Wednesday, July 15, 2020

  • Biden touts union jobs in US$2T plan to build clean energy

Joe Biden unveiled plans Tuesday to spend US$2 trillion galvanizing a clean energy economy, with ambitions to spur millions of union jobs building the wind turbines, sustainable homes and electric vehicles needed to rapidly throttle U.S. greenhouse gas emissions driving climate change.
“These investments are a win, win, win for our country,” Biden said in a speech in Wilmington, Delaware.
Biden’s clean energy blueprint, coming on top of separate initiatives seeking to pull the U.S. out of a pandemic-prompted recession, co-opts a hallmark of President Donald Trump’s re-election efforts by focusing on putting Americans to work rebuilding the nation’s infrastructure.
Biden’s plan also seeks to balance the desires of progressive Democrats who are demanding bold action to confront climate change while also protecting swing-state and manufacturing jobs.
“Even if we weren’t facing a pandemic and an economic crisis, we should be making these investments anyway,” he said.
Biden outlined a goal of “a carbon pollution-free power sector by 2035” -- a move that would require rapid acceleration in the deployment of renewable wind and solar power as well as electricity storage, while continuing to rely on emission-free nuclear power.
That rapid transition will enable the country to meet the threat of climate change while creating millions of jobs, according to campaign documents.
Biden has set a goal of spending US$2 trillion over four years on renewable energy infrastructure, getting cleaner cars on the road and creating zero-emission mass transit systems. The spending would also boost sustainable home building, clean energy innovation and conservation.
That pledge replaces an earlier initiative to dedicate US$1.7 trillion over 10 years to fighting climate change, and it adds to the US$3 trillion Biden committed last year to spend on infrastructure and clean energy, as well as the US$700 billion in new spending to spur manufacturing and innovation that he laid out last week.
A campaign official promised more details on how Biden would pay for his new proposals as well as the other pieces of his Build Back Better economic plan after the speech.
The official, who asked not to be identified prior to Biden’s announcement, said that tax increases on corporations and the wealthy that Biden has already proposed would be part of the plan.
The campaign has said those tax increases would raise US$4 trillion over a decade. Additional spending would likely be treated as one-time stimulus, meaning that Biden wouldn’t need to find a way to pay for the costs, further adding to the deficit.
Representative Steve Scalise, the House Republican whip from Louisiana, called Biden’s plan “Solyndra on steroids,” a reference to the solar manufacturer that received a US$535 million loan guarantee as part of the 2009 recovery package and later declared bankruptcy. Scalise predicted more such cases as a result of Biden’s plan, Scalise told reporters in a call Tuesday.
The Trump campaign also slammed the Biden plan, saying it would “devastate American families and businesses.”
Senior Biden campaign officials emphasized that his proposals cannot be easily undone by a successor, unlike Trump’s deregulatory agenda.
Washington state Governor Jay Inslee, who first charted the 2035 carbon-free power target Biden is now adopting, heralded the initiative in an emailed statement, saying it showed Biden is “serious about defeating climate change, and has a road map to become the climate president that America needs.”
Progressives, Unions
One challenge for Biden lies in convincing progressive voters that he hasn’t left them short even as he set aside some of the more ambitious moves called for in the Green New Deal championed by left-wing Democrats including Representative Alexandria Ocasio-Cortez.
Some arms of organized labor, key allies for Democrats, seemed to like the plan, while others could emerge as an obstacle. Biden’s emphasis on addressing climate change risks alienating blue-collar workers in Pennsylvania, Ohio and other swing states now producing natural gas and refining oil into gasoline.
The United Auto Workers welcomed the plan, calling it in an unsigned statement a “win-win” that “will ensure that the industry will thrive for decades to come with good paying union jobs.”
The Biden campaign says he would create 1 million new jobs in the American auto industry. Spending on transit would ensure that American cities with more than 100,000 residents would have access to zero-emission public transportation, built by union workers. Organized labor would also be employed upgrading 4 million buildings and weatherizing 2 million homes over the next four years.
Environmental Justice
The initiative also seeks to emphasize environmental justice, creating special divisions of the EPA and Justice Department dedicated to ensuring protection for front-line communities that are most exposed to the effects of pollution including criminal charges.
Gina McCarthy, head of the Environmental Protection Agency under President Barack Obama and now president of the National Resources Defense Council applauded the plan as “the most ambitious we have ever seen from any president in our nation’s history.”
Fracking
Environmentalists have pressured Biden to shut down hydraulic fracturing, the technique used to extract oil and gas from some 90 per cent of U.S. wells, but Biden has been cool to the idea, telling Pennsylvania’s WNEP-TV last week that “fracking is not going to be on the chopping block.”
Nevertheless, Biden has promised to curtail oil and gas development on federal lands and waters managed by the U.S. government, and a senior campaign official said Tuesday Biden is committed to no new fracking on federal lands.
As U.S. turns hostile, foreign student permits climb in Canada

Shelly Hagan, Bloomberg News 
Jul 13, 2020

The Open U.S. visa freeze could be a boon for Canada's effort to attract top talent
U.S. President Donald Trump's plan to put a chill on visas could be a boon for Canada's efforts to attract top talent from around the world. For more, BNN Bloomberg spoke with Shelly Hagan from Bloomberg News.

