It’s possible that I shall make an ass of myself. But in that case one can always get out of it with a little dialectic. I have, of course, so worded my proposition as to be right either way (K.Marx, Letter to F.Engels on the Indian Mutiny)
Wednesday, April 01, 2020
Jerry Falwell Jr seems to want credit from Trump for drinking his coronavirus Kool-Aid: op-ed March 31, 2020 By Sky Palma
Liberty University president Jerry Falwell Jr. has reopened the school’s campus in the midst of the coronavirus pandemic. Now, according to a report from the New York Times, “nearly a dozen” students at the evangelical school have developed symptoms similar to those of COVID-19 as of this Friday, with at least one student testing positive for the virus.
Falwell, an avid Trump supporter, has consistently downplayed the severity of the pandemic, even insisting at one point that attempts to control its spread are nothing more than a plot to undermine Donald Trump’s presidency. Writing in the Washington Post this Monday, Michael Gerson contends Falwell Jr’s response to the crisis “indicates the staggering level of ignorance” that informs his leadership skills, as evidenced by the “constant churn of mixed messages that Falwell has contributed to our national debate.” “Who is Falwell serving instead of students, parents, staff, his board and the Lynchburg, Va., community?” Gerson writes. “Let’s see. Falwell has contempt for the weak. He is dismissive of experts. He traffics in conspiracy theories. He attacks his critics with infantile putdowns and demeaning names. And he refuses to admit when he is dangerously wrong.”
“Falwell has laid down the cross to follow Trump,” he concludes.
Marriott says new data breach affects 5.2 million guests
by Dee-Ann Durbin
Marriott says guests' names, loyalty account information and other personal details may have been accessed in the second major data breach to hit the company in less than two years.
Marriott said Tuesday approximately 5.2 million guests worldwide may have been affected. The information taken may have included names, addresses, phone numbers, birthdays, loyalty information for linked companies like airlines and room preferences. Marriott said it's still investigating but it doesn't believe credit card information, passport numbers or driver's license information was accessed.
Marriott said it noticed an unexpected amount of guest information was accessed at the end of February using the login credentials of two employees at a franchised property. The company said it believes the activity began in mid-January.
Marriott has disabled those logins and is assisting authorities in their investigation. The company didn't say whether the employees whose logins were used were suspected.
In November 2018, Marriott announced a massive data breach in which hackers accessed information on as many as 383 million guests. In that case, Marriott said unencrypted passport numbers for at least 5.25 million guests were accessed, as well as credit card information for 8.6 million guests. The affected hotel brands were operated by Starwood before it was acquired by Marriott in 2016.
The FBI led the investigation of that data theft, and investigators suspected the hackers were working on behalf of the Chinese Ministry of State Security, the rough equivalent of the CIA.
Marriott said Tuesday it has informed guests of the new data breach. The Bethesda, Maryland-based company is offering affected guests free enrollment in a personal information monitoring service for up to one year.
"Marriott also remains committed to further strengthening its protections to detect and remediate incidents such as this in the future," the company said in a statement.
A new approach brings the hope of new therapeutic options for suppressing seasonal influenza and avian flu. On the basis of an empty and therefore non-infectious shell of a phage virus, researchers from Berlin have developed a chemically modified phage capsid that stifles influenza viruses.
Perfectly fitting binding sites cause influenza viruses to be enveloped by the phage capsids in such a way that it is practically impossible for them to infectlung cells. This phenomenon has been proven in preclinical trials using human lung tissue. Researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Freie Universität Berlin, Technische Universität Berlin (TU), Humboldt-Universität (HU), the Robert Koch Institute (RKI) and Charité-Universitätsmedizin Berlin report that the results are also being used for the immediate investigation of the coronavirus. The findings have now been published inNature Nanotechnology.
Influenza viruses are still highly dangerous. The World Health Organization (WHO) estimates that flu is responsible for up to 650,000 deaths per year worldwide. Current antiviral drugs are only partially effective because they attack the influenza virus after lung cells have been infected. It would be desirable—and much more effective—to prevent infection in the first place.
