Epidurals not linked to increased harm for newborns or children
Study provides strong evidence that epidural analgesia in labour is safe for newborns, say researchers
DECADES OF USE BEFORE THIS STUDY
Having an epidural during labour is not associated with clinically significant increased risks of harm to newborn babies, including brain injury, severe breathing problems, sepsis and death, or cerebral palsy later in childhood.
The researchers say these findings “support widening availability and equitable access to epidural analgesia as a safe component of intrapartum care.”
Epidural analgesia in labour provides effective pain relief and may help reduce complications in mothers after giving birth, but evidence of its effect on newborn and child health is limited.
To address this, researchers analysed data for 495,695 births in Scotland over a 13 year period (2007-2019) to examine whether epidural analgesia during labour was associated with serious neurological conditions occurring within 28 days of birth.
Only women who delivered a single baby vaginally or via unplanned caesarean section between 24 and 42 weeks of pregnancy were included in the analysis.
Further measures included other severe newborn illness, sepsis, low Apgar score (a routine test of a baby’s health) five minutes after birth, death within 28 days of birth, and cerebral palsy diagnosed at any point during childhood.
Factors such as mother’s age, ethnicity, weight, existing pre-eclampsia or diabetes, smoking history, birth location and gestational age at birth, were also taken into account.
Of nearly 500,000 women included in the study, around one in four had an epidural during labour. Overall, serious neurological conditions were rare, affecting fewer than 1 in 1,000 babies. These conditions occurred at the expected rate and were no more common among babies whose mothers had an epidural compared with those who did not.
No association was found between epidural analgesia in labour and serious neurological conditions, other severe newborn illness, sepsis, low Apgar score at five minutes, death at 28 days, or cerebral palsy in childhood.
This is an observational study so no firm conclusions can be drawn about cause and effect, and the authors acknowledge that the study was limited to women delivering in Scotland, a predominantly white population, so the findings may not apply to more ethnically diverse populations or other healthcare settings.
However, this was a large study with long term follow-up of newborn and childhood outcomes, and results were consistent after additional analyses across various groups including women considered to have high risk pregnancies and preterm births, supporting the reliability of the findings.
As such, the authors conclude: “These results should reassure parents and clinicians that epidural analgesia use in labour is safe for babies and support informed, evidence based decision making about analgesic options in labour.”
Method of Research
Observational study
Subject of Research
People
Article Title
Epidural analgesia in labour and neonatal and childhood outcomes: national population based cohort study
Article Publication Date
15-Jul-2026
COI Statement
: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: support form NHS Greater Glasgow and Clyde, Wellbeing of Women, Chief Scientist Office (Scotland), UK Medical Research Council, and British Heart Foundation; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work. Outside of the submitted work, RK is a board member of the Obstetric Anaesthetists’ Association. RK has declared funding from Wellbeing of Women (for research unrelated to this work in the past 36 months). SMN has participated in advisory boards and received speakers or consultancy fees from Access Fertility, Beckman Coulter, Ferring, Finox, Merck, MSD, Roche Diagnostics, and The Fertility Partnership. SMN has declared funding from the Chief Scientist Office, Wellbeing of Women, and National Institute of Health and Care Research (NIHR), for research unrelated to this work in the past 36 months. All funds for these grants go to and are managed and audited by the University of Glasgow. DAL has declared funding from the NIHR, Diabetes UK, and US National Institute of Research, for research unrelated to this work in the past 36 months. All funds for these grants go to and are managed and audited by the University of Bristol. DAL is a member of the UK Biobank strategic oversight committee, chair of the scientific advisory board for the Bradford Health Research Institute public health “ActEarly” Programme, and chair of the NIHR and BHF (British Heart Foundation) partnership working group on maternal cardiovascular health. She does not receive any payment for these activities. MS, AK, and SS certify they have no affiliations with or involvement in any organisation or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. The authors declare no other relationships or activities that could appear to have influenced the submitted work.