Tuesday, June 23, 2026

Protective human antibodies target West Nile and related viruses





Istituto di Ricerca in Biomedicina

Molecular reconstruction of WNV and mechanism of binding by virus neutralizing antibodies reported in the study 

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Molecular reconstruction of WNV and mechanism of binding by virus neutralizing antibodies reported in the study

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Credit: Christopher Barnes and Zaira Contejean, Stanford University





West Nile virus (WNV) is transmitted by mosquitoes and is increasingly relevant for Europe and worldwide. It can cause severe brain infection and death, yet there is no specific antiviral treatment or approved human vaccine. A collaborative study published in Immunity analyzed blood from WNV convalescents in Serbia to understand antibody immune responses and identify protective human monoclonal antibodies with potential to prevent or treat WNV and related orthoflavivirus infections.

Davide Robbiani's Laboratory at the Institute for Research in Biomedicine (IRB, affiliated with Università della Svizzera italiana) in Bellinzona, Switzerland, together with international collaborators, identified monoclonal antibodies that may help address this unmet medical need.

Among them, antibody W010 recognizes a distinct site on the virus envelope domain III, a key surface protein involved in viral attachment and infection. W010 protected mice when administered before and even 5 days after exposure to WNV. A second antibody, W014, showed broader cross-neutralization against pathogenic orthoflaviviruses, including Japanese encephalitis, Murray Valley encephalitis, Saint Louis encephalitis and Usutu viruses.

The findings define vulnerable sites on WNV that could inform vaccine development, and highlight antibody candidates with prophylactic and therapeutic potential. They may also guide interventions for a wider group of encephalitic orthoflavivirus infections.

Habits help animals survive



University of Exeter






The ability to form and break habits helps animals survive and find food efficiently – and may have benefitted our hunter-gatherer ancestors – according to new research.  

Forming habits can make complex tasks “automatic”, reducing the mental effort required. 

But breaking habits may also be essential if a habit is no longer beneficial.  

The research team – from universities of Exeter, Bristol, Humboldt (Berlin) and Stockholm – created simulations to test the evolutionary pros and cons of forming and breaking habits. 

They find that habits could help an animal forage for food while keeping attention free to look out for predators – suggesting evolutionary benefits for creatures of habit.  

“Lots of psychological research has examined habits in humans – but we don’t often ask the same questions about animals,” said Professor Olof Leimar, from Stockholm University. 

“Our aim is to change this, by investigating a possible evolutionary explanation for habits, namely that habits enhance an individual’s ability to multitask in a realistic ecological context for many animals.” 

The team created simulations where virtual animals had various food choices, which they could learn about to exploit efficiently, and had to watch for predators. 

Foraging habits could be formed, freeing up attention for evading predators, but sometimes the food environment changed – meaning new habits were required.  

“We show that forming and breaking foraging habits can substantially reduce the chance of being killed by a predator, without drastically reducing foraging success,” said Dr Sasha Dall, from the Centre for Ecology and Conservation on Exeter’s Penryn Campus in Cornwall.   

“This is effective as long as environmental conditions remain stable enough between changes. 

“We argue that the ability to form and break habits is a type of behavioural flexibility that is likely to be favoured evolutionarily in a range of ecological conditions.” 

Dr Dall added: “From morning coffee routines to familiar routes home, habits are often seen as mindless behaviours. But our study suggests habits may have evolved for a very good reason: they help animals stay alive. 

“This type of learning is likely to have helped our ancestors – but things have changed very radically in our world, so the way that habits form and break may not be well-tuned to the current pace of life that humans experience.” 

Dr Dall was supported by a Royal Society Leverhulme Trust Senior Fellowship for part of this work. 

The paper, published in the journal Evolution Letters, is entitled: “Evolution of behavioral flexibility and the forming and breaking of habits.” 

 

New technique filters PFAS forever chemicals using “molecular Velcro”





University of Florida






A new gel-based material developed by University of Florida chemical engineers filters  PFAS “forever chemicals” from water more efficiently than many widely used commercial options.

The advance offers a potential new path to filtering out PFAS, which has been linked to health effects including birth defects and some cancers. Importantly, the new material doesn’t itself use fluorine to trap PFAS, helping to reduce fluorinated chemicals in the filtration supply chain.

“One of the big challenges is that these chemicals are present at such low concentrations, so they’re very difficult to detect and separate, but they can still impact human health,” said Joshua Moon, Ph.D., a professor of chemical engineering at UF who led the new study. “It’s like putting a drop of food coloring in an Olympic-sized swimming pool and then trying to get all the food coloring back out. It’s not easy.”

Moon and his doctoral student Lakshay Dhamania published their findings June 8 in the journal Energy and Environmental Materials. Moon’s lab is now working to further test and refine their PFAS-filtering methods for potential application in commercial and municipal water filtration.

In what Moon describes as “molecular Velcro,” the new material uses electrical charges designed to trap PFOA, one of the most abundant versions of PFAS in the environment. The gel allows PFOA molecules to bind throughout the material rather than only on its surface, improving its filtration capacity.

The gel can then be used multiple times by flushing out the PFOA with common solvents.

One of the researchers’ goals was to identify a way to filter out PFAS without relying on fluorinated materials. If those materials break down, they can potentially release fluorinated compounds back into the environment.

“A lot of the materials out there either don’t work well or have to rely on using fluorinated stuff to bind PFAS. We were able to develop these gel-type adsorbents that work well without having PFAS-like substances in the material itself,” Moon said.

For Moon, the long-term goal extends beyond a single filtration material.

By building polymers whose chemistry can be adjusted piece by piece, the researchers hope to uncover broader rules for trapping PFAS. That includes compounds that are harder to remove from water than PFOA.

“Maybe we can create new design principles or a better understanding of existing materials to overcome some of the big challenges that commercial treatment processes can't really do,” Moon said.

 

Montana State researchers aim to autonomously eliminate plant-killing bacteria from hydroponic farming systems





Montana State University






BOZEMAN — Three researchers from Montana State University recently received a nearly $600,000 grant from the U.S. Department of Agriculture to develop a system that can autonomously detect and remove crop-killing microbes from hydroponic farms before they cause damage to plants. Hydroponic farming is a method of growing plants without soil by supplying nutrients through water.

“This work is important to maintain food safety for our growing world,” said Stephan Warnat, the project’s principal investigator and an associate professor in the Department of Mechanical and Industrial Engineering in MSU’s Norm Asbjornson College of Engineering. Co-project directors are the engineering college’s interim Dean Christine Foreman, who is also a professor of chemical and biological engineering, and Stephanie McCalla, an associate professor of chemical and biological engineering.

Certain crops, especially lettuces, tomatoes, strawberries and herbs, grow extremely well indoors hydroponically. Other benefits of hydroponic farming, compared to traditional soil-based agriculture, include higher water efficiency, faster plant growth, greater crop yield per square foot, year-round production, and control over the growing conditions, including nutrient levels and light exposure. Plus, hydroponic farms can thrive in environments inhospitable to traditional agriculture methods, including deserts and infertile land.

“A hydroponic system allows you to grow fresh produce all year round, which can be beneficial in harsh environments with cold winters,” Warnat said.

However, the challenges facing hydroponic farmers are substantial, including high startup costs and the fact that staple commodities such as wheat, corn and soybeans are considered far more economical to produce through traditional agriculture. The potential for toxic water-borne pathogens is another downside of hydroponic farming.

“The goal with this project is to keep pathogens out of the hydroponic system while allowing beneficial microbes to develop naturally,” Warnat said. “The challenge is that when you have a circulating water system with a microbial community, potentially some pathogens are developing and soon the entire harvest is dead.”

The team, Warnat said, plans to use electrochemical sensors to screen for harmful bacteria before they have a chance to harm the crops. The sensors are coated with aptamers, which are short, synthetic strands of DNA or RNA engineered to fold into a specific 3D shape. This unique shape allows it to act like a molecular “lock and key” to capture pathogens in the hydroponic systems. The electrochemical sensor changes its output based on the pathogen concentration. When they do, they trigger the release ofbiodegradable nanoparticles – made primarily from chitosan, a naturally occurring polymer – that have been engineered to capture bacteria, such as pathogenic Escherichia coli strains. When the chitosan binds to the harmful cells, it forms a larger agglomerate that can be removed by the hydroponic system's filtration equipment, protecting the harvest from pathogens.

The viability of the technologies involved in the three-step process – the detection, capture and removal of pathogens from a hydroponic farm – are each previously demonstrated to be effective. The system under development would combine the technologies in a way to automate the steps to protect hydroponic crops from harmful pathogens.

“The project addresses critical challenges faced by hydroponic farmers in Montana,” said Dilpreet Bajwa, head of the Department of Mechanical and Industrial Engineering. “It will enhance productivity, profitability and resilience of hydroponic operations while supporting local food production and strengthening the state's agricultural economy.”

Another benefit of early detection and eradication of harmful bacteria is it allows plant-nourishing microbes to develop into biofilms, which can be beneficial to the crops.

“Helpful biofilms can function as fertilizers,” Warnat said. “These biofilms are healthy for plants. But you have to be careful which kind of biofilm is forming. If the pathogen is inside the biofilm, then that can lead to a catastrophic event – meaning total crop loss.”

Examples of biofilms include plaque on teeth, the muck that sometimes grows inside plumbing fixtures, and the slippery coating commonly found on rocks in streams, rivers and lakes.

Foreman and Warnat are affiliated with MSU’s Center for Biofilm Engineering, which is the world’s first and largest biofilm research center.

The grant will fund two graduate students; one master’s student and one doctoral student. The grant provides funding through April 30, 2029.

-end-

This story is available on the Web at: http://www.montana.edu/news/25414

 

Research finds both rich and poor buy more counterfeits than the middle class



New study reveals that it’s the two ends of the economic spectrum responsible for most purchasing of counterfeit luxury goods




Institute for Operations Research and the Management Sciences





BALTIMORE, June 22, 2026 – Conventional wisdom suggests that counterfeit luxury goods are primarily purchased by consumers who cannot afford authentic products.

New research published in the INFORMS journal Marketing Science challenges that assumption, finding that both lower- and higher-income consumers are significantly more likely to purchase counterfeit goods than middle-income consumers.

The study, “Frontiers: The Demand for Counterfeits: A Descriptive Analysis,” by Nan Chen and Mengqi Xiang, both of the National University of Singapore, analyzed millions of counterfeit purchases made by American consumers through a major cross-border e-commerce platform.

Using large-scale transaction data spanning more than 24,000 U.S. ZIP codes, the researchers found that demand for counterfeit luxury goods was strongest at both ends of the income spectrum. Compared with middle-income households, both lower-income and higher-income consumers purchased more counterfeit products, bought them more frequently and showed stronger interest in premium counterfeit offerings.

“Our findings challenge the common assumption that counterfeit purchasing is primarily a budget-driven phenomenon,” said Chen. “Instead, demand appears to be strongest at both ends of the income spectrum, suggesting that social, psychological and status-related motivations play an important role.”

The findings suggest that counterfeit consumption is about more than affordability. For many consumers, purchasing counterfeit goods may also be tied to identity, aspiration and status.

The study found important differences between the two groups.

Lower-income consumers were more likely to purchase counterfeit versions of lower-tier luxury brands. Higher-income consumers, meanwhile, gravitated toward counterfeit versions of ultra-luxury brands such as Hermès and Chanel.

Perhaps most surprisingly, wealthier consumers were also more likely to purchase higher-priced counterfeit listings, suggesting a greater willingness to pay for higher-quality replicas rather than simply seeking the lowest-cost option.

The researchers also found that demand was strongest for counterfeit versions of iconic luxury products with broad brand recognition. Classic product lines such as the Hermès Birkin bag and Chanel Classic Flap generated stronger demand than newer or less recognizable collections.

Another unexpected finding involved product popularity.

The income-related demand pattern was even more pronounced for niche counterfeit products than for widely purchased items. This suggests that some consumers may be motivated not only by price or status, but also by the appeal of discovering products that feel distinctive or exclusive.

The findings carry implications for policymakers, intellectual property owners and luxury brands. Anti-counterfeiting efforts often focus on price-sensitive consumers, but the study suggests that counterfeit demand exists across very different income groups and may be driven by multiple motivations.

“For brand owners and enforcement agencies, understanding who buys counterfeits, and why they do, is essential,” said Xiang. “Strategies designed around a single consumer profile may overlook substantial counterfeit demand among both affluent and economically constrained consumers.”

The researchers note that the rise of cross-border e-commerce has dramatically expanded access to counterfeit goods, creating challenges for both regulators and luxury brands seeking to protect intellectual property and brand value.

The findings challenge a simple stereotype: counterfeit luxury goods are not primarily a lower-income phenomenon. Instead, demand appears to be strongest at both ends of the economic spectrum, suggesting that the motivations behind counterfeit purchasing are more complex than many brands and policymakers assume.

Read the study in full here.

About INFORMS and Marketing Science

INFORMS is the world’s largest association for professionals and students in operations research, AI, analytics, data science and related disciplines, serving as a global authority in advancing cutting-edge practices and fostering an interdisciplinary community of innovation. Marketing Science, a leading journal published by INFORMS, publishes research on quantitative marketing, consumer behavior, pricing, and strategy that informs managerial and policy decisions. INFORMS empowers its community to improve organizational performance and drive data-driven decision-making through its journals, conferences and resources. Learn more at www.informs.org or @informs.

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California has lost more than half of its coastal sand dunes, first-ever comprehensive assessment reveals






University of California - Santa Barbara






(Santa Barbara, Calif.) — A study conducted by UC Santa Barbara researchers and collaborators has found that California has lost more than half of its coastal dune systems. The researchers’ assessment — the first of its kind for the California coast — estimates that 60% of dune systems that existed from 1850, due to a combination of urban development, land-use changes and erosion.

“There are major implications of this loss for the California coast, including reduced habitats for plants, insects and other invertebrates, birds and small mammals,” said the paper’s lead author, postdoctoral researcher and physical geographer Tim Baxter. “Importantly, we also lose coastal protections against storms and sea level rise.”

This assessment, one of the largest and most detailed inventories of coastal sand dunes ever produced, is published in the journal Earth’s Future.

California’s coastal dunes through time

According to the study, around the time California emerged as the U.S.’s 31st state, it had about 739 km2 (about 285 square miles) of coastal dunes. After 165 years these dune fields, which capture and supply sand to nearby beaches, have dwindled in area to almost 300 km2 (about 116 square miles). That is mostly due to human activity, including migration and settlement, which started as early as the Gold Rush (1848), and subsequent development. While a small amount — roughly 18 km2 (seven square miles) — was lost through natural processes, including erosion at estuaries and rivermouths, the vast majority of dune loss is the result of human activity, including the development of roads and other infrastructure, agriculture and the introduction of invasive plants.

The biggest losses, according to the researchers, were in the areas of densest urban development.

“The thing that surprised me most was the scale of loss in San Francisco and Los Angeles,” said co-author Kyle Emery of UCSB’s Marine Science Institute. More than 95% (or 108 km2 or 42 square miles) of sand dunes that originally existed in those locations were removed to make room for roads, city infrastructure, housing and commercial buildings and other development. Meanwhile, Central California was also found to have lost 60% (331 km2 or about 128 square miles) of its coastal  dunes. Approximately half of what’s left of California’s coastal dune systems are isolated — cut off from coastal processes by infrastructure and transportation networks. Through the study, the researchers also document some dune growth in southern California, including places where dune restoration is taking place.

As communities up and down the California coast contend with the fate of their shores amidst sea level rise, dune systems have become an attractive restoration option, providing sustainable, self-healing protections against the encroaching ocean.

However, sand dunes may not be the best solution for every shrinking beach. A variety of factors, including cost, space, location and the priorities of municipalities that are making their plans for sea level rise, will dictate whether dunes are an effective investment. This uncertainty, coupled with the highly diverse, dynamic environment of the California coast highlighted deficiencies in the understanding of these sand dunes. It also prompted the researchers to take on the challenge of characterizing these coastal landforms, the forces that make them and the places that could host them.

“Coastal sand dunes are really challenging to map,” Baxter said. “It required months of careful analysis using a variety of analytical methods — historical archive analysis, machine learning tools, site visits — and datasets, including historical maps, high resolution aerial photographs, and LiDAR.” In the process, the researchers could see the evolution of California’s coastal dune systems in a wide variety of settings and conditions through time.

The method, according to researchers, can be applied to other areas in the world that are contending with sea level rise, and are considering dune systems as a defense.

“Our methods provide a framework for assessing large-scale habitat change that could be extended to coasts around the world to aid identification and prioritization of suitable restoration sites, helping to offset past dune losses and mitigate future climate change impacts.”

This work was funded by the UC Office of the President Climate Action Research Initiative.

Research in this paper was also conducted by Ian J. Walker (PI), Jenifer E. Dugan, David M. Hubbard, Karina K. Johnston, Sarah Smith, Dakota R. Fee and Dan Willett at UCSB; Laura Engeman and Jenna Wisniewski at UC San Diego, Sean Vitousek at the U.S. Geological Survey Pacific Coastal and Marine Science Center, and Andrea J. Pickart at the U.S. Fish and Wildlife Service.