Tuesday, May 05, 2026

 

‘They weren’t burned by accident’: burned stone, child’s bones, and lost jewelry could reveal prehistoric mining camp high in the Pyrenees



Archaeologists uncover possible evidence of ancient copper smelting spanning more than 2,000 years in a mountain cave more than 2,000 meters above sea level





Frontiers

Photo 6 

image: 

Malachite fragments, a mineral rich in copper, recovered during the excavation works at Cova 338. Authorship: Maria D. Guillén / IPHES-CERCA.

view more 

Credit: Maria D. Guillén / IPHES-CERCA.





High in the eastern Pyrenees, archaeologists are revealing the secrets of a prehistoric cave full of hearths containing fragments of green rock that could represent early copper mining. People visited this site for well-planned, well-supplied trips spanning two thousand years, overturning previous assumptions that prehistoric peoples didn’t spend long periods at high altitude. The discovery of a child’s finger bone and baby tooth suggest that, after more excavations, we may find that it was also a burial site.   

“For a long time, high-mountain environments were seen as marginal, places prehistoric communities passed through occasionally,” said Prof Carlos Tornero of the Catalan Institute of Human Paleoecology and Social Evolution, lead author of the article in Frontiers in Environmental Archaeology. “But we found a really rich archaeological sequence, including multiple combustion structures and a very large number of green mineral fragments. We can’t say exactly how long people stayed each time, but the repeated use of the space and the density of remains suggest occupations that were short to medium in duration, but happening again and again over long periods of time.” 

Burning questions 

Cave 338 is found at 2,235m above sea level in the Freser Valley. The scientists excavated an area of 6m2 at its entrance, identifying four layers of occupation. The first, most recent layer was thin, showing the cave was not frequently used at that time, and contained some artefacts from historical periods. The fourth, oldest layer contains only charcoal fragments, dated at 6,000 years old. 

The researchers hit the jackpot in the second and third layers of the excavation: a total of 23 hearths, containing many crushed, burned green mineral fragments. In-depth material analysis to confirm its identity is underway, but the fragments resemble malachite, which can be treated like this to produce copper. Cave 338 looks like an unexpectedly early high-altitude mining camp. 

“Many of these fragments are thermally altered, while other materials in the cave are not, which clearly suggests that fire played an important role in their processing and that there was a deliberate intention behind it,” said Dr Julia Montes-Landa of the University of Granada, co-author. “In other words, they weren’t burned by accident.” 

The hearths cut across each other, indicating that the visitors reused this space frequently, but are still distinct, which suggests that those visits were separated by plenty of time. Radiocarbon dating puts the hearth found in the second layer at about 3,000 years old, while the hearths in the third layer are around 5,500 to 4,000 years old.  

Secrets of the mountains 

The team also found human remains in the third layer — a finger bone and a baby tooth belonging to at least one child, about 11 years old — which could mean there are burials deeper within the cave. However, there isn’t enough evidence to suggest a cause of death or determine if the two bones belonged to the same child. Jewelry found in the second layer offered more information. 

“We recovered two pendants: one made from a shell and another from a brown bear tooth,” said Tornero. “They come from prehistoric contexts, most likely around the second millennium BC. The shell pendant is interesting because it has parallels in other sites in Catalonia, which suggests shared traditions or connections between different communities. The bear tooth pendant is much less common. That might point to something more specific or symbolic, possibly linked to the local environment.” 

Cave 338 wasn’t a full-time home, but the people who came here found their trips valuable enough to keep returning for millennia. The researchers still have a lot of questions about those trips which they hope to answer with future research. For example, further excavation will help us understand more about how and when humans used the cave. They also want to confirm the exact identity of the green mineral and find out where it came from. 

“The identification of the green mineral as malachite is still preliminary,” explained Tornero. “The research ongoing by the University of Granada and the Autonomous University of Barcelona will provide final answers shortly. Also, the excavation hasn’t yet reached the full depth of the site, so the sequence is not completely documented. This summer we will continue the archaeological work.” 

