$4M NIH grant will test worksite sleep health coaching for Arizona firefighters

Researchers at the UArizona Mel and Enid Zuckerman College of Public Health seek to improve firefighter health by focusing on behavioral interventions to improve sleep and recovery.

Grant and Award Announcement

UNIVERSITY OF ARIZONA HEALTH SCIENCES

A $4 million award from the National Heart, Lung, and Blood Institute, a division of the National Institutes of Health, will allow researchers in the University of Arizona Mel and Enid Zuckerman College of Public Health to identify key factors for the successful implementation of workplace sleep coaching to improve sleep health in Arizona firefighters.

Almost half of career firefighters report short sleep and poor sleep quality, and about 37% of firefighters screen positive for sleep disorders like sleep apnea, insomnia or shift work disorder, according to research led by the Harvard Work Hours Health and Safety Group. Unfortunately, firefighters face unique barriers, including long working shifts and mandatory overtime, that can prevent them from using evidence-based interventions to improve sleep.

“Other studies have showed us that firefighters’ personal circumstances and shift schedules often dictate their sleep,” said principal investigator Patricia Haynes, PhD, CBSM, DBSM, whose previous research found that more recovery sleep in firefighters during off-days is associated with less stress and irritability.

Researchers will work with 20 fire agencies across Arizona to evaluate a flexible, personalized sleep health intervention that can be administered in real-world situations. The study team also aims to train fire service managers and promote the benefits of sleep and recovery within the fire service.                                                                 

“A sleep intervention is most likely to be successful and utilized if it is tailored to the firefighter and a firefighter lifestyle,” said Dr. Haynes, one of several faculty at the Zuckerman College of Public Health’s Center for Firefighter Health Collaborative Research whose research focuses on aspects of firefighter health.

Partnering on the research are various nonprofit and advisory stakeholder groups committed to the health of first responders, including the 100 Club of Arizona, Greater Tucson Fire Foundation, Arizona Fire Chiefs Association and the Professional Fire Fighters of Arizona.

“Dr. Haynes’ innovative research and programs to support mental health and sleep health for firefighters have had proven results, and her work has benefited so many first responders,” said Iman Hakim, MD, PhD, MPH, dean of the Zuckerman College of Public Health, “We are so proud of the work she and her team members do to improve health for firefighters in Arizona, and this research can be used to help fire departments around the country.”

In addition to Dr. Haynes, the research team includes: Ed Bedrick, PhD, professor in the Zuckerman College of Public Health; David Glickenstein, PhD, professor in the UArizona College of Science’s Department of Mathematics; Michael Grandner, PhD, MTR, CBSM, FAASM, associate professor in the UArizona College of Medicine – Tucson’s Department of Psychiatry; and Daniel Taylor, PhD, professor in the College of Science’s Department of Psychology. Additional collaborators from the Arizona State University College of Health Solutions include professor Matthew Buman, PhD, and research professor Dana Epstein, PhD, RN.

Chemical contamination on International Space Station is out of this world

Peer-Reviewed Publication

UNIVERSITY OF BIRMINGHAM

Concentrations of potentially harmful chemical compounds in dust collected from air filtration systems on the International Space Station (ISS) exceed those found in floor dust from many American homes, a new study reveals.

In the first study of its kind, scientists analysed a sample of dust from air filters within the ISS and found levels of organic contaminants which were higher than the median values found in US and Western European homes.

Publishing their results today in Environmental Science and Technology Letters, researchers from the University of Birmingham, UK, as well as the NASA Glenn Research Center, USA, say their findings could guide the design and construction of future spacecraft.

Contaminants found in the ‘space dust’ included polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCDD), ‘novel’ brominated flame retardants (BFRs), organophosphate esters (OPEs), polycyclic aromatic hydrocarbons (PAH), perfluoroalkyl substances (PFAS), and polychlorinated biphenyls (PCBs).

BFRs and OPEs are used in many countries to meet fire safety regulations in consumer and commercial applications like electrical and electronic equipment, building insulation, furniture fabrics and foams.