U.S. visa freeze could be a boon for Canada's effort to attract top talent

Canada’s government is ramping up new permits to foreign students, a comforting sign for the nation’s universities who rely on international enrolment as a key source of funding.

The latest data show 30,785 new study permits were issued in May, double the average from the previous three months when they fell dramatically during COVID-19 lockdowns, according to Immigration Canada. The May figure is above the 27,810 permits issued during the same month last year, the first year-over-year increase in 2020.

A surge in foreign students in recent years has helped power the country’s biggest increase in net migration in more than a century. But the coronavirus pandemic now threatens that driver of growth, even as universities continue to admit international students. For one, it’s not clear travel restrictions will be lifted in time for the fall semester. There’s also concern the global recession may prompt international students to remain at home for their education.

“Still the question will be of course what comes in the fall,” Andrew Agopsowicz, a senior economist at Royal Bank of Canada, said by email.

The increase in student permits in Canada comes as the Trump administration announces international students won’t be able to remain in the country unless they take at least one in-person class. Canada has no such restrictions.

There were more than 642,000 foreign students in Canada at the end of last year.


How China's law is already changing the face of Hong Kong 

BNN BLOOMBERG 


When China passed its new Hong Kong security law on June 30, officials said it would only affect “extremely few criminals.” Less than two weeks later, it’s clear Beijing is trying to wipe away signs of the city’s protest movement from the streets.

The law uses vague language to ban subversion, secession, terrorism and collusion with foreign forces, with sentences as long as life in prison. The government has since issued statements that threaten to outlaw a range of political activity and give police broad surveillance powers that are spooking tech companies, banks, democracy activists and expats — some of whom are wondering whether they’ll even stay.

“The law has had an immediate, and deep, impact on the city,” said Antony Dapiran, a Hong Kong-based lawyer and author of “City on Fire: The Fight for Hong Kong.” “Many ordinary activities that were perfectly legal before — chanting political slogans or waving banners, borrowing political books from libraries, school students being politically engaged — have overnight become forbidden. Even at a visual level the streetscape has changed.”

Here’s how the law is already altering how Hong Kong looks on the ground:

Protest Slogans Are Illegal
A major rallying cry chanted and sung by hundreds of thousands of protesters during the city’s months-long pro-democracy movement — “Liberate Hong Kong! Revolution of our time!” — is now considered illegal. Other slogans have also been deemed a threat to national security, including “Hong Kongers, build a nation.”

On the July 1 anniversary of the city’s handover to Chinese rule, less than 24 hours after the law’s enactment, protesters arrested included a man holding a Hong Kong independence flag and a woman displaying a sign reading “Hong Kong Independence.” New rules also ban flags advocating the independence of Tibet, Taiwan and East Turkestan.

“Beijing probably wants Hong Kongers to start to learn how to live our lives legally,” said Claudia Mo, an opposition politician who’s been active in the protest movement. “The idea seems to introduce an eerie, insecure atmosphere, and fear of uncertainty could serve as a perennial reminder for obedience.”

Yellow Ribbons, Post-it Notes Removed


During last year’s pro-democracy protests, so-called “yellow businesses” — smaller locally owned shops that support the movement — displayed yellow ribbons and banners of support in their windows.

“They don’t define what can’t be done exactly, and that’s the scariest to shop owners,” said one of the restaurant owners with the surname Hung. His shop has displayed protest material since since August, but he took it down after July 1: “We have to keep wondering what will violate the law.”

Some of the multi-colored Lennon Walls — made up of bright sprays of Post-it notes — that popped up all over town during the protests have also come down, though it’s unclear who removed them and why.

Schools Ban Political Activity...


Hong Kong students — thousands of whom participated in the demonstrations — are now prohibited from political activity in schools, including singing, boycotting classes and forming human chains outside their schools.

