Wednesday, April 01, 2026

 

Air surveillance reveals hidden reservoirs of antibiotic resistance genes




Hiroshima University

Air resistome 

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An international team of researchers found that urban pollution and infrastructure shape the air microbiome, releasing clinically relevant ARGs—the kind most likely to reduce the effectiveness of medical treatments—into the air

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Credit: Fumito Maruyama/Hiroshima University





The air we breathe serves as a silent vector of antimicrobial resistance, calling for the need to integrate air monitoring into global public health strategies, according to a review by an international team of researchers.

While the fight against antimicrobial resistance (AMR) has traditionally focused on soil, water, and clinical settings, new research highlights that the air resistome—the collection of antibiotic resistance genes (ARGs) found in the atmosphere—is a critical but overlooked pathway for transmission. 

ARGs can spread both on their own and through microorganisms that carry them. Urban environments often carry a high diversity of these genes due to dense human activity and wastewater infrastructure. However, even rural air, thought to be “cleaner”, harbors ARGs linked to agricultural practices, such as livestock farming, manure and sludge application, wastewater treatment plants, composting facilities, and aquaculture, the researchers explained. “This means every breath we take can potentially connect us to the global challenge of antimicrobial resistance,” said Professor Fumito Maruyama at Hiroshima University’s The IDEC Institute, who led the team.

In a review published in Critical Reviews in Environmental Science and Technology, an international research team has examined how ARGs are distributed across different environments.

The team found that urban pollution and infrastructure shape the air microbiome, releasing clinically relevant ARGs—the kind most likely to reduce the effectiveness of medical treatments—into the air. In rural areas, the air resistome changes with the seasons because it is tied to the timing of specific agricultural tasks. For example, when farmers apply manure as fertilizer or manage large groups of livestock, they inadvertently release different sets of resistance genes into the air.

The researchers describe the air as an invisible library of ARGs that circulate silently between humans, animals, and the environment. By recognizing air as a key reservoir, scientists can begin to design more effective preventive strategies. Currently, the lack of standardized monitoring systems across different regions and seasons makes it difficult to assess the full scale of the risk. The researchers emphasize that understanding these airborne patterns is essential for strengthening global AMR control frameworks.

Moving forward, the team aims to establish standardized surveillance systems to track the air resistome across various cities and rural landscapes. The ultimate goal is to ensure that international health policies consider this atmospheric transmission route alongside waterborne and soilborne routes. By integrating air monitoring into global strategies, policymakers can better protect public health from hidden environmental risks.

The research team also includes Salametu Saibu of Lagos State University, Nigeria; Kyoko Yarimizu, Ishara Uhanie Perera, Yin Yue, and So Fujiyoshi of Hiroshima University, Japan; Sofya Pozdniakova of the Barcelona Institute for Global Health, Spain; Pierre Amato of CNRS–Université Clermont Auvergne, France; and Naomichi Yamamoto and Florent Rossi of Seoul National University, South Korea. Perera is also affiliated with Yamaguchi University, Japan, while Rossi and Fujiyoshi are additionally affiliated with Université du Québec à Chicoutimi, Canada. Fujiyoshi is also affiliated with Toyama Prefectural University, Japan.

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About Hiroshima University

Since its foundation in 1949, Hiroshima University has striven to become one of the most prominent and comprehensive universities in Japan for the promotion and development of scholarship and education. Consisting of 12 schools for undergraduate level and 5 graduate schools, ranging from natural sciences to humanities and social sciences, the university has grown into one of the most distinguished comprehensive research universities in Japan. English website: https://www.hiroshima-u.ac.jp/en

FAU study finds some dark web users share traits with those involved in crime





Florida Atlantic University

Dark Web Users 

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Dark web users are far more likely to have criminal histories, low self-control and deviant peers – revealing who is drawn to these hidden online spaces.

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Credit: Florida Atlantic University





The dark web is sometimes seen as a shadowy part of the internet, but it also has legitimate uses, including accessing censored information and sharing files securely. Its anonymity and privacy features, however, can make it appealing to those drawn to riskier or illicit online activity.

As interest in the dark web grows, researchers are taking a closer look at who accesses it. The platform creates conditions where motivated offenders, potential victims and little oversight converge, and traits like low self-control and peer influence may help explain who is drawn to it. Yet criminology-based studies comparing dark web and surface web users are scarce.

To help fill that gap, research from Florida Atlantic University and collaborators analyzed survey data collected from a national sample of 1,750 adults in the United States, examining whether factors such as prior criminal behavior, low self-control, deviant peer groups and attitudes toward crime are linked to self-reported dark web use.