PAH are present in hydrocarbon fuels and emitted from combustion processes, PCBs were used in building and window sealants and in electrical equipment as dielectric fluids, while PFAS have been used in applications like stain proofing agents for fabrics and clothing. However, their potential human health effects have led to some of them being banned or limited in use.

PCBs, some PFAS, HBCDD and the Penta- Octa-, and Deca-BDE commercial formulations of PBDEs, are classed as persistent organic pollutants (POPs) under the UNEP Stockholm Convention. In addition, some PAH are classified as human carcinogens, while some OPEs are under consideration for restriction by the European Chemicals Agency.

Co-author Professor Stuart Harrad, from the University of Birmingham, commented: “Our findings have implications for future space stations and habitats, where it may be possible to exclude many contaminant sources by careful material choices in the early stages of design and construction. 

“While concentrations of organic contaminants discovered in dust from the ISS often exceeded median values found in homes and other indoor environments across the US and western Europe, levels of these compounds were generally within the range found on earth.”

Researchers note that PBDE concentrations in the dust sample falling within the range of concentrations detected in US house dust may reflect use on the ISS of inorganic FRs like ammonium dihydrogen phosphate to make fabrics and webbing flame retardant. They believe that the use of commercially available ‘off-the-shelf’ items brought on board for the personal use of astronauts, such as cameras, MP3 players, tablet computers, medical devices, and clothing, are potential sources of many of the chemicals detected.

Air inside the ISS is constantly recirculated with 8-10 changes per hour. While CO2 and gaseous trace contaminant removal occurs, the degree to which this removes chemicals like BFRs is unknown. High levels of ionizing radiation can accelerate ageing of materials, including breakdown of plastic goods into micro and nanoplastics that become airborne in the microgravity environment. This may cause concentrations and relative abundance of PBDEs, HBCDD, NBFRs, OPEs, PAH, PFAS, and PCBs in ISS dust to differ notably from those in dust from terrestrial indoor microenvironments.

Scientists measured concentrations of a range of target chemicals in dust collected from the ISS. In a microgravity environment, particles float around according to ventilation system flow patterns, eventually depositing on surfaces and air intakes.

Screens covering the ISS HEPA filters accumulate this debris, requiring weekly vacuuming to maintain efficient filtration. Material in ISS vacuum bags comprises of previously airborne particles, clothing lint, hair and other debris generally identified as spacecraft cabin dust. Some vacuum bags were returned to Earth for studies of this unique dust, with a small sample shipped to the University of Birmingham for analysis in the study.

ENDS

For more information, interview requests or an embargoed copy of the research paper, please contact Tony Moran, International Communications Manager, University of Birmingham on +44 (0)782 783 2312 or t.moran@bham.ac.uk. For out-of-hours enquiries, please call +44 (0) 7789 921 165.

Notes to Editors

• The University of Birmingham is ranked amongst the world’s top 100 institutions, its work brings people from across the world to Birmingham, including researchers and teachers and more than 8,000 international students from over 150 countries.
• ‘Persistent Organic Contaminants in Dust from the International Space Station’ - Stuart Harrad, Mohamed Abou-Elwafa Abdallah, Daniel Drage, and Marit Meyer is published by Environmental Science and Technology Letters.

---

JOURNAL

Environmental Science & Technology Letters

METHOD OF RESEARCH

Experimental study

SUBJECT OF RESEARCH

People

ARTICLE TITLE

Persistent Organic Contaminants in Dust from the International Space Station

ARTICLE PUBLICATION DATE

8-Aug-2023

After 15 years, pulsar timing yields evidence of cosmic background gravitational waves

Groups report evidence that the cosmos is filled with a background of gravitational waves likely due to mergers of supermassive black hole binaries

 NEWS RELEASE 8-AUG-2023

UNIVERSITY OF CALIFORNIA - BERKELEY

 

IMAGE: ARTIST’S INTERPRETATION OF AN ARRAY OF PULSARS BEING AFFECTED BY GRAVITATIONAL RIPPLES PRODUCED BY A SUPERMASSIVE BLACK HOLE BINARY IN A DISTANT GALAXY. view more 

CREDIT: AURORE SIMONNET FOR THE NANOGRAV COLLABORATION

The universe is humming with gravitational radiation — a very low-frequency rumble that rhythmically stretches and compresses spacetime and the matter embedded in it.

