Monday, December 15, 2025

Southeast Europe rocked by wave of anti-corruption protests

Southeast Europe rocked by wave of anti-corruption protests
Tens of thousands of Bulgarians joined protests in Sofia (pictured) and other Bulgarian cities on December 10.
By Clare Nuttall in Glasgow December 15, 2025

A wave of anti-corruption protests is spreading across Southeast Europe, exposing deep public anger over graft, negligence and weak accountability.

Demonstrations have simmered for over a year in Serbia following a deadly infrastructure disaster, toppled Bulgaria’s coalition government last week and most recently erupted in Romania over allegations that the judiciary has been “captured” by political interests. In North Macedonia, the families of victims of a catastrophic nightclub fire returned to the streets last month as the landmark corruption trial began. Together, the protests highlight persistent governance challenges in the region. 

Bulgarian government falls after mass rallies

Bulgaria’s parliament on December 12 unanimously accepted the resignation of Prime Minister Rosen Zhelyazkov, a day after he stepped down ahead of a sixth no-confidence vote triggered by mass protests over corruption and contested budget plans.

Zhelyazkov resigned the previous day, less than three weeks before Bulgaria is due to adopt the euro on January 1, 2026. Officials have said the political turmoil will not derail the currency transition.

His year-old coalition government had come under mounting pressure after tens of thousands of people took to the streets on December 10 for the third major rally in two weeks. An estimated 150,000 protesters gathered in Sofia, with thousands more in other cities, denouncing corruption, government inefficiency and the political elite.

The cabinet, formed in January 2025, had survived five earlier no-confidence votes. Minutes before lawmakers were due to debate a sixth, Zhelyazkov announced his resignation at an emergency news conference in parliament, saying the decision reflected the “will of the people”.

Yet another snap election is now likely as the two largest parliamentary groups – former prime minister Boyko Borissov’s GERB party and the opposition Change Continues-Democratic Bulgaria alliance – have already ruled out attempts to form a new government within the current parliament.

Protests over Romania’s ‘captured’ judiciary

In neighbouring Romania, protests broke out last week after allegations of corruption within the judiciary.

More than 170 magistrates have joined an action group accusing the judicial system of being “captured”, following revelations by investigative outlet Recorder that alleged political interference in high-profile corruption cases.

The claims, confirmed publicly by judge Raluca Moroșanu, intensified street protests in Bucharest and several major cities on December 11. More than 1,000 people rallied in the capital, with hundreds more in Cluj-Napoca and Iași, demanding the resignation of High Court president Lia Savonea, National Anticorruption Directorate (DNA) head Liviu Voineag and Interior Minister Cătălin Predoiu, a former justice minister.

The demonstrations followed the broadcast of a two-hour Recorder documentary on public television alleging systematic pressure on judges and prosecutors.

At a tense press conference convened by the Bucharest Court of Appeal to rebut the allegations, Moroșanu publicly backed judge Laurențiu Beșu, whose testimony lay at the heart of the investigation.

“I came here to support my colleague, Laurențiu Beșu, and to say that everything he said there is true,” Moroșanu said. “If he is contradicted, it is a lie.”

She described a climate of intimidation within the courts, alleging that judges were “terrorised with disciplinary actions”. Explanations offered by court leadership were met with scepticism by journalists and civic groups.

Later, judge Daniela Panioglu told Euronews she believed corruption in the judiciary was pervasive. “I don’t know if anything works better in Romania than corruption in the judiciary,” she said, adding that Savonea “controls almost everything that happens”.

Savonea rejected the allegations, saying the testimonies cited were unsupported by verifiable facts and did not correspond to reality.

Sustained unrest in Serbia

Serbia has seen the region’s most sustained protest movement, driven by public outrage over corruption, urban development and a fatal infrastructure collapse that has become a national symbol of alleged negligence.

Protests over the November 2024 collapse of a railway station canopy in the northern city of Novi Sad that killed 16 people, one of the country’s worst infrastructure disasters, have been ongoing for more than a year. In the largest recent protest, 

Tens of thousands of people gathered in Novi Sad on November 1 to mark one year since the disaster. Citizens assembled at 16 locations across the city – one for each victim – before marching to the station for a minute’s silence.

The protests, which began as an outpouring of grief, have evolved into a broader challenge to President Aleksandar Vucic and his ruling Serbian Progressive Party (SNS), with demonstrators demanding accountability and early elections. They have already led to the resignation of former prime minister Milos Vucevic earlier this year. 

Days later, students in Belgrade staged a “warning protest” against plans to redevelop the former General Staff building, a bomb-damaged complex once declared a cultural monument, into a luxury hotel and residential project backed by Jared Kushner, the son-in-law of US President Donald Trump.

Under the slogan “We are a living wall”, demonstrators formed a human chain around the site, accusing the government of bypassing legal procedures and “selling off history”. The redevelopment was enabled by a special law adopted by parliament, which authorities said served the public interest.

