Tuesday, August 18, 2026

 

Ancient Egyptian tomb shows how burial trends changed over hundreds of years



Placement of mummies in a Theban tomb – from individual placement to stacking of bodies – shows how burial practices and their symbolic implications changed over time




Frontiers

Mummified individuals from TT 209 

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Figure 3 — Mummified individuals from Side Chamber 3 of Theban Tomb 209, showing variation in body orientation and arm position.

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Credit: Proyecto dos cero nueve, Universidad de La Laguna / Jared Carballo-Pérez.





The Theban Necropolis, opposite Luxor, is comprised of more than 400 tombs. In a new Frontiers in Environmental Archaeology study, researchers in Spain examined a part of one of these tombs – chamber three in tomb TT 209 – more closely to reconstruct how this burial space was used and reused between its construction during the Twenty-fifth Dynasty (754-656 BCE) and the Ptolemaic period (305–30 BCE), when it was abandoned.

“We found a total of 16 mummified human individuals, a mummified dog, and a disturbed deposit containing the remains of at least four individuals,” said first author Dr Jared Carballo-Pérez, a researcher at the University of La Laguna. “The detailed study of the bodies indicates neither chaotic accumulation nor a loss of the original ritual over time. Rather, there was a spatial logic in which each new deposition was adapted to the presence of previous bodies – a kind of funerary memory in the processes of reuse.”

Senior author Dr Miguel Ángel Molinero Polo, a professor of Egyptology at the University of La Laguna, added: “We have few details regarding how the people who entered tombs behaved, what their motivations were in each historical period, and how they conceptually reconfigured the pre-existing space.”

Tomb through time

To deepen the understanding of the deposition of bodies and the transformation of funerary space, the team excavated the chamber, photographed the mummies, and produced sketches and descriptions of their position, orientation, and relationship with the tomb’s structures. The chamber contains nine funerary deposits, comprising individual and multiple burials, as well as associated funerary objects.

For the earliest deposits, the team observed relatively separated burials where bodies were placed in coffins.

“The earliest individuals buried here appear to have been of high social standing, as they were interred in coffins, with funerary nets and amulets, and with an assemblage containing costly items, such as the contents held in Phoenician amphorae, a large number of which were found alongside them,” said Molinero Polo.

Later, towards the end of the 25th dynasty and the Persian period (around 680-404 BCE), bodies started being inserted into any space still available. This resulted in denser use of space. In some cases, a change could be seen in the positioning of limbs, for example a folded-in arm whereas in earlier burials arms were typically stretched out. Also in the Persian period, the team observed a shift from individual deposits to a vertical way of arranging bodies. Superposition of bodies was found in two thirds of the burials in the chamber.

Reconstructing funerary practices

In the southeastern section of the chamber, four mummies and one mummified dog are buried on top of one another in the Ptolemaic Period.

“The bodies buried in vertical superposition did not have coffins but were carefully mummified. They also can be associated with upright jars that point to a specific ritual not found in the earlier phases of the tomb’s use,” said Molinero Polo.

“One detail I find quite beautiful is the presence of a mummified dog placed directly on top of the mummies of a man and a woman,” said Carballo-Pérez. “This could indicate a close relationship between these human individuals and the animal, an idea that I think is quite easy to empathize with.”

“It could also reflect a further change in ritual practice, with an animal taking on the role of a psychopomp, a symbolic helper in the journey to the afterlife,” added Molinero Polo.

This, alongside certain changes in the arrangement of bodies – for example, in later deposits individuals were buried with both arms folded over their chests in what Egyptologists call the Osirian position – suggests that the tomb did not become disordered or without structure, or that cultural rites were lost. Instead, the chamber should be considered a repeatedly reactivated space, reconfigured by new burials that transformed the organization and meaning of space itself without erasing the past.

In some funerary deposits, it is difficult to identify the exact sequence of depositions and reconstruct the precise intentionality behind them, the team noted. This is due to century-long use during which the chamber flooded multiple times as well as fires and human re-entry that transported debris within the tomb.

“Nevertheless, what we present means that deposits that were previously considered ‘disordered’ can be reinterpreted,” concluded Carballo-Pérez. “This helps us develop a better understanding of the social behaviors behind funerary practices.”

