Saturday, April 29, 2023

UMD criminologist, Ph.D. alumnus find link between rising sea surface temps and piracy

New study sheds light on how climate change can impact maritime crime

Peer-Reviewed Publication

UNIVERSITY OF MARYLAND

Gary LaFree, UMD Department of Criminology and Criminal Justice Distinguished University Professor 

IMAGE: GARY LAFREE, UMD DEPARTMENT OF CRIMINOLOGY AND CRIMINAL JUSTICE DISTINGUISHED UNIVERSITY PROFESSOR view more 

CREDIT: JOHN CONSOLI

Climate change has long been blamed for extreme weather, food shortages and related price increases, and now, it can also be blamed for some of the crimes currently happening in our world’s oceans and seas.

According to new research published in the American Meteorological Society's Weather, Climate and Society journal by criminology and criminal justice Distinguished University Professor Gary LaFree and former graduate student Bo Jiang, an Assistant Professor at the University of Macau, rising sea temperatures are having an impact on piracy-related crimes.

“When we think of pirates, a guy with a peg leg and a parrot comes to mind, but modern piracy is a much more sophisticated phenomenon,” LaFree explained. “Piracy is an attempt to illegally board a ship—at sea or in port—with the purpose of stealing property and taking hostages for some sort of financial gain. It’s like burglary in common law: Breaking into somebody's house with the plan to enrich yourself either directly by stealing materials of value, or taking hostages and bargaining for some sort of remuneration.”

Looking at 15 years of sea surface temperatures and maritime piracy data from the South China Sea and the waters that border East Africa, LaFree and Jiang found that rising sea surface temperatures caused an increase in piracy attacks in East Africa due to decreased fish production, and a decrease in piracy attacks in the South China Sea due to increased fish production. The researchers explain that in some parts of the world, there are species of fish that do better when temperatures increase, like fish in the South China Sea, and others that do worse, like in the waters around East Africa.

“These results suggest that as climate change continues, its impact on violence and criminal behavior will likely be complex, with increases and decreases depending on the specific situational context and the rational choices changing sea temperatures generate,” Jiang said.

To LaFree, the findings also add to our understanding of who criminals are—or can be.

“Crime is much more of a dimmer switch than an on-off switch; these fishermen drift into crime when the economy is bad and they drift out of it when they're able to. This sort of hard dichotomy between criminals and noncriminals is way more porous,” he said.

The results also demonstrate how serious an impact offenses in these areas alone can have on our world economy.

“A huge proportion of all the world's trade comes through these areas; in terms of total value, we’re talking billions and billions of dollars, so if left unchecked, piracy in especially a few of these narrow straits and bottleneck areas where pirates tend to head can have a huge economic impact,” LaFree added.

Through a new Grand Challenges Individual Project Grant, LaFree and Jiang plan to do a deeper dive into the relationship between climate change and crime by collecting sea surface temperature data from 109 countries with coastlines and seeing how rising temperatures impact acts of political violence, and more specifically, acts of terrorism.

“The proposed research will tell us the extent to which climate change may alter the socio-political and environmental situations where terrorist organizations can proliferate, rise and grow, as well as offer insights into the individual decisions to engage in terrorism,” LaFree concluded. 

Disclaimer: AAAS and E

New pancreatic cancer research could boost survival rates

Treatment combining radiation and immunotherapy offers hope for a stubborn disease

Peer-Reviewed Publication

UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

A unique treatment combining radiation and immunotherapy can eradicate pancreatic tumors while stopping the cancer from spreading, according to a new study by researchers at the University of Colorado Cancer Center.

The study, published today in the journal Cancer Cell, offers new hope to those with this often deadly disease.

“This is the first time we’ve seen the eradication of a pancreatic tumor that suggests the cancer cell has memory, meaning we can stop the disease from coming back,” said lead author Sana Karam, MD, PhD, member of the CU Cancer Center at the University of Colorado Anschutz Medical Campus. “Ultimately, this could alter the way doctors treat pancreatic cancer patients in the near future.”

They hope to conduct clinical trials using this therapy.

The research, which used animal models, focused on pancreatic ductal adenocarcinoma, which accounts for 90 percent of pancreatic cancer cases. Karam and her colleagues found that radiation and a new immunotherapy can induce a significant systemic memory immune response resulting in an anti-tumor effect achieving eradication, even after being rechallenged.