This is exactly what the new approach from Berlin promises. The phage capsid, developed by a multidisciplinary team of researchers, envelops flu viruses so perfectly that they can no longer infect cells. "Pre-clinical trials show that we are able to render harmless both seasonal influenza viruses and avian flu viruses with our chemically modified phage shell," explained Professor Dr. Christian Hackenberger, Head of the Department Chemical Biology at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Leibniz Humboldt Professor for Chemical Biology at HU Berlin. "It is a major success that offers entirely new perspectives for the development of innovative antiviral drugs."
Multiple bonds fit like Velcro
The new inhibitor makes use of trivalent receptors on the surface of the influenza virus, referred to as hemagglutinin protein, that attach to sugar molecules (sialic acids) on the cell surfaces of lung tissue. In the case of infection, viruses hook into their victim—in this case, lung cells—like a hook-and-loop fastener. The core principle is that these interactions occur due to multiple bonds, rather than single bonds.
It was the surface structure of flu viruses that inspired the researchers to ask the following initial question more than six years ago: Would it not be possible to develop an inhibitor that binds to trivalent receptors with a perfect fit, simulating the surface of lung tissue cells?
They found that this is indeed possible with the help of a harmless intestinal inhabitant: The Q-beta phage has the ideal surface properties and is excellently suited to equip it with ligands—in this case, sugar molecules—as "bait." An empty phage shell does the job perfectly. "Our multivalent scaffold molecule is not infectious, and comprises 180 identical proteins that are spaced out exactly as the trivalent receptors of the hemagglutinin on the surface of the virus," explained Dr. Daniel Lauster, a former Ph.D. student in the Group of Molecular Biophysics (HU) and now a postdoc at Freie Universität Berlin. "It therefore has the ideal starting conditions to deceive the influenza virus—or, to be more precise, to attach to it with a perfect spatial fit. In other words, we use a phage virus to disable the influenza virus!"
To enable the Q-beta scaffold to fulfill the desired function, it must first be chemically modified. Produced from E. coli bacteria at TU Berlin, Professor Hackenberger's research group at FMP and HU Berlin use synthetic chemistry to attach sugar molecules to the defined positions of the virus shell.
Virus is deceived and enveloped
Several studies using animal models and cell cultures have proven that the suitably modified spherical structure possesses considerable bond strength and inhibiting potential. The study also enabled the Robert Koch Institute to examine the antiviral potential of phage capsids against many current influenza virus strains, and even against avian flu viruses. Its therapeutic potential has even been proven on human lung tissue, as fellow researchers from the Medical Department, Division of Infectiology and Pneumology, of Charité were able to show: When tissue infected with flu viruses was treated with the phage capsid, the influenza viruses were practically no longer able to reproduce.
The results are supported by structural proof by FU scientists from the Research Center of Electron Microscopy (FZEM): High-resolution cryo-electron microscopy and cryo-electron microscopy show directly and spatially that the inhibitor completely encapsulates the virus. In addition, mathematical-physical models were used to simulate the interaction between influenza viruses and the phage capsid on the computer. "Our computer-assisted calculations show that the rationally designed inhibitor does indeed attach to the hemagglutinin, and completely envelops the influenza virus," confirmed Dr. Susanne Liese from the AG Netz of Freie Universität Berlin. "It was therefore also possible to describe and explain the high bond strength mathematically."
Therapeutic potential requires further research
These findings must now be followed up by more preclinical studies. It is not yet known, for example, whether the phage capsid provokes an immune response in mammals. Ideally, this response could even enhance the effect of the inhibitor. However, it could also be the case that an immune response reduces the efficacy of phage capsids in the case of repeated-dose exposure, or that flu viruses develop resistances. And, of course, it has yet to be proven that the inhibitor is also effective in humans.
Nonetheless, the alliance of Berlin researchers is certain that the approach has great potential. "Our rationally developed, three-dimensional, multivalent inhibitor points to a new direction in the development of structurally adaptable influenzavirus binders. This is the first achievement of its kind in multivalency research," emphasized Professor Hackenberger. The chemist believes that this approach, which is biodegradable, non-toxic and non-immunogenic in cell culture studies, can in principle also be applied to other viruses, and possibly also to bacteria. It is evident that the authors regard the application of their approach to the current coronavirus as one of their new challenges. The idea is to develop a drug that prevents coronaviruses from binding to host cells located in the throat and subsequent airways, thus preventing infection.
