Thursday, August 14, 2025

CRT FOR REAL

In once-redlined city neighborhoods, ambulances still lag behind



Rutgers University





In parts of cities once marked “hazardous” on federal housing maps, an ambulance is still more likely to show up late than in neighborhoods that bankers favored nearly a century ago, according to a national analysis of 236 urban areas.

Rutgers researchers found that 7.06 % of residents in historically redlined Grade D tracts (considered “hazardous”) lacked rapid access to emergency medical services compared with 4.36 % in Grade A tracts, a gap that held across every U.S. region.

The study in JAMA Network Open used modern traffic data, 2020 Census block groups and historic Home Owners’ Loan Corporation (HOLC) maps to trace drive times from 42,472 emergency medical service (EMS) stations. The researchers found that 2.2 million of the 41 million people (5.34%) living inside the mapped zones cannot count on an ambulance arriving within five minutes, the National Fire Protection Association’s benchmark for critical calls.

The odds of EMS response times exceeding 5 minutes were 67% higher in the “redlined” neighborhoods that fell in the lowest of HOLC’s four color-coded rankings nearly a century ago.

Lead author Cherisse Berry, a professor of surgery and vice chair of academic surgery at the Rutgers New Jersey Medical School in Newark, said the pattern shows how a New Deal lending program still shapes who survives a stroke or car crash.

“Location alone determines whether people get the rapid care that saves lives,” said Berry, who is also a trauma surgeon and director of research and trauma surgeon at University Hospital’s Eric Munoz Trauma Center.

Berry’s team overlaid today’s street grid on the color-coded HOLC grades, green for “best,” blue for “still desirable,” yellow for “declining” and red for “hazardous.” (The grades were mostly used in the 30s, but their usage was not outlawed until 1968.) The researchers then measured the distance from each census block’s population center to the nearest EMS station, adjusting for average driving speeds.

The persistent inequity between differently coded neighborhoods emerged everywhere, but it was starkest in the Great Lakes. Residents of redlined parts of cities there were nearly three times as likely to be beyond the five-minute reach of an ambulance.

The findings echo earlier work by the same group that mapped areas called “ambulance deserts,” but Berry said this study is the first to tie EMS inequities directly to redlining. Because delays before hospital arrival raise trauma mortality by 8% for every extra 10 minutes, members of the team argue that targeting EMS systems development and investing resources in EMS operations with health equity in mind could yield immediate health gains.

The researchers also compared demographic data and found that redlined tracts still hold more Black and Hispanic residents, higher population density and lower median incomes than their Grade A counterparts. These persistent inequities, the researchers said, reflect the historical racist housing policy of redlining–a political determinant of health that produced residential segregation, concentrated poverty, and community disinvestment–and a structural determinant of health that has shaped the distribution of resources and opportunities, leading to inequitable EMS access and enduring adverse health outcomes.

Berry said improving EMS equity will take more than adding stations: “It is time to dismantle the structural determinants of health that perpetuate preventable deaths. Historical redlining and other discriminatory policies have hardwired inequities into our emergency response systems, leaving racially and economically marginalized communities to wait longer for lifesaving care.

“We must redesign prehospital systems to achieve spatial justice–by embedding equity metrics into EMS policy, targeting investments to historically excluded neighborhoods, and holding agencies accountable for equitable access,” she added. “National and state health policy must treat equitable EMS access as a non-negotiable public health standard, ensuring that the zip code where someone is injured never determines whether they live or die.”

She and co-authors urge creating public dashboards, using geographic information system tools to reposition units, and adding equity metrics to certificate-of-need reviews.

Policy shifts could matter quickly in places where residents already face longer 911 wait times and higher rates of chronic illness. By shortening ambulance drives even a minute or two, Berry said, “we can cut mortality significantly.”

The study has limits beyond the usual note that correlation doesn’t prove causation. Most importantly, it models travel distance, not real-world response records that include dispatch delays, traffic or hospital hand-offs. Still, outside experts argue in an accompanying editorial that the work offers a road map for righting persistent wrongs.

 

Binge gaming was associated with depression, anxiety, and poor sleep, with boys more likely to report binge gaming than girls



PLOS
The roles of binge gaming in social, academic and mental health outcomes and gender differences: A school-based survey in Hong Kong 

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Binge gaming was associated with depression, anxiety, and poor sleep, with boys more likely to report binge gaming than girls, in Hong Kong survey of 2,592 children and adolescents.

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Credit: lalesh aldarwish, Pexels, CC0 (https://creativecommons.org/publicdomain/zero/1.0/)



Binge gaming was associated with depression, anxiety, and poor sleep, with boys more likely to report binge gaming than girls, in Hong Kong survey of 2,592 children and adolescents

Article URLhttp://plos.io/4moOETZ

Article title: The roles of binge gaming in social, academic and mental health outcomes and gender differences: A school-based survey in Hong Kong

Author countries: China

Funding: This work was supported by the Health and Medical Research Fund (HMRF) [#16171001] and [#17180791] and General Research Fund (GRF) [#14607319] and [#14609820]. HMRF and GRF had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.

