Friday, June 20, 2025

 

More smokers quit after big hike in California tobacco tax


When tobacco taxes go up, more people quit, especially when the increase is big




University of California - San Diego





Researchers from University of California San Diego and UC San Francisco have found that Proposition 56, a major tobacco tax increase that was overwhelmingly approved by California voters in 2016, was associated with a significant increase in smoking cessation over the next three years. The study, published in the Journal of the National Cancer Institute, also reported significant differences in state tobacco spending and the proportion of people smoking daily.

“California’s tax increase was over 200%, and tobacco companies largely passed the increase on to their customers,” said Shu-Hong Zhu, Ph.D., a professor at the Herbert Wertheim School of Public Health and Human Longevity Science at UC San Diego and lead author of the study. “The resulting price hike likely motivated a lot of smokers to quit.”

Though the health impacts are well known, in 2022, 49.2 million (19.8%) — or nearly 1 in 5 — U.S. adults reported actively using tobacco. One strategy that many states have used to incentivize people to stop smoking is to increase taxes on tobacco products.

California Proposition 56 increased the state tobacco tax by $2 per cigarette pack, and much of the additional revenue generated through the tax was funneled back into the state’s tobacco prevention efforts.

To analyze the impact of the tax, the researchers utilized data from the Behavioral Risk Factor Surveillance System at the U.S. Centers for Disease Control and Prevention to determine smoking cessation rates before and after the tax. Cessation rate, also known as quit rate, was defined as the percentage of survey respondents who smoked within the last year, but had quit for at least three months.

They found that:

  • The three-month quit rate in California increased from 11.5% in the three years prior to the passage of Proposition 56 to 14.2% in the three years after.
  • Smoking quit rates were nearly unchanged in the 18 other states (including the District of Columbia) that raised their tobacco taxes at least once during the study period.
  • In the 32 states that did not raise tobacco taxes, quit rates declined significantly, from 9.5% to 9.0%.
  • California saw a 271.9% increase in tobacco prevention spending per capita in the study period. In contrast, other states that raised taxes saw a 12.8% decrease in spending, while states that did not raise taxes saw an 11.2% decrease.
  • Even among those who did not quit, the percentage of daily smokers decreased.

The researchers hypothesize that the large increase in cessation in California is a result of the price change in cigarettes after the tax. In the three years following Proposition 56, the average price of cigarettes in California was 30.8% higher than in the three years before the initiative passed, after adjusting for inflation. In contrast, prices only increased by 6.3% on average across the 18 other states that raised their taxes.

However, the researchers also note that these two factors are interrelated, so it’s difficult to parse out the precise reason for the change.

“We don’t know what’s more responsible for the increase in quitting in California, whether it’s the tax increase itself or the increased spending on prevention that the tax enabled,” added Zhu.

Either way, the results in California are promising and speak to the impact of tobacco tax increases on public health.

“Many Californians have advocated for years to increase the tobacco tax and shore up funding for tobacco prevention,” said Michael Ong, M.D., Ph.D., a professor of medicine and health policy and management at UCLA and chair of the Tobacco Education and Research Oversight Committee, which advises the California Tobacco Prevention Program. “This study shows one of the many ways we are reaping the rewards of that effort in California — by meaningfully increasing successful quitting.”

On the other hand, the researchers suggest that the results from other states offer a cautionary message: that creating meaningful change in tobacco usage requires a significant commitment by state governments.

“Raising tobacco excise taxes is one of the main public health tools for reducing smoking prevalence,” Zhu explained. “But to achieve a measurable increase in quitting on a population level, you may have to go big.”

Read the full study.

Additional study authors include Christopher Anderson and Yue-Lin Zhuang at UC San Diego Moores Cancer Center, Hai-Yen Sung at the Institute of Health and Aging at UC San Francisco, and Anthony Gamst at the Computational and Applied Statistics Laboratory in the San Diego Supercomputer Center and Department of Mathematics at UC San Diego.

This research was funded by the California Department of Public Health (contract #CDPH-22-1008).

Disclosures: The authors report no competing interests

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Smoking leaves lasting mark on teeth, research reveals


Researchers from Northumbria University have discovered that smokers have tell-tale signs of their smoking habits ingrained deep within their teeth, which remain even after a person has quit



Northumbria University

Example of smoking damage in an archaeological tooth. The magnified image shows variations in the tooth's cementum rings from smoking 

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Example of smoking damage in an archaeological tooth. The magnified image shows variations in the tooth's cementum rings caused by smoking

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Credit: Dr Ed Schwalbe, Northumbria University





Evidence of the permanent impact of smoking on people’s teeth has been uncovered by researchers for the first time. 