The unrest comes as Serbia faces mounting economic and diplomatic pressure, including US sanctions on its sole oil company, factory closures, criticism from the European Union and strained energy talks with Russia.

Nightclub fire trial begins in North Macedonia 

In North Macedonia, public anger has centred on a devastating nightclub fire in the town of Kocani that killed 63 people and injured more than 190 earlier this year.

Four days before the defendants were due to go on trial, families of the victims marched through Skopje on November 15, demanding truth and accountability. Hundreds of protesters dressed in black carried a banner bearing the faces of the dead as they walked from the main square to the Criminal Court.

Investigators said the club was operating illegally in a former warehouse, without adequate exits or safety permits, and had used unlawful pyrotechnics. Interior Minister Panče Toškovski acknowledged serious violations but did not resign.

Prime Minister Hristijan Mickoski, whose right-wing VMRO-DPMNE party returned to power in June 2024, described the disaster as a “mass murder” driven by corruption and institutional indifference, while placing blame on previous governments.

The case, involving 34 individuals and three legal entities, is seen as a critical test for the judiciary in a country plagued by low public trust and accusations of political influence. Human rights groups have said they will monitor the proceedings closely.

The tragedy was highlighted in the European Union’s latest progress report on North Macedonia, which warned that corruption remains widespread and a serious concern.

Cannabis derivatives could provide new ovarian cancer treatments



Lab studies find that a combination of THC and CBD kills ovarian cancer cells without harming healthy cells




Frontiers





In the future, scientists could use drugs made from cannabis to fight ovarian cancer. A team of scientists testing the effects of two chemical compounds sourced from cannabis on ovarian cancer cells have found that both show promising anti-cancer effects. While more research will be required to turn these results into drugs which can be delivered to patients, these findings are an important opportunity to develop effective new therapies for a cancer which is hard to diagnose and even harder to treat. 

“Ovarian cancer remains one of the deadliest gynecological malignancies, characterized by late diagnosis, high recurrence rates, and limited effective treatment options,” said Dr Siyao Tong of Khon Kaen University, lead author of the article in Frontiers in Pharmacology. “Our goal is to find alternative drugs that can improve efficacy and potentially reduce toxicity, ultimately bringing new hope to patients facing this challenging disease.”

A deadly illness

Of all the gynecological cancers, ovarian cancer kills most patients. Although there have been advances in treatment strategies, available drugs are not always effective and come with formidable side effects. New options are desperately needed. Since CBD (cannabidiol, which is not psychoactive) and THC (delta-9-tetrahydrocannabinol, which is) have shown potential against other cancers, the research team decided to test them against ovarian cancer cells. 

They took two different lines of ovarian cancer cells, one of which is sensitive to platinum-derived drugs and one of which is resistant, and challenged the lines with CBD, THC, or both, to see if the cells could survive and reproduce after exposure. The scientists also challenged a line of healthy cells, to see if the compounds damaged them.

They found that cells for both cancer lines which had been treated with CBD or THC formed fewer and smaller colonies of cells. Though both compounds worked to prevent cancer cells reproducing, combining them gave particularly good results. And although neither compound alone killed a large proportion of cancer cells, a combination of the two was very successful. It’s possible that THC and CBD act on the cancer cells in different ways, and when used together, their effects are amplified. 

“Notably, the inhibitory effect was most pronounced when CBD and THC were used in a 1:1 ratio,” said Tong.

Additional assays showed that the compounds prevented cells from migrating, which means they might be able to stop ovarian cancer spreading to other parts of the body. Many patients die of metastases, so a treatment which prevents metastasis could save lives.

Both cell lines were similarly affected, suggesting that the compounds could work equally well for different types of ovarian cancer. The compounds and their combinations also had minimal effects on healthy cells, which suggests that patients might find treatments made from them less toxic and easier to tolerate than current drugs. 

To understand the mechanism behind these anti-cancer effects, the scientists looked at cell signaling pathways. The PI3K/AKT/mTOR pathway is overactivated in ovarian cancer cells, which contributes to tumor development and treatment resistance. The CBD and THC compounds seemed to restore normal regulation of the pathway, which could explain why the cancer cells couldn’t reproduce and began to die off after treatment. 
    
Looking to the future

But much more work remains to be done before these results can be translated into practical treatments. The scientists call for further research which can establish if and how these compounds can be used as effective new ovarian cancer therapies.

“Although our study is still preliminary, it lays an important foundation for future research into the potential applications of CBD and THC in ovarian cancer treatment,” said Tong. “By confirming their anti-cancer activity and identifying key molecular mechanisms, our findings are expected to drive further preclinical research. If future studies confirm these effects, CBD-THC combination therapy may ultimately contribute to the development of new treatment strategies.”

“However, this study has some limitations,” Tong added. “All experiments were conducted in vitro, so the results may not fully reflect the complexity of tumor behavior in living organisms. We did not include in vivo models and pharmacokinetic data, which are crucial for determining whether CBD/THC can be safely and effectively used clinically. Finally, regulatory and legal issues surrounding cannabinoid therapy may also affect future translational research. While the results are encouraging, more studies are needed before these findings can be applied to patient treatment.”
 

