Thursday, November 06, 2025

Increased avoidance learning in chronic opioid users



JAMA Psychiatry



About The Study: 

The findings of this study confirm that negative reinforcement is a core mechanism in opioid addiction, which is well established in preclinical research but less represented in treatment. Importantly, it is not limited to the later stages of addiction but is even observed after regular opioid use, potentially contributing to the development of addiction, which may have important implications for the development of more effective preventive and therapeutic interventions. 




Corresponding Author: To contact the corresponding author, Karen D. Ersche, PhD, email ke220@cam.ac.uk.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(10.1001/jamapsychiatry.2025.3271)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Media advisory: This study is being presented at the annual conference of the Society for the Study of Addiction.

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EU awards an €8.33m ERC research grant for project How can we learn to live on Earth in new ways?



Universitat Autonoma de Barcelona
Principal investigators 

image: 

Principal investigators of the project during a hike in the Spanish Pyrenees. 

(Left- right)
Esteve Corbera, Jun Borras, Ian Scoones and Anna Tsing

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Credit: LAND project





Professors Jun Borras, Esteve Corbera, Ian Scoones and Anna Tsing, working at universities in the Netherlands, Spain, the UK and Denmark, have been awarded an €8.33 million European Research Council (ERC) Synergy Grant for their five-year project, Land and Life in the Anthropocene: Landscape reform (LAND). The project asks a pressing question: How can we learn to live on Earth in new ways?   

The innovation of the project is to move from land reform to landscape reform, that is, liveable and justice-based transformations for more-than-human life. LAND starts from the recognition that economies, politics, social and natural worlds are deeply interconnected.  

Working across four diverse landscapes – in the Colombian Amazon, southern African savannas, Mediterranean plains and coastal Southeast Asia – LAND researchers will explore how land, livelihoods and ecosystems can be reshaped to support both people and the planet.   

Quote Evaluation report ERC-Synergy panel  
‘LAND is an excellent proposal for research that addresses some of the most pressing scientific challenges of the time.’ 


Examining four layers 

Working across four diverse landscapes – the Colombian Amazon, southern African savannas, Mediterranean plains and coastal Southeast Asia – the LAND researchers will explore how land, livelihoods and ecosystems can be reshaped to support both people and the planet.  

At its core, LAND connects four intersecting layers: Planet, Profit, Property and Partners. These ‘4 Ps’ reveal how global systems of power, production and profit influence whether and how more just, sustainable landscapes can emerge. Through the lens of ‘landscape reform’, LAND aims to inspire new thinking and action for living on earth in new ways. 

Innovative framework 

Only when humans, land and nature are deeply connected can true transformations emerge. The 4Ps framework decentres the classic Western separation between humans, land and nature, while at the same time pushing back against relying solely on a top-down ‘planetary’ perspective. Through engaged public action the project aims for approaches that are inclusive, grounded and shaped by the realities of people and places.   

Researchers sharing a common goal 

Conceived during a hike in the Spanish Pyrenees, LAND brings together four leading social scientists who combine ethnography, livelihoods research, action research and systems analysis.  

The ERC-Synergy panel praised the researchers’ exceptional complementarity and proven career trajectories, noting that the team has extensive research networks and established relationships within the project’s study sites. 

Quote Evaluation report ERC-Synergy panel 
‘The panel recognized the academic strength, complementarity, and proven track record of the [researchers], who bring together a remarkable assembly of expertise across anthropology, political ecology, agrarian studies/development studies, climate research, and multispecies studies.’

 

About the ERC Synergy Grant  

The European Research Council (ERC) Synergy Grants foster collaboration between outstanding researchers, enabling them to combine their complementary skills, knowledge and resources in new ways. This funding is part of the EU’s Horizon Europe research and innovation programme. 

 

About the researchers  

Jun Borras is Professor of Agrarian Studies at the International Institute of Social Studies (ISS) of Erasmus University Rotterdam (EUR), the Netherlands. 

Ian Scoones is Professor of Resource Politics and Environmental Change at the Institute of Development Studies (IDS), United Kingdom. 

Esteve Corbera is Professor of Ecological Economics and Political Ecology at the Institute of Environmental Science and Technology of the Universitat Autònoma de Barcelona (ICTA-UAB), Spain. 

Anna Tsing is Professor of Anthropology at Aarhus University and at the University of California, Santa Cruz, Denmark and US. 