That is the conclusion of several groups of researchers from around the world who simultaneously published a slew of journal articles in June describing more than 15 years of observations of millisecond pulsars within our corner of the Milky Way galaxy. At least one group — the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) collaboration — has found compelling evidence that the precise rhythms of these pulsars are affected by the stretching and squeezing of spacetime by these long-wavelength gravitational waves.

"This is key evidence for gravitational waves at very low frequencies,” says Vanderbilt University’s Stephen Taylor, who co-led the search and is the current chair of the collaboration. “After years of work, NANOGrav is opening an entirely new window on the gravitational-wave universe."

Gravitational waves were first detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO) in 2015. The short-wavelength fluctuations in spacetime were caused by the merger of smaller black holes, or occasionally neutron stars, all of them weighing in at less than a few hundred solar masses.

The question now is: Are the long-wavelength gravitational waves — with periods from years to decades — also produced by black holes?

In one paper from the NANOGrav consortium, published Aug. 1 in The Astrophysical Journal Letters (ApJ Letters), University of California, Berkeley, physicist Luke Zoltan Kelley and the NANOGrav team argued that the hum is likely produced by hundreds of thousands of pairs of supermassive black holes — each weighing billions of times the mass of our sun — that over the history of the universe have gotten close enough to one another to merge. The team produced simulations of supermassive black hole binary populations containing billions of sources and compared the predicted gravitational wave signatures with NANOGrav’s most recent observations.

The black holes' orbital dance prior to merging vibrates spacetime analogous to the way waltzing dancers rhythmically vibrate a dance floor. Such mergers over the 13.8-billion-year age of the universe produced gravitational waves that today overlap, like the ripples from a handful of pebbles tossed into a pond, to produce the background hum. Because the wavelengths of these gravitational waves are measured in light years, detecting them required a galaxy-sized array of antennas — a collection of millisecond pulsars.

"I guess the elephant in the room is we're still not 100% sure that it's produced by supermassive black hole binaries. That is definitely our best guess, and it's fully consistent with the data, but we're not positive," said Kelley, UC Berkeley assistant adjunct professor of astronomy. "If it is binaries, then that's the first time that we've actually confirmed that supermassive black hole binaries exist, which has been a huge puzzle for more than 50 years now."

"The signal we're seeing is from a cosmological population over space and over time, in 3D. A collection of many, many of these binaries collectively give us this background," said astrophysicist Chung-Pei Ma, the Judy Chandler Webb Professor in the Physical Sciences in the departments of astronomy and physics at UC Berkeley and a member of the NANOGrav collaboration.

Ma noted that while astronomers have identified a number of possible supermassive black hole binaries using radio, optical and X-ray observations, they can use gravitational waves as a new siren to guide them where in the sky to search for electromagnetic waves and conduct detailed studies of black hole binaries.

Ma directs a project to study 100 of the closest supermassive black holes to Earth and is eager to find evidence of activity around one of them that suggests a binary pair so that NANOGrav can tune the pulsar timing array to probe that patch of the sky for gravitational waves. Supermassive black hole binaries likely emit gravitational waves for a couple of million years before they merge.

Other possible causes of the background gravitational waves include dark matter axions, black holes left over from the beginning of the universe — so-called primordial black holes — and cosmic strings. Another NANOGrav paper appearing in ApJ Letters today lays out constraints on these theories.

"Other groups have suggested that this comes from cosmic inflation or cosmic strings or other kinds of new physical processes which themselves are very exciting, but we think binaries are much more likely. To really be able to definitively say that this is coming from binaries, however, what we have to do is measure how much the gravitational wave signal varies across the sky. Binaries should produce far larger variations than alternative sources," Kelley said. "Now is really when the serious work and the excitement get started as we continue to build sensitivity. As we continue to make better measurements, our constraints on the supermassive black hole binary populations are just rapidly going to get better and better."