More information: Daniel Lauster et al, Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry, Nature Nanotechnology (2020). DOI: 10.1038/s41565-020-0660-2
By its very definition, essential means "something necessary, indispensable, or unavoidable".
When it comes to dealing with the COVID-19 pandemic, there are no recent precedents for governments. There is no pre-determined list in place on what is an essential service. Instead, "essential" appears a moving beast that is constantly evolving and that can be confusing.
Confused messages
On March 22 the Victorian premier Daniel Andrews called for "a shutdown of all non-essential activity" within 48 hours. Supermarkets, banks and pharmacies were some of the things he said were essential but he did not provide an exhaustive list of what was considered an essential service.
Naturally confusion reigned. For example, in the rural Victorian town of Ballan, some stores closed while others remained open.
We've now seen a number of retailers decide to voluntarily shutter stores for the safety of their workers and the public, considering their businesses "non-essential".
On Sunday, Prime Minister Scott Morrison said a meeting of the national cabinet had agreed to a raft of new restrictions, such as limiting "shopping for what you need, food and other essential supplies".
But he also described his wife's recent purchase of a number of jigsaw puzzles for the family as "absolutely essential". While toy and hobby retailers may find comfort in this statement, in reality such businesses may not be considered "essential".
Guns and pastries, essential?
There are differences too overseas in what people consider essential as part of any COVID-19 restrictions.
Is the United States, it's recommended employees of gun stores and gun manufacturers should be seen as "essential" workers, according to a memo from the Department of Homeland Security.
While in Europe, "necessities" are said to include Belgian Fries, French Baguettes and Dutch Cannabis. In France, it's also shops specialising in pastries, wine and cheese reportedly declared essential businesses.
In Ireland, reports say the government there has issued a detailed list of what it considers "essential workers". As for essential retailers, they include pharmacies, fuel stations and pet stores, but not opticians, motor repair and bicycle repair outlets.
The essential essentials
Here in Australia there is broad agreement supermarkets, service stations, allied health (pharmacy, chiropractic, physiotherapy, psychology, dental) and banks are essential business and services.
Similarly freight, logistics and home delivery are also considered essential. Australia Post says posties and delivery drivers continue but some posts offices are temporarily closed.
Some bottle shops can stay open but many are now imposing restrictions on how much people can buy.
The government has moved to progressively add more business, services and activities to its "non-essential services" list.
This includes cafés, food courts, pubs, licensed clubs (sports clubs), bars, beauty and personal care services, entertainment venues, leisure and recreation (gyms, theme parks), galleries, museums and libraries.
Some of these entities do have exceptions. A café can remain open for take-away only. A hairdresser or barber can trade if they comply with the one person per four square-metre rule.
Others remain convoluted, such as outdoor and indoor markets (farmers markets), which are a decision for each state and territory.
In and out of work
In reality, no worker should ever be considered, or consider themselves, as "non-essential".
But due to how the restrictions have been broadly applied, some workers in one industry may now find themselves out of a job, while others in that same industry remain fully employed.
Take for example chefs. Due to bans on restaurants and licensed clubs, chefs there are being stood down, but chefs inside hotels can continue to cook and provide room service meals.
A barista in a café can still be gainfully employed, as long as they only make take-away coffee, but a barista inside a licensed sports club, is unfortunately stood down.
Further restrictions and essentials
While we have seen many businesses reduce their operations and several retailers voluntarily close their doors, many are standing by waiting for further announcements to potentially close all "non-essential" services.
What should the government consider before deciding what is and isn't regarded as essential?
Some decisions are easy: we need health workers, police, fire fighters and other emergency services workers, and we need those who maintain services to the public such as food supply, clean water, sewerage and so on.
But we also need those services required to keep these people functioning. The military describe this as tooth to tail ratio: the number of people required to keep any soldier on the battlefield (estimated up to three for every soldier).
