The complex social life of rats uncovered with potential implications for human psychiatry

The discovery not only deepens our understanding of rat social structures but also implies important lessons for developing psychiatric medications.

Eötvös Loránd University

 

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The researchers at ELTE observed varied patterns of dominance and coexistence, challenging preconceived notions about rats and potentially human social interactions. In some instances, hierarchies stabilized only after numerous conflicts, while peaceful cohabitation was the norm in other scenarios. These dynamics were influenced significantly by the composition and reorganization of the rat groups, showcasing the profound impact of the social environment on behavior.

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Credit: Photo credit: The Department of Biological Physics at ELTE Eötvös Loránd University

The social behaviors of the Rattus norvegicus, commonly known as the Norway rat,  are far more complex than previously thought - as a team of researchers from ELTE Eötvös Loránd University revealed in a pioneering study published in the journal Scientific Reports. This discovery not only deepens our understanding of rat social structures but also implies important lessons for developing psychiatric medications.

The biological properties of rats show much greater similarities to human cells and organs than most people would expect. In simplified terms,

nearly 90% of the genes in humans and rats share significant similarities.

The researchers at ELTE observed varied patterns of dominance and coexistence, challenging preconceived notions about rats and potentially human social interactions. In some instances, hierarchies stabilized only after numerous conflicts, while peaceful cohabitation was the norm in other scenarios. These dynamics were influenced significantly by the composition and reorganization of the rat groups, showcasing the profound impact of the social environment on behavior.

When rats from a hierarchical group were mixed with those from a non-hierarchical group, the outcome was sometimes a hierarchical group, and sometimes a peaceful one. Another unexpected result was that there was relatively little correlation between the "personality" traits defined in standard personality and social tests (commonly used in drug or behavioral research) and the actual behavior observed within the real groups.

This suggests that rats' social lives, socialization, and relationship to their traits are far more complex than can be interpreted using any simple mechanism. One interesting aspect of this result is that when examining the effects of certain psychotropic drugs in animal experiments,

researchers must be extremely cautious with their conclusions, as rat group behavior contains paradoxes.

The rats were color-coded so that the automated system could track them 24 hours a day for eight months.

The Department of Biological Physics at ELTE, in collaboration with Enikő Kubinyi at the Department of Ethology, conducted this important, gap-filling research and published it in „Scientific Reports”, part of the „Nature” portfolio. The research began as part of an ERC Advanced Grant previously awarded to Tamás Vicsek, professor emeritus at the Institute of Physics, but processing the vast dataset generated took years.

The resulting publication is a unique work in its field, due to the enormous amount of data behind it, the design of the experiments, and the wide range of evaluation methods used. Máté Nagy played a key role in the design and execution, while Gábor Vásárhelyi developed highly innovative software solutions for processing the visual data.

At the end of the experiment, the researchers made efforts to take care of the animals, and they were delighted that all of them found adoptive homes.

(A) Photo of the rats with color-codes for individual identification and tracking.

(C) Continuous tracking allowed for the reconstruction of each individual’s space use. The heatmap shows the space use of two rats during a 3-week period at the beginning of phase 3. Areas used only by a3 are shown with red, only by β1 with green, and areas visited by both (e.g. at the water and the feeder) are shown with yellow.

For more information: https://www.nature.com/articles/s41598-024-72437-5/figures/1 

Credit

Photo credit: The Department of Biological Physics at ELTE Eötvös Loránd University

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Journal

Scientific Reports

DOI

10.1038/s41598-024-72437-5 

Article Title

Long-term tracking of social structure in groups of rats

Article Publication Date

1-Oct-2024