They hope this finding will improve survival rates for a disease that has not historically responded to immunotherapy.

According to Karam, combining the two therapies allows them to focus on eradicating ‘bad’ T-cells within the immune system.

“When a disease is metastatic, you want to recognize and attack the cell type everywhere, from the pancreas to the liver, blood and more,” she said. “This approach does exactly that in our study.”

The researchers used a novel variant antibody complex (aPD1-IL2v) that allowed for the expansion of tumor-antigen specific T-cells. This alone had a significant effect on local and distant tumor growth. It was further enhanced by adding radiation therapy.

Similar immunotherapy research aimed at other cancers is being conducted in Europe. But this is the first time it’s been combined with radiation therapy and focused on pancreatic cancer tumors.

“In just one radiation session, we saw a remarkable immune response that could change how we treat pancreatic cancer patients,” Karam said. “I’ve never been more hopeful about the possibility of improving the survival rate for this disease.”

About the University of Colorado Anschutz Medical Campus

The University of Colorado Anschutz Medical Campus is a world-class medical destination at the forefront of transformative science, medicine, education and patient care. The campus encompasses the University of Colorado health professional schools, more than 60 centers and institutes and two nationally ranked independent hospitals - UCHealth University of Colorado Hospital and Children's Hospital Colorado - that treat more than two million adult and pediatric patients each year. Innovative, interconnected and highly collaborative, the University of Colorado Anschutz Medical Campus delivers life-changing treatments, patient care and professional training and conducts world-renowned research fueled by over $690 million in research grants. For more information, visit www.cuanschutz.edu.

 

Newly developed hydrogel nanocomposite for the mass production of hydrogen

A new type of floatable photocatalytic platform composed of hydrogel nanocomposites efficiently proceeds hydrogen evolution reaction, even by using plastic wastes

Peer-Reviewed Publication

INSTITUTE FOR BASIC SCIENCE

Figure 1 

IMAGE: A. FLOATABLE PHOTOCATALYTIC PLATFORMS ARE COMPOSED OF BILAYER STRUCTURES, A PHOTOCATALYTIC LAYER, AND A SUPPORTING LAYER. B. THE POROUS STRUCTURE OF THE PLATFORM. C. THE POROUS STRUCTURE OF THE PLATFORM FEATURES FLOATABILITY. view more 

CREDIT: INSTITUTE FOR BASIC SCIENCE

A research team led by Prof. HYEON Taeghwan at the Center for Nanoparticle Research within the Institute for Basic Science (IBS) in Seoul, South Korea has developed a new photocatalytic platform for the mass production of hydrogen. The group’s study on the photocatalytic platform led to the development of a floatable photocatalytic matrix, which allows efficient hydrogen evolution reaction with clear advantages over conventional hydrogen production platforms such as film or panel types.

The importance of alternative energy has recently increased due to global challenges such as environmental pollution and climate change. Among several candidates for alternative energy sources, hydrogen energy harvested by photocatalysis is particularly highlighted for its sustainable green energy production. Accordingly, much research and development have been made to enhance the intrinsic reaction efficiency of photocatalysts. However, research on the form factor of photocatalytic systems, which is critical for their practical application and commercialization, has not yet been actively explored.

Usually, current systems fix catalyst powder or nanoparticles onto different surfaces, such as particulate sheet-type, film-type, and flat panel-type platforms, which are submerged under water. They also face practical issues such as the leaching of catalysts, poor mass transfer, and reverse reactions. They also require additional devices to separate and collect the generated hydrogen from water, which adds to the complexity of the device and increases the costs.

The team at the Center for Nanoparticle Research within the IBS, led by Prof. Hyeon, designed a new type of photocatalytic platform that floats on the water for efficient hydrogen production. This new platform has a bilayer structure, which consists of an upper photocatalytic layer and a lower supporting layer (Figure 1A). Both layers are composed of a porous structural polymer that endows high surface tension to the platform (Figure 1B). In addition, the platform is fabricated in the form of cryo aerogel, a solid substance filled with gas inside, exhibiting low density. As a result, this elastomer-hydrogel embedded with photocatalysts can float on water (Figure 1C).