Archaeological excavation works at Cova 338 from the inside. Authorship: IPHES-CERCA.

Detail of the pendant made of Glycymeris sp. recovered during the excavation works at Cova 338. Authorship: IPHES-CERCA.

Pendant made from a bear incisor recovered during the excavation works at Cova 338. Authorship: IPHES-CERCA.

Above 2,000 meters: Cova 338 redefines Pyrenean prehistory



Universitat Autonoma de Barcelona
Above 2,000 meters: Cova 338 redefines Pyrenean prehistory 

image: 

Archaeological excavations in the interior of Cova 338. Authorship: IPHES-CERCA.

view more 

Credit: IPHES-CERCA.





Above 2,000 meters: Cova 338 redefines Pyrenean prehistory

  • The site, located in the Núria Valley, documents recurrent human occupations spanning more than 5,000 years and provides some of the earliest evidence of copper-rich mineral exploitation in Western Europe
     
  • The study, led by the Universitat Autònoma de Barcelona and IPHES-CERCA and published in Frontiers in Environmental Archaeology, challenges the traditional view of high mountain areas as marginal

An international research team led by the Universitat Autònoma de Barcelona (UAB) and the Institut Català de Paleoecologia Humana i Evolució Social (IPHES-CERCA) has documented the highest-altitude prehistoric cave with evidence of intense human occupation known to date in the Pyrenees. The site, known as Cova 338, is located at 2,235 meters above sea level in the Núria Valley (Queralbs, Ripollès - Girona) and currently represents the most significant high-mountain prehistoric site documented in the range.

The results show that the cave was repeatedly occupied between the 5th millennium BCE and the end of the 1st millennium BCE, providing new evidence on the exploitation of high-mountain resources in prehistoric times and challenging the traditional idea that these areas were used only sporadically or marginally. Dating indicates that these occupations occurred in several distinct phases, separated by periods of abandonment, suggesting a planned and recurrent use of this space.

This is the main conclusion of the article published in Frontiers in Environmental Archaeology, led by Carlos Tornero, professor in the Department of Prehistory at the UAB and researcher at IPHES-CERCA, with the participation of researchers from IPHES-CERCA, the Universitat Rovira i Virgili, the University of Granada, the Pompeu Fabra University, and the University of the Balearic Islands, among other institutions.

Intense and organized occupation in a high-mountain environment

For decades, archaeological research has interpreted areas above 2,000 meters in altitude as marginal territories, occupied only occasionally. Cova 338 breaks with this model.

Extensive excavations carried out between 2021 and 2023 have revealed “an exceptional archaeological sequence, including numerous combustion structures, faunal remains, ceramic fragments, and a remarkable assemblage of green minerals, likely malachite, a copper-rich mineral”, explains Carlos Tornero. “For the first time in the Pyrenees, high-mountain prehistoric occupations of significant intensity have been documented, characterized by repeated activities and the direct exploitation of mineral resources within the cave.”

Among the recovered materials are also two pendants: one made from a marine shell (Glycimeris) and another from a brown bear tooth, evidencing personal ornamentation practices. The former has parallels in other Catalan sites, while the latter is much rarer and possibly linked to a specific symbolic meaning.

Cova 338 forces us to rethink the role of high mountain environments in Pyrenean prehistoric societies”, highlights Carlos Tornero. “For a long time, these spaces were assumed to be marginal. What we document here is recurrent occupation, with complex activities and a clear exploitation of mineral resources.”

The evidence suggests that mineral fragments were brought into the cave and subsequently fragmented or processed inside, indicating systematic exploitation of copper-rich minerals in a high-mountain environment throughout the Late Neolithic and the Bronze Age. These data place Cova 338 among the earliest known examples of this type of activity in Western Europe.

Spatial analysis of the site shows a clear internal organization of activities, with differentiated structures and areas. Researchers interpret the cave as a logistical site integrated within well-structured seasonal mobility systems, where human groups returned recurrently to carry out specific tasks.