The researchers first examined whether people who reported having a criminal record were more likely to have accessed the dark web. Next, they looked at self-control, assessing whether individuals with lower self-control – a trait tied to impulsive and risk-taking behavior – were more likely to use the platform. Finally, they explored the role of social influences and attitudes by analyzing whether having more peers who engage in online deviance, as well as holding more favorable views toward rule-breaking and violence, were associated with dark web access.

Results of the study, published in the Journal of Crime and Justice, reveal clear differences between dark web users and surface web users across each of the criminological factors examined. About one-third of dark web users reported a prior criminal conviction – nearly three times the rate of surface web users (33.6% vs. 12.6%). They also scored significantly higher on measures of low self-control, peer cyber deviance, and criminal attitudes, including support for larceny, online deviance, and especially concerning, physical violence against others.

Across all models, being male and being younger were also linked to a higher likelihood of dark web use, with some models also suggesting that being heterosexual and having more education is also associated with dark web use.

Overall, these findings suggest that past criminal behavior, impulsiveness, social influences and favorable attitudes toward deviance all play a role in who chooses to access the dark web, providing strong empirical support for criminological theories in this digital context.

“It’s important to be clear: accessing the dark web is not inherently deviant or illegal, and it supports many legitimate activities, from private communication to accessing censored information,” said  Ryan C. Meldrum, Ph.D., senior author and director of the School of Criminology and Criminal Justice within FAU’s College of Social Work and Criminal Justice. “What our research shows, however, is that the platform also tends to attract some individuals whose behavioral, social and attitudinal profiles resemble those involved in criminal activity. In this sense, the dark web is a risky digital environment – one that can facilitate crime and increase the likelihood of victimization, all while operating under limited law enforcement oversight.”

Supplemental analyses from the study reveal that social learning factors may help explain why low self-control links to dark web access. Specifically, nearly half of the connection between low self-control and using the platform appears to be explained through the peers individuals associate with and the attitudes they form. This suggests that people with lower self-control may select peers who reinforce risky or deviant behaviors and attitudes, giving them the knowledge and skills needed to navigate the dark web.

The study underscores the need for further research into the small but important subpopulation of internet users who access the dark web, particularly those with the intent to engage in illicit activities.

“As the internet continues to evolve, understanding who accesses the dark web and why is critical,” Meldrum said. “Our study points to the importance of balancing awareness of potential risks with recognition of the legitimate, everyday uses of these hidden online spaces.”

Study co-authors are Raymond D. Partin, Ph.D., Department of Criminology and Criminal Justice, University of Alabama; and Peter S. Lehmann, Ph.D., Department of Criminal Justice and Criminology, Sam Houston State University.

- FAU -

About Florida Atlantic University:

Florida Atlantic University serves more than 32,000 undergraduate and graduate students across six campuses along Florida’s Southeast coast. Recognized as one of only 13 institutions nationwide to achieve three Carnegie Foundation designations - R1: Very High Research Spending and Doctorate Production,” “Opportunity College and University,” and Carnegie Community Engagement Classification - FAU stands at the intersection of academic excellence and social mobility. Ranked among the Top 100 Public Universities by U.S. News & World Report, FAU is also nationally recognized as a Top 25 Best-In-Class College and cited by Washington Monthly as “one of the country’s most effective engines of upward mobility.” To learn more, visit www.fau.edu.

 

 

Soft sensor gives robots a better sense of touch




Aerospace Information Research Institute, Chinese Academy of Sciences

Systematic overview of the humanoid dexterous hand with multi-degree-of-freedom posture perception. 

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Systematic overview of the humanoid dexterous hand with multi-degree-of-freedom posture perception. a The humanoid dexterous hand in various delicate operational scenarios. b The omnidirectional soft bending sensor in the humanoid dexterous hand.

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Credit: Microsystems & Nanoengineering





A new soft sensing system could help humanoid robots move their hands with far greater precision in delicate, human-like tasks. The study introduces a dexterous robotic hand equipped with omnidirectional bending sensors that can track both pitch and yaw at the finger joints, allowing the system to perceive complex finger posture in real time. By combining flexible sensing with a rigid-soft hand design, the researchers created a platform that not only moves more naturally but also performs demanding actions such as using scissors, operating a mouse, and playing the piano with improved control and stability. 