“Schools must not allow their students to play, sing or broadcast any songs which will disrupt the normal operation of schools, affect students’ emotions or contain political messages,” Education Secretary Kevin Yeung said in a directive. He cited the popular protest anthem “Glory to Hong Kong,” which is regularly sung at rallies across the city.

...And Only Use ‘Appropriate’ Books

The Education Bureau is also reviewing the curriculum to make sure textbooks don’t lead students astray. Books and materials “should be appropriate and of high quality,” the bureau said.

“Whether or not there is a national security law, the reading materials provided by schools to students should not involve any acts that endanger national security,” it said. Although it said the aim wasn’t to infringe on free speech and schools will be the ultimate gatekeeper, the bureau planned to follow up in a “serious manner” if there were “any issues.”

Library Books Banned?


The public library system is reviewing a number of political books that may now fall afoul of the new security law. That reportedly includes books by noted activist Joshua Wong and pro-democracy politician Tanya Chan.

The library “will review whether certain books violate the stipulations of the National Security Law,” the Leisure and Cultural Services Department, which oversees the Hong Kong Public Libraries, said in a statement. “While legal advice will be sought in the process of the review, the books will not be available for borrowing and reference in libraries.”

Scrubbing Social Media Accounts


In the days before and after the law passed, a number of Hong Kong citizens scrubbed or took down Twitter and Facebook accounts. U.S. Secretary of State Michael Pompeo slammed the ruling Communist Party of Chinese leader Xi Jinping for “Orwellian censorship” in Hong Kong.

Wong and other prominent activists cut ties with political groups after the law’s enactment, an apparent bid to avoid implicating each other. As Wong withdrew from Demosisto, a party he founded, he said he would continue his activism in a personal capacity. Other well-known founding members and activists — Nathan Law, Agnes Chow and Washington-based Jeffrey Ngo — announced their departure as well.

Tech Firms Deny Data Requests


International tech giants including Google, Facebook Inc., Microsoft Corp. and Twitter Inc. have suspended processing user data requests from Hong Kong authorities, as concerns grow that the law will criminalize protests. ByteDance Ltd. also pulled its hugely popular TikTok app from Hong Kong.

While it’s unclear right now exactly how the government will respond to non-compliance, the moves have prompted businesses to worry about some form of the mainland’s Great Firewall now coming to Hong Kong.

“There’s a new scenario called ‘Exceptional Circumstances,’ which has not been defined, which really allows police to basically raid and seize any types of materials,” Sharron Fast, a lecturer in media law at the University of Hong Kong, told Bloomberg Television. She said police could now force companies to take down content that only needed to be considered “potentially unlawful.”

Demographic Shift?


The security law may change the demographics of Hong Kong. The U.K. has offered a path to citizenship for some three million Hong Kong British National Overseas passport holders, while Australia suspended its extradition agreement with the city and offered skilled migrants a five-year visa. Some members of the expat population, which numbers in the hundreds of thousands, are also mulling an exit after a year that saw protests, a pandemic and the new law

“The government has on the one hand sought to reassure people that the law targets only a small minority, but on the other hand taken actions to target wide ranges of what has previously been acceptable behaviour,” said Dapiran, the lawyer. “As a result, the uncertainty and fear is pervasive.

Ford CEO resists employees' push to end sales of police vehicles


Ford Motor Co.’s top executive has pushed back against some employees calling for the top seller of vehicles to U.S. police departments to exit the business.
Chief Executive Officer Jim Hackett sent a more than 600-word letter to senior staff in response to messages he’s received both from within and outside Ford’s ranks to reconsider producing police vehicles.
Hackett, 65, said that while he and Executive Chairman Bill Ford support the Black Lives Matter movement and believe police should operate with more transparency and accountability, first responders “play an extraordinarily important role in the vitality and safety of our society.”
“Our world wouldn’t function without the bravery and dedication of the good police officers who protect and serve,” Hackett wrote. “But safety of community must be inclusive of all members and today, it is not.”
Embedded Image
“Holding these two thoughts together in one’s mind is possible, but now there is tension,” Hackett continued. “It’s our belief the recent issues surfacing from the George Floyd tragedy are bringing a very intensive and necessary spotlight on police training and reform.”
The second-largest U.S. automaker by sales joins household-name companies including Facebook Inc. and PepsiCo Inc. in being pressured to reconsider or change business practices following the police killing of Floyd, an unarmed Black man, in May.
The fallout has been significant for some — Facebook is being hit by a major advertiser boycott — while Pepsi and others have abandoned brands rooted in racism. Amazon.com Inc. has implemented a one-year moratorium on police use of its facial-recognition software.
Ford Police Interceptor sedans and sport-utility vehicles — souped-up versions of its Fusion and Explorer models — are a small sliver of the more than two million cars the automaker sells in the U.S. every year. But its domination of the segment has long been a point of pride. The company boasted less than a year ago that it accounted for almost two-thirds of U.S. police vehicle sales.
“It’s not controversial that the Ford Police Interceptor helps officers do their job,” Hackett wrote. But he pushed back against the notion that supporting police accountability and producing vehicles for departments across the U.S. are mutually exclusive.
“The issues plaguing police credibility have nothing to do with the vehicles they’re driving,” Hackett said.