Researchers from Northumbria University have discovered that smokers have tell-tale signs of their smoking habits ingrained deep within their teeth, which remain even after a person has quit. 

Their findings, which are now published in the scientific journal PLOS One, could help to shine new insights on forensic and historical investigations. 

Teeth consist of three main hard tissues: enamel, dentine and cementum. Cementum, which covers the tooth root, develops characteristic “rings” that grow each year as we age – much like tree rings. 

The research team had initially set out to see if these rings could be used to predict the age of an individual in a forensic setting, such as identifying disaster victims or for situations when an individual’s DNA is not on a DNA database. 

After examining a total of 88 teeth provided by both living dental patients and from archaeological remains, they were surprised to find signs of disruption in the cementum rings of some teeth, but not in others. 

The disruption appeared as variations in the thickness and regularity of the rings within the teeth. 

The researchers realised that these disruptions were associated with those who had identified as current or ex-smokers. 

Their study revealed evidence of smoking damage in the teeth of 70% of ex-smokers and 33% of current smokers, compared to just 3% of non-smokers. 

They also found that the cementum is thicker in ex-smokers. They believe this is a result of the cementum returning to its normal levels when smoking ceases, leaving ‘stronger’ deposits on top of the damaged rings which makes them thicker, whereas current smokers continue to have disruption to their cementum levels. 

“Our research shows that it’s possible to tell if someone was a smoker just by examining their teeth,” said Dr Ed Schwalbe, Associate Professor in Northumbria University’s Department of Applied Sciences

“We found that the regular annual deposition of rings was disrupted for some individuals and realised that these disruptions were associated with current or ex-smokers, but were very rare in non-smokers.” 

Forty-six individuals who were undergoing dental treatment requiring tooth extraction consented to take part in the study, providing 70 teeth between them along with their medical and smoking histories.  

Notably, the researchers found smoking damage in one of the teeth provided by a living donor which they estimated to have occurred between the ages of 22 and 41.  

On checking the information provided, they found that the donor, who was aged 58 at the time of tooth extraction, was a smoker during that period. They had begun smoking when they were 28 years old and stopped at the age of 38. 

Dr Schwalbe and Dr Valentina Perrone worked with Dr Sarah Inskip, UKRI Fellow at the University of Leicester’s School of Archaeology and Ancient History, to sample a further 18 teeth from archaeological remains dating from 1776-1890.

Evidence of the age, biological sex and date of death was available for 13 of the 18 teeth provided.  

Some of the archaeological teeth bore clear evidence of smoking activity, displaying staining and even notches from pipe smoking. 

Remarkably, cementum analysis of the archaeological samples revealed that the rings within the teeth of smokers who died in the 18th and 19th centuries displayed the same signs of disruption as those from living donors who were current or ex-smokers.  

The findings could prove to be especially important for forensic science and historical studies in future, added Dr Schwalbe. 

“This could help us learn more about people’s lifestyles in the past, especially in archaeological studies where patterns of tobacco use can reveal important cultural insights,” he said.

 “The identification of 'smoking damage' in archaeological teeth opens up further avenues to understand how the long-term consumption of tobacco in populations has affected our health through time,” added Dr Inskip, who leads the Tobacco, Health and History Project which looks at the long-term consequences of tobacco use on health between 1600-1900.

“By looking at growth rings in the teeth, we can also estimate a person’s age when the tooth was removed, or when they died,” said Dr Schwalbe. “Together, this information could help identify unknown individuals – such as disaster victims or those buried in mass graves – and offer new tools for forensic and historical investigations.” 

Cementochronology – the study of what is more formally known as acellular extrinsic fibre cementum (AEFC) – has been widely used to estimate age at death and conditions such as pregnancy or disease, but this is believed to be the first time it has been used to predict tobacco use. 

Dr Valentina Perrone, who is now working as a Research Assistant at Leicester University, added: “We compared the cemental deposition of smokers, ex-smokers and non-smokers visually and statistically to identify irregularities that were potentially connected to smoking activity. We found that individuals with a history of smoking – whether as a current or former smoker – were significantly more likely to have disruption to their cementum than those who did not.  

“Smoking is known to have a systemic impact on the body and numerous studies have highlighted the correlation between smoking, peridontitis and tooth loss. This study shows, for the first time, the biological record of smoking-related oral health damage within the dental structure.” 