Galaxy mergers lead to black hole mergers

Most large galaxies are thought to have massive black holes at their centers, though they're hard to detect because the light they emit — ranging from X-rays to radio waves produced when stars and gas fall into the black hole — is typically blocked by surrounding gas and dust. Ma recently analyzed the motion of stars around the center of one large galaxy, M87, and refined estimates of its mass — 5.37 billion times the mass of the sun — even though the black hole itself is totally obscured.

Tantalizingly, the supermassive black hole at the center of M87 could be a binary black hole. But no one knows for sure.

"My question for M87, or even our galactic center, Sagittarius A*, is: Can you hide a second black hole near the main black hole we've been studying? And I think currently no one can rule that out," Ma said. "The smoking gun for this detection of gravitational waves being from binary supermassive black holes would have to come from future studies, where we hope to be able to see continuous wave detections from single binary sources."

Simulations of galaxy mergers suggest that binary supermassive black holes are common, since the central black holes of two merging galaxies should sink together toward the center of the larger merged galaxy. These black holes would begin to orbit one another, though the waves that NANOGrav can detect are only emitted when they get very close, Kelley said — something like 10 to 100 times the diameter of our solar system, or 1,000 to 10,000 times the Earth-sun distance, which is 93 million miles.

But can interactions with gas and dust in the merged galaxy make the black holes spiral inward to get that close, making a merger inevitable?

"This has kind of been the biggest uncertainty in supermassive black hole binaries: How do you get them from just after galaxy merger down to where they're actually coalescing," Kelley said. "Galaxy mergers bring the two supermassive black holes together to about a kiloparsec or so — a distance of 3,200 light years, roughly the size of the nucleus of a galaxy. But they need to get down to five or six orders of magnitude smaller separations before they can actually produce gravitational waves."

"It could be that the two could just be stalled," Ma noted. "We call that the last parsec problem. If you had no other channel to shrink them, then we would not expect to see gravitational waves."

But the NANOGrav data suggest that most supermassive black hole binaries don't stall.

"The amplitude of the gravitational waves that we're seeing suggests that mergers are pretty effective, which means that a large fraction of supermassive black hole binaries are able to go from these large galaxy merger scales down to the very, very small subparsec scales," Kelley said.

NANOGrav was able to measure the background gravitational waves, thanks to the presence of millisecond pulsars — rapidly rotating neutron stars that sweep a bright beam of radio waves past Earth several hundred times per second. For unknown reasons, their pulsation rate is precise to within tenths of milliseconds. When the first such millisecond pulsar was found in 1982 by the late UC Berkeley astronomer Donald Backer, he quickly realized that these precision flashers could be used to detect the spacetime fluctuations produced by gravitational waves. He coined the term "pulsar timing array" to describe a set of pulsars scattered around us in the galaxy that could be used as a detector.

In 2007, Backer was one of the founders of NANOGrav, a collaboration that now involves more than 190 scientists from the U.S. and Canada. The plan was to monitor at least once each month a group of millisecond pulsars in our portion of the Milky Way galaxy and, after accounting for the effects of motion, look for correlated changes in the pulse rates that could be ascribed to long-wavelength gravitational waves traveling through the galaxy. The change in arrival time of a particular pulsar signal would be on the order of a millionth of a second, Kelley said.

"It's only the statistically coherent variations that really are the hallmark of gravitational waves," he said. "You see variations on millisecond, tens of millisecond scales all the time. That's just due to noise processes. But you need to dig deep down through that and look at these correlations to pick up signals that have amplitudes of about 100 nanoseconds or so."

The NANOGrav collaboration monitored 68 pulsars in all, some for 15 years, and employed 67 in the current analysis. The group publicly released their analysis programs, which are being used by groups in Europe (European Pulsar Timing Array), Australia (Parkes Pulsar Timing Array) and China (Chinese Pulsar Timing Array) to correlate signals from different, though sometimes overlapping, sets of pulsars than used by NANOGrav.

The NANOGrav data allow several other inferences about the population of supermassive black hole binary mergers over the history of the universe, Kelley said. For one, the amplitude of the signal implies that the population skews toward higher masses. While known supermassive black holes max out at about 20 billion solar masses, many of those that created the background may have been bigger, perhaps even 40 or 60 billion solar masses. Alternatively, there may just be many more supermassive black hole binaries than we think.