CONSERVATIVE 
Ontario Premier Ford decries 'reckless' U.S. reopening efforts 
WILL MIRACLES NEVER CEASE
HE ALSO CALLED ANTI LOCK DOWN PROTESTERS "IDIOTS"! WHEN THEY PROTESTED IN TORONTO TWO MONTHS AGO

Kait Bolongaro, Bloomberg News

The U.S. response to COVID-19 has been “reckless,” the leader of Canada’s largest province said as the two countries moved closer to a deal to extend limits on cross-border travel.

Premier Doug Ford’s blunt assessment bolsters the position of Prime Minister Justin Trudeau, who has so far resisted calls from some Canadian business leaders to relax restrictions put in place this spring to help contain the spread of coronavirus.

“Don’t get me wrong. I love the Americans. I don’t want them up here right now” Ford told reporters Tuesday in Cambridge, Ontario. “After this pandemic, you’re welcome to come up, but it’s been reckless down there.”

Trudeau and President Donald Trump spoke about border restrictions this week, with the prime minister saying Monday talks on extending them were ongoing. Canada and the U.S. have since agreed to maintain the non-essential travel ban until August, according to a report Tuesday by the Canadian Broadcasting Corp.

With the tourism sector and airline industry taking a heavy hit from COVID-19 shutdowns, pressure is growing on Trudeau to loosen up. Last month, heads of 27 Canadian companies wrote to him asking the government to make it easier to fly.

But at the same time provincial leaders like Ford are watching Canada’s largest trading partner grapple with a potential second wave of the virus. Florida has just set a new state record for deaths and recorded the biggest daily increase in cases across all the U.S.

“That’s the only way I can describe it. They’ve been reckless, they moved forward too quickly, and we’re going right at the right speed,” the Ontario premier said.

Potential causal role of human papilloma viruses (HPVs) in prostate cancers

BMC (BIOMED CENTRAL)
Human papilloma viruses (HPVs) - a common group of viruses known to cause cervical cancers - may also have a causal role in prostate cancer, according to a literature review published in the open access journal Infectious Agents and Cancer, supporting the case for universal HPV vaccination.
James Lawson and Wendy Glenn, at the University of New South Wales, Australia reviewed results from 26 previous studies on HPVs and their links to prostate cancer. They assessed the existing evidence using a common set of nine causal criteria, including the strength and consistency with which HPVs were associated with prostate cancers and whether HPVs were detected in prostate tissues that later went on to develop cancer.
James Lawson said: "Although HPVs are only one of many pathogens that have been identified in prostate cancer, they are the only infectious pathogen we can vaccinate against, which makes it important to assess the evidence of a possible causal role of HPVs in prostate cancer."
The authors found that the high risk HPV types 16 and 18, which cause the majority of cervical cancers, have been identified in normal, benign and malignant prostate tissues. In several case control studies, the prevalence of high risk HPV DNA, which indicates the presence of cancer-causing types, was significantly higher in prostate cancers compared to normal and benign prostate controls. More specifically, recent studies found that 231 of 1071 prostate cancers (21.6%) were HPV positive, whereas only 74 of 1103 benign prostate controls (6.7%) were HPV positive.
Wendy Glenn said: "Across several studies conducted in a wide range of countries and using different methods to identify HPVs, we found reasonably consistent evidence that high risk HPVs are significantly more prevalent in prostate cancers than in normal prostate tissues and benign prostate tissues. Previous studies have also shown that high risk HPVs were present in benign prostate tissues that up to ten years later developed HPV positive prostate cancer of the same HPV type."
The authors also found that in countries where mortality from cervical cancer was high, mortality from prostate cancer was also high, whereas in countries where mortality from cervical cancer was low, mortality from prostate cancer was also low.
James Lawson said: "As high risk HPV infections are associated with the majority of cervical cancers and the most frequent means of HPV transmission is probably by sexual activity, the data may indicate that HPV infection may be transmitted during sexual activity and play causal role in prostate cancer, as well as cervical cancer."
The authors suggest that the evidence for a causal role of HPVs in prostate cancer is sufficiently sound to encourage universal vaccination against HPV infections.
James Lawson said: "Many people assume that HPV infections mainly lead to cancers in women. This is not the case. HPVs are a common cause of cancers in men. These are mainly genital cancers of the anus and penis but also include cancers of the mouth, tongue and throat. It is therefore plausible that HPVs may also play a role in prostate cancer and that HPV vaccination may help prevent prostate cancer development."
The authors caution that the exact mechanisms for how HPV infection may lead to prostate cancer formation are not clear and studies exposing normal prostate cells to HPVs are needed to investigate these mechanisms. The evidence reviewed by the authors suggests that possible mechanisms may include an indirect role of HPVs in cancer formation by inhibiting the protective function of specific enzymes against virus infections. HPVs may also collaborate with other pathogens in prostate oncogenesis or play a role in inflammation of the prostate, which may lead to benign prostate enlargement and later prostate cancer.
###
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Notes to editor:
1. Research article:
Evidence for a causal role by humanpapillomaviruses in prostate cancer-asystematic review
Infectious Agents and Cancer 2020
DOI: 10.1186/s13027-020-00305-8
During the embargo period the article is available here: https://bit.ly/31RWRKb
After the embargo lifts, the article will be available here: https://infectagentscancer.biomedcentral.com/articles/10.1186/s13027-020-00305-8
Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BMC's open access policy.
2. Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer.
3. A pioneer of open access publishing, BMC has an evolving portfolio of high quality peer-reviewed journals including broad interest titles such as BMC Biology and BMC Medicine, specialist journals such as Malaria Journal and Microbiome, and the BMC series. At BMC, research is always in progress. We are committed to continual innovation to better support the needs of our communities, ensuring the integrity of the research we publish, and championing the benefits of open research. BMC is part of Springer Nature, giving us greater opportunities to help authors connect and advance discoveries across the world.