 

North American monarch butterflies use magnetic fields to migrate to and from their overwintering sites - using cold temperatures to tune how they use magnetic fields - per experimental study, which might be disrupted under climate change





PLOS
Monarch butterflies (Danaus plexippus) only use magnetic cues for migratory directionality with orientation re-calibrated by coldness 

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Migratory monarch butterflies use magnetic field cues to guide them during migration and refuel during the trip by nectaring on flowers.

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Credit: Patrick A. Guerra, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)





North American monarch butterflies use magnetic fields to migrate to and from their overwintering sites - using cold temperatures to tune how they use magnetic fields - per experimental study, which might be disrupted under climate change

Article URLhttp://plos.io/4fhCt8X

Article title: Monarch butterflies (Danaus plexippus) only use magnetic cues for migratory directionality with orientation re-calibrated by coldness

Author countries: U.S.

Funding: The author(s) received no specific funding for this work.

Specially adapted drones successfully use a "tap and go" approach to apply monitoring tags to whales, speeding up the process and avoiding human interference




PLOS
Drone-based application of whale tags: A “tap-and-go” approach for scientific animal-borne investigations 

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Tagging method overview. A: Looking for whales. B: Launching the drone from the boat. C: Aligning the drone behind the whale prior to tag deployment. D: Tag deployment on the whale via “tap-and-go”. E: Drone return on the boat. F: Data recording on the whale. G: Tag retrieval. H: Data offload and tag reconditioning for the next deployment.

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Credit: Vogt et al., 2025, PLOS One, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)




Specially adapted drones successfully use a "tap and go" approach to apply monitoring tags to whales, speeding up the process and avoiding human interference

Article URLhttp://plos.io/4meypZo

Article title: Drone-based application of whale tags: A “tap-and-go” approach for scientific animal-borne investigations

Author countries: U.S., Dominica, Canada

Funding: This study was financially supported by Project CETI (https://www.projectceti.org) via Dalio Philanthropies (https://www.daliophilanthropies.org), OceanX (https://oceanx.org), Sea Grape Foundation (http://www.seagrapefoundation.org), Virgin Unite (https://unite.virgin.com) and Rosamund Zander/Hansjorg Wyss in the form of grants received by DFG, SG and RW through The Audacious Project: a collaborative funding initiative housed at TED (https://www.audaciousproject.org). This study was also financially supported by the National Geographic Society (https://www.nationalgeographic.org/society) in the form of a grant (NGS-72337T-20) received by DFG, SG and RW. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


Drone-based application of whale tags: A “tap-and-go” approach for scientific animal-borne investigations [VIDEO] |

 

Stalagmites in Mexican caves reveal duration and severity of drought during the Maya collapse




University of Cambridge
Stalagmites in Mexican caves reveal duration and severity of drought during the Maya collapse 

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Tourists explore the ‘Dome of the Cathedral’, the largest chamber in Grutas Tzabnah (Yucatán, Mexico), and the origin of Tzab06-1. The artificial well ‘La Noria’ now illuminates the cave. 

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Credit: Mark Brenner





A drought lasting 13 years and several others that each lasted over three years may have contributed to the collapse of the Classic Maya civilisation, chemical fingerprints from a stalagmite in a Mexican cave have revealed.

A detailed analysis of oxygen isotopes in the stalagmite allowed a team of researchers, led by the University of Cambridge, to determine rainfall levels for individual wet and dry seasons between 871 and 1021 CE, which overlaps with the Terminal Classic period of Maya civilisation. This is the first time it has been possible to isolate rainfall conditions for individual wet and dry seasons during the Terminal Classic, the time of societal decline historically referred to as the Maya collapse.

During the Terminal Classic, limestone Maya cities in the south were abandoned and dynasties were ended, as one of the ancient world’s great civilisations shifted north and lost much of its political and economic power.

The data contained within the stalagmite, from a cave in the Yucatán, showed that there were eight wet season droughts that lasted for at least three years during this period, with the longest drought lasting for 13 consecutive years.

This climate data aligns with existing historical and archaeological evidence: construction of monuments and political activity at several major northern Maya sites, including the famous city of Chichén Itzá, stopped at different times during this period of climate stress.

The accurately and precisely dated droughts provide a new framework for fine-grained analysis of the timing and dynamics of human-climate interactions in the region. The results are reported in the journal Science Advances.

“This period in Maya history has been a cause of fascination for centuries,” said lead author Dr Daniel H. James, who conducted the research while a PhD student at Cambridge’s Department of Earth Sciences. “There have been multiple theories as to what caused the collapse, such as changing trade routes, war or severe drought, based on the archaeological evidence the Maya left behind. But in the past few decades, we’ve started to learn quite a lot about what happened to the Maya and why, by combining the archaeological data with quantifiable climate evidence.”

Starting in the 1990s, researchers began to piece together climate records with those left by the Maya, such as the dates they recorded on key monuments, to show that a series of droughts during the Terminal Classic was a likely contributor to the massive socio-political upheaval in Maya society.