"While the observed amplitude of the gravitational wave signal is broadly consistent with our expectations, it's definitely a bit on the high side," he said. "So we need to have some combination of relatively massive supermassive black holes, a very high occurrence rate of those black holes, and they probably need to be able to coalesce quite effectively to be able to produce these amplitudes that we see. Or maybe it's more like the masses are 20% larger than we thought, but also they merge twice as effectively, or some combination of parameters."

As more data comes in from more years of observations, the NANOGrav team expects to get more convincing evidence for a cosmic gravitational wave background and what's producing it, which could be a combination of sources. For now, astronomers are excited about the prospects for gravitational wave astronomy.

"This is very exciting as a new tool," Ma said. "This opens up a completely new window for supermassive black hole studies."

NANOGrav's data came from 15 years of observations by the Arecibo Observatory in Puerto Rico, a facility that collapsed and became unusable in 2020; the Green Bank Telescope in West Virginia; and the Very Large Array in New Mexico. Future NANOGrav results will incorporate data from the Canadian Hydrogen Intensity Mapping Experiment (CHIME) radio telescope, which was added to the project in 2019.

The NANOGrav collaboration receives support from National Science Foundation Physics Frontiers Center award numbers 1430284 and 2020265, the Gordon and Betty Moore Foundation, NSF AccelNet award number 2114721, a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant, and the Canadian Institute for Advanced Research (CIFAR).

---

JOURNAL

The Astrophysical Journal Letters

DOI

10.3847/2041-8213/ace18b 

METHOD OF RESEARCH

Computational simulation/modeling

SUBJECT OF RESEARCH

Not applicable

ARTICLE TITLE

The NANOGrav 15 yr Data Set: Constraints on Supermassive Black Hole Binaries from the Gravitational-wave Background

 

World’s largest study shows the more you walk, the lower your risk of death, even if you walk fewer than 5,000 steps

Peer-Reviewed Publication

EUROPEAN SOCIETY OF CARDIOLOGY

The number of steps you should walk every day to start seeing benefits to your health is lower than previously thought, according to the largest analysis to investigate this.

 

The study, published in the European Journal of Preventive Cardiology [1] today (Wednesday), found that walking at least 3967 steps a day started to reduce the risk of dying from any cause, and 2337 steps a day reduced the risk of dying from diseases of the heart and blood vessels (cardiovascular disease).

 

However, the new analysis of 226,889 people from 17 different studies around the world has shown that the more you walk, the greater the health benefits. The risk of dying from any cause or from cardiovascular disease decreases significantly with every 500 to 1000 extra steps you walk. An increase of 1000 steps a day was associated with a 15% reduction in the risk of dying from any cause, and an increase of 500 steps a day was associated with a 7% reduction in dying from cardiovascular disease.

 

The researchers, led by Maciej Banach, Professor of Cardiology at the Medical University of Lodz, Poland, and Adjunct Professor at the Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, found that even if people walked as many as 20,000 steps a day, the health benefits continued to increase. They have not found an upper limit yet.

 

“Our study confirms that the more you walk, the better,” says Prof. Banach. “We found that this applied to both men and women, irrespective of age, and irrespective of whether you live in a temperate, sub-tropical or sub-polar region of the world, or a region with a mixture of climates. In addition, our analysis indicates that as little as 4,000 steps a day are needed to significantly reduce deaths from any cause, and even fewer to reduce deaths from cardiovascular disease.”

 

There is strong evidence that a sedentary lifestyle may contribute to an increase in cardiovascular disease and a shorter life. Studies have shown that insufficient physical activity affects more than a quarter of the world’s population. More women than men (32% versus 23%), and people in higher income countries compared to low-income countries (37% versus 16%) do not undertake a sufficient amount of physical activity. According to World Health Organization data, insufficient physical activity is the fourth most frequent cause of death in the world, with 3.2 million deaths a year related to physical inactivity. The COVID-19 pandemic also resulted in a reduction in physical activity, and activity levels have not recovered two years on from it.