In the civilian context this includes those responsible for the supply of consumables, personal protection equipment, transport, power, fuel, computer systems, and someone to look after their families while they do the heavy lifting. Luxembourg imposes more virus restrictions Provided by The Conversation
'Tequila' powered biofuels more efficient than corn or sugar University of Sydney
Blue agave (Agave tequilana) Credit: University of Sydney
The agave plant used to make tequila could be established in semi-arid Australia as an environmentally friendly solution to Australia's transport fuel shortage, a team of researchers at the University of Sydney, University of Exeter and University of Adelaide has found.
The efficient, low-water process could also help produce ethanol for hand sanitiser, which is in high demand during the COVID-19 pandemic.
In an article published this week in the Journal of Cleaner Production, University of Sydney agronomist Associate Professor Daniel Tan with international and Australian colleagues have analysed the potential to produce bioethanol (biofuel) from the agave plant, a high-sugar succulent widely grown in Mexico to make the alcoholic drink tequila.
The agave plant is now being grown as a biofuel source on the Atherton Tablelands in Far North Queensland by MSF Sugar, and it promises some significant advantages over existing sources of bioethanol such as sugarcane and corn, Associate Professor Tan said.
"Agave is an environmentally friendly crop that we can grow to produce ethanol-based fuels and healthcare products," said Associate Professor Tan from the Sydney Institute of Agriculture.
"It can grow in semi-arid areas without irrigation; and it does not compete with food crops or put demands on limited water and fertiliser supplies. Agave is heat and drought tolerant and can survive Australia's hot summers."
Associate Professor Tan assembled the research team and led its economic analysis.
Lead author Dr. Xiaoyu Yan from the University of Exeter, who led the lifecycle assessment, said: "Our analysis highlights the possibilities for bioethanol production from agave grown in semi-arid Australia, causing minimum pressure on food production and water resources.
Associate Professor Daniel Tan is an agronomist at the Sydney Institute of Agriculture and the School of Life and Environmental Sciences at the University of Sydney. Photographed here in front of blue agave in north Queensland. Credit: University of Sydney
"The results suggest that bioethanol derived from agave is superior to that from corn and sugarcane in terms of water consumption and quality, greenhouse gas emissions, as well as ethanol output."
This study used chemical analyses of agave from a pilot agave farm in Kalamia Estate, Queensland (near Ayr) undertaken by Dr. Kendall Corbin for her University of Adelaide Ph.D., supervised by Professor Rachel Burton.
"It is fabulous that the results of my chemical analysis can be used in both an economic and environmental footprint study and have real-world applications", Dr. Corbin said.
"The economic analysis suggests that a first generation of bioethanol production from agave is currently not commercially viable without government support, given the recent collapse in the world oil price," Associate Professor Tan said. "However, this may change with the emerging demand for new ethanol-based healthcare products, such as hand sanitisers."
"This is the first comprehensive lifecycle assessment and economic analysis of bioethanol produced from a five-year agave field experiment in north Queensland. Our analysis shows a bioethanol yield of 7414 litres a hectare each year is achievable with five-year-old agave plants."
The study found that sugarcane yields 9900 litres a hectare each year. However, agave outperforms sugarcane on a range of measures, including freshwater eutrophication, marine ecotoxicity and—crucially—water consumption.
Agave uses 69 percent less water than sugarcane and 46 percent less water than corn for the same yield. For US corn ethanol, the yield was lower than agave, at 3800 litres a hectare a year.
"This shows agave is an economic and environmental winner for biofuel production in the years to come," Associate Professor Tan said.
More information: Xiaoyu Yan et al, Agave: A promising feedstock for biofuels in the water-energy-food-environment (WEFE) nexus, Journal of Cleaner Production (2020). DOI: 10.1016/j.jclepro.2020.121283
'Pandemic drones': Useful for enforcing social distancing, or for creating a police state?
The Federal Bureau of Investigation (FBI) used drones to capture
scenes from the 2017 Black Lives Matter protests in Baltimore. Credit: FBI / ACLU
People in Western Australia may soon see more than birds in the sky, as the state's police force has announced plans to deploy drones to enforce social distancing. The drones will visit parks, beaches and cafe strips, ensuring people comply with the most recent round of gathering rules.
As COVID-19 restrictions tighten around the world, governments are harnessing the potential of drones. From delivering medical supplies, to helping keep people indoors—drones can do a lot in a pandemic.
It's clear drones are helping combat COVID-19, as governments use them to control and monitor.
