Wednesday, February 15, 2023

Does risk for heart disease start before birth?

A new American Heart Association scientific statement summarizes the intergenerational impact of prepregnancy heart health

Peer-Reviewed Publication

AMERICAN HEART ASSOCIATION

Statement Highlights:

  • The time before pregnancy is considered a critical life period for impacting the cardiovascular health of pregnant individuals and the children born to them.
  • The biological processes leading to pregnancy complications often begin before pregnancy; therefore, interventions that begin after someone becomes pregnant may miss the opportunity to alter the trajectory of cardiovascular risk for either the pregnant individual or their child.
  • The statement suggests increasing public health and research efforts to optimize pre-pregnancy cardiovascular health, particularly among people who are part of historically underrepresented racial and ethnic groups.

Embargoed until 1 p.m. CT / 2 p.m. ET Monday, Feb. 13, 2023

DALLAS, Feb. 13, 2023 — Preventing heart disease starts much earlier than you may realize,  according to a new American Heart Association scientific statement published today in a Go Red For Women spotlight issue of the Association’s flagship, peer-reviewed journal Circulation.

The statement, “Optimizing Prepregnancy Cardiovascular Health to Improve Outcomes in Pregnant and Postpartum Individuals and Their Offspring,” summarizes the available data connecting a woman’s heart health ― including the physical, environmental and cognitive experiences in childhood and young adulthood ― to the health of the children born to her. It also highlights the need for more research and for public health interventions to support improving women’s heart health throughout life.

“The biological processes that contribute to adverse pregnancy outcomes begin before a person is pregnant,” said Sadiya S. Khan, M.D., M.Sc., FAHA, chair of the scientific statement writing group and an assistant professor of medicine (cardiology) and preventive medicine (epidemiology) at Northwestern University’s Feinberg School of Medicine in Chicago. “Therefore, it is necessary to focus on optimizing cardiovascular health before pregnancy. The data indicate cardiovascular health has an intergenerational relationship. The time prior to pregnancy is a critical life stage that affects the health of the person who becomes pregnant, and the children born to them.”

The status of prepregnancy health:

The key factors to measure cardiovascular health are based on the American Heart Association’s Life’s Essential 8, which includes a heart-healthy diet, regular physical activity, nonsmoking; healthy weight, blood pressure, blood cholesterol, and blood sugar; and healthy sleep. Using Life’s Essential 8 to assess cardiovascular health in the Unites States, researchers found that just 1 in 5 people in the U.S. ages 2 and older have optimal cardiovascular health.

Low levels of pre-pregnancy cardiovascular health are associated with several pregnancy complications, such as preterm birth, gestational diabetes, high blood pressure, preeclampsia or giving birth to an infant who is small for gestational age. These pregnancy complications are also linked to higher risk for cardiovascular disease among the offspring, according to the latest research:

  • Being born preterm is associated with a 53% higher risk for heart disease by age 43.
  • Having Type 2 diabetes before becoming pregnant is associated with a 39% higher risk of cardiovascular disease among offspring by age 40.

Critical research gap

Despite the evidence linking an individual’s pre-pregnancy health to their offspring’s health, there are no large trials with enough people and data to test whether improving overall cardiovascular health before pregnancy will reduce pregnancy complications, pregnancy-related cardiovascular death or cardiovascular risk for offspring.

“If a research trial focused on cardiovascular health before pregnancy successfully reduced pregnancy complications and improved the mother’s and child’s cardiovascular health, it could be practice-changing,” Khan said.

Future research direction

New studies to address the research gap in maternal cardiovascular health need to be carefully planned to include people from diverse racial and ethnic backgrounds who are underrepresented in clinical trials. The incidence of pregnancy complications and cardiovascular disease is disproportionately higher among people from diverse racial and ethnic groups, and this needs to be better understood.

The statement also suggests that research on preventing or treating cardiovascular disease should investigate lifestyle changes like heart-healthy diet and physical activity in pregnant individuals, as well as strategies with medications known to be safe during pregnancy.

Psychological health, stress and resilience also need to be considered in optimizing cardiovascular health. Importantly, interventions are needed for women from groups who have been historically excluded from public health and research that are sensitive to the psychosocial stress of racial discrimination. Research shows that long-term stressors like continuing episodes of discrimination are associated with unfavorable cardiovascular health and a higher risk of pregnancy complications. Culturally responsive stress reduction and mindfulness-based interventions may offer a means to buffer stress from these lived experiences.

Community and policy

Community-based interventions are crucial to improving health equity among all individuals before pregnancy, especially for people from historically marginalized races and ethnicities who often face multiple barriers to optimal health. In addition, the influence of structural and social determinants of health requires interventions that change society more broadly, such as policies affecting health systems, education, income, housing and food supply.

“There is substantial opportunity to improve health across the life course and for multiple generations by improving pre-pregnancy cardiovascular health. However, the responsibility is one that should be embraced by all of us, not placed solely on individual women,” Khan said. “The pre-pregnancy period offers a unique window of opportunity to equitably address the increased incidence of adverse pregnancy outcomes, and to interrupt and improve the intergenerational relationship of poor cardiovascular health by focusing on individual-, community- and policy-level solutions.”

This scientific statement was prepared by the volunteer writing group on behalf of the American Heart Association’s Council on Epidemiology and Prevention; the Council on Clinical Cardiology; the Council on Cardiovascular and Stroke Nursing; the Council on Arteriosclerosis, Thrombosis and Vascular Biology; the Council on Hypertension; the Council on Lifestyle and Cardiometabolic Health; the Council on Peripheral Vascular Disease; and the Stroke Council. American Heart Association scientific statements promote greater awareness about cardiovascular diseases and stroke issues and help facilitate informed health care decisions. Scientific statements outline what is currently known about a topic and what areas need additional research. While scientific statements inform the development of guidelines, they do not make treatment recommendations. American Heart Association guidelines provide the Association’s official clinical practice recommendations.

Co-authors are Holly Gooding, M.D., M.Sc., vice chair; LaPrincess C. Brewer, M.D., M.P.H.; Mary M. Canobbio, R.N., M.N., FAHA; Marilyn J. Cipolla, Ph.D., FAHA; William A. Grobman, M.D., M.B.A.; Jennifer Lewey, M.D., M.P.H.; Erin D. Michos, M.D., M.H.S.; Eliza C. Miller, M.D.; Amanda M. Perak, M.D., M.S., FAHA; and Gina S. Wei, M.D., M.P.H., FAHA. Authors’ disclosures are listed in the manuscript.

The Association receives funding primarily from individuals. Foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers, and the Association’s overall financial information are available here.

Additional Resources:

About the American Heart Association

The American Heart Association is a relentless force for a world of longer, healthier lives. We are dedicated to ensuring equitable health in all communities. Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public’s health and share lifesaving resources. The Dallas-based organization has been a leading source of health information for nearly a century. Connect with us on heart.org, Facebook, Twitter or by calling 1-800-AHA-USA1.

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JOURNAL

Circulation

DOI

10.1161/CIR.0000000000001124 

ARTICLE TITLE

Optimizing prepregnancy cardiovascular health to improve outcomes in pregnant and postpartum individuals and offspring: A scientific statement from the American Heart Association

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