Severely damaged human lungs can now be successfully recovered

Columbia Engineering and Vanderbilt researchers demonstrate that human lungs rejected for transplant can be recovered using cross-circulation, to provide much larger number of donor lungs to critically ill patients
COLUMBIA UNIVERSITY SCHOOL OF ENGINEERING AND APPLIED SCIENCE

New York, NY--July 10, 2020--Respiratory disease is the third leading cause of death worldwide, and lung transplantation is still the only cure for patients with end-stage lung disease. Despite advances in the field, lung transplantation remains limited by the low availability of healthy donor organs, and most donor lungs cannot be used due to severe but potentially reversible injuries. Currently, a method known as ex vivo lung perfusion (EVLP) is used to provide lung support outside the body and recover marginal quality donor lungs before transplantation. However, EVLP provides only a limited duration of six to eight hours of support--a time that is too short to recover the majority of severely damaged donor lungs.
A multidisciplinary team from Columbia Engineering and Vanderbilt University has now demonstrated that severely injured donor lungs that have been declined for transplant can be recovered outside the body by a system that uses cross-circulation of whole blood between the donor lung and an animal host. For the first time, a severely injured human lung that failed to recover using the standard clinical EVLP was successfully recovered during 24 hours on the team's cross-circulation platform. The study is published today in Nature Medicine.
The investigators, led by Gordana Vunjak-Novakovic, University Professor and The Mikati Foundation Professor of Biomedical Engineering and Medical Sciences at Columbia Engineering, and Matthew Bacchetta, Surgical Director of the Vanderbilt Lung Institute, attributed the accomplishment of their major milestone to the physiologic milieu and systemic regulation that their unique platform provides to explanted human lungs.
"It is the provision of intrinsic biological repair mechanisms over long-enough periods of time that enabled us to recover severely damaged lungs that cannot otherwise be saved," said the study's lead authors, Ahmed Hozain (surgical research fellow at Columbia Engineering) and John O'Neill (adjunct associate research scientist at Columbia Engineering).