Raising strong yeast as a petroleum substitute

Mutated baker’s yeast at the forefront of alternative 2,3-butanediol production methods



Osaka Metropolitan University

Strengthened Saccharomyces cerevisiae 

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This common yeast is a strong contender for replacing petroleum in 2,3-butanediol production.

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Credit: Osaka Metropolitan University





As fossil fuels rise in cost and green initiatives gain traction, alternative methods for producing useful compounds using microorganisms have the potential to become sustainable, environmentally friendly technologies.

One such process involves the common bread yeast, Saccharomyces cerevisiae (S. cerevisiae), to produce 2,3-butanediol (2,3-BDO), an organic compound often used in pharmaceuticals and cosmetics. However, this yeast has a low tolerance for 2,3-BDO under high concentrations, which leads to a decline in its production ability and hinders the mass commercialization of this method.

To work around this, Associate Professor Ryosuke Yamada’s team at Osaka Metropolitan University’s Graduate School of Engineering attempted to enhance S. cerevisiae by introducing mutations into the genomic DNA. The researchers engineered four altered strains and subjected them to ethanol, heat, and low pH stressors.

As a result, they successfully obtained the YPH499/Co58 mutant strain that proliferates 122 times more than the parent strain in a high-concentration 2,3-BDO environment. Furthermore, gene expression analysis confirmed that the activation of genes associated with proteasome, peroxisome, the tricarboxylic acid cycle, mitochondria, and transcriptional regulation played a crucial role in 2,3-BDO tolerance.

“The technology used to mutate the yeast’s genomic DNA is a highly effective base technology for enhancing its capabilities,” stated Professor Yamada. “This method could contribute to creating a sustainable society by not only producing 2,3-BDO but also facilitating the development of robust microorganisms capable of efficiently producing other useful substances.”  

The study was published in Applied Microbiology and Biotechnology.

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Clues to the origin of hot Jupiter's hidden in their orbits

New research finds a distinct group of hot Jupiter's whose circular orbits defy tidal-migration timescales, pointing to formation within protoplanetary disks.

Graduate School of Arts and Sciences, College of Arts and Sciences, The University of Tokyo

An illustration of a Jupiter mass planet migrating through a protoplanetary disk 

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An illustration of a Jupiter mass planet migrating through a protoplanetary disk

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Credit: Graduate School of Arts and Sciences, College of Arts and Sciences, The University of Tokyo





The first exoplanet ever discovered in 1995 was what we now call a “hot Jupiter”, a planet as massive as Jupiter with an orbital period of just a few days. Today, hot Jupiters are thought to have formed far from their stars—similar to Jupiter in our Solar System—and later migrated inward. Two main mechanisms have been proposed for this migration: (1) high-eccentricity migration, in which a planet’s orbit is disturbed by the gravity of other celestial bodies and subsequently circularized by tidal forces near the star; and (2) disk migration, in which the planet moves gradually inward within the protoplanetary disk.

However, it is not straightforward to distinguish the mechanism a particular hot Jupiter experienced from observations alone. In the case of high-eccentricity migration, the gravitational perturbations can tilt the planet’s orbital axis relative to the star’s rotational axis, resulting in a measurable misalignment. However, tidal forces can realign these axes over time, meaning that an aligned orbit does not necessarily imply disk migration. As a result, there has long been no reliable observational method to identify planets that formed through disk migration.

To address this challenge, a research group led by PhD student Yugo Kawai and Assistant Professor Akihiko Fukui at the Graduate School of Arts and Sciences, the University of Tokyo, proposed a new observational method that takes advantage of the timescale of high-eccentricity migration itself.

In high-eccentricity migration, a planet’s orbit becomes highly elongated before tidal forces circularize it as it passes close to the star. The timescale of this circularization depends on factors such as the planet’s mass, orbital period, and tidal forcing. If a hot Jupiter indeed formed through high-eccentricity migration, its circularization time must be shorter than the system’s age. However, by calculating the circularization times for over 500 known hot Jupiters, the researchers identified a group of about 30 planets for which this condition is not satisfied—they have circular orbits despite circularization times longer than their system ages.

Moreover, this group of hot Jupiters exhibits characteristics consistent with other predictions of disk migration, such as regarding the alignment of orbits and planet multiplicity. None of the planets in this subset show orbital misalignment, implying they migrated smoothly within the disk without strong perturbations. Additionally, several of these hot Jupiters belong to multi-planet systems. Such an arrangement is unlikely if they had formed via high-eccentricity migration, which tends to eject other planets.
Identifying planets that have preserved the memory of their migration is crucial for understanding planetary system evolution. Future observations of atmospheric compositions and elemental ratios in these planets are expected to reveal where within the disk they formed, shedding new light on the origins of hot Jupiter's.