This platform exhibits clear advantages in the photocatalytic hydrogen evolution reaction: first, light attenuation by water is prevented, resulting in efficient solar energy conversion. Second, the product, hydrogen gas, can be easily diffused into the air, avoiding reverse oxidation reactions and preserving high reaction yield. Third, the water can be easily supplied to the catalysts located inside the elastomer-hydrogel matrix due to its porosity. Last, catalysts are stably immobilized inside the matrix for long-term operation without leaching issues (Figure 2).

The researchers experimentally proved the superior hydrogen evolution performance of the floatable platform, compared to that of the conventional submerged platform (Figure 3A, B). Furthermore, the scalability of the platform, which is essential for potential industrialization, was also demonstrated under natural sunlight. It was confirmed that about 80 mL of hydrogen can be produced by the floatable photocatalytic platform using copper single atom and titania catalysts with an area of 1 m(Figure 3C-E). Even after 2 weeks of operation in seawater containing various microorganisms and floating matter, the hydrogen evolution performance of the platform was not compromised.

Prof. Kim states, “The proposed platform can even produce hydrogen from solutions that dissolve household waste, such as polyethylene terephthalate bottles. Consequently, the platform can be a solution for recycling wastes, which contributes to an environment-friendly society.”

Notably, this study presents a generalized platform for efficient photocatalysis that is not just limited to hydrogen production. It is possible to replace the catalytic component for various desired uses, without changing the floatable aerogel material properties of the overall platform. This guarantees the wide applicability of the platform to other photocatalytic reactions, such as oxygen evolution reaction, hydrogen peroxide production, and generation of various organic compounds.

“This study makes great progress in the field of photocatalysis and showcases the potential of green hydrogen production at sea with world-class performance. The distinctive material features, high performance, and broad applicability in the field of photocatalysis of our platform will undoubtedly open a new chapter in alternative energy,” remarked Prof. Hyeon.

Floatable photocatalytic platforms have clear advantages in hydrogen evolution reaction, in terms of efficient light delivery, facile gas separation, enhanced surface tension, stable catalyst immobilization, suppressed back-oxidation (reverse reaction), and facile supply of water

Mandatory vs recommendation: Norway assessed mobility during times of mandatory and non-mandatory COVID-19 measures 

Using mobile phone data provides mobility metrics to assess the effect of non-pharmaceutical interventions on mobility


Peer-Reviewed Publication

EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL (ECDC)

Effects of national non-pharmaceutical interventions on mobility in less populated regions, Norway, 2021 

IMAGE: THE PERCENTAGE OF MOBILITY CHANGE IN EACH OF THE THREE MOBILITY METRICS FROM THE WEEK BEFORE TO THE WEEK AFTER DIFFERENT INTERVENTION DATES IS SHOWN FOR SELECTED REGIONS. THE INTERVENTION DATES INCLUDE A CONTROL TIME POINT IN NOVEMBER AND THREE INTERVENTIONS IN DECEMBER, WITH ONLY NON-MANDATORY MEASURES ON 3 DECEMBER, MOSTLY NON-MANDATORY MEASURES ON 9 DECEMBER AND MANDATORY FOLLOW-UP MEASURES ON 15 DECEMBER. view more 

CREDIT: EUROSURVEILLANCE

Norway, like other Nordic countries, widely utilised non-mandatory advice during the COVID-19 pandemic in the attempt to reduce social contacts among people and occasionally turned to obligatory measures, specifically during peaks in transmission. In comparison with stricter interventions, non-mandatory measures are usually less invasive and costly and have been recommended in previous pandemics, including influenza.

Mobile phone data provides mobility metrics

In their research article published in Eurosurveillance today, Kamineni et al. compare the impact on mobility when previously non-mandatory interventions to curb COVID-19 transmission were turned into obligatory non-pharmaceutical (NPI) measures. [1]

Based on mobile phone data from the largest Norwegian operator, the authors investigated the effects of interventions that regulated e.g. use of face mask, teleworking, physical distancing, alcohol serving, events, schooling, gyms, restaurants as well as shops and businesses between January 2021 and January 2022. They collected three mobility metrics per day per person for each of the 365 municipalities of Norway: (i) radius of gyration, (ii) time spent away from home and (iii) the maximum distance from home.