Human lung that failed on EVLP (left) and then recovered on cross-circulation (right)
Over the past eight years, the researchers have been developing their radically new method to provide more lungs for patients in dire need of organ transplantation. In 2017, they demonstrated the feasibility of cross-circulation support of whole lungs outside the body. In 2019, they demonstrated the efficacy of cross-circulation by regenerating severely damaged swine lungs, and in 2020, they successfully extended the duration of cross-circulation support to an unprecedented four days.
Now, in this new paper, the team shows that explanted human lungs, already declined for transplantation, can be recovered on their cross-circulation platform, which successfully maintained lung integrity and resulted in functional lung recovery. Throughout the 24 hours of cross-circulation, the team saw substantial improvements of cell viability, tissue quality, inflammatory responses and--most importantly--respiratory function.
"We were able to recover a donor lung that failed to recover on the clinical ex vivo lung perfusion system, which is the current standard of care. This was the most rigorous validation of our cross-circulation platform to date, showing great promise for its clinical utility," Vunjak-Novakovic said.
This particular donor lung demonstrated persistent swelling and fluid buildup that could not be resolved, and it was declined for transplantation by multiple transplant centers and eventually offered for research. By the time the team received this lung, it had experienced two periods of cold ischemia that totaled 22.5 hours, plus five hours of clinical EVLP treatment. Remarkably, after 24 hours on cross-circulation, the lung showed functional recovery.
Vunjak-Novakovic noted that the size and profile of their multi-institutional research team--25 investigators with expertise in bioengineering, surgery, immunology, stem cells, and various clinical disciplines--reflects the complexity of this translational project.
Zachary Kon, Director of Lung Transplantation Program, NYU Langone Health, who was not involved in the study, commented: "As a lung transplant surgeon, I have seen many patients not receive lung transplants they desperately needed. I find this work intriguing and hope this technology will make more donor lungs available."
The investigators emphasize that more work needs to be done before cross-circulation can become a clinical reality. For clinical application of the cross-circulation platform, they envision two clinical scenarios for application of the cross-circulation platform, which they are planning to pursue. One approach is to directly translate the method demonstrated in this new study, with the human donor lung recovered by "xenogeneic" cross-circulation with a medical-grade, pathogen-free animal host. To this end, the safety, feasibility, risk profiles, and outcomes of xenogeneic cross-circulation will need to be evaluated in large numbers of lungs.
Another approach is that critically ill patients already awaiting transplantation on artificial lung support could serve as the cross-circulation host to recover an injured donor lung, which they would receive for transplant as soon as the organ recovers. As described in the paper, the xenogeneic cross-circulation platform may also serve as a research tool to investigate organ regeneration, transplant immunology, and the development of novel therapeutics.
Looking ahead, the researchers hope to extend the benefits of their cross-circulation platform to the recovery of other human organs, including livers, hearts, kidneys, and limbs.




About the Study
The study is titled "Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs."
Authors are: Ahmed E. Hozain,1,2, John D. O'Neill1, Meghan R. Pinezich1, Yuliya Tipograf2, Rachel Donocoff3, Katherine M. Cunningham1, Andrew Tumen4, Kenmond Fung5, Rei Ukita4, Michael Simpson2, Jonathan A. Reimer1,2, Edward C. Ruiz1, Dawn Queen6, John W. Stokes4, Nancy L. Cardwell4, Jennifer Talackine4, Jinho Kim7, Hans-Willem Snoeck8,9, Ya-Wen Chen8,10, Alexander Romanov3, Charles C. Marboe11, Adam D. Griesmer9, Brandon A. Guenthart1,12, Matthew Bacchetta1,4,16,17 and Gordana Vunjak-Novakovic1,8
1 Department of Biomedical Engineering, Columbia University
2 Department of Surgery, Columbia University Medical Center
3 Institute of Comparative Medicine, Columbia University Medical Center
4 Department of Thoracic Surgery, Vanderbilt University
5 Department of Clinical Perfusion, Columbia University Medical Center
6 Vagelos College of Physicians and Surgeons, Columbia University Medical Center
7 Department of Biomedical Engineering, Stevens Institute of Technology
8 Department of Medicine, Columbia University Medical Center
9 Department of Microbiology and Immunology, Columbia University Medical Center
10 Columbia Center for Human Development, Columbia University Medical Center
11 Department of Medicine, University of Southern California
12 Department of Stem Cell Biology and Regenerative Medicine, University of Southern California
13 Department of Pathology and Cell Biology, Columbia University Medical Center
14 Center for Translational Immunology, Columbia University Medical Center
15 Department of Cardiothoracic Surgery, Stanford University
16 Department of Cardiac Surgery, Vanderbilt University
17 Department of Biomedical Engineering, Vanderbilt University
The study was supported by grants from the National Institutes of Health (HL134760, EB27062, HL120046, HL007854), Blavatnik Foundation, and the Mikati Foundation.
The authors declare no competing financial interests.
LINKS:
DOI: 10.1038/s41591-020-0971-8
Columbia Engineering
Columbia Engineering, based in New York City, is one of the top engineering schools in the U.S. and one of the oldest in the nation. Also known as The Fu Foundation School of Engineering and Applied Science, the School expands knowledge and advances technology through the pioneering research of its more than 220 faculty, while educating undergraduate and graduate students in a collaborative environment to become leaders informed by a firm foundation in engineering. The School's faculty are at the center of the University's cross-disciplinary research, contributing to the Data Science Institute, Earth Institute, Zuckerman Mind Brain Behavior Institute, Precision Medicine Initiative, and the Columbia Nano Initiative. Guided by its strategic vision, "Columbia Engineering for Humanity," the School aims to translate ideas into innovations that foster a sustainable, healthy, secure, connected, and creative humanity.