 

Fiber-optic cable reveals hidden crevasses within the ice




ETH Zurich
Tent next to the Gornergletscher 

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ETH researcher Thomas Hudson camped overnight beside the Gorner Glacier, with Monte Rosa and the Dufourspitze (4,634 m) visible in the background. 

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Credit: Thomas Hudson / ETH Zurich





In recent years, the Alps have experienced devastating glacier collapses: in September 2023, a section of the Marmolada glacier in the Dolomites collapsed, resulting in the deaths of seven mountaineers. Just over a year and a half later, in May 2025, the Birch Glacier above Blatten collapsed, keeping Switzerland and the entire world in suspense. 

Crevasses are crucial to the stability of glaciers, not only those that satellites and drones can detect on the surface but also those hidden within the ice. This is because meltwater can deepen them and accelerate the collapse of glaciers and ice sheets. 

Researchers use seismic techniques to explore the inner workings of glaciers. Microearthquakes occur when crevasses open within the ice, and seismometers can detect them to pinpoint their sources. However, these measurements lack high spatial resolution, and deploying many seismometers is challenging due to high costs and the difficulty of installing them on a glacier ridden with crevasses. 

One cable replaces hundreds of measuring instruments 

ETH researchers led by Assistant Professor Thomas Hudson from the Environmental and Exploration Geophysics Group have demonstrated in a new study published in Science Advances that this can be done more simply, cost-effectively and with significantly higher spatial resolution. 

For testing, the researchers laid a single fibre-optic cable on the surface of the Gorner Glacier in Valais. This enabled them to explore the glacier’s internal structure down to a depth of 25 metres. “A single fibre-optic cable replaces hundreds of seismometers,” emphasises Hudson. 

The cable simply needs to be connected to what is known as an interrogator, which injects a light signal into the fibre and records the scattered light signals that are reflected back. Seismic waves are generated when a microearthquake occurs, such as a crevasse opening up in the ice. These waves cause a slight local deformation as they hit the fibre, leading to changes in how the injected light is deflected and reflected. This results in a change in the baseline signal, alerting researchers to the location and depth of a crevasse. 

Using computational methods, the researchers can determine the structure of the ice and gain an insight into its internal composition, similar to an ultrasound scan performed by a doctor. Analysing the data is computationally demanding due to the vast amount of data generated. The researchers use an algorithm to assist with this. 

Employing this method on the Gorner Glacier, the wave physicists uncovered a surprisingly large number of hidden crevasses, which accounted for more than eight percent of the ice volume at the measurement site. “That’s far more than we expected,” says Hudson. The crevasses contained water or air, while the rest of the ice ؎ 92 percent – remained undisturbed. 

Not all crevasses are visible from the air. Hudson emphasises that they greatly impact the glacier’s stability. “Laypeople often assume that large, visible surface crevasses indicate whether a glacier is stable or not. However, scientists pay more attention to internal cracks and crevasses inside the ice,” he explains. Consequently, analysing these internal fractures is essential for researchers when determining whether a glacier is at risk of calving. 

Measurement method proves its worth 

The researcher states, “We are very pleased with the test runs on the Gorner Glacier. The method has proven its worth.” In future, it could assist in monitoring unstable glaciers and providing early warnings of calving events at glacier fronts. This would improve our ability to evaluate the risk of major calving events. 

The researchers could extend their mapping of crevasses to other glaciers in the Alps and the ice sheets of Greenland or Antarctica to better understand their stability. Data collected from within the glaciers could complement satellite surface observations. 

How crevasses affect sea level 

The ETH researchers plan to further test their technique on other glaciers across the Swiss Alps and on polar ice sheets. They aim to understand the development of crevasses over time and space, as well as the connection between surface crevasses and those deeper within the ice. Glacier crevasses influence more than just the glacier – they alter its overall behaviour. Water that enters these crevasses acts as a lubricant at the glacier’s base, potentially accelerating its movement. This effect is globally significant, especially for the gigantic ice sheets of Greenland and Antarctica, which greatly impact sea levels. “Our method could therefore help to predict changes in the ice sheets and sea levels,” Hudson explains.

Reference

Hudson T, Walter F, Noe S et al.: Quantifying subsurface fracture damage in glaciers using fiber-optic seismology, Science Advances 2026. 12: eaef1107, DOI: 10.1126/sciadv.aef1107


Gornergletscher 

ETH researcher Thomas Hudson camped overnight beside the Gorner Glacier, with Monte Rosa and the Dufourspitze (4,634 m) visible in the background. 