“The mountain was not a barrier, but an active place within the economic and territorial organization of prehistoric communities”, notes Eudald Carbonell, researcher at IPHES-CERCA and co-author of the study.

A research project under extreme conditions

The research is part of the ARRELS project, a program promoted by the Ministry for Culture of the Government of Catalonia and led by the UAB and IPHES-CERCA, focused on studying the prehistoric roots of human mobility and occupation in the Upper Ripollès region.

Excavations at Cova 338 have posed a major logistical challenge, as access to the cave is only possible on foot from the Núria Valley, with no motorized support allowed. This has required all materials and sediments generated during the digs to be transported manually.

Conducting an archaeological excavation to current scientific standards under these conditions is extraordinarily demanding”, explains Tornero. The work incorporated high-resolution methodologies, including 3D recording of all materials, systematic sediment sampling, and techniques such as washing and flotation, which allow even the smallest remains to be recovered and provide highly detailed information on the activities carried out in the cave.

Given its scientific importance and excellent state of preservation, the site has been protected and access restricted to ensure the conservation of the deposits and facilitate future research.

The work has also been made possible thanks to the logistical and institutional support of the Queralbs Town Council and the Ter and Freser Headwaters Natural Park, which have facilitated fieldwork in this high-mountain environment.

A key reference for European prehistory

Researchers consider Cova 338 to be a key reference for understanding human occupation of the Pyrenean high mountains and the exploitation of their resources during recent prehistory.

This site demonstrates that the Pyrenees were not a marginal territory for prehistoric communities, but a space fully integrated into their mobility strategies and territorial exploitation”, concludes Carlos Tornero.

The results open new lines of research into the role of alpine environments in prehistoric societies and the earliest forms of mineral resource exploitation in high-mountain contexts.

Funding source:This research is funded through the project led by Carlos Tornero and Eudald Carbonell Arrels prehistòriques de la transhumància a l’Alt Ripollès: projecte arqueològic 2022–2025 (code CLT009/22/00060; AGAUR-DGPC, Departament de Cultura, Generalitat de Catalunya) and has had the logistic and institutional support of the Queralbs Town Council and the Ter and Freser Headwaters Natural Park, which have facilitated the development of the excavations in this high mountain environment.

 

Updated alcohol warning labels may prompt people to cut back: Study




Journal of Studies on Alcohol and Drugs
"Government warning" alcohol label 

image: 

"Government warning" alcohol label

view more 

Credit: Journal of Studies on Alcohol and Drugs





by W.B. Kagan

PISCATAWAY, NJ – Although the United States requires a warning label on alcoholic beverages, alcohol-related deaths have risen steadily over the past two decades. However, new labels warning of specific disease risks, including cancer and liver disease, could better motivate reduced drinking, according to a new study in the Journal of Studies on Alcohol and Drugs.

The warning label currently required on alcohol containers in the United States has not changed since its adoption in 1988, despite new evidence linking alcohol to several diseases. The label states the risks of drinking during pregnancy and while driving or operating machinery and warns generally that drinking alcohol “may cause health problems.” The label often goes unnoticed and unremembered by consumers. 

“We wanted to test whether new warnings could better inform consumers about alcohol’s harms and better encourage people to consider cutting back on their drinking,” says lead author Anna H. Grummon, Ph.D., M.S.P.H., assistant professor at the Stanford University School of Medicine. The study was conducted as part of a larger project co-led with Marissa G. Hall, Ph.D., associate professor at the University of North Carolina.

Designed to compare the effects of differently worded and designed warning labels, the study recruited a nationally representative sample of 1,036 adults of legal drinking age (21 and older) who reported drinking at least once a week. 

Participants viewed 10 messages -- one control, eight new warning labels, and the current U.S. warning label -- in random order. They then rated each message on how well it encouraged them to drink less alcohol, reminded them of alcohol’s harms, and informed them of something new. 

“Each participant rated multiple warnings covering a range of health harms -- such as cancer, liver disease, hypertension, and dementia, among others -- so we could make direct, apples-to-apples comparisons between them,” says Grummon. 