 

Dr Ibadete Bytyçi from the University Clinical Centre of Kosovo, Pristina, Kosovo, senior author of the paper, says: “Until now, it’s not been clear what is the optimal number of steps, both in terms of the cut-off points over which we can start to see health benefits, and the upper limit, if any, and the role this plays in people’s health. However, I should emphasise that there were limited data available on step counts up to 20,000 a day, and so these results need to be confirmed in larger groups of people.”

 

This meta-analysis is the first not only to assess the effect of walking up to 20,000 steps a day, but also to look at whether there are any differences depending on age, sex or where in the world people live.

 

The studies analysed by the researchers followed up participants for a median (average) of seven years. The mean (average) age was 64, and 49% of participants were female.  

 

In people aged 60 years or older, the size of the reduction in risk of death was smaller than that seen in people aged younger than 60 years. In the older adults, there was a 42% reduction in risk seen in those who walked between 6,000 and 10,000 steps a day, while there was a 49% reduction in risk in younger adults who walked between 7,000 and 13,000 steps a day.

 

Prof. Banach says: “In a world where we have more and more advanced drugs to target specific conditions such as cardiovascular disease, I believe we should always emphasise that lifestyle changes, including diet and exercise, which was a main hero of our analysis, might be at least as, or even more effective in reducing cardiovascular risk and prolonging lives. We still need good studies to investigate whether these benefits may exist for intensive types of exertion, such as marathon running and iron man challenges, and in different populations of different ages, and with different associated health problems. However, it seems that, as with pharmacological treatments, we should always think about personalising lifestyle changes.”

 

Strengths of the meta-analysis include its size and that it was not restricted to looking at studies limited to a maximum of 16,000 steps a day. Limitations include that it was an observational study and so cannot prove that increased step counts cause the reduction in the risk of death, only that it is associated with it. The impact of step counts was not tested on people with different diseases; all the participants were generally healthy when they entered the studies analysed. The researchers were not able to account for differences in race and socioeconomic status, and the methods for counting steps were not identical in all the studies included in this meta-analysis.

 

(ends)

 

[1] “The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis”, by Maciej Banach et al. European Journal of Preventive Cardiology. doi:10.1093/eurjpc/zwad229

 

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JOURNAL

European Journal of Preventive Cardiology

DOI

10.1093/eurjpc/zwad229 

METHOD OF RESEARCH

Observational study

SUBJECT OF RESEARCH

People

ARTICLE TITLE

The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis

ARTICLE PUBLICATION DATE

9-Aug-2023

COI STATEMENT

M.B.: speakers bureau: Amgen, Daiichi Sankyo, Kogen, KRKA, Polpharma, Novartis, Novo-Nordisk, Sanofi-Aventis, Teva, Viatris, Zentiva; consultant to Amgen, Daiichi Sankyo, Esperion, Freia Pharmaceuticals, NewAmsterdam, Novartis, Novo-Nordisk, Polfarmex, Sanofi-Aventis; Grants from Amgen, Daiichi Sankyo, Sanofi, Valeant, and Viatris, CMDO at Longevity Group; CMO at Nomi Biotech Corporation; P.E.P. owns four shares in AstraZeneca PLC and has received honoraria and/or travel reimbursement for events sponsored by AKCEA, Amgen, AMRYT, Link Medical, Mylan, Napp, Sanofi. S.S.M. has received research support from Apple, Google, and iHealth, all companies that sell devices that measure step counts. All other authors report no competing interests.

Booster shot being developed to avoid recapturing koalas to fight Chlamydia disease

QUT researchers are developing a booster vaccine to “let koalas be koalas” using implant technology in the fight against the deadly Chlamydia disease that’s decimated local colonies.

Grant and Award Announcement

QUEENSLAND UNIVERSITY OF TECHNOLOGY

 

IMAGE: PROFESSOR KEN BEAGLEY, CENTRE, AND HIS TEAM ARE DEVELOPING A BOOSTER VACCINE USING IMPLANT TECHNOLOGY FOR KOALAS IN THE FIGHT AGAINST THE DEADLY CHLAMYDIA DISEASE. L/R- PROFESSOR TIM DARGAVILLE, HOLDING AN IMPLANT, PROFESSOR KEN BEAGLEY, DR EMILY BRYAN AND FREYA MCCARTHY (BACKGROUND). view more 

CREDIT: QUT MEDIA

A booster vaccine using implant technology for koalas is being developed by QUT researchers in the fight against the deadly Chlamydia disease.