The paper, Reconstructing smoking history through dental cementum analysis – a preliminary investigation on modern and archaeological teeth is now published in PLOS One

 

The ‘Montreal Model’ of ketamine therapy yields more sustained depression relief



McGill-led study could reshape how this novel treatment is delivered in hospitals and clinics




McGill University

Montreal Ketamine Clinic at the Jewish General Hospital 

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The Montreal Ketamine Clinic at the Jewish General Hospital is decorated with soft lighting and greenery for patient comfort.

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Credit: McGill University





A first-of-its-kind clinical trial found that ketamine’s benefits for treating severe depression can be improved when combined with psychotherapy and supportive treatment environments.

Led by researchers at McGill University, the study suggests this approach can yield valuable therapeutic experiences that lead to longer-lasting relief than standard treatment.

The study enrolled patients with chronic, treatment-resistant depression, most of which were experiencing suicidal thoughts and struggling with other mental health conditions.

Patients’ depression scores dropped by an average of about 30 per cent, and both suicidal thoughts and anxiety improved significantly by the end of the four-week intervention. Unlike typical ketamine treatments, where benefits tend to fade within days, participants’ improvement lasted for at least eight weeks.

“Ketamine has been called the most exciting antidepressant innovation in decades but major questions remain about how it works,” said lead author Dr. Kyle Greenway, Assistant Professor in McGill’s Division of Social and Transcultural Psychiatry and a researcher at the Lady Davis Institute for Medical Research.

The study was co-led by Dr. Nicolas Garel, Assistant Professor at the University of Montreal and psychiatrist at the Centre hospitalier de l'Université de Montréal, who added: “As ketamine clinics emerge in hospitals and private retreats across Canada, there’s also an urgent need for more standardized treatment models.”

Unwanted side effect or source of healing?

Ketamine, an anesthetic medication increasingly used for its fast-acting antidepressant properties, can cause altered perceptions, a distorted sense of time, out-of-body sensations and many other mind-bending effects. In this study, participants who rated their sessions as particularly emotional or mystical saw the greatest improvements.

While often dismissed as side effects, these experiences may actually be central to the healing process, the researchers say.

“There’s been a lot of debate about whether the unusual experiences that ketamine induces are part of what makes it effective, similar to ‘classical’ psychedelic drugs like psilocybin,” Greenway said. “The study is the first to strongly link certain aspects of ketamine experiences to its benefits in severe depression.”

Prioritizing patients’ experiences

In the randomized trial, 32 adults received ketamine infusions in rooms with soft lighting and plants, and either curated music or guided mindfulness, depending on group assignment. They also received weekly psychotherapy sessions.

“We know that how people feel in the room can shape how they respond to treatment,” said Greenway. “Most of our patients have spent years in clinical settings. Creating a space that feels safe enough to allow for psychological exploration during ketamine treatments may be part of what made this approach so effective.”

The Montreal Ketamine Clinic at the Jewish General Hospital is decorated with soft lighting and greenery for patient comfort.

The ‘Montreal Model’

The treatment approach used in the study – known as the Montreal Model – was developed by Dr. Greenway and Dr. Garel during their psychiatry residencies at McGill, under the supervision of Dr. Stephane Richard-Devantoy and a wide network of collaborators. Dr. Greenway and Dr. Garel both now direct ketamine-therapy programs in academic hospitals in Montreal.

The Montreal Model blends traditional psychiatry with strategies developed for psychedelic therapies. It is increasingly being applied in and private healthcare services in Canada and internationally.

“Our study shows that our approach not only yields more durable relief, but that it can be implemented safely and effectively in real-world, resource-lean public healthcare settings that care for patients who are much more complex than those typically enrolled in clinical studies,” said Greenway. “It could bring some order and structure to a field that’s currently a bit of a Wild West.”

The research team recently hosted the first training session on the Montreal Model of ketamine therapy for 80 healthcare professionals from around the world at McGill’s Jewish General Hospital.

About the study

The Music for Subanesthetic Infusions of Ketamine randomised clinical trial: ketamine as a psychedelic treatment for highly refractory depression” Kyle Greenway, Nicolas Garel and Stéphane Richard-Devantoy et al. was published in the British Journal of Psychiatry.

This study was funded by the Réseau québécois sur le suicide, les troubles de l’humeur et les troubles associés, and supported by the Jewish General Hospital Foundation.

US Car dealers don’t rip off subprime borrowers


Rather than exploiting buyers with low credit scores, dealers lose an average of $301 arranging loans to them




University of Texas at Austin

Car Dealers Don’t Rip Off Subprime Borrowers 

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Research from Texas McCombs Associate Professor of Finance Samuel Kruger finds that rather than exploiting buyers with low credit scores, dealers lose an average of $301 arranging loans to them.

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Credit: The University of Texas at Austin McCombs School of Business

 

Websites are tracking you via browser fingerprinting




Texas A&M University




Clearing your cookies is not enough to protect your privacy online. 

