Wednesday, January 24, 2024

 

New tool predicts flood risk from hurricanes in a warming climate


Using New York as a test case, the model predicts flooding at the level experienced during Hurricane Sandy will occur roughly every 30 years by the end of this century.


Peer-Reviewed Publication

MASSACHUSETTS INSTITUTE OF TECHNOLOGY




Coastal cities and communities will face more frequent major hurricanes with climate change in the coming years. To help prepare coastal cities against future storms, MIT scientists have developed a method to predict how much flooding a coastal community is likely to experience as hurricanes evolve over the next decades. 

When hurricanes make landfall, strong winds whip up salty ocean waters that generate storm surge in coastal regions. As the storms move over land, torrential rainfall can induce further flooding inland. When multiple flood sources such as storm surge and rainfall interact, they can compound a hurricane’s hazards, leading to significantly more flooding than would result from any one source alone. The new study introduces a physics-based method for predicting how the risk of such complex, compound flooding may evolve under a warming climate in coastal cities.

One example of compound flooding’s impact is the aftermath from Hurricane Sandy in 2012. The storm made landfall on the East Coast of the United States as heavy winds whipped up a towering storm surge that combined with rainfall-driven flooding in some areas to cause historic and devastating floods across New York and New Jersey. 

In their study, the MIT team applied the new compound flood-modeling method to New York City to predict how climate change may influence the risk of compound flooding from Sandy-like hurricanes over the next decades.  

They found that, in today’s climate, a Sandy-level compound flooding event will likely hit New York City every 150 years. By midcentury, a warmer climate will drive up the frequency of such flooding, to every 60 years. At the end of the century, destructive Sandy-like floods will deluge the city every 30 years — a fivefold increase compared to the present climate. 

“Long-term average damages from weather hazards are usually dominated by the rare, intense events like Hurricane Sandy,” says study co-author Kerry Emanuel, professor emeritus of atmospheric science at MIT. “It is important to get these right.”

While these are sobering projections, the researchers hope the flood forecasts can help city planners prepare and protect against future disasters. “Our methodology equips coastal city authorities and policymakers with essential tools to conduct compound flooding risk assessments from hurricanes in coastal cities at a detailed, granular level, extending to each street or building, in both current and future decades,” says study author Ali Sarhadi, a postdoc in MIT’s Department of Earth, Atmospheric and Planetary Sciences. 

The team’s open-access study appears online today in the Bulletin of the American Meteorological Society. Co-authors include RaphaĆ«l Rousseau-Rizzi at MIT’s Lorenz Center, Kyle Mandli at Columbia University, Jeffrey Neal at the University of Bristol, Michael Wiper at the Charles III University of Madrid, and Monika Feldmann at the Swiss Federal Institute of Technology Lausanne. 

The seeds of floods

To forecast a region’s flood risk, weather modelers typically look to the past. Historical records contain measurements of previous hurricanes’ wind speeds, rainfall, and spatial extent, which scientists use to predict where and how much flooding may occur with coming storms. But Sarhadi believes that the limitations and brevity of these historical records are insufficient for predicting future hurricanes’ risks.

“Even if we had lengthy historical records, they wouldn’t be a good guide for future risks because of climate change,” he says. “Climate change is changing the structural characteristics, frequency, intensity, and movement of hurricanes, and we cannot rely on the past.”

Sarhadi and his colleagues instead looked to predict a region’s risk of hurricane flooding in a changing climate using a physics-based risk assessment methodology. They first paired simulations of hurricane activity with coupled ocean and atmospheric models over time. With the hurricane simulations, developed originally by Emanuel, the researchers virtually scatter tens of thousands of “seeds” of hurricanes into a simulated climate. Most seeds dissipate, while a few grow into category-level storms, depending on the conditions of the ocean and atmosphere. 

When the team drives these hurricane simulations with climate models of ocean and atmospheric conditions under certain global temperature projections, they can see how hurricanes change, for instance in terms of intensity, frequency, and size, under past, current, and future climate conditions. 