All the new alcohol warnings in the study outperformed the current U.S. warning label, but those highlighting cancer risk were particularly effective. This finding is notable as policymakers in the United States and abroad debate whether to adopt a cancer warning on alcohol products. 

“Ireland, for example, is set to require cancer warnings on alcohol containers in the coming years, and Alaska already requires a cancer warning to be posted in bars, restaurants, and liquor stores where alcohol is sold,” says Grummon. “Our findings suggest these policies could help people understand the risks of drinking and potentially reduce consumption.”

Study participants also rated the effectiveness of warning icons and label design. Triangles and octagons were perceived as more effective and attention-grabbing than other icons, such as a magnifying glass.

More research is underway. Grummon and Hall are currently running a randomized trial to test whether new alcohol warnings effectively lead people to drink less. The study will also measure whether the warnings improve knowledge of alcohol-related harms over time.

“We know from tobacco control that well-designed warnings can inform consumers and encourage healthier choices,” says Grummon. “Given that alcohol-related deaths are increasing, we hope policymakers will consider whether updating alcohol warnings should be part of a broader strategy to address alcohol-related harms.”
-----
Grummon, A. H., Lee, C. J. Y., Campos, A. D., Lazard, A. J., Brewer, N. T., Whitesell, C., Ruggles, P. R., Greenfield, T. K., & Hall, M. G. (2026). New alcohol warnings outperform the current U.S. warning in a national survey experiment. Journal of Studies on Alcohol and Drugs, 87(3), 433-443. https://doi.org/10.15288/jsad.25-00226
 

 

Lesions as a window into cause: a psychiatrist bets that circuits, not regions, explain psychiatric disorders



Gonçalo Cotovio of the Champalimaud Foundation is mapping the networks that produce psychiatric symptoms and using them to personalize brain stimulation.





Genomic Press

Gonçalo Cotovio, MD, PhD, Champalimaud Foundation, Portugal 

image: 

Gonçalo Cotovio, MD, PhD, Champalimaud Foundation, Portugal

view more 

Credit: Gonçalo Cotovio, MD, PhD





LISBON, PORTUGAL, 5 May 2026 – If a small stroke in one corner of the brain can tip a previously healthy person into mania or set off obsessions and compulsions where none existed before, then the circuit connected to that lesion is telling us something rare in psychiatry. It is telling us about the cause. Gonçalo Cotovio, MD, PhD, a psychiatrist and clinical researcher at the Champalimaud Foundation in Lisbon, has built his early career on that premise and is using it to push the field beyond a century of descriptive diagnosis toward treatments targeting the networks that actually produce symptoms.

A Bet on Causality in a Field Built on Correlation

Psychiatry is a field saturated with associations. Brain region X lights up in depression, connectivity pattern Y differs in schizophrenia, and yet the causal arrows usually remain unresolved. Cotovio approaches that problem by looking at patients in whom the arrow is, in a sense, already drawn. In the Genomic Press interview published this week in Brain Medicine, he frames the logic with unusual clarity.

If a focal brain lesion can precipitate a syndrome such as mania or obsessive-compulsive symptoms, the connected network may reveal something fundamental about disease mechanisms,” he says. The technique at the heart of this work is lesion network mapping, which traces the broader functional circuit linked to each small area of injury. Symptoms that look scattered across the brain when viewed one patient at a time often converge onto a shared network when viewed across many.

The method has produced striking findings in mania and, more recently, in lesional obsessive-compulsive disorder, two syndromes Cotovio has worked on directly. He is now extending the strategy to disordered feeding behaviour. His ambition is modest in tone and immodest in substance: to identify the networks that are not merely correlated with psychiatric symptoms but capable of producing them, and to use those networks as targets for intervention.

Dinner-Table Conversations, Then a Lifetime of Them

Born in Lisbon and still working there, Cotovio traces his interest in the brain to a household where the adult conversation rarely strayed from behaviour and emotion. His father is a psychiatrist. The questions that surface at a family dinner when one parent treats psychiatric illness for a living tend to shape a child, and in this case they shaped a career. Medicine drew him in because it sits where human stories meet biology and decision-making. Psychiatry held him because it demanded all of those at once.