The new technology is designed to avoid problems for wild koalas and wildlife handlers having to recapture or hold the animals for 30 days, to receive a second immunisation.

• Koala chlamydia is a bacterial infection and is one of the leading causes of death for Australian koalas.
• QUT researchers have been successfully testing a two-shot vaccine on an isolated wild koala colony in a five-year treat-and-track study.
• The new booster vaccine will be like other drug-eluting implant devices used in humans, slightly larger than a pet microchip.

Professor Ken Beagley, from QUT’s School of Biomedical Science, is leading the research team after being awarded a health grant to develop the technology from the Saving Koalas Fund. 

“This technology will significantly increase our ability to vaccinate wild koalas to protect against chlamydial infections, a major cause of infertility and population decline,” Professor Beagley said.

Professor Beagley developed the first koala vaccine for Chlamydia in 2010. Since then, the leading immunologist spearheaded the first immunisations of a wild koala colony in the Gold Coast hinterland after 10 years developing the vaccine in the lab.

Working with Dr Michael Pyne OAM and the team at Currumbin Wildlife Hospital, the project has now resulted in up to 300 vaccinated koalas, with grand joeys being born to healthy females, using a two-shot vaccine approach.

Development of one-shot vaccine implants to further protect koalas against Chlamydia will allow in-the-field vaccination of wild koalas.

“It will also allow all koalas being treated at Currumbin Wildlife hospital and other koala care facilities, to be vaccinated prior to release, without the need to hold the animals for a further 30 days,” he said.

“We want a vaccine that reduces human interference, letting koalas be koalas.”

The implant device is being designed to release the booster at four to five weeks after the first vaccination.

Professor Beagley is working with QUT polymer chemist Professor Tim Dargaville and postdoctoral research fellow Dr Emily Bryan to develop the device.

The grant is worth $749, 687 with the research to be completed by April 2026.

A project partner involves the Currumbin Wildlife Hospital Foundation.

Koala chlamydia is a bacterial infection and one of the leading causes of death for Australian koalas

A microscope view of Chlamydia. Professor Ken Beagley and his team are developing a booster vaccine using implant technology for koalas in the fight against the deadly Chlamydia disease.

Professor Ken Beagley, centre, and his team are developing a booster vaccine using implant technology for koalas in the fight against the deadly Chlamydia disease. l/r- Professor Tim Dargaville, Dr Emily Bryan, Professor Ken Beagley and Freya McCarthy.

CREDIT

QUT Media

Does access to assisted suicide affect trends of conventional suicide among patients with cancer?

Peer-Reviewed Publication

WILEY

An analysis published in Cancer Medicine reveals the trends of self-initiated deaths—including assisted suicide (AS) and conventional suicide (CS)—in Switzerland over a 20-year period, focusing on people who suffered from cancer. Although supporters of assisted dying state that access to AS should lead to a reduction in violent CS, the study’s findings do not confirm this assumption. The situations and motivations for cancer-associated CS seem to be clearly different from those for cancer-related AS.

In Switzerland, assisting in a suicide is not punishable as long as it does not serve selfish motives. In this analysis of data from 1999–2018, investigators found that cancer was the most often listed principal disease for AS: 3,580 people with cancer died by AS, representing 41.0% of AS cases. Cancer was listed in only a small minority of CS cases (832 people, representing 3.8% of CS cases).

There was approximately a doubling of AS cases among patients with cancer every 5 years. Also, the percentage of cancer-associated AS in relationship with all cancer-associated deaths increased over time to 2.3% in 2014–2018. The numbers of cancer-associated CS showed a downward trend in 1999–2003 and were stable through 2009–2018.

“Obviously, the situations and motivations for cancer-associated CS seem to be clearly different from those for cancer-related AS,” said corresponding author Uwe Güth, MD, of the University of Basel.

URL upon publication: https://onlinelibrary.wiley.com/doi/10.1002/cam4.6323

 

Additional Information
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com.