New research led by Texas A&M University found that websites are covertly using browser fingerprinting — a method to uniquely identify a web browser — to track people across browser sessions and sites.

“Fingerprinting has always been a concern in the privacy community, but until now, we had no hard proof that it was actually being used to track users,” said Dr. Nitesh Saxena, cybersecurity researcher, professor of computer science and engineering and associate director of the Global Cyber Research Institute at Texas A&M. “Our work helps close that gap.”

When you visit a website, your browser shares a surprising amount of information, like your screen resolution, time zone, device model and more. When combined, these details create a “fingerprint” that’s often unique to your browser. Unlike cookies — which users can delete or block — fingerprinting is much harder to detect or prevent. Most users have no idea it’s happening, and even privacy-focused browsers struggle to fully block it.

“Think of it as a digital signature you didn’t know you were leaving behind,” explained co-author Zengrui Liu, a former doctoral student in Saxena’s lab. “You may look anonymous, but your device or browser gives you away.”

This research marks a turning point in how computer scientists understand the real-world use of browser fingerprinting by connecting it with the use of ads.

“While prior works have studied browser fingerprinting and its usage on different websites, ours is the first to correlate browser fingerprints and ad behaviors, essentially establishing the relationship between web tracking and fingerprinting,” said co-author Dr. Yinzhi Cao, associate professor of computer science and technical director of the Information Security Institute at Johns Hopkins University.

To investigate whether websites are using fingerprinting data to track people, the researchers had to go beyond simply scanning websites for the presence of fingerprinting code. They developed a measurement framework called FPTrace, which assesses fingerprinting-based user tracking by analyzing how ad systems respond to changes in browser fingerprints. This approach is based on the insight that if browser fingerprinting influences tracking, altering fingerprints should affect advertiser bidding — where ad space is sold in real time based on the profile of the person viewing the website — and HTTP records — records of communication between a server and a browser. 

“This kind of analysis lets us go beyond the surface,” said co-author Jimmy Dani, Saxena’s doctoral student. “We were able to detect not just the presence of fingerprinting, but whether it was being used to identify and target users — which is much harder to prove.”

The researchers found that tracking occurred even when users cleared or deleted cookies. The results showed notable differences in bid values and a decrease in HTTP records and syncing events when fingerprints were changed, suggesting an impact on targeting and tracking.

Additionally, some of these sites linked fingerprinting behavior to backend bidding processes — meaning fingerprint-based profiles were being used in real time, likely to tailor responses to users or pass along identifiers to third parties. 

Perhaps more concerning, the researchers found that even users who explicitly opt out of tracking under privacy laws like Europe’s General Data Protection Regulation (GDPR) and California’s California Consumer Privacy Act (CCPA) may still be silently tracked across the web through browser fingerprinting.

Based on the results of this study, the researchers argue that current privacy tools and policies are not doing enough. They call for stronger defenses in browsers and new regulatory attention on fingerprinting practices. They hope that their FPTrace framework can help regulators audit websites and providers who participate in such activities, especially without user consent. 

This research was conducted in collaboration with Johns Hopkins University and presented at the ACM Web Conference (WWW) 2025.

Funding for this research is administered by the Texas A&M Engineering Experiment Station (TEES), the official research agency for Texas A&M Engineering.

By Texas A&M University College of Engineering

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Hey Doc, you got something for snails?



Studying tiny parasites in Japanese sea cucumbers




Kyoto University

Hey Doc, you got something for snails? 

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Holothuria leucospilota discharging Cuvierian tubules from its anus, and parasitic Melanella snails in and on Holothuria leucospilota

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Credit: Illustration by Mari Nakano





Kyoto, Japan -- Sea cucumbers spend their lives prowling the ocean floor, scavenging for food and generally minding their own business. We can see snails leading similar lives, slimy but not bothering anyone.

Yet some species of tiny sea snails are a bother: they are common parasites of sea cucumbers. Extensive taxonomic research has been conducted on these host-parasite interactions in Japan, where sea cucumbers are a seafood delicacy -- for humans.

Despite these previous studies, however, local species richness still contains some unknowns. Parasites of the sea cucumber species Holothuria atra have been thoroughly investigated, but those of Holothuria leucospilota have not. This is likely because this latter species discharges Cuvierian tubules as a defense mechanism when stressed, making them difficult to dissect.

Motivated to learn more, a team of researchers at Kyoto University has now conducted a comprehensive sampling of Melanella snails parasitizing H. leucospilota in Shirahama, a beach resort in central Wakayama prefecture. They anesthetized the sea cucumbers using menthol to prevent discharge of the tubules, and after examining both internal and external parasites, the scientists were able to differentiate the parasitic snails based on their shell morphology and mitochondrial DNA.