He earned his medical degree at NOVA Medical School in 2014, joined the Champalimaud Foundation as a research intern in 2015, completed his PhD in Biomedicine in 2023, and finished his psychiatry residency in 2024. Under the mentorship of Albino J. Oliveira-Maia, head of the Neuropsychiatry Unit, he trained across clinical psychiatry, neuroimaging, and translational neuroscience, with further periods at Harvard Medical School alongside Alvaro Pascual-Leone, Michael D. Fox and Daniel Press. That combination, he says, taught him how to move between the clinic and the laboratory. It also explains why he refuses to let one displace the other.

From Causal Maps to Personalised Stimulation

The second strand of Cotovio's work picks up where the first leaves off. Once a causal circuit has been identified, how should it be engaged? His answer, in practice, is magnetic resonance imaging and connectivity-informed transcranial magnetic stimulation. Rather than applying a standard coil position to every patient, Cotovio aims to explore the use each person's own connectivity profile to individualise targeting. A third strand studies cortical excitability and functional connectivity as candidate biomarkers that might one day help clinicians decide which patient should receive which intervention.

Cotovio is careful about the gap between promise and proof. “The most interesting questions usually demand patience, nuance, and a willingness to revise one’s assumptions,” he says, a line that reads as both scientific temperament and something like a working motto. He levels the same demand at the field itself: “Elegant methods are not enough. The field should stay accountable for whether our research helps explain suffering and improve people’s lives.”

The Part That Does Not Fit on a CV

Asked about his greatest pride, he does not name a paper. He names his family. Asked which living person he most admires, he names his father. His motto, given in Portuguese and translated almost apologetically into English, is concentração, descontração e vamos para a frente, which he renders as focus, calmness, and keep moving forward. Running is where he thinks most clearly. Long meals and quiet evenings at home are where he refuels. For a clinician-scientist whose subject is the circuitry that produces human suffering, the balance seems less like a luxury than a professional tool.

What Cotovio is building in Lisbon is, in the end, a quiet argument. It says that psychiatry can be mechanistic without being reductive, that causality can be pursued in human beings and not only in mice, and that non-invasive stimulation guided by the right map has a chance to do something that symptom-based prescribing cannot. The work is early. The bet is not.

Gonçalo Cotovio’s Genomic Press interview is part of a larger series called Innovators and Ideas that highlights the people behind today’s most influential scientific breakthroughs. Each interview in the series offers a blend of cutting-edge research and personal reflections, providing readers with a comprehensive view of the scientists shaping the future. By combining a focus on professional achievements with personal insights, this interview style invites a richer narrative that both engages and educates readers. This format provides an ideal starting point for profiles that explore the scientist’s impact on the field, while also touching on broader human themes. More information on the research leaders and rising stars featured in our Innovators and Ideas – Genomic Press Interview series can be found on our interview website: https://interviews.genomicpress.com/.

The Genomic Press Interview in Brain Medicine titled “Gonçalo Cotovio: Mapping causal brain circuits to personalize neuromodulation in psychiatry,” is freely available via Open Access, starting on 5 May 2026 in Brain Medicine at the following hyperlink: https://doi.org/10.61373/bm026k.0033.

About Brain Medicine: Brain Medicine (ISSN: 2997-2639, online and 2997-2647, print) is a peer-reviewed medical research journal published by Genomic Press, New York. Brain Medicine is a new home for the cross-disciplinary pathway from innovation in fundamental neuroscience to translational initiatives in brain medicine. The journal’s scope includes the underlying science, causes, outcomes, treatments, and societal impact of brain disorders, across all clinical disciplines and their interface.

Visit the Genomic Press Virtual Library: https://issues.genomicpress.com/bookcase/gtvov/

Our media website is at: https://media.genomicpress.com/

Our full website is at: https://genomicpress.com/