The team then sought to precisely predict the level and degree of compound flooding from future hurricanes in coastal cities. The researchers first used rainfall models to simulate rain intensity for a large number of simulated hurricanes, then applied numerical models to hydraulically translate that rainfall intensity into flooding on the ground during landfalling of hurricanes, given information about a region such as its surface and topography characteristics. They also simulated the same hurricanes’ storm surges, using hydrodynamic models to translate hurricanes’ maximum wind speed and sea level pressure into surge height in coastal areas. The simulation further assessed the propagation of ocean waters into coastal areas, causing coastal flooding. 

Then, the team developed a numerical hydrodynamic model to predict how two sources of hurricane-induced flooding, such as storm surge and rain-driven flooding, would simultaneously interact through time and space, as simulated hurricanes make landfall in coastal regions such as New York City, in both current and future climates.  

“There’s a complex, nonlinear hydrodynamic interaction between saltwater surge-driven flooding and freshwater rainfall-driven flooding, that forms compound flooding that a lot of existing methods ignore,” Sarhadi says. “As a result, they underestimate the risk of compound flooding.”

Amplified risk

With their flood-forecasting method in place, the team applied it to a specific test case: New York City. They used the multipronged method to predict the city’s risk of compound flooding from hurricanes, and more specifically from Sandy-like hurricanes, in present and future climates. Their simulations showed that the city’s odds of experiencing Sandy-like flooding will increase significantly over the next decades as the climate warms, from once every 150 years in the current climate, to every 60 years by 2050, and every 30 years by 2099. 

Interestingly, they found that much of this increase in risk has less to do with how hurricanes themselves will change with warming climates, but with how sea levels will increase around the world. 

“In future decades, we will experience sea level rise in coastal areas, and we also incorporated that effect into our models to see how much that would increase the risk of compound flooding,” Sarhadi explains. “And in fact, we see sea level rise is playing a major role in amplifying the risk of compound flooding from hurricanes in New York City.”

 

The team’s methodology can be applied to any coastal city to assess the risk of compound flooding from hurricanes and extratropical storms. With this approach, Sarhadi hopes decision-makers can make informed decisions regarding the implementation of adaptive measures, such as reinforcing coastal defenses to enhance infrastructure and community resilience.

 

“Another aspect highlighting the urgency of our research is the projected 25 percent increase in coastal populations by midcentury, leading to heightened exposure to damaging storms,” Sarhadi says. “Additionally, we have trillions of dollars in assets situated in coastal flood-prone areas, necessitating proactive strategies to reduce damages from compound flooding from hurricanes under a warming climate.”

This research was supported, in part, by Homesite Insurance. 

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Written by Jennifer Chu, MIT News

Paper: “Climate change contributions to increasing compound flooding risk in New York City”

https://journals.ametsoc.org/doi/10.1175/BAMS-D-23-0177.1

 

 

Offshore wind farms are vulnerable to cyberattacks, new Concordia study shows


The emerging technology lacks the regulatory framework necessary to protect itself


Peer-Reviewed Publication

CONCORDIA UNIVERSITY

Hang Du, Jun Yan, Juanwei Chen 

IMAGE: 

LEFT TO RIGHT: HANG DU, JUN YAN, JUANWEI CHEN: “AS WE ADVANCE THE INTEGRATION OF RENEWABLE ENERGIES, IT IS IMPERATIVE TO RECOGNIZE THAT WE ARE VENTURING INTO UNCHARTED TERRITORY, WITH UNKNOWN VULNERABILITIES AND CYBER THREATS.”

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CREDIT: CONCORDIA UNIVERSITY





The hurrying pace of societal electrification is encouraging from a climate perspective. But the transition away from fossil fuels toward renewable sources like wind presents new risks that are not yet fully understood.

Researchers from Concordia and Hydro-Quebec presented a new study on the topic in Glasgow, United Kingdom at the 2023 IEEE International Conference on Communications, Control, and Computing Technologies for Smart Grids (SmartGridComm). Their study explores the risks of cyberattacks faced by offshore wind farms. Specifically, the researchers considered wind farms that use voltage-source-converter high-voltage direct-current (VSC-HVDC) connections, which are rapidly becoming the most cost-effective solution to harvest offshore wind energy around the world.