Credit

Thomas Hudson / ETH Zurich

 

Mapping plant-fungus symbiosis, cell by cell




Vlaams Instituut voor Biotechnologie





Ghent, 18 August 2026 – Scientists at VIB and Ghent University have produced the first high-resolution, cell-by-cell map of how tomato roots respond to colonization by arbuscular mycorrhizal fungi. These ancient fungal partners help plants absorb nutrients from the soil. The study, published in Current Biology, reveals the precise molecular programs that unfold as the symbiosis progresses through different stages, and identifies promising new genetic regulators that could one day be used to engineer more efficient, sustainable crops.

In short:

  • Single-cell study by VIB-UGent researchers led by Prof. Sofie Goormachtig reveals how tomato roots respond to arbuscular mycorrhizal fungi.

  • Gene activity was mapped in nearly 66,000 individual root cells colonized by the fungus Rhizophagus irregularis.

  • The researchers identified four successive stages of fungal colonization and nutrient-exchange development.

  • These insights could help develop crops that use nutrients more efficiently and reduce reliance on synthetic fertilizers.

An ancient partnership, newly decoded

Arbuscular mycorrhizal fungi form symbioses with the vast majority of land plants, a relationship that dates back more than 400 million years. In exchange for sugars supplied by the plant, the fungi dramatically improve the plant's access to phosphate, nitrogen, and other nutrients, which reduces the need for chemical fertilizers.

"Despite decades of research," says Prof. Sofie Goormachtig (VIB-UGent Center for Plant Systems Biology), "the molecular details of how plants accommodate fungal structures called arbuscules – the main sites of nutrient exchange – inside their root cells remained poorly understood, largely because different stages of colonization occur simultaneously in the same root, making them difficult to separate using conventional methods."

A molecular snapshot, cell by cell

To tackle this challenge, the team of Prof. Sofie Goormachtig, with the help of the VIB Single Cell Core, used a cutting-edge technology that reads the activity of genes in individual cells one by one. Applied to tomato roots colonized by the fungus Rhizophagus irregularis, the approach generated gene activity profiles for nearly 66,000 individual cells. To ensure the team was looking at the right material, they used a fluorescent tag to light up root regions where the fungus was actively present, allowing them to zoom in on the most relevant tissue.

Within this dataset, the researchers identified a group of cells that responded specifically to fungal colonization.

"We found four successive stages of the interaction," explains Dr. Naomi Stuer (VIB-UGent), first author of the study. "Root surface cells sensing the arriving fungus, inner cells gearing up to let it in, cells in the process of building nutrient-exchange structures, and finally cells housing fully functional fungal structures ready for nutrient trade. Each stage has its own characteristic molecular signature, which helps us understand how the plant gradually rewires its cells as the partnership develops."

New molecular switches discovered

To find out which molecular switches, known as transcription factors, are pulling the strings at each stage, the team used MINI-EX, a computational tool to predict which regulators control which genes. The analysis confirmed many regulators already known to play a role in this symbiosis, but it also uncovered several previously unsuspected candidates. Three of these new candidates were then tested directly in living tomato roots, where they showed exactly the stage-specific activity the computational tool had predicted.

The study also brought several broader insights. First, a key signaling pathway previously thought to act only at the root surface turns out to remain active much deeper inside the root, throughout the formation of the fungal nutrient-exchange structures. Parts of this pathway may help prepare specific inner cortical cells for arbuscule formation by altering their metabolism and development. Because these cells look identical to other inner cortical cells, they have remained largely understudied, making this dataset one of the first glimpses into the early processes that precede arbuscule formation. Finally, the cells hosting mature fungal arbuscules appear to integrate information about the plant's overall nutrient status, suggesting that the plant carefully fine-tunes how much it invests in the symbiosis depending on how well-fed it already is.

"What excites me most about this dataset is that it doesn't just confirm what we suspected; it opens entirely new doors," said Dr. Judith Van Dingenen (VIB-UGent), co-senior author. "We can now pinpoint, with single-cell resolution, which genes are switched on or off at each stage of fungal colonization, and start asking why."

Towards smarter, more sustainable crops

Understanding the molecular logic of mycorrhizal symbiosis has direct practical relevance: plants that form more efficient partnerships with fungi can access soil nutrients more effectively, reducing dependence on synthetic fertilizers and improving resilience under stress conditions. The dataset and the candidate regulators identified in this study represent a valuable resource for future efforts to optimize the symbiosis in crops.