The analysis looked at effect of three national interventions in December 2021 that ranged from recommendations to work from home and reduce close contacts beginning of December to regulations of events, banning serving of alcohol after midnight and a face mask requirement in indoor environments about one week later and ultimately making working from home mandatory, banning alcohol serving, imposing digital teaching for universities and a continued face mask requirement as of 15 December 2021. Kamineni et al. investigated the impact of the measures on national level, in the bigger cities Oslo, Stavanger, Tromso, Trondheim and Bergen and in less populated regions of Norway. 

Non-mandatory: less invasive and costly but sufficient
On national level, mobility declined following initial non-mandatory measures – all further measures, including compulsory ones as of mid-December 2021, yielded only comparatively small effects on radius and maximum distance away from home.

Based on their data, the authors found that people in Norway travelled shorter distances from home after non-compulsory measures were introduced. In urban areas, the distance people travelled decreased further when the measures became mandatory. Travelling times also became shorter, and this effect was stronger following the legal mandate than after non-compulsory interventions - in both rural and urban regions.

Stricter metre rules and reopening of gyms, restaurants and shops prompted changes in people’s behaviour.

The authors note that “interestingly, after follow-up mandates, all metrics decreased in urban areas, while only time travelled decreased in rural areas” and that “interventions affected distance and time travelled separately. Nationally, follow-up mandates impacted time more than distance, and these metrics were influenced by different interventions stricter metre rules and reopening of gyms influenced distance, while reopening of restaurants and shops and easing physical distancing affected time.”

Kamineni et al. argue that their findings give valuable insights on the choice of NPI and whether to make them mandatory or not in regional or national settings, making the case that “less invasive and costly non-mandatory measures may be sufficiently effective for rural areas in the case of Norway.”  

 

----Ends----

References/notes to editors:
[1] Kamineni Meghana, Engø-Monsen Kenth, Midtbø Jørgen E, Forland Frode, de Blasio Birgitte Freiesleben, Frigessi Arnoldo, Engebretsen Solveig. Effects of non-compulsory and mandatory COVID-19 interventions on travel distance and time away from home, Norway, 2021.
Euro Surveill. 2023;28(17):pii=2200382
Available from: https://doi.org/10.2807/1560-7917.ES.2023.28.17.2200382

In their analysis, Kaminen et al. considered a NPI mandatory, when obligation to follow was based on a regulation or law while non-mandatory recommendations would not lead to any legal consequences in case of non-compliance

Limitations of the study

With the before–after analysis, potential confounders include temperature and weather. While the authors analysed mobility trends before interventions were enacted, there were no controls.
 

US should begin laying the foundation for new and advanced nuclear reactors, says new report

New and advanced nuclear reactors could play an important role in helping the U.S. meet its climate goals, but a range of challenges must first be overcome, says a new report from the National Academies of Sciences, Engineering, and Medicine

Peer-Reviewed Publication

NATIONAL ACADEMIES OF SCIENCES, ENGINEERING, AND MEDICINE

WASHINGTON — New and advanced types of nuclear reactors could play an important role in helping the U.S. meet its long-term climate goals, but a range of technical, regulatory, economic, and societal challenges must first be overcome, says a new report from the National Academies of Sciences, Engineering, and Medicine. Development, testing, and widespread deployment of these reactors could take several decades. The report makes recommendations for the U.S. Department of Energy, the Nuclear Regulatory Commission, other federal and state agencies, and private industry to lay the groundwork required for advanced reactors to become a viable part of the U.S. energy system.

Currently, the U.S. electricity system includes large light water reactors (LWRs) that produce electricity for commercial use. LWRs use water to cool the reactor and moderate the speed of the nuclear chain reactions taking place. Many advanced reactor concepts use conventional fuels, materials, and manufacturing methods, but some also employ a wide array of new coolants, designs, fuels, materials, and technologies. Among these are modular LWRs that are smaller, simpler, and rely mainly on passive safety features. Other examples include reactors that use liquid metal, molten salt, or high-temperature gas as coolants.

The U.S. electricity system is already undergoing massive shifts, but economy-wide decarbonization efforts will span decades, and electricity demand is projected to continually grow over that period. Advanced nuclear technologies likely will not be able to markedly contribute to electricity generation until the 2030s at the earliest, the report says, but there are opportunities for them to compete with other energy technologies in the long term. Innovative ideas for reactors, if fulfilled, may provide on-demand power generation to complement variable sources of energy, such as solar and wind energy, and help decarbonize challenging industrial sectors by providing high-temperature heat for chemical processes, such as hydrogen production.   