 

Long-lived contrails usually form in natural ice clouds



Research team identifies common environmental conditions for the formation of contrails and provides initial insights into their impact on the climate



Johannes Gutenberg Universitaet Mainz

Contrails over Jülich 

image: 

Contrails over Jülich, embedded in very thin and therefore barely visible cirrus clouds

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Credit: Photo/©: Andreas Petzold




Long-lived contrails form predominantly not in cloud-free skies, but within already existing ice clouds. This is the conclusion reached by a team of scientists from Forschungszentrum Jülich, the University of Cologne, the University of Wuppertal, and Johannes Gutenberg University Mainz (JGU). Using extensive observational data, the researchers were able, for the first time, to systematically determine the atmospheric conditions under which long-lasting contrails form – whether in cloudless skies, in very thin and barely visible ice clouds, or in more clearly visible ice clouds, known as cirrus clouds. The result: more than 80 percent of all persistent contrails form within pre-existing clouds, mostly within natural cirrus clouds. The effects of this on the climate are not yet clearly understood. The study, now published in Nature Communications, provides important insights for further research – and, beyond that, strong arguments for taking cloud cover into account when planning flight routes adapted to climate considerations.

Effect of natural and man-made ice clouds on the climate

Contrails are a visible signature of daily air traffic in the sky. They form when the hot exhaust gases from aircraft engines mix with the cold air at an altitude of around ten kilometers. In dry air, most contrails dissipate quickly. In cold and humid air, however, they can persist for several hours and develop into extensive ice clouds or cirrus clouds. Cirrus clouds are thin ice clouds that occur at altitudes of about eight to twelve kilometers and often appear as fine, fibrous veils in the sky. The overall climate impact of these cirrus clouds formed from contrails is greater than that of the direct CO₂ emissions produced by air traffic.

The decisive factor for their climate impact is whether the man-made clouds form in a blue, cloudless sky or within existing natural cirrus clouds. High ice clouds, whether natural or man-made, exist at cold temperatures below -40°C. Although they often appear optically very thin, they can act like a blanket that prevents heat from escaping from the atmosphere into space, thereby contributing to the greenhouse effect. Only when the clouds are very dense and the sun is barely visible does the amount of sunlight reflected back into space become large enough to produce a cooling effect on the climate.

Accordingly, artificial clouds formed by contrails affect the climate differently depending on their environment: Under clear conditions – such as blue skies or very thin cirrus clouds – they tend to contribute to warming, because they trap some of the Earth's radiation that would otherwise escape into space, while allowing sunlight to pass through. In dense, clearly visible cirrus clouds, however, the opposite effect can occur: Contrails reflect more sunlight than they absorb heat radiation, leading to a slight cooling effect. How exactly contrails and natural cirrus clouds influence each other is still poorly understood.

"Our results show that we need to take a more differentiated view of the climate impact of contrails in the future," says Professor Andreas Petzold from the Institute of Climate and Energy Systems – Troposphere (ICE-3) at Forschungszentrum Jülich. "If most persistent contrails occur within natural clouds anyway, it might be more effective to plan climate-relevant flight routes not only according to clear skies but also with regard to existing ice cloud structures."

For the study, the research team used measurement data on temperature and water vapor collected by commercial aircraft flying over the North Atlantic between 2014 and 2021. These aircraft are part of the European research infrastructure IAGOS (In-service Aircraft for a Global Observing System, https://www.iagos.org/), which is co-coordinated by Forschungszentrum Jülich. IAGOS aircraft are equipped with instruments that continuously collect atmospheric data during scheduled operations – something unique worldwide.

Mainz contribution to the study: model calculations of radiative forcing

The data evaluation was supplemented by model calculations on radiative forcing. "Our analysis shows that contrails in thick cirrus clouds actually have hardly any effect," says Professor Peter Spichtinger from JGU, who contributed this aspect to the study. "However, additional effects in more complex scenarios – such as those arising from multiple layers of contrails and cirrus clouds on top of each other – are difficult to estimate and will be investigated in more detail in the future."

The results of the study are being incorporated into ongoing international activities of the World Meteorological Organization (WMO), the International Civil Aviation Organization (ICAO), the European Aviation Safety Agency (EASA), and the aviation industry. The goal is to develop a sustainable flight-planning strategy to reduce climate-relevant contrails by designing flight routes with climate impact in mind. IAGOS aircraft will continue to play a key role in evaluating such strategies in the future.