Jumping course 

New models detail how major rivers will respond to changing environmental conditions
UNIVERSITY OF CALIFORNIA - SANTA BARBARA

From the Nile to the Mississippi and from the Amazon to the Yangzi, human civilization is inextricably linked to the great rivers along which our societies developed. But rivers are mutable, and the benefits they bestow can quickly become disasters when these waterways change course.
Scientists are working to understand how environmental changes alter river dynamics. A new study in the Proceedings of the National Academy of Sciences coauthored by UC Santa Barbara geomorphologist Vamsi Ganti has outlined the factors that dictate how often rivers jump course, or avulse, and the effects this will have on river deltas. The results promise to help scientists and planners prepare for a future of sea-level rise and changing land use.
Deltas counteract sea level rise by building up sediment, which mostly occurs near a river channel itself. Every once in a while, the river will switch course through an avulsion and begin building up the delta somewhere else. "So avulsions are the way that the river spreads its sediment out over the whole landscape," said first author Austin Chadwick, a postdoctoral scholar at University of Minnesota.
"The questions we're asking are how often do rivers naturally change their course," he continued, "and how is that going to change with climate change and human interference."
Unfortunately, there has previously been no consensus on how rivers responded to climactic shift. Some scientists thought avulsion rates would increase as sea level rises, while others predicted they'd decrease. "There simply was no unifying theory to explain how river avulsion frequency is dependent on sea level," Ganti said.
To straighten out the situation, Ganti, Chadwick and their coauthor Michael Lamb of Caltech, combined observations from the geologic and historical records with a mathematical model of river dynamics. By focusing on this specific issue, they aimed to finally get definitive answers and useful predictions.
Large rivers tend to flatten out and decelerate as they approach the ocean. After a certain point, the downstream conditions of the sea level begin to influence the river's behavior in what scientists call backwater hydrodynamics. "This is a dynamic zone where deposition and erosion occurs in coastal rivers," Ganti explained.
In a previous paper, the team had shown that avulsions occur within this backwater region, which can extend quite far inland. For instance, the backwater zone of the Mississippi River reaches 500 kilometers from the coast. Deeper, flatter rivers like the Mississippi, which have larger backwater regions, therefore have larger deltas.
The researchers goal with this study was to apply their newfound understanding of the impact of backwater hydrodynamics to learn about the frequency of avulsions themselves.
Using the model, and comparing their results to field data, the team discovered that there are three ways that deltas can respond to sea level rise, which depend on the balance between the rate of sea-level change and the sediment supplied by the river.
The first: when a river has a lot of sediment and sea-level rise is relatively slow. According to the model, these rivers are resilient to sea-level rise, and their avulsion rates remain stable. China's Yellow River is one example.
The second case occurs when a river has less sediment or the sea level rises more quickly. In this scenario, avulsions become more frequent. The rising ocean promotes sedimentation, and once a channel fills to a certain depth, the river will jump its course.
And representing the extreme, in which sea level rise outpaces a river's ability to deposit sediment, is the third case. As the ocean infiltrates the delta, the river will reach its maximum avulsion rate, and the whole system will begin migrating inland. Scientists hadn't known about this case before, and the discovery of the three regimes together explains the previous inconsistencies in the scientific literature.
The researchers inputted observations and data into their model to see whether various river deltas would behave differently under predicted climate conditions. "The answer is yes, for most of them," Chadwick said. "Many rivers will experience more frequent avulsions and some rivers will also have avulsions farther inland."
River avulsions have huge societal implications, with the potential to cause economic and civil unrest. Archaeologists believe that a course change of the Indus River in western India directly contributed to the decline of the Bronze Age Harappan civilization. More recently, avulsions led to the 1877 Yellow River flood and 1931 China floods, two of the deadliest natural disasters in modern history.
An avulsion could have dire consequences for rivers like the Mississippi, where a system called the Old River Control Structure has prevented the river from jumping course since 1963. If the backwater region migrated inland, the river could change course upstream from the facility and bypass it altogether. Millions of gallons of water per minute would course through previously dry land, while the downstream portion of the channel would go completely dry.
The authors have made their model available and accessible to anyone who might want to use it. They were even able to reduce several formulas into a single equation by implementing a few basic assumptions about river conditions and dynamics.
"Groups like the Army Corps of Engineers and the Department of the Interior can use this tool to apply to any delta," said Chadwick. "And hopefully it will help inform our decisions in these places as we cope with climate change."
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Well-off countries need trade to cut environmental woes