Some advanced nuclear reactor concepts, due to their size or the way they are to be produced, offer new ways for nuclear power to be used, including:

  • Major portions or even the entirety of the reactor system could be produced in factories, potentially reducing project costs and uncertainties and increasing quality.
  • Existing power generation sites using fossil fuel (e.g., coal plants) could be repurposed for nuclear power generation.
  • Small reactors or microreactors could be transported to meet off-grid emergency needs.
  • Reactors could produce localized thermal energy for industrial applications that otherwise have hard-to-abate emissions because of high temperature requirements, such as cement, hydrogen, and steel production; for district heating (heat distributed through pipes to keep residences or businesses warm); or for desalination. 

“Our report shows new and advanced nuclear reactors could play an important role as the U.S. works to decarbonize the economy,” said Richard A. Meserve, Senior Of Counsel for Covington & Burling LLP, former chair of the Nuclear Regulatory Commission, and chair of the committee that wrote the report. “But there are significant hurdles that must be overcome to enable advanced nuclear reactors to succeed and reach commercial and globally competitive viability ― among them, economic challenges, technological challenges, regulatory changes, and societal acceptance.  If we want the ability to pursue this option, the U.S. should address these barriers now.”

Meeting the Technological Promise

There are many differences between nuclear reactors currently in use and proposed advanced nuclear reactors. For advanced reactors to be able to compete in a decarbonized economy, the report makes a range of recommendations, including:

  • DOE’s Office of Nuclear Energy should initiate a research program that sets aggressive goals for improving performance of fuels and materials used to build or operate reactors.
  • The nuclear industry and DOE should fully develop a structured, ongoing program to ensure the best-performing technologies (as measured by technical, financial, regulatory, and social acceptance milestones) move rapidly through demonstration.
  • DOE should expand its efforts in advanced construction technology research and development and make advanced construction technologies broadly available to reduce costs.
  • Significant incentives, such as those that have nurtured solar and wind technologies, should be provided to enable the wide commercial deployment of advanced reactors. 
  • Widespread deployment of advanced reactors will require more skilled workers. DOE should initiate a whole of government partnership, and work with labor organizations, industry, regulatory agencies, and other organizations to identify gaps in critical skills, and fund training and development solutions.

Policies and Regulations for Economic Competitiveness

Nuclear power reactors are tightly regulated by the NRC in all phases of their life cycle ― design, construction, operations, and decommissioning. The report says that the NRC must maintain its overarching commitment to safety, but regulations governing existing reactors are not suitable for advanced reactors, which could present novel regulatory issues, particularly reactors that use new coolants, have advanced safety capabilities, or are factory made or transportable. Congress should provide the NRC with more resources to enhance its capability to deal with these differences and create efficient, effective, and flexible regulatory processes.

In addition, differing regulatory requirements between countries can discourage international sales, which may be an essential part of making nuclear vendors’ business plans competitive. The report urges broader international regulatory harmonization, in the short term through bilateral arrangements ― such as the U.S. agreement with Canada ― and in the long term through engagement with the International Atomic Energy Agency and Nuclear Energy Agency.

There are considerable regulatory and economic risks that can deter potential investors in the advanced nuclear industry, including uncertainties around whether the NRC might reject a new approach, impose new design or operational requirements, or bring about added costs through delayed action. Some regulatory risks are particularly difficult for industry to evaluate because there is often no past guidance that would apply to novel reactor designs, so more regulatory certainty will help industry and its investors make informed plans.

Federal and state governments should take actions that enable the industry to be cost-competitive with other low-carbon energy technologies, including through tailored financial incentives, the report says. The U.S. should also foster a healthy international market for advanced nuclear technologies, and better equip itself to swiftly negotiate nuclear cooperation arrangements. The report recommends steps for Congress and the federal government to help U.S. vendors compete with state-owned and state-financed vendors in the international energy market.