But these measures may be difficult to rollback once the pandemic passes. And safeguards will be needed to prevent unwanted surveillance in the future.
Drone use: clever, quirky and sometimes concerning
With cities on lockdown, drones have shown uncanny images of emptied urban landscapes from Wuhan and metros across the globe.
Social distancing has inspired some quirky uses by individuals, including walking the dog and asking for a date.
But the main game has been about control. China is using drones to enforce quarantine rules and deter gatherings that violate social distancing rules.
One viral video showed a drone scolding an elderly woman for not wearing a mask. In some cases, traffic police and municipal officials used drones fitted with speakers to order people home and break up mahjong games.
Flying at high altitudes, drones can help police and other officials monitor large areas to identify those violating restrictions. Similar tactics are being used in Madrid and Nice, with talk of deployment in many other places.
A defense for the 'good drone'?
There are huge advantages in sending drones into disaster zones such as bushfires, or remote landscapes for search and rescue. Pilots can safely stream crucial vision from a drone's optical and thermal cameras.
Like all technologies, the question with drones should be about how they are used. For instance, inspecting the breached nuclear reactor at Fukushima with drones is sensible. But embedding systems of control that can be turned against civilians is its own disaster in the making.
Normalising surveillance
With high definition and infrared images streamed to command stations, China's drones may be able to use facial recognition to identify specific individuals using its Social Credit System, and fine them for indiscretions.
This level of social control may be appealing in a pandemic that could cost millions of lives. But it could also have chilling effects on social and political life.
Surveillance tools typically work best for social control when people know they are being watched. Even in liberal societies, people might think twice about joining climate or racial justice protests if they know they'll be recorded by a drone overhead.
Feeling like you're constantly being watched can can create a kind of atmospheric anxiety, particularly for marginalized groups that are already closely monitored because of their religion or welfare status.
Putting more drones in the sky raises concerns about trust, privacy, data protection and ownership. In a crisis, those questions are often ignored. This was clear after 9/11, when the world learned the lessons of surveillance systems and draconian national security laws.
A team at the University of South Australia is currently designing a "pandemic" drone to detect virus symptoms such as fever and coughing from a distance. Valuable as that is now, this tool could easily be used to intrusively manage the public's health after the crisis is over.
It can be difficult to see the long term impacts of choices made in an emergency. But now is the best time for policymakers to set limits on how drones an be used in public space.
They need to write sunset clauses into new laws so that surveillance and control systems are rolled back once the pandemic eases, and create accountability mechanisms to ensure oversight.
Researchers take another step closer to mind-reading computer
by Bob Yirka , Medical Xpress The decoding pipeline. Credit: Nature Neuroscience (2020). DOI: 10.1038/s41593-020-0608-8
A team of researchers at the University of California, San Francisco, has taken another step toward the development of a computer able to decipher speech in the human mind. In their paper published in the journal Nature Neuroscience, the group describes their approach to using AI systems to read and translate human thoughts. Gregory Cogan with Duke University has published a News & Views piece outlining the work by the team in California in the same journal issue.
Over the past century, people have wondered if it might be possible to create a machine that could read the human mind. Such ideas have most often been expressed in movies where scientists try to read the mind of a spy or terrorist. Recently, such systems have come to be seen as a possible way for people with speech disability to communicate. The advent of artificial intelligence, and more specifically neural networks, has brought the possibility ever closer, with machines able to read brain waves and translate some of them into words. In this new effort, the research team has taken the idea a step forward by developing a system able to decipher whole sentences.
The work by the team involved developing a more advanced AI system and recruiting the assistance of four women with epilepsy—each of whom had been fitted with brain-implanted electrodes to monitor their condition. The researchers used readings from the electrodes to capture brain signals in different parts of their brain as the women read sentences out loud. The data from the electrodes was sent to a neural network that processed the information linked certain brain signals to words as they were being processed and spoken by the volunteer. Each of the sentences was spoken twice by each of the volunteers, but only the first was used for training the neural network—the second was used for testing purposes. After processing the brain signal data, the first neural network sent the results to a second neural network that tried to form sentences from them.