About the Journal
Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. 

About Wiley
Wiley is a knowledge company and a global leader in research, publishing, and knowledge solutions. Dedicated to the creation and application of knowledge, Wiley serves the world’s researchers, learners, innovators, and leaders, helping them achieve their goals and solve the world's most important challenges. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, Twitter, LinkedIn and Instagram.

---

JOURNAL

Cancer Medicine

DOI

10.1002/cam4.6323 

ARTICLE TITLE

Conventional and Assisted Suicide in Switzerland: Insights into a Divergent Development Based on Cancer-associated Self-initiated Deaths

ARTICLE PUBLICATION DATE

9-Aug-2023

 

New survey confirms need for more menopause education in residency programs

Lack of standardized menopause curriculum and access to menopause-specific educational materials leaves many healthcare professionals ill-equipped to manage needs of record numbers of menopausal women

Peer-Reviewed Publication

THE MENOPAUSE SOCIETY

CLEVELAND, Ohio (August 9, 2023)—Despite the fact that nearly 90 million women in the United States are projected to be postmenopausal by 2060, menopause remains low on the priority list of many residency programs. A new survey reveals the lack of a standardized menopause curriculum and limited access to menopause educational resources for residents. Results of the survey are published online today in Menopause, the journal of The Menopause Society.  

Because women today are living longer, it is not surprising that there are a record number of postmenopausal women. And, that number is only expected to grow, with women spending roughly onethird of their lifetimes in menopause. Despite the increased demand for menopause care and education, many obstetrics and gynecology trainees graduate from their residency programs with gaps in their education regarding the management of menopause symptoms and related conditions.  

When the last needs assessment was published for menopause education in 2013, it confirmed that most residents felt that they had limited knowledge and needed to learn more about the various areas of menopause medicine, including hormone therapy and bone health and related conditions such as cardiovascular disease and metabolic syndrome. At the time, only 20.8% of residents stated that their program had a formal menopause curriculum. Based on the results of this newest survey, it appears that the situation has not improved much, with only 31.3% of the obstetrics and gynecology residency program directors who responded reporting they had any type of menopause curriculum as part of their residents’ training. Nearly 20% claimed they had a curriculum confined to a rotation block.  

Of the programs with a menopause curriculum, 96.8% used lectures and 77.4% used assigned readings. All programs with a menopause curriculum included five or fewer menopause lectures per year for trainees, with 71.0% reporting two or fewer lectures per year. Of the respondents, 83.8% agreed or strongly agreed that their program needs more menopause educational resources.  

Based on the results, researchers concluded that, nationally, most obstetrics and gynecology training programs lack the curriculum necessary to effectively prepare residents to manage menopausal women. Moreover, there is a lack of consistency in the menopause curriculums that do exist such that there is no true level of standardized care.  

Survey results are published in the article “Needs assessment of menopause education in United States obstetrics and gynecology residency training programs.”

“This study highlights the ongoing problem of the lack of education of medical trainees in menopause management. An easily accessible, standardized menopause curriculum would benefit trainees across  multiple residency training programs, including obstetrics and gynecology, internal medicine, and family medicine, with the ultimate goal of ensuring that all women have access to competent menopause care,” says Dr. Stephanie Faubion, medical director for The Menopause Society.  

For more information about menopause and healthy aging, visit www.menopause.org.  

The Menopause Society (formerly The North American Menopause Society) is dedicated to empowering healthcare professionals and providing them with the tools and resources to improve the health of women during the menopause transition and beyond. As the leading authority on menopause since 1989, the nonprofit, multidisciplinary organization serves as the independent, evidence-based resource for healthcare professionals, researchers, the media, and the public and leads the conversation about improving women’s health and healthcare experiences. To learn more, visit menopause.org. 

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JOURNAL

Menopause

DOI

10.1097/GME.0000000000002234 

METHOD OF RESEARCH

Survey

SUBJECT OF RESEARCH

People

ARTICLE TITLE

Needs assessment of menopause education in United States obstetrics and gynecology residency training programs

ARTICLE PUBLICATION DATE

9-Aug-2023