Robotic hands have made major progress in grasping and pinching, but many still struggle with the finer motions that make the human hand so versatile. One key limitation is proprioception: while human fingers constantly sense their own position and movement, most humanoid hands remain weak at perceiving posture across multiple degrees of freedom. Existing soft sensors often detect only one bending mode or suffer from coupling problems when fingers flex and move sideways at the same time. This leaves a gap between robotic grasping and true dexterous manipulation. Based on these challenges, deeper research was needed into soft sensing systems capable of decoupling and accurately tracking multidirectional finger motion.

Researchers from Zhejiang University, Hangzhou Dianzi University, and Lishui University reported (DOI: 10.1038/s41378-026-01179-3) the work in Microsystems & Nanoengineering in 2026. The study presents a humanoid dexterous hand designed to solve a central problem in advanced robotics: how to give robot fingers a reliable sense of their own posture during complex motion. By embedding a new omnidirectional soft bending sensor into the hand, the team enabled real-time perception of both flexion and side-to-side movement in delicate manipulation tasks.

The hand features 18 active degrees of freedom and five rigid-flexible fingers, with each finger integrating a soft optical sensor built from segmented PMMA fibers, a trichromatic LED, and a chromatic detector. The design works by tracking how red, green, and blue light attenuate differently as the sensor bends. Because the fiber layout separates responses to pitch and yaw, the system can decouple the two motions instead of mixing them together. The paper reports strong repeatability over 100 cycles, with RMSE values of 2.1%, 1.9%, and 3.2% across the three optical channels. Under single bending, the average measurement error was only ±2.13° for pitch and ±2.34° for yaw. Crosstalk remained low: pure yaw contributed 3.2% to pitch, while pure pitch contributed 4.1% to yaw, with signal-to-crosstalk ratios of 50.68 dB and 30.81 dB, respectively. The team then moved beyond bench testing and demonstrated the hand in three visually compelling tasks—cutting with scissors, clicking a mouse, and playing piano keys—showing closed-loop posture control in actions that require subtle coordination rather than simple gripping.

The researchers suggest that the real advance is not just a new sensor, but a new way of giving robotic hands a more human-like internal awareness of motion. In their conclusion, they emphasize that the integrated rigid-soft design supports natural movement, while the sensing system delivers the stability, repeatability, and multi-DoF posture perception needed for complex operations. That combination could make future humanoid hands more capable in tasks where precision matters most.

This work points toward robotic hands that are not only stronger or faster, but more skillful. Better posture perception could improve humanoid robots used in service settings, industrial assembly, rehabilitation devices, and other environments where fingers must adapt to fragile or highly varied objects. The study’s demonstrations also hint at broader possibilities in human-robot interaction, where smoother and safer hand motion is essential. By showing that soft optical sensing can remain accurate while supporting complex multidirectional movement, the research moves robotic manipulation closer to the responsiveness and finesse of the human hand.

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References

DOI

10.1038/s41378-026-01179-3

Original Source URL

https://doi.org/10.1038/s41378-026-01179-3

Funding Information

This research was supported by the National Natural Science Foundation of China (No. 52475573), the Natural Science Foundation of Zhejiang Province (No. LTGY23E050002), the National Key Research and Development Program of China (No. 2023YFC2811500), the Science and Technology Innovation Project of the General Administration of Sport of China (24KJCX074), the Key Research and Development Programme of Zhejiang (No. 2024C03259, No. 2023C03196), and the Fundamental Research Funds for the Central Universities.

About Microsystems & Nanoengineering

Microsystems & Nanoengineering is an online-only, open access international journal devoted to publishing original research results and reviews on all aspects of Micro and Nano Electro Mechanical Systems from fundamental to applied research. The journal is published by Springer Nature in partnership with the Aerospace Information Research Institute, Chinese Academy of Sciences, supported by the State Key Laboratory of Transducer Technology.

 

Large-scale collaboration releases new findings on research credibility



Results from the SCORE program, published in Nature and several preprints, assess multiple dimensions of credibility in social and behavioral science research.




Center for Open Science

Findings from the Systematizing Confidence in Open Research and Evidence (SCORE) program—a collaborative effort involving 865 researchers—have been published in Nature as a collection of three papers alongside a release of five additional preprints. The SCORE program offers new empirical evidence on the reproducibility, robustness, and replicability of research across the social and behavioral sciences, and the predictability of replicability.

The SCORE program examined the capability of humans and machines to predict the replicability of research findings. In the process, SCORE accumulated an enormous database of information about the credibility of a large sample of findings from across the social and behavioral sciences. The program’s outcomes will contribute to strengthening how research is interpreted and communicated, work that supports authors, reviewers, funders, policymakers, and readers' understanding and use of research evidence. Improving credibility assessment will help direct attention and resources for further research to where they have the greatest impact in accelerating production of knowledge and solutions.