 

Muscle-boosting molecule released during exercise




University of Leeds





Scientists have discovered that a key molecule released during exercise strengthens muscles, improves exercise performance and could be a therapeutic treatment for muscle damage caused by type 2 diabetes.

Research has revealed that the molecule L-β-aminoisobutyric acid (L-BAIBA) is required for muscle to adapt to exercise, making it stronger and protecting against damage and weakness.

The study, which is published today (18 August) in Nature Communications and funded by Diabetes UK and the Biotechnology and Biological Sciences Research Council (BBRSC) identifies that L-BAIBA is a central regulator of how muscles remodel, strengthen, and improve their endurance in response to exercise training.

How exercise impacts on the body’s ability to respond to challenges is not fully understood. Given the health benefits of exercise, the research team, led by Professor Lee Roberts at the University of Leeds, set out to discover whether this mechanism could hold the potential for treatment for chronic conditions such as type 2 diabetes.

L-BAIBA has been studied in the past and Professor Roberts carried out research in 2014 which showed that it had beneficial effects on metabolism, boosting the fat-burning effects of exercise. It can now be purchased as a nutritional supplement.

His most recent study found that it also triggers muscles to respond and change, linking exercise to beneficial alternations in muscle structure and metabolism.

Lee Roberts, Professor of Molecular Physiology and Metabolism at the University of Leeds, said: "Our research identifies L-BAIBA as an exercise-induced signal that helps muscles adapt, improve their metabolic capacity and ability to contract, and ultimately enhances physical performance.

“This gives us exciting new insight into how exercise benefits the body and highlights a promising target for future therapies aimed at preserving muscle function in chronic conditions such as diabetes.

L-BAIBA also protects muscle from damage that occurs in type 2 diabetes which can limit a person’s quality of life, such as loss of muscle and strength, and impaired metabolism. Improving muscle resistance to fatigue could be transformative, as exercise can help to manage diabetes.

Type 2 diabetes is a serious condition which can lead to complications such as heart attacks and strokes. The reasons why type 2 diabetes develops are complex. Risk factors include age, ethnicity, genetics and living with obesity or overweight. Type 2 diabetes has historically been associated with older people, but cases among under-40s have been rising in recent years and are now increasing at a faster rate than among people over 40.

Anna Morris, Assistant Director of Research Strategy and Partnership at Diabetes UK, said: “Exercise plays an important role in managing type 2 diabetes, but for many people muscle weakness and fatigue can make staying active a real challenge. This research helps us better understand how muscles adapt to exercise and identifies a potential new target for improving muscle health. While these findings are still at an early stage, they could help shape future approaches that support people with type 2 diabetes to remain active and live healthier, longer lives.” 

Further information 

The study, metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis, is published at 10am on Tuesday 18 August 2026 in Nature Communications. The DOI is 10.1038/s41467-026-76307-8.

The research was led by the University of Leeds in partnership with

  • Harvard Medical School, USA
  • University of Sau Paulo, Brazil
  • Wageningen University, Netherlands
  • Newcastle University UK

The research was funded by Diabetes UK and BBSRC.

 

Emotion-regulation training reduces distress, changes the brain, team reports


Spontaneous resting-state functional connectivity changed after 5 weeks of training




University of Illinois at Urbana-Champaign, News Bureau

The researchers at Illinois 

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A new study led by U. of I. psychology professors Sanda and Florin Dolcos and a colleague at the Phoenix VA Healthcare Center, pictured below, found that college students benefited from training in techniques to regulate their negative emotions. 

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Credit: Photo by Fred Zwicky





CHAMPAIGN, Ill. — A five-week training intervention taught college students to better regulate their emotions in response to negative events, a new study finds. After the training, the students reported less emotional distress when viewing negative images or thinking about difficult events from their own lives, and brain scans revealed corresponding changes in the spontaneous functional connectivity of their brains.

The findings are detailed in the journal Scientific Reports.

The new work builds on insights from a 2021 study of emotional resilience in veterans. That study trained the veterans to use two emotion-regulation strategies: one in which they focused their attention on neutral contextual features of photos or memories of negative events, and the other a method called “cognitive reappraisal,” which involved reflecting on the potentially positive dimensions of otherwise distressing memories or images. The veterans who were trained in these techniques experienced less emotional distress in response to the memories and images afterward, the researchers found. Functional MRI brain scans also showed changes in how the trainees processed cognitive and emotional information.

