were to Alzheimer's disease patterns identified by the machine learning tool, specifically brain changes in regions found to be vulnerable to Alzheimer's disease. Scores ranged from zero to one, with higher scores showing more brain changes. Overall, the women's scores changed from 0.28 at the start of the study to 0.44 five years later.
For each 3 μg/m3 increase in air pollution exposure levels, researchers found a broader range of scores between the two scans and an average increase of 0.03, showing a greater extent of brain shrinkage over five years, which was equivalent to a 24% increased risk of Alzheimer's disease. The increases remained the same even after adjusting for age, education, employment, cardiovascular disease, high blood pressure, physical activity and other factors that could affect brain shrinkage.
"Our findings have important public health implications, because not only did we find brain shrinkage in women exposed to higher levels of air pollution, we also found it in women exposed to air pollution levels lower than those the EPA considers safe," said Younan. "While more research is needed, federal efforts to tighten air pollution exposure standards in the future may help reduce the risk of Alzheimer's disease in our older populations."
Limitations of the study include that it only looked at the brains of older women, so results may not be the same for men or younger women. It also examined only regional fine particle pollution, not other sources of pollution such as traffic emissions. Researchers were also not able to estimate participants' exposure to fine particle pollution in middle-age and young adulthood due to nationwide data not being available for those years.
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The study was supported by the National Institute on Aging.
Learn more about dementia at BrainandLife.org, home of the American Academy of Neurology's free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life® on Facebook, Twitter and Instagram.
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The American Academy of Neurology is the world's largest association of neurologists and neuroscience professionals, with over 36,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, stroke, migraine, multiple sclerosis, concussion, Parkinson's disease and epilepsy.
For more information about the American Academy of Neurology, visit AAN.com or find us on Facebook, Twitter, Instagram, LinkedIn and YouTube.
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