Funded by the U.S. Defense Advanced Research Projects Agency (DARPA), SCORE is a large-scale, multi-method research initiative designed to improve how scientific credibility is assessed in the social and behavioral sciences. The program examines multiple dimensions of research repeatability—including reproducibility, robustness, and replicability—to better understand the credibility of published findings from multiple perspectives. The SCORE team sampled claims from 3,900 papers published from 2009-2018 in 62 journals spanning criminology, economics, education, finance, health, management, marketing, organizational behavior, psychology, political science, public administration, and sociology. These claims were subjected to a variety of methods of credibility assessment.

The contributions of hundreds of researchers was coordinated by several lead teams. Sampling of claims, gathering of credibility measures, and conducting of replication and reproduction studies was coordinated by the Center for Open Science (COS). Human expert assessments were conducted by two independent teams, the repliCATS project and Replication Markets, to evaluate the viability and accuracy of forecasting research replicability. Three teams led by researchers at Pennsylvania State University, TwoSix Technologies, and the University of Southern California implemented machine-learning and algorithmic approaches to predicting replicability. And, the Metascience Lab from Eötvös Loránd University coordinated the robustness assessments.

A basic contribution of the program is to affirm emerging standards for some terminology related to credibility and trustworthiness of research. Specifically, reproducibility, robustness, and replicability refer to distinct aspects of the repeatability of evidence—an important component of creating generalizable knowledge. A preprint from Nosek and colleagues explains the terminology to support clear and consistent understanding.

Across its studies, SCORE findings suggest that reproducibility, robustness, and replicability each capture distinct aspects of research credibility, and that published claims vary in how well they hold up under these distinct forms of scrutiny. The following are brief summaries of each of the three papers appearing in Nature.

Reproducibility refers to conducting the same analysis on the same data and assessing whether the finding is the same as reported in the original paper.

As reported by Miske and 127 co-authors, SCORE revealed limited transparency, which makes reproducibility and robustness assessment infeasible. Data was available for only 24% of a sample of 600 assessed papers. For the 143 papers that were subjected to reproduction tests, 74% successfully reproduced at least approximately and 54% precisely. Success was associated with how much was shared from the original paper. Approximate (91%) and precise (77%) reproducibility was highest for papers where both original data and code were shared, and lowest (38% and 11%) when reanalysis required reconstructing the original dataset from public sources (e.g., retrieving census data and reconstructing the data management and analysis steps reported in the paper). 

Robustness refers to conducting alternative reasonable analyses on the same data and assessing whether the findings are similar to what was reported in the original paper.

As reported by Aczel and 490 co-authors, SCORE revealed hidden uncertainty in research findings by conducting systematic testing of analytical robustness of 100 papers. For each paper, at least five independent analysts tested the same question with the same data, applying their own decisions about how to best analyze the data. 34% of independent reanalyses revealed the same result as the original finding within a narrow tolerance range (+/- 0.05 Cohen’s d units), and 57% revealed the same result with a tolerance range four times the size.  Regarding the conclusions drawn, 74% of analyses were reported to arrive at the same conclusion as in the original investigation; 24% to no effects/inconclusive result, and 2% to the opposite effect as in the original investigation.

Replicability refers to testing the same question in new data and assessing whether the findings are similar to what was reported in the original paper.

As reported by Tyner and 291 co-authors, SCORE revealed that it is challenging to replicate original findings with independent data. Of 164 papers subjected to replication attempts, 49% replicated successfully according to the most common criterion for assessing replication (statistical significance with the same pattern as the original study), and the observed effect sizes for replication studies (0.10 in Pearson’s r units) were less than half the magnitude of the original studies (0.25).

The five preprints released alongside the Nature collection provide additional evidence about credibility and predictability of research findings: 

  • Abatayo and 85 co-authors combined evidence across the SCORE program and observed that measures of repeatability and credibility are only weakly related with one another. This suggests that credibility is multidimensional and it is unlikely that there are broadly applicable shortcuts to establishing the validity and reliability of research findings. 
  • Mody and 33 co-authors reported evidence from two distinct methods of eliciting predictions from people about the replicability of findings: repliCATS and Replication Markets. They observed that human assessments are reasonably accurate at predicting replication outcomes (76% and 78% success rates by best performing metric for the two methods respectively). 
  • Rajtmajer and 39 co-authors reported evidence from three distinct automated methods of eliciting predictions from machines about the replicability of findings: Synthetic Markets, MACROSCORE, and A+. None of the three methods were consistently effective at predicting which claims would replicate successfully or not, suggesting some caution for earlier evidence of successful use of machine methods for such assessments.
  • Eight of the leaders of the SCORE program (Nosek, Aczel, Errington, Fidler, Mody, Rajtmajer, Szászi, and Tyner) comment on the implications of the SCORE program and the opportunity to reimagine assessment of research credibility.
  • Five members of the Center for Open Science provided a brief review of the reproducibility, robustness, and replicability terminology that underlies the meaning and interpretation of the findings from the SCORE program.