Assurance of Safety, Security, and Safeguards

New deployment scenarios can introduce new physical and cyber risks, which should be dealt with through safety, security, and safeguards requirements as appropriate. NRC staff have proposed significant modifications to the physical security requirements for nuclear facilities to take into account novel designs and operations of advanced reactors. However, clear regulatory guidance is still needed, the report notes, and the NRC will need sufficient expert staff to provide this guidance.

Earning Societal Acceptance

While nuclear power must be safe and secure, it must also be accepted by society and by the communities in which new reactors are built. The advanced nuclear industry should adopt consent-based approaches for new facilities, adjusted for place, time, and culture, the report says. Consent-based processes ― still nascent in the industry, where plans for new reactors are typically only reviewed after design and siting are completed ― should include participatory site selection methods and incorporate more value-focused thinking. Industry should adopt research-backed approaches to community engagement, enduring through the life of a project, and these should be treated with the same seriousness as technological development. The report charts a path forward for better engagement, recommending a set of best practices for the industry.

2022 National Academies report, written by a separate committee, discusses nuclear fuel cycle options for both existing and advanced reactors, nonproliferation and security considerations for these fuel cycles, as well as issues related to the waste associated with advanced nuclear reactors.

This study, undertaken by the Committee on Laying the Foundation for New and Advanced Nuclear Reactors in the United States, was supported by a gift donation by James J. Truchard, a National Academy of Engineering member, and by the U.S. Department of Energy.

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide independent, objective analysis and advice to the nation to solve complex problems and inform public policy decisions related to science, engineering, and medicine. They operate under an 1863 congressional charter to the National Academy of Sciences, signed by President Lincoln.

Contact:
Joshua Blatt, Media Relations Officer
Office of News and Public Information
202-334-2138; e-mail news@nas.edu

 

Chinese medicine herb may have the power to help heart attack patients

Peer-Reviewed Publication

NEWCASTLE UNIVERSITY

Professor Ioakim Spyridopoulos 

IMAGE: IOAKIM SPYRIDOPOULOS, A PROFESSOR OF CARDIOLOGY AND CARDIOVASCULAR GERONTOLOGY AT NEWCASTLE UNIVERSITY. view more 

CREDIT: NEWCASTLE UNIVERSITY, UK

A plant-based compound purified from the traditional Chinese herb, Astragalus, has the potential to improve the outcome of heart attack patients, new research has revealed.

Experts at Newcastle University, UK, have found that the product, known as TA-65®, significantly reduces inflammation and, unlike current cardiovascular treatments, does not negatively impact immunity.

A study, published in GeroScience, showed that when TA-65® was given to older patients for over a year after their heart attack, it specifically increased lymphocytes, improving immunity of patients.

In addition, patients treated with the drug experienced far less complications, or issues such as chest or joint pains, following their heart attack.

Reducing inflammation

Ioakim Spyridopoulos, a Professor of Cardiology and Cardiovascular Gerontology at Newcastle University, has led the study, working with the heart team at The James Cook University Hospital in Middlesbrough.

Professor Spyridopoulos said: “It has become widely recognised that inflammation plays a key role in the formation, progression, and rupture of a coronary plaque, which induces heart attack, but, importantly, it is also a major risk factor for further complications.

“Reducing inflammation is, therefore, considered a key treatment target following a heart attack for patients and our study showed that TA-65® reduced inflammation by up to 62%.

“While some potent anti-inflammatory drugs have been shown to improve outcomes after heart attacks, they result in suppression of the immune system and increase the risk of severe infections.

“In our study, the widely available drug TA-65® was shown to reduce inflammation but also appears to improve immunity by increasing a patient’s immune cells.”

Scientists, including experts at The James Cook University Hospital, carried out a randomised controlled pilot study in which patients were given a placebo drug or TA-65®.

The study was carried out on 90 patients aged 65 and over and performed as a Clinical Trial for Medicines under the Medicines and Healthcare products Regulatory Agency conditions.

Patients had blood measurements taken at baseline, six months, and a year, to assess the study outcomes. Participants were reviewed regularly in the clinic to check them for any side effects.

TA-65® is a patented, plant-based compound that helps maintain or rebuild telomeres. It is isolated from the herb Astragalus, a traditional Chinese medicine for thousands of years.

Those who received the TA-65® drug had few adverse effects, such as a fever or new medical problem, following their heart attack and, in fact, they showed 30% less adverse effects than the group given the dummy drug.