“As we advance the integration of renewable energies, it is imperative to recognize that we are venturing into uncharted territory, with unknown vulnerabilities and cyber threats,” says Juanwei Chen, a PhD student at the Concordia Institute for Information Systems Engineering (CIISE) at the Gina Cody School of Engineering and Computer Science.

“Offshore wind farms are connected to the main power grid using HVDC technologies. These farms may face new operational challenges,” Chen explains.

“Our focus is to investigate how these challenges could be intensified by cyber threats and to assess the broader impact these threats might have on our power grid.”

Concordia PhD student Hang Du, CIISE associate professor Jun Yan and Gina Cody School dean Mourad Debbabi, along with Rawad Zgheib from the Hydro-Quebec Research Institute (IREQ), also contributed to the study. This work is part of a broad research collaboration project involving the group of Prof. Debbabi and the IREQ cybersecurity research group led by Dr. Marthe Kassouf and involving a team of researchers including Dr. Zgheib.

Complex and vulnerable systems

Offshore wind farms require more cyber infrastructure than onshore wind farms, given that offshore farms are often dozens of kilometres from land and operated remotely. Offshore wind farms need to communicate with onshore systems via a wide area network. Meanwhile, the turbines also communicate with maintenance vessels and inspection drones, as well as with each other.

This complex, hybrid-communication architecture presents multiple access points for cyberattacks. If malicious actors were able to penetrate the local area network of the converter station on the wind farm side, these actors could tamper with the system’s sensors. This tampering could lead to the replacement of actual data with false information. As a result, electrical disturbances would affect the offshore wind farm at the points of common coupling.

In turn, these disturbances could trigger poorly dampened power oscillations from the offshore wind farms when all the offshore wind farms are generating their maximum output. If these cyber-induced electrical disturbances are repetitive and match the frequency of the poorly dampened power oscillations, the oscillations could be amplified. These amplified oscillations might then be transmitted through the HVDC system, potentially reaching and affecting the stability of the main power grid. While existing systems usually have redundancies built in to protect them against physical contingencies, such protection is rare against cyber security breaches.

“The system networks can handle events like router failures or signal decays. If there is an attacker in the middle who is trying to hijack the signals, then that becomes more concerning,” says Yan, the Concordia University Research Chair (Tier 2) in Artificial Intelligence in Cyber Security and Resilience.

Yan adds that considerable gaps exist in the industry, both among manufacturers and utilities. While many organizations are focusing on corporate issues such as data security and access controls, much is to be done to strengthen the security of operational technologies.

He notes that Concordia is leading the push for international standardization efforts but acknowledges the work is just beginning.

“There are regulatory standards for the US and Canada, but they often only state what is required without specifying how it should be done,” he says. “Researchers and operators are aware of the need to protect our energy security, but there remain many directions to pursue and open questions to answer.”

This research is supported by the Concordia/Hydro-QuƩbec/Hitachi Partnership Research Chair, with additional support from NSERC and PROMPT.

Read the cited paper: “A Data Integrity Attack Targeting VSC-HVDC-Connected Offshore Wind Farms

 

Talking tomatoes: How their communication is influenced by enemies and friends


Peer-Reviewed Publication

CARL R. WOESE INSTITUTE FOR GENOMIC BIOLOGY, UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

Researcher image 

IMAGE: 

ESTHER NGUMBI, LEFT, AND ERINN DADY STUDIED THE EFFECT OF ARBUSCULAR MYCORRHIZAL FUNGI, CATERPILLARS, AND THE VARIETY OF TOMATO PLANTS ON PLANT CHEMISTRY.

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CREDIT: FRED ZWICKY





Plants produce a range of chemicals known as volatile organic compounds that influence their interactions with the world around them. In a new study, researchers at the University of Illinois Urbana-Champaign investigated how the type and amount of these VOCs change based on different features of tomato plants.

The smell of cut grass is one of the defining fragrances of summer. Smells like that are one of the ways plants signal their injury. Because they cannot run away from danger, plants have evolved to communicate with each other using chemical signals. They use VOCs for a variety of reasons: to help prepare their own defenses, to warn each other of threats, to recruit beneficial soil microbes that can help plants grow, and to alert insect predators that there is a pest chewing on that plant’s leaves.