The researchers found that their system had a best-case scenario error rate of just 3%. But they note that it was also working with a very limited vocabulary of just 250 words—far fewer than the hundreds of thousands that most humans are able to recognize. But they suggest it might be enough for someone who cannot speak any words at all.
More information: Joseph G. Makin et al. Machine translation of cortical activity to text with an encoder–decoder framework, Nature Neuroscience (2020). DOI: 10.1038/s41593-020-0608-8
Jason Kenney Claims Many Albertans at Risk of Eviction Are Involved in Vandalism or Growing Marijuana
Recently laid off workers are struggling to make rent after losing jobs thanks to the coronavirus pandemic and crashing oil prices
March 24, 2020
Facing a deadly pandemic and crashing oil prices, Alberta Premier Jason Kenney appeared to downplay the possibility that many newly unemployed workers will have trouble making ends meet.
“Mr. Premier, you’ve talked about the government looking into what it can do to protect people from evictions,” one reporter asked. “We’re now eight days away from April 1, is there any movement on that? Will the government ban evictions?”
Kenney’s response?
“Well, first of all, there is a significant backlog on evictions and we are considering a potential short-term stay on enforcement of evictions, but please note that most of the eviction orders that would currently be in the system predate the COVID crisis.
Many of them would be renters who have not paid their rent for several months or who have been engaged in criminal activity or vandalism or operating grow-ops. Landlords need to be able to continue to protect the value of their property from bad tenants …”
Contrary to Kenney’s claims, PressProgress has spoken to a number of newly unemployed workers in Alberta who say their landlords are refusing to show any flexibility on rent deadlines.
Karen, a Calgary renter who recently lost her job due to the coronavirus pandemic, said her landlord is refusing to grant an extension on rent: “I’ve been in this house 10 years and paid rent early every month for 10 years. I want to pay rent in full, I just need an extension.”
Karen said she is currently “trying to eat only one meal a day to save money.”
Another renter in Edmonton named Megan told PressProgress that both she and her roommate “got laid off from both our jobs due to the COVID-19 problems.”
Megan said she asked her landlord about “delaying rent until at least June or July as we will both be out of work for at least three months,” but her landlord said “no and rent is still to proceed as normal.”
To date, only the provincial governments of Ontario and Quebec have issued evictions bans, while the BC government has banned evictions in subsidized housing units.
Hand sanitizer has an expiration date. Does it matter amid coronavirus outbreak?
by Mark Price
Credit: CC0 Public Domain
The Food and Drug Administration just pointed out something about bottles of hand sanitizer people are hoarding during the coronavirus pandemic: They have an expiration date.
It's likely few notice the fine print while grabbing handfuls off shelves in recent weeks. It's hard enough just to find a bottle lately.
Should we worry, given 86,000 Americans have been infected with COVID-19?
Good news: Adding some kind of expiration date is a standard on all over-the-counter drug products "unless they have data showing they are stable for more than three years," the agency said Thursday.
Bad news: "FDA does not have information on the stability or effectiveness of drug products past their expiration date."
So, if the expiration date on your hand sanitizer is pre-2017, you're gambling on effectiveness.
The chief concern, according to Healthline.com, is that alcohol is a key ingredient of handsanitizer and it evaporates when exposed to air. If the bottle is not airtight, the percentage of alcohol diminishes.
"The manufacturer estimates how long it will take for the percentage of the active ingredient to drop below 90% of the percentage stated on the label," Healthline.com says. "That time estimate becomes the expiration date."
The FDA is not offering advice on what to do with expired sanitizer, but emergency measures implemented to speed up production suggest the agency is willing to ignore expiration dates for the time being.
"Hand sanitizer produced under the temporary policies for hand sanitizer production and compounding may not have an expiration date listed because they are expected to be used during this public health emergency," the agency says.
Washing hands often with soap and water for at least 20 seconds is one way to stop the spread of the virus, according to the Centers for Disease Control and Prevention.
"If soap and water are not available, CDC recommends consumers use an alcohol-based hand sanitizer that contains at least 60% alcohol," the agency reports.
Meanwhile, "FDA recommends that consumers do not make their own hand sanitizer. If made incorrectly, hand sanitizer can be ineffective, and there have been reports of skin burns from homemade hand sanitizer."