Clinical outcomes

Professor Spyridopoulos, who also works at Newcastle upon Tyne Hospitals NHS Foundation Trust, said: “If we can show that TA-65® improves the clinical outcomes of patients who have suffered a heart attack, on top of modern treatment options, it will become an important addition to patients’ medical care.”

The research team would like to follow up with a further study to confirm the results in a larger trial, if funded, and further research will focus on whether TA-65® reduces adverse cardiac events, such as more heart attacks or even death.

Dr David Austin, Consultant Cardiologist at The James Cook University Hospital, who was an author on the research paper, said: “The James Cook University Hospital’s heart unit serves more than 1.5 million people and has an excellent reputation.

“Our partnership with Newcastle University in this research study is part of our drive to continually improve treatment options for patients.”

The independent study was funded by TA Science, a company that makes the TA-65® drug, and was an investigator-initiated trial, meaning the company had no say in how the study was conducted or analysed.

Reference:

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction. Bilal Bawamia et al. GeroScience. DOI: 10.1007/s11357-023-00794-6

At least one in three family members of those with serious mental illness feel stigmatized


New study by York University researchers points to need to reach out to ‘very marginalized group’ who’ve been made to feel they don’t matter


YORK UNIVERSITY

TORONTO, April 27, 2023  Families of those with serious mental health issues feel stigmatized and alone, say York University researchers in a new study.

“We are avoided. When we told our family, they shut us out, I am so hurt, and so angry” – 62-year-old mom with an adult son with serious mental illness, as described to York researchers.

It’s well known that those who have serious mental illnesses such as schizophrenia face a great deal of stigma in society, but what has been less understood is the concept of “stigma by association” – the discrimination people close to them experience.

A team of York researchers looked at just that in a recent study, published in the International Journal of Environmental Research and Public Health, and found that one in three family members living with relatives who have serious mental illnesses experience stigma. Ahead of Canadian Mental Health Association (CMHA) Mental Health Week, starting May 1, Joel Goldberg, lead author on the study describes this figure as “startling” and points to the need to do more outreach.

“We wanted to reach out to a group of people who we think have been especially marginalized and one of the things that we noticed right away, is that this is a group of people who have really not been well studied. And that really speaks to how isolated they are,” says Goldberg, a York Faculty of Health Professor with the Department of Psychology. “We found that family members were not receiving the social support they needed, even from other family members.”

Professor Joel Goldberg

The researchers, including York graduate researchers Suzanne McKeagAlison Rose and Heather Lumsden-Ruegg and York Psychology Professor and Canada Research Chair Gordon Flett, reached out to groups like the Schizophrenia Society of Ontario, Reconnect Community Health Services, the CMHA and The Schizophrenia Society of York and were able to connect with 120 family members who were living with relatives with severe mental health challenges.

In surveys, family members described chronic feelings of blame, failure and loneliness. Overall, the researchers found many felt stigmatized, unsupported, and that their lives don’t matter. This last main finding builds on other work by Flett, who studies mattering, which is essentially the idea that all of us need to feel like we matter, and feeling like we don’t, a concept Flett describes as anti-mattering, can lead to a host of problems.

About one per cent of the population is affected by schizophrenia, commonly characterized by auditory hallucinations (“hearing voices”), delusions, and disordered thinking that can affect daily functioning.

“Unfortunately, it's a condition which has been really misrepresented in media portrayals. The few times when the public hears stories about people with schizophrenia, they hear about someone who hasn't been taking their medicine, or acts of violence,” says Goldberg. “These ideas become the basis of the stigma, and families are then associated with it.”

Goldberg says that it is very probable that the numbers of family members facing stigma are actually much higher as the cohort they studied were people already connected to support groups. From a public-health perspective, the study points to the need to reach out to not only those who have  the illness, but also their families, who he describes as “very marginalized.”

“If you're made to feel insignificant, if you are feeling like those around you treat you as if you're invisible, this can have really harmful effects on your sense of well-being,” he says. “We're hoping with this Mental Health Week that this will give great attention to family members, and let them know that we do not see their lives as being insignificant, that we don't see them as being invisible, that their lives matter.”