“When a caterpillar chews on a leaf, the plant sends out a signal that calls out to the caterpillar’s predators. It’s like a billboard that tells them where lunch is,” said Erinn Dady, a graduate student in the Ngumbi lab.

Studying the factors that influence VOC emissions, therefore, is key to understanding plant health. In the past, other studies have looked at how soil microbes like arbuscular mycorrhizal fungi or caterpillars or the variety of tomato plant can influence VOCs. In the current study, the researchers studied the collective influence of all these factors on plant chemistry using four tomato varieties—two heirlooms and two hybrids.

“Previous studies looked at tomato varieties that are grown conventionally at a massive scale for processing, and are not usually grown by small farmers, so we decided to ask Illinois farmers what they grow. Based on their feedback, we chose tomato varieties that are commonly grown in central Illinois,” Dady said. The hybrids used were Mountain Fresh and Valley Girl, and the organic heirlooms were Amish Paste and Cherokee Purple.

The researchers compared the responses of untreated plants to those that had been exposed to AMF, caterpillars, or both. They studied the VOCs by enclosing the eight-week-old tomato plants with an odor-blocking oven bag for an hour. They drew out the air around the plants and analyzed the different chemicals produced by each plant using gas chromatography-mass spectrophotometry.

The AMF and the caterpillars, separately, decreased the volatile emissions in all four varieties of tomato plants. Their effect when present together was minimal compared to the effects when either one was present.

Although it is unclear why the beneficial fungal associations decreased the VOCs, it is concerning that the plants were not as responsive to the caterpillars. Furthermore, the hybrid tomatoes emitted lower quantities of volatiles compared to the heirloom tomatoes. “Heirloom tomatoes—the big, juicy tomatoes we all love—are bred for flavor. Meanwhile, hybrids are grown for large scale conventional production, which comes at a cost to the plant,” said Esther Ngumbi (CIS/MMG), an assistant professor of integrative biology. “Our work suggests that we are compromising plant defenses through our breeding processes.”

The plants were also evaluated based on their growth both above the ground and in the soil. The researchers found that plants that had associations with the fungi had higher leaf biomass and more complex root structures.

“AMF form partnerships in over 80% of the land plants, setting up a trade where the fungi extract nutrients from the soil in exchange for carbon from plants,” Dady said. “We found that, especially in Cherokee Purple, AMF may confer additional benefits, including enhanced growth and greater emission of VOCs.”

Surprisingly, the plants that were treated with caterpillars had greater plant growth. “These plants had more biomass in both their roots and above the ground, which seems counterintuitive because they’ve actively been eaten. I would assume they would have less biomass,” Dady said. “It is possible that the caterpillars triggered a growth response, similar to how you prune a tree to make it produce new growth.”

The researchers are interested in further investigating the growth response to caterpillars. “It’s possible that the plants decided that the number of caterpillars we were using were not sufficient to be considered a threat and that’s why they kept growing. It is also possible that the caterpillars weren’t hungry enough to cause enough damage,” Ngumbi said.

“There’s a lot going on behind the scenes that we don’t yet understand. For example, we are barely scratching the surface in understanding the role of different microbes,” Dady said. “People tend to think that plants are not intelligent, but our studies have shown that they are actively responding to the environment around them using chemistry.”

“We are trying to spread the gospel of plant chemistry, it’s the language plants use to communicate and we are excited to learn more,” Ngumbi said.

The study “Plant Variety, Mycorrhization, and Herbivory Influence Induced Volatile Emissions and Plant Growth Characteristics in Tomato” was published in the Journal of Chemical Ecology and can be found at https://doi.org/10.1007/s10886-023-01455-w. The work was funded by the University of Illinois Urbana-Champaign.

 

Fast-charging lithium battery seeks to eliminate ‘range anxiety’


Peer-Reviewed Publication

CORNELL UNIVERSITY





ITHACA, N.Y. – Cornell University engineers have created a new lithium battery that can charge in under five minutes – faster than any such battery on the market – while maintaining stable performance over extended cycles of charging and discharging.