The team found four species of snail parasites: two on the exterior and two more inside the host's body cavity. Molecular analysis identified one of the external parasites as M. spina, the first ever case recorded in Japan. The two inside remain unidentified.

"Our results represent the first record of eulimids exploiting the internal habitat of H. leucospilota," says corresponding author Tomoyuki Nakano. "To the best of our knowledge, it is also the first record of a single holothurian species, like sea cucumbers, being utilized by both external and internal Melanella parasites."

The researchers noted that the infection rates of the two internal Melanella species must be extremely low in Shirahama. Though the team found two parasitic snails inside sea cucumber bodies in 2022, the following two years they did not encounter these parasites in any of the sea cucumbers studied.

The snails' invasion routes into the hosts' body cavities, meanwhile, remain unknown, but the team has some promising clues. Both snails were found around the mouth, with previous research suggesting a strong tendency of other Melanella species to attach to the outer surface around their hosts' mouths. It is possible the tiny snails were taken into the body cavity -- even passively along with sediment -- when the host retracted its mouth.

This seems likely, but it is not the only possibility. Another specimen of one of the unidentified Melanella species partly buried its shell into the hosts body wall, suggesting it may be able to invade the host by penetrating its body. This mystery of the parasitic snails' invasion route is what the research team hopes to decipher next.

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The paper "Co-occurrence of gastropods of the genus Melanella (Mollusca: Eulimidae) parasitizing the black sea cucumber Holothuria leucospilota in central Japan: Implications for their geographic distribution and parasitic ecology" appeared on 18 June 2025 in Zoological Science, with doi: 10.2108/zs250003

About Kyoto University

Kyoto University is one of Japan and Asia's premier research institutions, founded in 1897 and responsible for producing numerous Nobel laureates and winners of other prestigious international prizes. A broad curriculum across the arts and sciences at undergraduate and graduate levels complements several research centers, facilities, and offices around Japan and the world. For more information, please see: http://www.kyoto-u.ac.jp/en

Study finds that foreign multinational firms engage in limited tax-motivated income shifting out of the United States




Carnegie Mellon University





Income shifting by multinational firms has been researched extensively, yet few studies have examined foreign-owned businesses shifting income out of the United States. In a new study, Jim Albertus at Carnegie Mellon University evaluated the impact of tax incentives on foreign-owned U.S. businesses’ income shifting, employment, and investment decisions. He found that foreign multinational firms engage in a modest degree of tax-motivated income shifting out of the United States. The results inform the potential effects of the “Revenge Tax” provisions of the June 2025 tax bill under consideration in the U.S. Congress.

The study is published in The Review of Financial Studies.

“I analyzed the implementation of controlled foreign corporation rules,” explains Albertus, Assistant Professor of Finance at Carnegie Mellon’s Tepper School of Business, who conducted the study. “The results indicate that foreign multinational firms shift a modest amount of income out of the U.S. for tax reasons, and this income shifting in turn supports a modest amount of employment and investment in the United States.”

Research on income shifting out of the United States by foreign multinational firms is limited for two reasons. First, company-level data on foreign multinationals’ U.S. operations are not publicly available. To address this challenge, Albertus assembled a comprehensive, confidential data set of the U.S. operations of foreign multinational firms.

The panel includes information from each subsidiary’s income statement and balance sheet, and was constructed from responses to mandatory surveys conducted by the Bureau of Economic Analysis. The study used these data to evaluate how the U.S. subsidiaries of foreign multinational firms report income and operate in the United States. 

Second, studying foreign firms’ income shifting out of the United States requires variation in firms’ incentives to engage in this activity. Changes in U.S. federal tax policy apply to all firms, leaving no control group. Albertus addressed this and other challenges by considering the staggered implementation of foreign countries’ controlled foreign corporation rules, which provided a natural control group and allowed analysis of tax incentives for income shifting by foreign-owned U.S. businesses.

Albertus finds that foreign multinational firms primarily rely on tax-motivated transfer pricing to shift income out of the United States. Additional results suggest that foreign-owned U.S. businesses do not typically engage in earnings stripping, in which intracompany loans are used to shift income.

When foreign tax policy changes inhibited income shifting, foreign-owned U.S. subsidiaries’ investment and employment declined by modest amounts. The results indicate that the U.S. economy has limited exposure to tax policies set abroad through foreign direct investment in the United States.

The study received financial support from New York University’s Stern Center for Global Economy and Business.