MICHIGAN STATE UNIVERSITY
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IMAGE: A NEW STUDY SHOWS INTERNATIONAL TRADE CAN IMPROVE A DEVELOPED NATION'S SUSTAINABLE DEVELOPMENT GOALS, BUT SOMETIMES AT THE EXPENSE OF LESS DEVELOPED COUNTRIES. THIS SHIP MOVES THROUGH THE PANAMA CANAL.... view more 
CREDIT: SUE NICHOLS, MICHIGAN STATE UNIVERSITY
International trade wins and losses don't just show up in the stock market, but also on a nation's environmental sustainability scores, a new study in Nature Sustainability shows.
In a first analysis of its kind, scientists at Michigan State University's Center for Systems Integration and Sustainability (CSIS) and in China examine how international trade affected seven of the 17 United Nations Sustainable Development Goals (SDGs) in countries trading both with other countries at a distance, as well as countries with which they shared borders.
Their study shows these environmental measures reflect a common problem between haves and have-nots. Trading internationally was generally good developed countries like the United States, Canada and most of Europe, but resulted in environmental losses for developing countries such as Russia and part of East Asia struggling to make gains in their SDGs scores.
It also showed not only was international trade an environmental plus for developed countries - it's an environmental savior. Using an innovative analysis, the researchers found the SDGs scores of developed countries would sink lower than those of developed countries after excluding the function of international trade in the current world.
"A nation's sustainability progress is not only dependent on deliberate actions within the nation, it also can become a victim of unintended, and often hard-to-see consequences," said Jianguo "Jack" Liu, MSU Rachel Carson Chair in Sustainability and CSIS director. "Clearly, everyone wants to make positive economic progress, but we can only make crucial environmental improvements by being very clear-eyed about how one action affects another, even if these actions take place over hundreds or thousands of miles. Sustainability is a complicated business."
The group assessed the impacts of international trade starting in 1995 on nine environment-related SDG target likely affected by trade and for which there are clear quantitative metrics - goals that address sustainable water use, energy, economic growth, industrialization, forest management, and consumption and production; and combating climate change. They compared these impacts with a scenario of what each country would be like were there no international trade in today's world.
It's been known that trading goods and services can help save local resources that are essential for production but can also transfer production burdens to the countries that become exporters. For example, if the United States decides to buy wooden furniture from southeast Asia that saves forests in the States but can cause biodiversity loss and deforestation in southeast Asia.
But the extent of impact on environmental sustainability has not been fully revealed. At the national level, international trade improved the SDG scores of 70% of the evaluated developed countries but reduced the SDG scores of over 60% of the evaluated developing countries.
An example can be carbon emissions. International trade has displaced 16 Gt of carbon dioxide from developed to developing countries from 1990 to 2008, which largely stabilized the carbon emissions of developed countries but doubled the carbon emissions of developing countries, the paper notes.
Using the framework of metacoupling (human-nature interactions within as well as between adjacent and distant places), the researchers also found that distant trade offered more environmental benefit, partly because there was more trading to customers further away, and partly because close neighbors likely also shared the same constraints that spurred distant trade in the first place.
"Many critics of trade have raised the concerns that trade can generate negative spillover effects such as enlarging the social and environmental inequality between developed and developing countries," said Yingjie Li, a PhD student at MSU CSIS and a lead author. "But national policymakers may not be aware that international trade can play a big role in their efforts towards achieving the UN SDGs."
Findings in "Impacts of International Trade on Global Sustainable Development" offer an opportunity for policymakers to view international trade beyond financial balance sheets.
"This is the first study about how international trade affects SDG targets," said co-lead author Zhenci Xu, a former MSU-CSIS PhD student and now research associate at University of Michigan. "As the countries connected with each other more in the globalization era, understanding how trade shapes progress toward national and global sustainable development can provide useful information for policy making aiming at achieving SDGs together."
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In addition to Li, Xu and Liu, authors are Sophia Chau, Thomas Dietz, Canbing Li, Luwen Wan, Yunkai Li, Liwei Zhang, Jindong Zhang and Min Gon Chung.
The work was supported by the National Science Foundation, MSU, Michigan AgBioResearch, the Environmental Science and Policy Program Doctoral Recruiting Fellowships, and the China Scholarship Council.