Together, these eight papers offer the following conclusions:

  • These findings replicate and extend prior systematic replication efforts in fields such as cancer biology and psychology with about half of attempts successfully replicating original findings across a diverse sample of research from the quantitative social and behavioral sciences.
  • These findings also replicate and extend prior reproduction and robustness attempts in a variety of fields. A quarter to a third of attempts failed to show the same or similar results when either trying to repeat the same analysis as the original paper (reproducibility), and came to different conclusions when conducting reasonable alternative analyses for the same question (robustness).
  • These findings replicate and extend prior evidence that humans can forecast replication success with reasonable accuracy, and provide weaker evidence than prior studies that machines can provide similarly accurate forecasts.
  • No particular field in the social and behavioral sciences demonstrated consistently higher repeatability than other fields across the three approaches. However, for reproducibility specifically, there were substantial differences in data availability that were associated with higher reproducibility rates in Economics and Political Science compared with other fields.
  • Reform efforts in the social and behavioral sciences over the last 10 years might result in higher repeatability compared with the findings from SCORE which were based on papers published from 2009 to 2018. For example, as highlighted by Miske and colleagues, journal policies across the social and behavioral sciences have strengthened since that time to require sharing data and code and even including reproducibility checks as part of the publication process.
  • Repeatability and credibility assessments are highly diverse. There is no singular assessment of the credibility of a research findings, highlighting the complex process of knowledge production.

“The main message of SCORE is a simple one: research is hard. And, in some ways, the hard work begins after making a discovery. A tremendous amount of effort is needed to verify and have enough confidence in new discoveries to build foundations for further discovery,” said Tim Errington, Senior Director of Research at COS and one of the SCORE project leaders.

The results reveal that there is no single indicator of the repeatability of evidence, or research credibility more generally. There is substantial opportunity for innovation in development of indicators to assess credibility to diversify the understanding of how trustworthy findings are established.

As another SCORE project leader, Fiona Fidler, Professor at the University of Melbourne, shared, “There are a lot of open questions about the factors that foster credibility and repeatability of research findings. Like many productive research efforts, SCORE generated insights, and has prompted even more questions about how to evaluate research in practice.”

In addition to its primary scientific findings, SCORE has generated openly accessible datasets, algorithms, and replication and reanalysis materials. These outputs will support further research on scientific credibility, potentially including development and validation of indicators to improve credibility assessment and accelerate discovery.

“With contributions from almost 900 researchers, the SCORE program provides an enormous amount of evidence to explore and inspire hypotheses for the next round of research. The data and materials are shared publicly so that others might build on this work,” said Sarah Rajtmajer, a SCORE project leader and Associate Professor at Pennsylvania State University.

Visit the website for an overview of the SCORE program, links to the papers, press releases for each paper, and other context to understand the project, findings, and implications.

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About A+
The A+ system for automated assessment of replicability of claims was developed at TwoSix Technologies (Principal Investigator: James Gentile).

About the Center for Open Science (COS)
Founded in 2013, COS is a nonprofit culture change organization with a mission to increase openness, integrity, and trustworthiness of scientific research. COS pursues this mission by building communities around open science practices, supporting metascience research, and developing and maintaining free, open source software tools, including the Open Science Framework (OSF).

About MACROSCORE
A team led by Principal Investigator, Jay Pujara, at the University of Southern California, developed the MACROSCORE system for automated assessment of replicability of claims.

About Metascience Lab
The Metascience Lab at Eötvös Loránd University (Principal Investigator: Balazs Aczel) led the robustness studies conducted in association with the SCORE program. 

About Replication Markets
A team of researchers led by Charles Twardy at Amentum developed and conducted prediction markets of human assessments of the replicability of research claims.

About the repliCATS project
A team led by Fiona Fidler at the University of Melbourne used a group structured deliberation approach to crowdsource human assessments of replicability of claims.

About Synthetic Markets
A team led by Sarah Rajtmajer at The Pennsylvania State University, developed bot-populated prediction markets to predict replicability of claims.