The breakthrough could alleviate “range anxiety” among drivers who worry electric vehicles cannot travel long distances without a time-consuming recharge.

“Range anxiety is a greater barrier to electrification in transportation than any of the other barriers, like cost and capability of batteries, and we have identified a pathway to eliminate it using rational electrode designs,” said Lynden Archer, professor of engineering and dean of Cornell’s College of Engineering, who oversaw the project. “If you can charge an EV battery in five minutes, I mean, gosh, you don’t need to have a battery that’s big enough for a 300-mile range. You can settle for less, which could reduce the cost of EVs, enabling wider adoption.”

The team’s paper, “Fast-Charge, Long-Duration Storage in Lithium Batteries,” published in Joule. The lead author is Shuo Jin, a doctoral student in chemical and biomolecular engineering.

Lithium-ion batteries are among the most popular means of powering electric vehicles and smartphones. The batteries are lightweight, reliable and relatively energy-efficient. However, they take hours to charge, and lack the capacity to handle large surges of current.

The researchers pinpointed indium as an exceptionally promising material for fast-charging batteries. Indium is a soft metal, mostly used to make indium tin oxide coatings for touch-screen displays and solar panels.

The new study shows indium has two crucial characteristics as a battery anode: an extremely low migration energy barrier, which sets the rate at which ions diffuse in the solid state; and a modest exchange current density, which is related to the rate at which ions are reduced in the anode. The combination of those qualities – rapid diffusion and slow surface reaction kinetics – is essential for fast charging and long-duration storage.

“The key innovation is we’ve discovered a design principle that allows metal ions at a battery anode to freely move around, find the right configuration and only then participate in the charge storage reaction,” Archer said. “The end result is that in every charging cycle, the electrode is in a stable morphological state. It is precisely what gives our new fast-charging batteries the ability to repeatedly charge and discharge over thousands of cycles.”

That technology, paired with wireless induction charging on roadways, would shrink the size – and the cost – of batteries, making electric transportation a more viable option for drivers.

However, that doesn’t mean indium anodes are perfect, or even practical.

“While this result is exciting, in that it teaches us how to get to fast-charge batteries, indium is heavy,” Archer said. “Therein lies an opportunity for computational chemistry modeling, perhaps using generative AI tools, to learn what other lightweight materials chemistries might achieve the same intrinsically low Damkƶhler numbers. For example, are there metal alloys out there that we’ve never studied, which have the desired characteristics? That is where my satisfaction comes from, that there’s a general principle at work that allows anyone to design a better battery anode that achieves faster charge rates than the state-of-the art technology.”

The research was supported by the U.S. Department of Energy Basic Energy Sciences Program through the Center for Mesoscale Transport Properties, an Energy Frontiers Research Center. The researchers made use of the Cornell Center for Materials Research, which is supported by the National Science Foundation’s Materials Research Science and Engineering Center program.

For additional information, see this Cornell Chronicle story.

Cornell University has dedicated television and audio studios available for media interviews.

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Chemists use the blockchain to simulate over 4 billion chemical reactions essential to the origins of life


CELL PRESS



Cryptocurrency is usually “mined” through the blockchain by asking a computer to perform a complicated mathematical problem in exchange for tokens of cryptocurrency. But in research appearing in the journal Chem on January 24, a team of chemists have repurposed this process, asking computers to instead generate the largest network ever created of chemical reactions which may have given rise to prebiotic molecules on early Earth.

This work indicates that at least some primitive forms of metabolism might have emerged without the involvement of enzymes, and it shows the potential to use blockchain to solve problems outside the financial sector that would otherwise require the use of expensive, hard to access supercomputers.

“At this point we can say we exhaustively looked for every possible combination of chemical reactivity that scientists believe to had been operative on primitive Earth,” says senior author Bartosz A. Grzybowski (http://grzybowski-group.net/default.asp) of the Korea Institute for Basic Science and the Polish Academy of Sciences.

To generate this network, the researchers chose a set of starting molecules likely present on early Earth, including water, methane, and ammonia, and set rules about which reactions could occur between different types of molecules. They then translated this information into a language understandable by computers and used the blockchain to calculate which reactions would occur over multiple expansions of a giant reaction network.