Now, James and his co-authors from the UK, US and Mexico have used the chemical fingerprints contained in stalagmites from a cave in the northern Yucatán to bring those droughts into much sharper focus.

Stalagmites form when water drips from the ceiling of a cave, and the minerals contained in the water grow into large deposits on the cave floor. By dating and analysing the layers of oxygen isotopes within the stalagmite, the researchers extracted highly detailed information about the climate in the Terminal Classic period. Earlier research has measured the oxygen isotopes contained in lake sediment to determine the severity of drought, but lake sediment does not contain enough detail to pinpoint climate conditions in any given year at a particular site.

“It hasn’t been possible to directly compare the history of individual Maya sites with what we previously knew about the climate record,” said James, who is now a postdoctoral researcher at University College London (UCL). “Lake sediment is great when you want to look at the big picture, but stalagmites allow us to access the fine-grained detail that we’ve been missing.”

Earlier research on stalagmites has determined annual average rainfall amounts during the Terminal Classic, but the Cambridge-led team have now been able to go further, and isolate information from individual wet and dry seasons, thanks to relatively thick (about 1mm) annual layers in the stalagmite used in this study. The specific oxygen isotopes in each layer are a proxy for wet season drought.

“Knowing the annual average rainfall doesn’t tell you as much as knowing what each individual wet season was like,” said James. “Being able to isolate the wet season allows us to accurately track the duration of wet season drought, which is what determines if crops succeed or fail.”

According to the information contained in the stalagmite, there were eight wet season droughts lasting for at least three years between 871 and 1021 CE. The longest drought of the period lasted for 13 years. Even with the water management techniques that the Maya had, a drought that long would have had major impacts on society.

The climate information contained in the stalagmite lines up with the dates inscribed by the Maya on their monuments. In the periods of prolonged and severe drought, date inscription at sites such as Chichén Itzá stopped entirely.

“This doesn’t necessarily mean that the Maya abandoned Chichén Itzá during these periods of severe drought, but it’s likely that they had more immediate things to worry about than constructing monuments, such as whether the crops they relied on would succeed or not,” said James.

The researchers say that stalagmites from this and other caves in the region could be vital in putting the puzzle of the Terminal Classic period together.

“In addition to what stalagmites can tell us about this period in Maya history, they might also be able to tell us about the frequency and severity of tropical storms, for instance,” said James. “As a case study for fine-grained comparisons between climate and historical data, it’s exciting being able to apply methods usually associated with the deeper past to relatively recent history.”

The research was supported in part by the National Geographic Society and the Leverhulme Trust.

 

Research Alert: A genetic twist that sets humans apart




University of California - San Diego





Research from scientists at University of California San Diego School of Medicine have shed new light on an age-old question: what makes the human brain unique?

The team’s discovery comes from their investigation of human-accelerated regions (HARs) — sections of the human genome that have accumulated an unusually high level of mutations as humans have evolved. There is a lot of scientific interest in HARs, as they are hypothesized to play an essential role in conferring human-specific traits, and also have links to neurodevelopmental disorders, such as autism.

One reason why scientists think that HARs confer human-specific traits is because they have undergone rapid changes in their genetic sequences since we split from our closest living relative—the chimpanzee—approximately 5 million years ago.

Now, UC San Diego researchers have identified one particular HAR—called HAR123—that appears to be instrumental in shaping the human brain.

The researchers found:

  • HAR123 itself is not a gene, but is instead a type of molecular “volume control" known as a transcriptional enhancer. Transcriptional enhancers control which genes are activated, how much they are activated, and at what times they are activated during an organism’s development.
  • Through its role as a transcriptional enhancer, HAR123 promotes the development of neural progenitor cells, the cells that give rise to the two main types of brain cells — neurons and glial cells.
  • HAR123 also influences the ratio of neurons and glial cells that form from neural progenitor cells. 

Ultimately, HAR123 promotes a particularly advanced human trait called cognitive flexibility, or the ability to unlearn and replace previous knowledge.

In addition to providing new insights into the biology of the human brain, the results also offer a molecular explanation for some of the radical changes that have occurred in the human brain over the course of our evolution. This is supported, for example, by the authors’ finding that the human version of HAR123 exerts different molecular and cellular effects than the chimpanzee version in both stem cells and neuron precursor cells in a petri dish.

Further research is needed to more fully understand the molecular action of HAR123 and whether the human version of HAR123 does indeed confer human-specific neural traits. This line of research could lead us to a better understanding of the molecular mechanisms underlying many neurodevelopmental disorders, such as autism.

The study, published online in Science Advances, was led by Miles Wilkinson, Ph.D., distinguished professor, and Kun Tan, Ph.D., assistant professor, both within the Department of Obstetrics, Gynecology, & Reproductive Sciences at UC San Diego School of Medicine. Wilkinson is also affiliate faculty of the UC San Diego Institute for Genomic Medicine. The study was funded, in part, by grants from the National Institutes of Health and 10x Genomics. The authors declare no competing interests.

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