“After seeing promising results in veterans, we extended the intervention to college students,” said University of Illinois Urbana-Champaign psychology professor Sanda Dolcos, who led the new work with Kelly Hohl, a postdoctoral resident at the Phoenix VA Healthcare Center, and U. of I. psychology professor Florin Dolcos. “We wanted to know whether training in the flexible use of focused attention and cognitive reappraisal could help young adults develop more adaptive responses to stress, while also uncovering the cognitive mechanisms supporting resilience.”

The researchers wanted to test the same emotion-regulation techniques in young people experiencing low-level chronic stress at a time in their lives when brain systems supporting self-regulation continue to mature. While veterans face significant stress, including trauma-related symptoms, college students encounter different but important challenges related to academic demands, social transitions and emerging adulthood, Sanda Dolcos said.

For the focused-attention training, “we taught the college students to focus on the background of certain emotional images,” she said. “We directed them to look more at the neutral, more contextual aspects of a scene.”

In a photo of a traffic accident, for example, participants might practice focusing on background elements such as trees, intact cars on the roadway or a blue sky.

“Eye-tracking research has shown that emotion regulation is reflected in modulations of gaze patterns,” the researchers wrote. Reducing one’s fixation on the emotional parts of an image and turning one’s attention to neutral background elements has been found to aid in regulating emotions.

For the cognitive reappraisal training, researchers asked participants to practice reinterpreting potentially negative emotional situations in a more positive light. These situations included those depicted in photos provided by the researchers as well as the students’ own experiences.

The participants engaged in the training exercises twice a week for five weeks. The researchers also encouraged them to practice the emotion-regulation techniques in their daily lives.

Before and after the training, the students answered questions about their mood, levels of anxiety and worry and potential PTSD symptoms. Most of those in the training group also underwent neuroimaging scans while awake but not engaged in a task. This approach captures a person’s spontaneous, or resting state “functional connectivity,” a baseline measure of how various brain regions communicate with one another.

Follow-up questionnaires, eye-tracking patterns and brain scans revealed that participants were increasingly engaged in the focused attention method and relied less on cognitive reappraisal. The trainees experienced less emotional distress in response to negative images and memories at the end of the five weeks than at the beginning, and less than those in the control group, who were not trained. They spent less time looking at emotionally charged areas of pictures without being prompted to do so.

The brain scans revealed significant changes in the way different brain networks were communicating, with more reliance on “top-down” versus “bottom-up” processing after the training, the researchers said.

Top-down processing involves several brain structures, many in the prefrontal cortex at the front of the brain behind the forehead, while bottom-up processing engages the limbic system, including brain regions like the amygdala, which lie deeper within the brain, the researchers said.

“Bottom-up processing helps us detect and respond to important information in our environment; whereas top-down processing allows us to intentionally guide our attention and responses based on our goals,” Hohl said. “For adaptive functioning, the brain needs to flexibly balance both processes.”

The brain scans of trained individuals revealed more connectivity in parts of the prefrontal cortex, and “a reduction in the sensitivity of regions associated with negative emotions” after the training, Florin Dolcos said. The training also led to more efficient brain connectivity, he said.

The study shows that emotional resilience is something that can be trained, and the evidence for that is seen in the documented changes in behavior and in the brain, Sanda Dolcos said.

“We are seeing that resilience is about flexibility,” she said. “The key to resilience is not avoiding negative emotions or just simply trying to feel positive all the time; it’s more about developing the flexibility to respond to emotions in ways that fit the situation.”

A follow-up analysis is more closely examining the impact of training on the participants’ written narratives of their distressing memories and the associated brain changes, the researchers said.

Sanda and Florin Dolcos are faculty in the Beckman Institute for Advanced Science and Technology at the U. of I.

 

Editor’s note:  

To reach Sanda Dolcos, email sdolcos@illinois.edu

To reach Kelly Hohl, email kmhohl12@gmail.com

To reach Florin Dolcos, email fdolcos@illinois.edu

The paper “Enhancing resilience, flexibility, and well-being through cognitive-emotional training: behavioral and evidence” is available online.

DOI: 10.1038/s41598-026-63059-0