“The computer takes the primordial molecules and the accepted prebiotic chemistries. We coded it into the machine, and then we released it onto the world,” says Grzybowski.

Grzybowski’s team worked with chemists and computer-specialists at Allchemy, a company that uses AI for chemical synthesis planning, to generate the network using Golem, a platform that orchestrates portions of the calculations over hundreds of computers across the world, which receive cryptocurrency in exchange for computing time.

The resulting network, termed NOEL for the Network of Early Life, started off with over 11 billion reactions, which the team narrowed down to 4.9 billion plausible reactions. NOEL contains parts of well-known metabolic pathways like glycolysis, close mimics of the Krebs cycle, which organisms use to generate energy, and syntheses of 128 simple biotic molecules like sugars and amino acids.

Curiously, of the 4.9 billion reactions generated, only hundreds of reaction cycles could be called “self-replicating,” which means that the molecules produce additional copies of themselves. Self-replication has been postulated to be central to the emergence of life, but the vast majority of its known manifestations require complex macromolecules like enzymes.   

“Our results mean that with only small molecules present, self-amplification is a rare event. I don’t think that this type of self-replication was operative on primitive earth, before larger molecular structures were somehow formed,” says Grzybowski. “We see emergence of primitive metabolism, but we don’t see self-replication, so maybe self-replication appeared later in evolution.”

“If you asked me two years ago, I’d be thinking we’d need years for this type of work,” says Grzybowski. “But for a fraction of the cost, in two or three months, we finished a task of 10 billion reactions, 100k times bigger than we did previously.”

This work not only advances what we know about early prebiotic chemistry, but it also demonstrates how science can be made more accessible to researchers at smaller universities and institutions.

“Our system of education is based on elite universities mostly in the western world. It’s very hard for the developing world to even compete with these universities because they don’t have access to supercomputers,” says Grzybowski. “But if you can distribute computing in this way for a fraction of the cost, you can give other people opportunities to play.”

While the network generated in this work was performed on hundreds of computers around the world, Grzybowski suggests that this method can be used at institutions without having to pay out cryptocurrency tokens to the computers performing the calculations.

“With a platform like Golem you can connect your institution’s network and harness the entire idle power of its computers to perform calculations,” says Grzybowski. “You could create this computing infrastructure without any capital expenditure.”

Grzybowski hopes that repurposing the blockchain in this way can revolutionize the way we perform large scale calculations across the world and change how we see the value of cryptocurrency.

“I hope people in computer science can figure out how can we tokenize cryptocurrencies in some way that can benefit global science,” says Grzybowski. “Maybe society could be happier about using cryptocurrencies, if you could tell people that in the process we could discover new laws of biology or some new cancer drug,” says Grzybowski.

###

Development of all codes and algorithms described in this work described was supported by internal funds of Allchemy, Inc. and Golem Factory, GmbH. Analysis of pathways and writing of the paper by Bartosz Grzybowski was supported by the Institute for Basic Science, Korea. Grzybowski has no financial stake in Golem although he is a stakeholder of Allchemy. Additional information about declarations of interest can be found in the paper.

Chem, Roszak et al. “Emergence of metabolic-like cycles in blockchain-orchestrated reaction networks” https://cell.com/chem/fulltext/S2451-9294(23)00611-3

Chem (@Chem_CP) is the first physical science journal published by Cell Press. A sister journal to Cell, Chem, which is published monthly, provides a home for seminal and insightful research and showcases how fundamental studies in chemistry and its sub-disciplines may help in finding potential solutions to the global challenges of tomorrow. Visit https://www.cell.com/chem. To receive Cell Press media alerts, contact press@cell.com

 

Syphilis-like diseases were already widespread in America before the arrival of Columbus


Peer-Reviewed Publication

UNIVERSITY OF BASEL

Skeleton at the site in Jubuicabeira II, Brazil. 

IMAGE: 

SKELETON AT THE SITE IN JUBUICABEIRA II, BRAZIL.