Watch a video of Joel Goldberg explain the research

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York University is a modern, multi-campus, urban university located in Toronto, Ontario. Backed by a diverse group of students, faculty, staff, alumni and partners, we bring a uniquely global perspective to help solve societal challenges, drive positive change, and prepare our students for success. York's fully bilingual Glendon Campus is home to Southern Ontario's Centre of Excellence for French Language and Bilingual Postsecondary Education. York’s campuses in Costa Rica and India offer students exceptional transnational learning opportunities and innovative programs. Together, we can make things right for our communities, our planet, and our future. 

Media Contact: Emina Gamulin, York University Media Relations, 437-217-6362, egamulin@yorku.ca

A versatile deep-learning model for accurate prediction of plant growth


Scientists from Korea have designed a new machine learning model to predict plant growth with greater efficiency and accuracy

Peer-Reviewed Publication

NANJING AGRICULTURAL UNIVERSITY THE ACADEMY OF SCIENCE

Fig. 2. Modeling concept. 

IMAGE: TARGET CROP GROWTH AND MORPHOLOGY WERE ABSTRACTED AS ONE-BIG ORGANS. AVERAGES CAN BE CALCULATED WITH TOTAL VALUES AND THE NUMBER OF ORGANS. view more 

CREDIT: PLANT PHENOMICS

Crop yield can be maximized when the best genetic variety and most effective crop management practices are used for cultivation. Scientists have developed various machine learning models to predict the factors that produce the greatest yield in specific crop plants. However, traditional models cannot accommodate high levels of variation in parameters or large data inputs. This can lead to the failure of models under certain circumstances. Also, since crop models are restricted to the types of input they can accommodate, improvements to one model may not apply to other models.

To overcome this limitation, researchers from Korea led by Professor Jung Eok Son from Seoul National University have created a novel deep-learning based crop model known as “DeepCrop”, for hydroponic sweet peppers. The model can accommodate several input variables and has fewer limitations on the amount of data it can process. Hence, it can be employed in most settings and can be extended to similar applications. The researchers tested the predictions of DeepCrop by cultivating the crop twice a year for two years in greenhouses. Their results were published in Plant Phenomics on March 01, 2023.

We selected deep-learning algorithms as a potential solution to mitigate fragmentation and redundancy. Deep learning has high applicability to broad target tasks as well as remarkable abstraction ability for enormous sets of data,” explains Prof. Son.

DeepCrop is a process-based model that can simulate crop growth in response to various factors and environmental conditions. It can be scaled up to include many input types or greater amount of data. One reason for the high versatility of DeepCrop is that it is constructed exclusively with neural networks. Neural networks are combinations of algorithms that process the interactions between input data to make useful predictions.

Since simulations are created on a computer-based platform, DeepCrop requires minimal infrastructure. “With its applicability, a complicated task conducted at the enterprise became accessible with a personal computer,” says Prof. Son.

Deep-learning algorithms must be fed data before they can make any predictions. DeepCrop algorithms on plant growth simulation were trained in a similar manner. However, it did not need the programming of sophisticated concepts in plant physiology or crop modeling to produce useful predictions. “DeepCrop simulation adequately followed the growing tendency from scratch according to the scores, but the model should be inspected because it has potential to be improved ,” Prof. Son notes.

To validate the predictions of DeepCrop, the team cultivated sweet peppers in preset greenhouse conditions. A comparison of predicted and actual plant growth patterns suggested that DeepCrop outperformed other existing process-based crop models, as indicated by its modeling efficiency. The model was also the least likely to make prediction errors.

The capacity of DeepCrop to produce useful predictions even with varying inputs and parameters suggests that it can determine relationships between input data regardless of data type. The results of this study also suggest that deep-learning models can be useful for a wide range of applications in crop science. “We expect that the developed DeepCrop can improve the accessibility of crop models and mitigate fragmentation problems in crop model studies”, concludes a hopeful Prof. Son.

Kudos to the research team for developing such an effective and cost-efficient crop model!

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Reference

Authors

Taewon Moon1,3, Dongpil Kim2, Sungmin Kwon1, Jung Eek Son1,3

Affiliations

1 Department of Agriculture, Forestry and Bioresources, Seoul National University, Seoul 08826, Republic of Korea

2 Protected Horticulture Research Institute, National Institute of Horticultural & Herbal Science, Rural Development Administration, Haman 52054, Korea

3 Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea