Thursday, July 16, 2026

 

A hospital that pays for itself? Sounds like a fairy tale



Smarter hospital design isn’t just better for patients and staff, it can return millions in savings in as little as two years


Texas A&M University

Fable Hospital rendering 

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A rendering of “Fable Hospital,” a model in regenerative design where a hospital serves the whole community, not just minimizing harm, but actively supporting health.

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Credit: Perkins&Wills Inc.





Once upon a time, in Anywhere, USA, there’s a place called “Fable Hospital” where patients heal faster, staff stay longer and the building is designed to work with — not against — the people inside it. It’s not a real place, but it was designed to solve a very real problem: why hospitals can be expensive to run, hard on staff and not always built for the best patient care.

In a new study published in BMJ Leader, researchers including Texas A&M University Distinguished Professor Dr. Leonard Berry, imagine this fictional hospital from the ground up to show that better design doesn’t just improve care, it can pay for itself.

High-performing hospitals are not too expensive to build

The study models a 300-bed community hospital and asks a simple question: what happens when architects and designers rethink everything, including airflow, daylight, building materials and energy systems? The goal was to demonstrate the business case for investing more up-front to build a hospital the right way.

By investing an additional $25 million to $30 million (about 3% of total construction costs), a hospital could recover that cost within the first two years of operation, the study finds. After that, the savings continue to grow.

“This research shows that designing a better hospital is not a luxury, it’s a smart investment,” said Berry, an expert in healthcare services at Mays Business School. “When you build with evidence in mind, you improve care, support staff and reduce costs all at the same time.”

Lower costs and shorter stays

The model draws on existing research linking hospital environments — such as access to nature, improved air quality and reduced noise — to better patient outcomes and staff performance, then applies those effects using conservative assumptions.

“Design features that improve air quality, reduce noise and provide access to nature are associated with shorter hospital stays,” Berry said. “Even a modest reduction in length of stay produces millions in annual savings, making it one of the largest impacts of the model.”

Across the hospital, those design changes add up quickly; they include:

  • Shorter patient stays: about $7.25 million in annual savings
  • Fewer medical errors: roughly $1 million saved each year
  • Stronger staff retention: more than $1.2 million annually
  • Lower energy and water use: about $350,000 combined per year
  • Fewer renovations and lower material costs: millions saved in initial and long-term building expenses

Taken together, the model suggests more than $100 million in net financial gains is possible over the first decade of operations.

Hospitals and regenerative design

The study reflects a broader shift in how hospitals are designed, from minimizing harm to actively supporting health.

The researchers describe this approach as “regenerative design.”

“Regenerative design looks at how a hospital can contribute positively not only to those using the building but to the broader community as well,” Berry said. “That includes reducing energy demand, improving air and water systems and creating spaces that support healing for patients and better working conditions for staff.”

In practical terms, that might mean accessible gardens, patient rooms with views of nature, and cleaner materials and designs that help buildings withstand extreme weather. “The idea is to think of a hospital not as a standalone structure, but as part of a larger system that influences patient outcomes, workforce well-being and community health,” Berry said.

The work brings together a wide range of design strategies — many already used in other settings — and evaluates their combined impact in one place.

“These are not abstract ideas,” Berry said. “They’re practical strategies that can be implemented today. The real opportunity is putting them together in a way that delivers meaningful results.”

A 20-year commitment to better hospitals

The current study of Fable Hospital 3.0 builds on more than 20 years of research. Berry says that concepts outlined in two previous Fable Hospital articles (2004, 2012) have already shown benefits when applied and have clearly contributed to the evidence-based design movement in healthcare.

“Fable Hospital is fictional, but it is based on the use of design initiatives that are evidenced-based, i.e., proven in practice,” he said. “Many newer hospitals have incorporated some of these design elements and are benefiting from doing so.”

In addition to Berry, the original author team included Texas A&M Professor Emeritus of Architecture Dr. Kirk Hamilton and Blair Sadler, retired CEO of Rady Children’s Hospital in San Diego. Fable 3.0 was done in partnership with the architecture firm of Perkins&Will.  

The moral of the story

The hospital in the study may be fictional, but the challenges it addresses are not. Hospitals are long-term investments, and once built, they shape care for decades.

That’s why the researchers argue that getting the design right the first time matters, not just for patients and staff, but for the bottom line.

“In the story of Fable Hospital, the moral is simple,” Berry said, “a better hospital isn’t just possible, it’s practical and it pays off.”

By Lesley Henton, Texas A&M University Division of Marketing and Communications

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Could tiny water droplets hold the key to dissolving the global plastic waste crisis?



International team of scientists develop catalyst-free plastic recycling process with just water and oxygen




Cardiff University






A new way of converting stubborn plastic waste into high-value chemicals using only water and oxygen, has been developed by an international team of scientists.

The researchers from Zhejiang University, in collaboration with Cardiff University, the University of Tokyo and others, successfully transformed a wide range of everyday plastic waste including polyethylene, polypropylene, and even rubber tyres into value-added organic acids.

These acids are essential chemical building blocks widely used in medicines, food additives, and the manufacturing of biodegradable materials.

Recycling processes of this kind are usually kick-started by expensive and sometimes toxic catalytic technology, according to the team.

Their study, published in the journal Nature, instead offers a simple, economically viable and catalyst-free recycling strategy to one of the world's most pressing environmental challenges.

Professor Yong Wang, the study’s lead author from the Zhejiang Provincial Key Laboratory of Low-carbon Synthesis of High-value Chemicals at Zhejiang University, said: “By eliminating the need for expensive or toxic catalysts entirely, we have removed one of the major economic and environmental barriers to the industrial adoption of chemical plastic recycling.”

The team’s innovation is powered by tiny water droplets.

By simply melting and stirring the plastic in water, the polymer disperses into microscopic droplets.

This process creates a dynamic water-oil interface where highly reactive hydroxyl radicals are generated spontaneously.

These natural radicals act as “chemical scissors,” neatly cleaving the tough bonds of the polymer chain.

Using polyethylene as a model, the team achieved near-complete plastic conversion with a 69% yield of short-chain diacids under mild conditions, leaving no microplastic residues behind.

Professor Graham Hutchings, one of the study’s co-authors and Regius Professor of Chemistry at Cardiff University’s Cardiff Catalysis Institute, added: “We are awash with plastic waste, and we need viable solutions for its effective recycle. Our discovery shows the way, demonstrating that water and oxygen alone – under the right microdroplet conditions – are powerful enough to drive the selective oxidation of some of the most chemically inert and durable materials on Earth.”

While the unique chemical properties of microdroplet interfaces have fascinated scientists for years, this study marks the first time the phenomenon has been harnessed at a practically relevant scale.

The researchers successfully scaled up the process to a 300g batch in the lab, demonstrating its commercial viability.

Crucially, the method is robust enough to tolerate commercial additives and mixed waste streams that would typically poison and deactivate conventional catalysts. Furthermore, it works perfectly using both tap water and seawater.

The paper, ‘Catalyst-free, microdroplet-mediated waste plastic conversion to diacids’, is published in Nature.

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Low carbon dioxide levels improve microbial production of biodegradable plastic



Nonflammable gas mixtures improve carbon dioxide conversion efficiency for production of biodegradable plastic



Institute of Science Tokyo

How CO₂ Levels Affect the Production of Biodegradable Plastic P(3HB) 

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Researchers found that low CO₂ levels under non-combustible gas conditions can increase P(3HB) production by improving carbon utilization efficiency.

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Credit: Institute of Science Tokyo (Science Tokyo), Japan






In an innovative gas fermentation process, reducing the concentration of carbon dioxide was found to significantly improve microbial production of the biodegradable plastic, poly[(R)-3-hydroxybutyrate]. Researchers found that hydrogen-oxidizing bacteria grown under safe, nonflammable gas conditions enable more efficient production of biodegradable plastic at lower CO2 levels. The study provides a promising strategy for sustainable carbon recycling and efficient CO2 utilization.

 

As the efforts to reduce carbon dioxide (CO2) emissions accelerate worldwide, scientists are exploring ways to transform this abundant greenhouse gas into useful products. One of these approaches is microbial CO2 conversion, which uses naturally occurring microorganisms to convert CO2 into sustainable materials. Particularly, Ralstonia eutropha (a hydrogen-oxidizing bacterium) is widely used in this process, and uses hydrogen, oxygen, and CO2 for synthesis of biodegradable plastics such as poly[(R)-3-hydroxybutyrate] (P(3HB)).

Conventional gas fermentation systems often require high hydrogen concentrations in flammable range, which affects the safety of the process. To address this, a research team from Institute of Science Tokyo (Science Tokyo), Japan, had previously developed a noncombustible gas culture system. Now, the group used the noncombustible system and investigated how adjusting the concentration of CO2 could improve the production of P(3HB) under safe operating conditions. The study was led by Assistant Professor Yuki Miyahara from the Department of Materials Science and Engineering, Science Tokyo, in collaboration with graduate student Chih-Ting Wang, Postdoctoral Researcher Ramamoorthi M Sivashankari, and Professor Takeharu Tsuge, all from Science Tokyo. The findings were made available online on April 17, 2026, and published in Volume 14, Issue 16 of the journal ACS Sustainable Chemistry & Engineering on April 27, 2026.

“We observed that reducing CO2 concentration resulted in higher production of P(3HB),” explains Miyahara.

On the contrary to the conventional expectations, the researchers discovered that lowering the supply of CO2 to approximately 1.4% by volume, significantly increased the accumulation of P(3HB) inside the cells. Moreover, the bacteria not only produced more plastic but also converted the CO2 more efficiently than the cultures grown under higher CO₂ concentrations.

To further understand why low CO₂ concentrations improved polymer production, the team investigated the role of carbonic anhydrase (Can), which is an enzyme that rapidly converts CO2 into bicarbonate. Since this reaction plays an important role in supplying inorganic carbon for cellular metabolism, the researchers tested whether increasing the enzyme’s activity could enhance the production of P(3HB). The results revealed that increasing Can expression boosted the accumulation of P(3HB), but only under low CO₂ conditions. This suggests that efficient carbon processing within the cells is very important when external CO2 is limited. The increased expression of Can enzyme ensured ample supply of inorganic carbon, allowing the cells to produce larger amounts of biodegradable plastic.

“The combined effect of low CO2 and enhanced Can activity reveals an effective strategy for improving microbial carbon utilization, making it safer and more efficient,” comments Miyahara.

According to the authors, low CO₂ availability triggers adaptive cellular responses within the bacterial cells, which improve the carbon utilization efficiency. Therefore, instead of limiting the growth, moderate CO2 scarcity encourages the cells to use available carbon more effectively, which results in greater polymer accumulation. However, under higher CO₂ concentrations, these adaptive responses become less pronounced as carbon is already readily available.

Overall, the study inspires the development of industrial processes that are capable of converting low-concentration CO2 sources, such as exhaust gases, into biodegradable plastics. By combining safer gas handling along with improved carbon conversion, the approach offers a promising path for sustainable carbon recycling and reducing the emission of greenhouse gases, while also producing eco-friendly materials.

In the future, the researchers plan to further improve the process and extend this strategy to other microorganisms and products. These advances could accelerate the development of new processes that could transform waste carbon into a wide range of renewable materials, supporting the transition towards a circular carbon economy.

 

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About Institute of Science Tokyo (Science Tokyo)

Institute of Science Tokyo (Science Tokyo) was established on October 1, 2024, following the merger between Tokyo Medical and Dental University (TMDU) and Tokyo Institute of Technology (Tokyo Tech), with the mission of “Advancing science and human wellbeing to create value for and with society.”

 

Reference

DOI: https://doi.org/10.1021/acssuschemeng.6c00126

 

This AI tool doesn’t just speak languages—it invents them



University of Miami machine learning researcher Morris Alper developed ConlangCrafter, a tool that constructs new languages




University of Miami





Artificial intelligence isn’t just capable of translating between existing languages—it can also create entirely new ones.

That’s according to a recent paper published in the Proceedings of the Association for Computational Linguistics on ConlangCrafter, a tool the authors developed that leverages large language models (LLMs) to create novel languages with their own grammar rules and vocabulary.

“The idea of ConlangCrafter is: ‘How can we make new languages that have different linguistic features than what we normally see in natural languages?’” explained Morris Alper, the paper’s first author and an incoming assistant professor in the Department of Computer Science at the University of Miami College of Arts and Sciences.

Morris and co-authors Moran Yanuka, Raja Giryes, and Gašper Beguš designed ConlangCrafter to build new languages step by step, generating a system of sounds as well as grammar rules and vocabulary. They have so far used the tool to create more than 60 different languages and have shared their code on the ConlangCrafter website so others can generate their own.

Users can give ConlangCrafter specific parameters for the constructed languages. The researchers asked the tool to create a language with no consonant sounds, for example, as well as a language for an alien cephalopod species that uses colors and gestures to communicate.

An example of a language created by ConlangCrafter.

Once it creates a new language, ConlangCrafter translates sentences from natural languages into the constructed one and reviews and revises its work, identifying inconsistencies and fixing them. It continually updates a “language sketch,” akin to a design document that keeps track of the new language’s rules.

The resulting languages are more diverse and internally consistent than those generated by simply asking a general-purpose LLM, like Gemini, to create its own language from scratch.

“Imagine if you just say, ‘Make me a language.’ It will give you something that doesn’t make sense,” Alper said. “What we did is build this pipeline where you say, ‘Okay, what are the sounds? And then let’s check them. And then, what are the rules for building words? What about syntax?’ We split the problem apart and have the LLMs solve each sub-problem and combine them together.”

There are numerous potential applications for ConlangCrafter, including helping human language designers create fictional languages for video games, movies, books, and TV shows (think “Game of Thrones” and “The Lord of the Rings,” both of which feature constructed languages).

Beyond creative applications, the authors foresee potential uses in linguistics and computer science research. The tool could potentially help researchers develop technologies for poorly documented languages, for example, for which detailed descriptions exist but not large collections of text. It could also be used to study how languages evolve over time and how AI agents can use constructed languages to communicate with each other.

Morris Alper

The most challenging aspect of the research was figuring out how best to evaluate the new languages, Alper said.

“The hardest part of the work was defining an objective measure to give us numbers that say, ‘How well is the model performing at this task?’” he explained. “That’s really hard to do for creative things.”

The research team created a framework to test how consistently the translations followed each language’s rules and how diverse the new languages are in terms of linguistic features such as the presence of unique sounds and different sentence structures.

Although ConlangCrafter was only recently released, it has already garnered attention in the technology sector. It was recently highlighted in articles in Science and IEEE Spectrum.

Alper developed ConlangCrafter while working as a postdoctoral researcher at Carnegie Mellon University’s Language Technologies Institute. He completed his Ph.D. in multimodal machine learning at Tel Aviv University and his bachelor’s degree in mathematics and linguistics at the Massachusetts Institute of Technology.

As a machine learning researcher studying the intersection between language and multimodal AI, Alper has collaborated with faculty members from other disciplines, including archaeologists studying ancient inscriptions. He is a co-first author of a paper on leveraging artificial intelligence to help read cuneiform, an ancient writing system used across Mesopotamia.

Alper said he was drawn to the University of Miami in large part by its focus on interdisciplinary research.

“It felt to me like the University really encourages collaboration between fields, and I am a very interdisciplinary person,” he said. “My research is on the seam between computer science, linguistics, and digital humanities, and I found that the University of Miami really appreciates that.”

 

At-home, lab-quality HIV tests awarded $1.3 million for development at UMass Amherst



In early studies, the prototype detected cases of HIV not caught by lab tests



University of Massachusetts Amherst



Thakur and Liu 

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Postdoctoral fellow, Rajiv Ranjan Thakur, left, and Associate Professor Chang Liu

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Credit: UMass Amherst


 

In early studies, the prototype detected cases of HIV not caught by lab tests 

 

AMHERST, Mass. — Chang Liu, associate professor in the Riccio College of Engineering at the University of Massachusetts Amherst, wants people to have access to at-home HIV tests sensitive enough for early diagnosis comparable to—or exceeding—lab standards. A new two-year, $1.3 million award from the National Institutes of Health will help him advance his proof-of-concept work toward commercialization. 

 

With 40 years of intervention, AIDS-related mortality has significantly declined to approximately 630,000 deaths per year globally. Despite this progress, 1.3 million new infections occur annually. In the U.S., the “Ending the HIV Epidemic” initiative has made strides, but there are still more than 30,000 new transmissions yearly.  

 

A major bottleneck in progressing further is meeting the “first 95” benchmark: aiming for 95% of people living with HIV to know their status. Globally, 87% of people know their status, meaning that roughly 5.3 million individuals are unaware of their infection.  

 

“This population serves as a silent reservoir of transmission,” says Liu, primary investigator of this research. “This lack of awareness of the HIV status is even more serious in resource-limited settings, such as rural areas within the U.S.” 

 

One of the primary barriers to meeting the “first 95” is access to diagnostic technology. Existing home self-tests have made some headway in these diagnostic deserts, but they are less sensitive than in-lab tests, showing a positive result about 25 days after infection. These tests measure for HIV antibodies. PCR tests that measure viral RNA can detect HIV about 10 days after infection—but can only be conducted in a clinic or hospital setting, require advanced equipment to prepare and run, and are much more expensive.  

 

There is a third type of HIV test that measures for proteins shed by the HIV virus (namely p24 antigen). Historically, these tests have been deemed too insensitive for early detection—taking closer to 20 days post-infection to yield a positive response—and are administered in a clinic or hospital setting. But where others saw a technological barrier, Liu saw an opportunity: Proteins do not require the same kind of pre-processing to be detected as PCR tests do.  

 

Designing a proprietary mechanism called Click Chemistry Amplified Nanopore (CAN) sensing, Liu and colleagues invented a device capable of detecting extremely low concentrations of the p24 antigen. In Liu’s first test validating this device with real patients, it detected p24 in 87.3% of patients with low viral load, where ELISA only detects 18.2%, and 100% in patients with high viral load, where ELISA only detects 42.1%. These results were met with a prototype about the size of a shoebox. 

 

Phase one of this NIH-supported work demonstrated the technology’s feasibility. This new grant for phase two supports the development of their prototype to make it ready for commercialization. This includes refining the prototype design and clinically validating it for self-testing use with 300 patients at Prisma Health in South Carolina, with Helmut Albrecht, medical director of the Center of Infectious Diseases Research and Policy at Prisma Health and the University of South Carolina. 

 

“The device should be very easy for them to operate, even if they have limited education or no technical background,” says Liu. In addition to the initial screening, this new phase will also evaluate the device’s ability to track antigen fluctuations in patients undergoing antiretroviral therapy. 

 

Ultimately, the grant’s target outcome is to create a spinoff startup to bring this technology from the lab to the public. 


The device, about the size of a shoebox, can detect cases of HIV not caught by standard ELISA tests. 

Credit

UMass Amherst