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CREDIT: PHOTO: DR. JOSE FILIPPINI





Researchers at the Universities of Basel and Zurich have discovered the genetic material of the pathogen Treponema pallidum in the bones of people who died in Brazil 2,000 years ago. This is the oldest verified discovery of this pathogen thus far, and it proves that humans were suffering from diseases akin to syphilis – known as treponematoses – long before Columbus’s discovery of America. The new findings, published in the scientific journal Nature, call into question previous theories concerning the spread of syphilis by the Spanish conquistadors.

The history of the emergence and spread of infectious diseases was of great importance for global health even before the Covid-19 pandemic. With modern laboratory methods, researchers can now detect the tiniest traces of DNA from pathogens in prehistoric finds. That means they can trace back how these pathogens spread historically and their evolutionary development.

An international research group led by Professor Verena SchĆ¼nemann from the University of Basel, formerly at the University of Zurich, in collaboration with ETH Zurich and the Universities of Vienna and Sao Paulo, examined prehistoric bones belonging to four individuals who died 2,000 years ago in the coastal region of Santa Caterina in Brazil. For some of the individuals visible pathological changes to the prehistoric bones were detected which could indicate that the deceased were suffering from an illness similar to syphilis.

Prehistoric DNA from bones dating over 2,000 years old

The researchers used dentists’ drilling tools to remove minuscule samples of bone under sterile conditions. From those samples they isolated prehistoric genetic material (ancient DNA) belonging to the syphilis pathogen. Their study, published in the renowned scientific journal Nature, demonstrates that all the bacterial genomes that have been investigated can be attributed to the Treponema pallidum endemicum strain – that is, the pathogen that leads to bejel.

Treponematoses are a group of infectious diseases that includes the sexually transmitted disease syphilis. While syphilis as a venereal disease presents a global health risk, bejel, which is spread by skin contact, only occurs today in very arid regions of Africa and Asia.

“Our study has been able to show that endemic syphilis was already present in humid zones of Brazil around 2,000 years ago,” says SchĆ¼nemann. This means that people were already becoming infected with endemic syphilis, probably via skin contact, more than 1,000 years before the arrival of Columbus in the New World.

Syphilis-like diseases originated pre-Columbus

Intense debates are still ongoing today among specialists and medical historians concerning whether Christopher Columbus’s sailors and soldiers brought sexually transmitted syphilis from the New World to the Old upon their return in 1492. The illness spread rapidly from the end of the 15th century onwards, particularly in harbor towns.

“The fact that the findings represent an endemic type of treponemal diseases, and not sexually transmitted syphilis, leaves the origin of the sexually transmitted syphilis still unsettled,” says Kerttu Majander, postdoctoral researcher at the University of Basel and one of the lead authors of the study. However, the authors consider that there is a lot to suggest that treponematoses were already widespread in Europe before Columbus’s time.

“As we have not found any sexually transmitted syphilis in South America, the theory that Columbus brought syphilis to Europe seems to appear more improbable,” agrees SchĆ¼nemann. In point of fact, earlier discoveries by her group, for example in Finland and Poland, suggest that some forms of treponematoses already existed in Europe too.

Recombination could have driven the development of syphilis-like diseases

Many species of bacteria exchange traits that are of evolutionary benefit via what is known as horizontal gene transfer, or recombination. A comparison between the prehistoric DNA in the bones from Brazil and today’s pathogens shows that such recombination events have indeed taken place. “We cannot pinpoint exactly when this exchange took place, but it is probably one of the driving mechanisms in the divergence between the subspecies that cause different treponemal infections,” says Marta Pla-DĆ­az of the University of Basel, the other lead author of the study.

The DNA comparison also allows the date of the Treponema pallidum family’s emergence to be deduced. Their investigations show that these pathogens have arisen at some point between 12,000 and 550 BCE. The history of these pathogens therefore stretches much further back than previously assumed.

“Although the origin of syphilis still leaves room for imagination, at least we now know beyond a doubt that treponematoses were no strangers to the American inhabitants who lived and died centuries before the continent was explored by Europeans,” concludes SchĆ¼nemann. She and her team are confident that advances in the analysis of prehistoric DNA could also lead to the discovery of the origin of venereal syphilis.